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Transcription factor bHLH63 (Basic helix-loop-helix protein 63) (AtbHLH63) (bHLH 63) (Protein CRYPTOCHROME INTERACTING BASIC-HELIX-LOOP-HELIX 1) (Transcription factor EN 84) (bHLH transcription factor bHLH063)
BH063_ARATH Reviewed; 335 AA.
Q8GY61; O65678; Q8L851; Q8S3D9;
16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
13-FEB-2019, entry version 111.
RecName: Full=Transcription factor bHLH63;
AltName: Full=Basic helix-loop-helix protein 63;
Short=AtbHLH63;
Short=bHLH 63;
AltName: Full=Protein CRYPTOCHROME INTERACTING BASIC-HELIX-LOOP-HELIX 1;
AltName: Full=Transcription factor EN 84;
AltName: Full=bHLH transcription factor bHLH063;
Name=BHLH63; Synonyms=CIB1, EN84; OrderedLocusNames=At4g34530;
ORFNames=T4L20.110;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
NOMENCLATURE.
STRAIN=cv. Columbia;
PubMed=12679534; DOI=10.1093/molbev/msg088;
Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
"The basic helix-loop-helix transcription factor family in plants: a
genome-wide study of protein structure and functional diversity.";
Mol. Biol. Evol. 20:735-747(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617198; DOI=10.1038/47134;
Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G.,
Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N.,
Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M.,
Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M.,
Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T.,
Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I.,
Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P.,
Langham S.-A., McCullagh B., Bilham L., Robben J.,
van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F.,
Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W.,
Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P.,
Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H.,
De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R.,
van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S.,
Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R.,
Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S.,
Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H.,
Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R.,
Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S.,
Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E.,
Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A.,
Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T.,
Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C.,
Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S.,
Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K.,
Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L.,
Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J.,
Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J.,
Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D.,
Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D.,
Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C.,
Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C.,
Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R.,
Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S.,
Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A.,
Chen E., Marra M.A., Martienssen R., McCombie W.R.;
"Sequence and analysis of chromosome 4 of the plant Arabidopsis
thaliana.";
Nature 402:769-777(1999).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=11910074; DOI=10.1126/science.1071006;
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
Shibata K., Shinagawa A., Shinozaki K.;
"Functional annotation of a full-length Arabidopsis cDNA collection.";
Science 296:141-145(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[6]
GENE FAMILY.
PubMed=12897250; DOI=10.1105/tpc.013839;
Toledo-Ortiz G., Huq E., Quail P.H.;
"The Arabidopsis basic/helix-loop-helix transcription factor family.";
Plant Cell 15:1749-1770(2003).
[7]
GENE FAMILY, AND NOMENCLATURE.
PubMed=14600211; DOI=10.1105/tpc.151140;
Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E.,
Heim M.A., Jakoby M., Werber M., Weisshaar B.;
"Update on the basic helix-loop-helix transcription factor gene family
in Arabidopsis thaliana.";
Plant Cell 15:2497-2502(2003).
[8]
FUNCTION, INTERACTION WITH CRY2, AND SUBCELLULAR LOCATION.
PubMed=18988809; DOI=10.1126/science.1163927;
Liu H., Yu X., Li K., Klejnot J., Yang H., Lisiero D., Lin C.;
"Photoexcited CRY2 interacts with CIB1 to regulate transcription and
floral initiation in Arabidopsis.";
Science 322:1535-1539(2008).
[9]
INTERACTION WITH IBH1.
PubMed=23161888; DOI=10.1105/tpc.112.105023;
Ikeda M., Fujiwara S., Mitsuda N., Ohme-Takagi M.;
"A triantagonistic basic helix-loop-helix system regulates cell
elongation in Arabidopsis.";
Plant Cell 24:4483-4497(2012).
[10]
BIOTECHNOLOGY.
PubMed=22847441; DOI=10.1073/pnas.1211305109;
Idevall-Hagren O., Dickson E.J., Hille B., Toomre D.K., De Camilli P.;
"Optogenetic control of phosphoinositide metabolism.";
Proc. Natl. Acad. Sci. U.S.A. 109:E2316-E2323(2012).
