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Transcription factor p65 (V-rel reticuloendotheliosis viral oncogene homolog A (Avian))

 G2HHW9_PANTR            Unreviewed;       551 AA.
G2HHW9;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
25-OCT-2017, entry version 46.
SubName: Full=Transcription factor p65 {ECO:0000313|EMBL:BAK63327.1};
SubName: Full=V-rel reticuloendotheliosis viral oncogene homolog A (Avian) {ECO:0000313|EMBL:JAA03168.1};
Name=RELA {ECO:0000313|EMBL:JAA03168.1,
ECO:0000313|Ensembl:ENSPTRP00000054405};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598;
[1] {ECO:0000313|Ensembl:ENSPTRP00000054405, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136134; DOI=10.1038/nature04101;
Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
Rozen S., Wilson R.K., Page D.C.;
"Conservation of Y-linked genes during human evolution revealed by
comparative sequencing in chimpanzee.";
Nature 437:100-103(2005).
[3] {ECO:0000313|EMBL:BAK63327.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Testis {ECO:0000313|EMBL:BAK63327.1};
PubMed=21484476; DOI=10.1007/s10142-011-0220-9;
Kim R.N., Kim D.W., Choi S.H., Chae S.H., Nam S.H., Kim D.W., Kim A.,
Kang A., Park K.H., Lee Y.S., Hirai M., Suzuki Y., Sugano S.,
Hashimoto K., Kim D.S., Park H.S.;
"Major chimpanzee-specific structural changes in sperm development-
associated genes.";
Funct. Integr. Genomics 11:507-517(2011).
[4] {ECO:0000313|Ensembl:ENSPTRP00000054405}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[5] {ECO:0000313|EMBL:JAA03168.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03168.1},
Skeletal muscle {ECO:0000313|EMBL:JAA35546.1},
Skin {ECO:0000313|EMBL:JAA29161.1}, and
Smooth vascular {ECO:0000313|EMBL:JAA17092.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from
NextGen mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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EMBL; AACZ03082534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03082535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AK306333; BAK63327.1; -; mRNA.
EMBL; GABC01008170; JAA03168.1; -; mRNA.
EMBL; GABF01005053; JAA17092.1; -; mRNA.
EMBL; GABD01003939; JAA29161.1; -; mRNA.
EMBL; GABE01009193; JAA35546.1; -; mRNA.
RefSeq; NP_001233559.1; NM_001246630.1.
STRING; 9598.ENSPTRP00000054405; -.
Ensembl; ENSPTRT00000061861; ENSPTRP00000054405; ENSPTRG00000003889.
GeneID; 466665; -.
KEGG; ptr:466665; -.
CTD; 5970; -.
eggNOG; ENOG410IG8F; Eukaryota.
eggNOG; ENOG410XT64; LUCA.
GeneTree; ENSGT00500000044765; -.
KO; K04735; -.
OMA; EFSPMVF; -.
OrthoDB; EOG091G08JD; -.
TreeFam; TF325632; -.
Proteomes; UP000002277; Chromosome 11.
Bgee; ENSPTRG00000003889; -.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0033256; C:I-kappaB/NF-kappaB complex; IBA:GO_Central.
GO; GO:0035525; C:NF-kappaB p50/p65 complex; IEA:Ensembl.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0042805; F:actinin binding; IEA:Ensembl.
GO; GO:0033613; F:activating transcription factor binding; IEA:Ensembl.
GO; GO:0071532; F:ankyrin repeat binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
GO; GO:0042301; F:phosphate ion binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
GO; GO:0070491; F:repressing transcription factor binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0000983; F:transcription factor activity, RNA polymerase II core promoter sequence-specific; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; IEA:Ensembl.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO; GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
GO; GO:0071354; P:cellular response to interleukin-6; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0071223; P:cellular response to lipoteichoic acid; IEA:Ensembl.
GO; GO:0071316; P:cellular response to nicotine; IEA:Ensembl.
GO; GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Ensembl.
GO; GO:0071224; P:cellular response to peptidoglycan; IEA:Ensembl.
GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0001889; P:liver development; IEA:Ensembl.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1901223; P:negative regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0042177; P:negative regulation of protein catabolic process; IEA:Ensembl.
GO; GO:0033234; P:negative regulation of protein sumoylation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:0038061; P:NIK/NF-kappaB signaling; IBA:GO_Central.
GO; GO:0070431; P:nucleotide-binding oligomerization domain containing 2 signaling pathway; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IEA:Ensembl.
GO; GO:2000630; P:positive regulation of miRNA metabolic process; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0050862; P:positive regulation of T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:1901522; P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; IEA:Ensembl.
GO; GO:0043620; P:regulation of DNA-templated transcription in response to stress; IEA:Ensembl.
GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
GO; GO:0034097; P:response to cytokine; IBA:GO_Central.
GO; GO:0032495; P:response to muramyl dipeptide; IEA:Ensembl.
GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
GO; GO:0010224; P:response to UV-B; IEA:Ensembl.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
CDD; cd01177; IPT_NFkappaB; 1.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 2.60.40.340; -; 1.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT.
InterPro; IPR033926; IPT_NFkappaB.
InterPro; IPR000451; NFkB/Dor.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR030495; RelA.
InterPro; IPR030492; RHD_CS.
InterPro; IPR032397; RHD_dimer.
InterPro; IPR011539; RHD_DNA_bind_dom.
InterPro; IPR037059; RHD_DNA_bind_dom_sf.
PANTHER; PTHR24169; PTHR24169; 1.
PANTHER; PTHR24169:SF1; PTHR24169:SF1; 1.
Pfam; PF16179; RHD_dimer; 1.
Pfam; PF00554; RHD_DNA_bind; 1.
PRINTS; PR00057; NFKBTNSCPFCT.
SMART; SM00429; IPT; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF81296; SSF81296; 1.
PROSITE; PS01204; REL_1; 1.
PROSITE; PS50254; REL_2; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Reference proteome {ECO:0000313|Proteomes:UP000002277}.
DOMAIN 16 190 RHD. {ECO:0000259|PROSITE:PS50254}.
SEQUENCE 551 AA; 60233 MW; C079C75A9F4F3558 CRC64;
MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT
IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY EAELCPDRCI HSFQNLGIQC
VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG DYDLNAVRLC FQVTVREPSG RPLRLPPVLS
HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS
QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE
KRKRTYETFK SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP FTSSLSTINY
DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV SALAQAPAPV PVLAPGPPQA
VAPPAPKPTQ AGEGTLSEAL LQLQFDDEDL GALLGNSTDP AVFTDLASVD NSEFQQLLNQ
GIPVAPHTTE PMLMEYPEAI TRLVTGAQRP PDPAPAPLGA PGLPNGLLSG DEDFSSIADM
DFSALLSQIS S


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