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Transcription factor hamlet

 HAM_DROME               Reviewed;         990 AA.
Q8I7Z8; Q9VJ50; Q9VJ52;
24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
23-MAY-2018, entry version 115.
RecName: Full=Transcription factor hamlet;
Name=ham; ORFNames=CG31753;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
TISSUE=Embryo;
PubMed=12193790; DOI=10.1126/science.1072387;
Moore A.W., Jan L.Y., Jan Y.-N.;
"Hamlet, a binary genetic switch between single- and multiple-dendrite
neuron morphology.";
Science 297:1355-1358(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=15075290; DOI=10.1101/gad.1170904;
Moore A.W., Roegiers F., Jan L.Y., Jan Y.-N.;
"Conversion of neurons and glia to external-cell fates in the external
sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-
type respecification.";
Genes Dev. 18:623-628(2004).
-!- FUNCTION: Transcription factor that plays a crucial role in
external sensory organ (ESO) that elaborates from a single
precursor cell (ESOP cell). Mediates the differentiation of
lineage branch that generates the internal 'ES' and 'th' cells
(external sensory neuron and thecogen cells, respectively) from
the IIIB cell. Its absence leads to re-specification of IIIB
daughter cells into external tormagen cells (tr cells), or
internal multidendritic neurons (MD cells). One of its role in the
development of the ESO lineage is to modulate the activity of
Notch and PAX2 signals. {ECO:0000269|PubMed:12193790,
ECO:0000269|PubMed:15075290}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12193790}.
-!- TISSUE SPECIFICITY: Expressed in the developing peripheral nervous
system (PNS). Expressed in the ventral patch in the cephalic
region of the embryo from stage 5, and continues in cephalic
region through stage 15. Expressed in the developing PNS from
stage 11 to 15, with a transient expression in each PNS cluster.
In the ESOP lineage, it is first expressed in the IIIB cell, and
in both ES and th cells, although it is only transiently expressed
in th cells. In the ESOP lineage in the adult, it is also
expressed in the IIIB cell and inherited by its daughter cells, as
in the embryo. {ECO:0000269|PubMed:12193790,
ECO:0000269|PubMed:15075290}.
-!- MISCELLANEOUS: Was named 'hamlet' because of its 'to be or not to
be' role in ESOP cells differentiation.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AY166585; AAN86032.1; -; mRNA.
EMBL; AE014134; AAF53703.4; -; Genomic_DNA.
RefSeq; NP_001246081.1; NM_001259152.1.
RefSeq; NP_001260543.1; NM_001273614.1.
RefSeq; NP_724130.3; NM_165262.3.
UniGene; Dm.17971; -.
ProteinModelPortal; Q8I7Z8; -.
SMR; Q8I7Z8; -.
BioGrid; 61129; 2.
IntAct; Q8I7Z8; 1.
STRING; 7227.FBpp0304333; -.
PaxDb; Q8I7Z8; -.
PRIDE; Q8I7Z8; -.
EnsemblMetazoa; FBtr0305620; FBpp0294066; FBgn0045852.
EnsemblMetazoa; FBtr0305621; FBpp0294067; FBgn0045852.
EnsemblMetazoa; FBtr0332015; FBpp0304333; FBgn0045852.
GeneID; 35135; -.
KEGG; dme:Dmel_CG31753; -.
UCSC; CG31753-RA; d. melanogaster.
CTD; 35135; -.
FlyBase; FBgn0045852; ham.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00900000140928; -.
InParanoid; Q8I7Z8; -.
KO; K22410; -.
OrthoDB; EOG091G0BYE; -.
PhylomeDB; Q8I7Z8; -.
Reactome; R-DME-3214841; PKMTs methylate histone lysines.
Reactome; R-DME-8943724; Regulation of PTEN gene transcription.
GenomeRNAi; 35135; -.
PRO; PR:Q8I7Z8; -.
Proteomes; UP000000803; Chromosome 2L.
Bgee; FBgn0045852; -.
ExpressionAtlas; Q8I7Z8; baseline and differential.
Genevisible; Q8I7Z8; DM.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0003700; F:DNA binding transcription factor activity; IMP:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0048813; P:dendrite morphogenesis; TAS:FlyBase.