[11]
FUNCTION, AND INTERACTION WITH CRY2.
PubMed=24130508; DOI=10.1371/journal.pgen.1003861;
Liu Y., Li X., Li K., Liu H., Lin C.;
"Multiple bHLH proteins form heterodimers to mediate CRY2-dependent
regulation of flowering-time in Arabidopsis.";
PLoS Genet. 9:E1003861-E1003861(2013).
[12]
INDUCTION BY BLUE LIGHT.
STRAIN=cv. Columbia;
PubMed=24101505; DOI=10.1073/pnas.1308987110;
Liu H., Wang Q., Liu Y., Zhao X., Imaizumi T., Somers D.E.,
Tobin E.M., Lin C.;
"Arabidopsis CRY2 and ZTL mediate blue-light regulation of the
transcription factor CIB1 by distinct mechanisms.";
Proc. Natl. Acad. Sci. U.S.A. 110:17582-17587(2013).
[13]
INTERACTION WITH CRY2.
PubMed=24780222; DOI=10.1016/j.ab.2014.04.023;
Cui Y., Choudhury S.R., Irudayaraj J.;
"Quantitative real-time kinetics of optogenetic proteins CRY2 and
CIB1/N using single-molecule tools.";
Anal. Biochem. 458:58-60(2014).
[14]
BIOTECHNOLOGY.
PubMed=24718798; DOI=10.1007/978-1-4939-0470-9_8;
Idevall-Hagren O., Decamilli P.;
"Manipulation of plasma membrane phosphoinositides using photoinduced
protein-protein interactions.";
Methods Mol. Biol. 1148:109-128(2014).
[15]
BIOTECHNOLOGY.
PubMed=25963241; DOI=10.1016/j.chembiol.2015.04.014;
Duan L., Che D., Zhang K., Ong Q., Guo S., Cui B.;
"Optogenetic control of molecular motors and organelle distributions
in cells.";
Chem. Biol. 22:671-682(2015).
-!- FUNCTION: Transcription factor that binds DNA to G box 5'-CACGTG-
3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds
to chromatin DNA of the FT gene and promotes its expression, and
thus triggers flowering in response to blue light.
{ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:24130508}.
-!- SUBUNIT: Homodimer (Probable). Interacts with IBH1
(PubMed:23161888). Binds reversibly to CRY2 after blue light
illumination (PubMed:18988809, PubMed:24780222, PubMed:24130508).
{ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:23161888,
ECO:0000269|PubMed:24130508, ECO:0000269|PubMed:24780222,
ECO:0000305}.
-!- INTERACTION:
Q9C8Z9:BHLH148; NbExp=3; IntAct=EBI-4469930, EBI-4434374;
Q96524:CRY2; NbExp=3; IntAct=EBI-4469930, EBI-531555;
Q9SKX1:IBH1; NbExp=3; IntAct=EBI-4469930, EBI-4433589;
Q9LXU1:PIM1; NbExp=3; IntAct=EBI-4469930, EBI-15193025;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00981, ECO:0000269|PubMed:18988809}.
-!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, and
stems. {ECO:0000269|PubMed:12679534}.
-!- INDUCTION: Accumulates strongly in response to blue light due to
reduced preventing 26S proteasome-mediated degradation in an
ADO1/ZTL and ADO2/LKP2 dependent manner, but levels decrease in
the absence of blue light via 26S proteasome degradation (at
protein level). {ECO:0000269|PubMed:24101505}.
-!- BIOTECHNOLOGY: The blue light-mediated interaction between CRY2
and BHLH63/CIB1 is used to design an optogenetic control of target
proteins or organelles. {ECO:0000269|PubMed:22847441,
ECO:0000269|PubMed:24718798, ECO:0000269|PubMed:25963241}.
-!- SEQUENCE CAUTION:
Sequence=CAA18832.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAB80170.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; AF488596; AAM10952.1; -; mRNA.
