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Transcription factor kayak, isoforms D/sro (AP-1) (Fos-related antigen) (Dfos) (dFra)

 FOSLD_DROME             Reviewed;         722 AA.
A8MPH9; A8MPH8;
16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
16-JUN-2009, sequence version 2.
12-SEP-2018, entry version 86.
RecName: Full=Transcription factor kayak, isoforms D/sro {ECO:0000250|UniProtKB:P21525, ECO:0000303|PubMed:18571877, ECO:0000312|EMBL:ABI74757.1};
AltName: Full=AP-1 {ECO:0000250|UniProtKB:P21525};
AltName: Full=Fos-related antigen {ECO:0000250|UniProtKB:P21525};
Short=Dfos {ECO:0000250|UniProtKB:P21525};
Short=dFra {ECO:0000250|UniProtKB:P21525};
Name=kay {ECO:0000303|PubMed:18571877};
Synonyms=Fra {ECO:0000250|UniProtKB:P21525}; ORFNames=CG15509;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1] {ECO:0000305, ECO:0000312|EMBL:ABI74757.1}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SRO), NUCLEOTIDE SEQUENCE [MRNA]
OF 1-215 (ISOFORM D), ALTERNATIVE PROMOTER USAGE, ALTERNATIVE
SPLICING, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
PubMed=18571877; DOI=10.1016/j.gene.2008.05.001;
Hudson S.G., Goldstein E.S.;
"The gene structure of the Drosophila melanogaster proto-oncogene,
kayak, and its nested gene, fos-intronic gene.";
Gene 420:76-81(2008).
[2] {ECO:0000305}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3] {ECO:0000305}
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4] {ECO:0000305}
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515, AND IDENTIFICATION
BY MASS SPECTROMETRY.
TISSUE=Embryo {ECO:0000269|PubMed:18327897};
PubMed=18327897; DOI=10.1021/pr700696a;
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
J. Proteome Res. 7:1675-1682(2008).
[5] {ECO:0000305}
FUNCTION, INTERACTION WITH JRA, AND SUBCELLULAR LOCATION.
TISSUE=Embryo {ECO:0000269|PubMed:2116361};
PubMed=2116361; DOI=10.1101/gad.4.5.822;
Perkins K.K., Admon A., Patel N., Tjian R.;
"The Drosophila Fos-related AP-1 protein is a developmentally
regulated transcription factor.";
Genes Dev. 4:822-834(1990).
-!- FUNCTION: Developmentally regulated transcription factor AP-1
binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'.
May play a role in the function or determination of a particular
subset of cells in the developing embryo. It is able to carry out
its function either independently of or in conjunction with Jra.
{ECO:0000269|PubMed:2116361}.
-!- SUBUNIT: Homodimer. Heterodimer with Jra. The kay-Jra heterodimer
binds more stably to the AP-1 site than either of the two proteins
alone.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00978, ECO:0000269|PubMed:2116361}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative promoter usage, Alternative splicing; Named isoforms=5;
Name=D {ECO:0000269|PubMed:10731132}; Synonyms=alpha
{ECO:0000269|PubMed:18571877};
IsoId=A8MPH9-1; Sequence=Displayed;
Note=Produced by alternative promoter usage.
{ECO:0000269|PubMed:18571877};
Name=sro {ECO:0000269|PubMed:18571877}; Synonyms=shroud
{ECO:0000269|PubMed:18571877};
IsoId=A8MPH9-2; Sequence=VSP_053112, VSP_053113;
Note=May perform a regulatory function, acting as a dominant
negative regulator of isoform alpha.;
Name=A {ECO:0000269|PubMed:10731132}; Synonyms=beta
{ECO:0000269|PubMed:18571877};
IsoId=P21525-2; Sequence=External;
Note=Produced by alternative promoter usage.
{ECO:0000269|PubMed:18571877};
Name=B {ECO:0000269|PubMed:10731132}; Synonyms=gamma
{ECO:0000269|PubMed:18571877};
IsoId=P21525-3; Sequence=External;
Note=Produced by alternative promoter usage.
{ECO:0000269|PubMed:18571877};
Name=F {ECO:0000269|PubMed:10731132};
IsoId=P21525-5; Sequence=External;
Note=No experimental confirmation available. {ECO:0000305};
-!- DEVELOPMENTAL STAGE: Isoform D and isoform sro are expressed both
maternally and zygotically. Zygotic expression is present
throughout embryogenesis, fading by second larval instar. Isoform
D has higher expression level than isoform sro.
{ECO:0000269|PubMed:18571877}.
-!- DISRUPTION PHENOTYPE: Loss of isoform D causes embryonic
lethality. {ECO:0000269|PubMed:18571877}.
-!- MISCELLANEOUS: Mammals typically have four copies of fos,
Drosophila has a single gene with multiple transcription start
sites giving rise to multiple protein isoforms.
-!- SIMILARITY: Belongs to the bZIP family. Fos subfamily.
{ECO:0000255}.
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EMBL; DQ858474; ABI74756.1; -; mRNA.
EMBL; DQ858475; ABI74757.1; -; mRNA.
EMBL; AE014297; AAZ83991.1; -; Genomic_DNA.
RefSeq; NP_001027580.1; NM_001032408.3. [A8MPH9-1]
UniGene; Dm.6968; -.
ProteinModelPortal; A8MPH9; -.
SMR; A8MPH9; -.
BioGrid; 533679; 61.
iPTMnet; A8MPH9; -.
PRIDE; A8MPH9; -.
EnsemblMetazoa; FBtr0099988; FBpp0099941; FBgn0001297. [A8MPH9-1]
GeneID; 3772082; -.