GO; GO:0008285; P:negative regulation of cell proliferation; IMP:FlyBase.
GO; GO:0014017; P:neuroblast fate commitment; IMP:FlyBase.
GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
GO; GO:0050773; P:regulation of dendrite development; IMP:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR030413; Ham.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
PANTHER; PTHR24393:SF0; PTHR24393:SF0; 1.
SMART; SM00355; ZnF_C2H2; 9.
SUPFAM; SSF57667; SSF57667; 5.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
2: Evidence at transcript level;
Complete proteome; Developmental protein; Differentiation;
DNA-binding; Metal-binding; Notch signaling pathway; Nucleus;
Reference proteome; Repeat; Transcription; Transcription regulation;
Zinc; Zinc-finger.
CHAIN 1 990 Transcription factor hamlet.
/FTId=PRO_0000046941.
ZN_FING 221 245 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 251 274 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 280 303 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 309 331 C2H2-type 4. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 337 359 C2H2-type 5. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 366 388 C2H2-type 6; atypical.
{ECO:0000255|PROSITE-ProRule:PRU00042}.
ZN_FING 817 839 C2H2-type 7. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 845 868 C2H2-type 8. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 874 896 C2H2-type 9. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
COMPBIAS 150 158 Poly-Ala.
COMPBIAS 170 173 Poly-Gly.
COMPBIAS 400 418 His-rich.
COMPBIAS 434 440 Poly-Ser.
COMPBIAS 441 448 Poly-Ala.
COMPBIAS 732 738 Poly-Ala.
COMPBIAS 961 981 Asn-rich.
SEQUENCE 990 AA; 109228 MW; 3CF038543CA63717 CRC64;
MDAFFKDRAQ AEHILQEWVR RREPVCELDI RDSGGVYAKT PLQRGTRYGP FPMKLSHQPN
DPQLAWKAHS RHYNGWLEPT EDVSTWLKKI RSVQDDCIGE ANLQSYINAG YLWYETNRYV
NAGSEMVVDG RPKSPVQLNE DFMNGGKVLA AAAAAAAAVV AASSSGAKSG GGGSSAPSDD
RSDRDNGSLY SGDEFSKDKK NSSLIREGDI DFTDDENGFD IRCEVCDKVY PDLDLLDDHL
IGAHHFKQDE FPCKQCALRF CHRPLLIKHE AISHNNIRKY SCENCSKVFC DPSNLQRHIR
AYHVGARCHP CPECGKTFGT SSGLKQHQHI HSSVKPFACE VCSKAYTQFS NLCRHKRMHA
TCRMQIKCDK CNQSFSTLTS LTKHKKFCDS TGPGPYRNQH VNRHHQHPHQ HPLPHQPHLA
ATATSTCPAP PRESSESSSS AAAAAVAAMS TPPNPFLMFR TAPSFFPGFP PYGFPPFLPQ
NPLHPTNIPM FFSKNPMDLG CGGPEITSPV SAFDQKLPFG FLKGENSESQ AYDKVTEKEL
VFKAEEKLKK EPLVQAFEGE EDESRSSLDI KGKLEDTRND SKSEEQDDMK QEPERVSTPD
QQQAEDDRKS IDIMSTPPPA DTPSGGDGPL DLSICRKRSA GSFFTAPAED NLMLHRFMPR
LHEFEAERGQ PLKMRKSHSS AESSTSQKSH KGSSPTPTPT ASPGLTPSPS PPTSAGGELS
STSEGGAVPT MAAAAFAADH SALASGPTLP QTHPTFHPLL LEEIYRSGFP FLCQPGGRRG
IEALLAGAAS AAAPKRPLPP VKFSAGSVVG LKTKDRYSCK FCGKVFPRSA NLTRHLRTHT
GEQPYPCKYC DRAFSISSNL QRHVRNIHNK ERPFRCELCD RSFGQQTNLD RHVKKHESEG
NNFRDSPSSS GIAEREEYFD DIRKFMNRVY TPNSLAGNEG DTEEYPNSDD QSVNLEKDSG
NFNNNSSNIS NNNSSSGNNN NSSKAITISS


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