EMBL; AL023094; CAA18832.1; ALT_SEQ; Genomic_DNA.
EMBL; AL161585; CAB80170.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002687; AEE86389.1; -; Genomic_DNA.
EMBL; AK117846; BAC42487.1; -; mRNA.
EMBL; AY120741; AAM53299.1; -; mRNA.
EMBL; BT005313; AAO63377.1; -; mRNA.
PIR; T05273; T05273.
RefSeq; NP_195179.2; NM_119618.3.
UniGene; At.48937; -.
ProteinModelPortal; Q8GY61; -.
SMR; Q8GY61; -.
BioGrid; 14886; 40.
DIP; DIP-59356N; -.
IntAct; Q8GY61; 37.
STRING; 3702.AT4G34530.1; -.
PaxDb; Q8GY61; -.
EnsemblPlants; AT4G34530.1; AT4G34530.1; AT4G34530.
GeneID; 829604; -.
Gramene; AT4G34530.1; AT4G34530.1; AT4G34530.
KEGG; ath:AT4G34530; -.
Araport; AT4G34530; -.
TAIR; locus:2139484; AT4G34530.
eggNOG; ENOG410IGTK; Eukaryota.
eggNOG; ENOG410YGAM; LUCA.
HOGENOM; HOG000238007; -.
InParanoid; Q8GY61; -.
OMA; GYSHEMV; -.
OrthoDB; 1022319at2759; -.
PhylomeDB; Q8GY61; -.
PRO; PR:Q8GY61; -.
Proteomes; UP000006548; Chromosome 4.
GO; GO:0005634; C:nucleus; IDA:TAIR.
GO; GO:0003677; F:DNA binding; IDA:TAIR.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
GO; GO:0009911; P:positive regulation of flower development; IMP:TAIR.
GO; GO:0009637; P:response to blue light; IDA:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IDA:TAIR.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR024097; bHLH_ZIP_TF.
InterPro; IPR036638; HLH_DNA-bd_sf.
PANTHER; PTHR12565; PTHR12565; 1.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
1: Evidence at protein level;
Activator; Complete proteome; DNA-binding; Flowering; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 335 Transcription factor bHLH63.
/FTId=PRO_0000358758.
DOMAIN 178 228 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
CONFLICT 86 86 L -> F (in Ref. 5; AAM53299).
{ECO:0000305}.
CONFLICT 110 110 M -> V (in Ref. 1; AAM10952).
{ECO:0000305}.
SEQUENCE 335 AA; 37540 MW; 05F0CA14FC2B3C7A CRC64;
MNGAIGGDLL LNFPDMSVLE RQRAHLKYLN PTFDSPLAGF FADSSMITGG EMDSYLSTAG
LNLPMMYGET TVEGDSRLSI SPETTLGTGN FKKRKFDTET KDCNEKKKKM TMNRDDLVEE
GEEEKSKITE QNNGSTKSIK KMKHKAKKEE NNFSNDSSKV TKELEKTDYI HVRARRGQAT
DSHSIAERVR REKISERMKF LQDLVPGCDK ITGKAGMLDE IINYVQSLQR QIEFLSMKLA
IVNPRPDFDM DDIFAKEVAS TPMTVVPSPE MVLSGYSHEM VHSGYSSEMV NSGYLHVNPM
QQVNTSSDPL SCFNNGEAPS MWDSHVQNLY GNLGV
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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1066: Eukaryotic Transcription Initiation
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1182: Eukaryotic Transcription Initiation
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1238: Eukaryotic Transcription Initiation
WP1541: Energy Metabolism
WP177: Eukaryotic Transcription Initiation
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1822: Generic Transcription Pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1906: RNA Polymerase II Transcription
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1930: Transcription
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP272: Blood Clotting Cascade
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP344: Eukaryotic Transcription Initiation
WP405: Eukaryotic Transcription Initiation
WP425: Eukaryotic Transcription Initiation
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP491: Eukaryotic Transcription Initiation
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