CTD; 3772082; -.
FlyBase; FBgn0001297; kay.
eggNOG; KOG1414; Eukaryota.
eggNOG; ENOG4111CH5; LUCA.
GeneTree; ENSGT00730000110541; -.
OrthoDB; EOG091G0FN2; -.
Reactome; R-DME-2559580; Oxidative Stress Induced Senescence.
Reactome; R-DME-2871796; FCERI mediated MAPK activation.
Reactome; R-DME-450341; Activation of the AP-1 family of transcription factors.
ChiTaRS; kay; fly.
GenomeRNAi; 3772082; -.
Proteomes; UP000000803; Chromosome 3R.
Bgee; FBgn0001297; Expressed in 49 organ(s), highest expression level in wing disc (Drosophila).
ExpressionAtlas; A8MPH9; baseline and differential.
Genevisible; A8MPH9; DM.
GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005667; C:transcription factor complex; IPI:FlyBase.
GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
GO; GO:0046982; F:protein heterodimerization activity; IPI:FlyBase.
GO; GO:0070491; F:repressing transcription factor binding; IPI:FlyBase.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IDA:FlyBase.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:FlyBase.
GO; GO:0048085; P:adult chitin-containing cuticle pigmentation; IMP:FlyBase.
GO; GO:0019730; P:antimicrobial humoral response; IMP:FlyBase.
GO; GO:0007298; P:border follicle cell migration; IGI:FlyBase.
GO; GO:0048674; P:collateral sprouting of injured axon; IMP:FlyBase.
GO; GO:0048749; P:compound eye development; IMP:FlyBase.
GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
GO; GO:0007391; P:dorsal closure; IMP:FlyBase.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:UniProtKB.
GO; GO:0001736; P:establishment of planar polarity; NAS:FlyBase.
GO; GO:0007281; P:germ cell development; IMP:FlyBase.
GO; GO:0046529; P:imaginal disc fusion, thorax closure; IMP:FlyBase.
GO; GO:0007254; P:JNK cascade; NAS:FlyBase.
GO; GO:0045475; P:locomotor rhythm; IMP:FlyBase.
GO; GO:0007297; P:ovarian follicle cell migration; IMP:FlyBase.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
GO; GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
GO; GO:0031660; P:regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle; IMP:FlyBase.
GO; GO:0009611; P:response to wounding; IMP:FlyBase.
GO; GO:0016330; P:second mitotic wave involved in compound eye morphogenesis; IMP:FlyBase.
GO; GO:0051124; P:synaptic growth at neuromuscular junction; IGI:FlyBase.
GO; GO:0035220; P:wing disc development; IMP:FlyBase.
GO; GO:0042060; P:wound healing; IMP:FlyBase.
InterPro; IPR000837; AP-1.
InterPro; IPR004827; bZIP.
PANTHER; PTHR23351; PTHR23351; 1.
Pfam; PF00170; bZIP_1; 1.
PRINTS; PR00042; LEUZIPPRFOS.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
1: Evidence at protein level;
Activator; Alternative promoter usage; Alternative splicing;
Complete proteome; DNA-binding; Nucleus; Phosphoprotein;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 722 Transcription factor kayak, isoforms
D/sro.
/FTId=PRO_0000377385.
DOMAIN 385 448 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 387 406 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 413 420 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
COMPBIAS 17 201 Gln-rich. {ECO:0000255}.
MOD_RES 515 515 Phosphoserine.
{ECO:0000269|PubMed:18327897}.
VAR_SEQ 202 210 LGNFETGQS -> VSGLVKCVR (in isoform sro).
{ECO:0000303|PubMed:18571877}.
/FTId=VSP_053112.
VAR_SEQ 211 722 Missing (in isoform sro).
{ECO:0000303|PubMed:18571877}.
/FTId=VSP_053113.
SEQUENCE 722 AA; 78320 MW; F7BD3A403A1E8770 CRC64;
MIALKATEMQ HNNNALQQQQ QLQHQLLQQH QQQHQQQLQQ QLNSPDNNYI WATTHNANIS
RNNAMLQLQQ QQLRAPWITD CNKQHHINNN NSMNVNYNQQ LTQQPQQQQQ QTQYMQHNYN
NYTQQQQQQH LVPATTSQSN SHFYQCNQQQ QQQQFLAPTT TTAAVVVAAA HQQHQTQQQH
QSQQQQQHQR QDYASLQMGR QLGNFETGQS VLTLTTPTLT PTTTRNIEDT LGHLLSDTQT
DRVAGCAGFA VPKVLPNAID VLGMGIPTGV SSLPLQQTFD LSLGQGSESE DSNASYNDTQ
MNEEQDTTDT SSAHTDSTSY QAGHIMAGSV NGGGVNNFSN VLAAVSSSRG SASVGSSNAN
TSNTPARRGG GRRPNRSTNM TPEEEQKRAV RRERNKQAAA RCRKRRVDQT NELTEEVEQL
EKRGESMRKE IEVLTNSKNQ LEYLLATHRA TCQKIRSDML SVVTCNGLIA PAGLLSAGSS
GSGASSHHNH NSNDSSNGTI TGMDATLNST GRSNSPLDLK PAANIDSLLM HIKDEPLDGA
IDSGSSLDQD GPPPSKRITL PPMSTMPHVH LSTILTPTGA SSGSLQTPIT STAPGGFGSA
FPVTSNGSSI NNINSIGNNM NSPTLNAHNK VPKERPNTLA FQRPLGQMHL TMANNKAGGP
TQIQGVPIQT PSTGTFNFDS LMDGGTGLTP VSGPLVPNSS STNKHPLELP TPTAEPSKLV
SL


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