Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Transcription factor tau 95 kDa subunit (TFIIIC 95 kDa subunit) (Transcription factor C subunit 1)

 TFC1_YEAST              Reviewed;         649 AA.
P32367; D6VQC1;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
12-SEP-2018, entry version 150.
RecName: Full=Transcription factor tau 95 kDa subunit;
AltName: Full=TFIIIC 95 kDa subunit;
AltName: Full=Transcription factor C subunit 1;
Name=TFC1; OrderedLocusNames=YBR123C; ORFNames=YBR0919;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 36-48;
108-118; 194-201; 246-251; 372-376; 405-422 AND 616-631.
PubMed=2052571; DOI=10.1073/pnas.88.11.4887;
Swanson R.N., Conesa C., Lefebvre O., Carles C., Ruet A.,
Quemeneur E., Gagnon J., Sentenac A.;
"Isolation of TFC1, a gene encoding one of two DNA-binding subunits of
yeast transcription factor tau (TFIIIC).";
Proc. Natl. Acad. Sci. U.S.A. 88:4887-4891(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1737746;
Parsons M.C., Weil P.A.;
"Cloning of TFC1, the Saccharomyces cerevisiae gene encoding the 95-
kDa subunit of transcription factor TFIIIC.";
J. Biol. Chem. 267:2894-2901(1992).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=7900426; DOI=10.1002/yea.320101014;
Mannhaupt G., Stucka R., Ehnle S., Vetter I., Feldmann H.;
"Analysis of a 70 kb region on the right arm of yeast chromosome II.";
Yeast 10:1363-1381(1994).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=7813418;
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J.,
Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C.,
Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M.,
Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L.,
Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J.,
Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T.,
Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A.,
Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B.,
Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I.,
Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M.,
Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A.,
van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I.,
Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H.,
Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.;
"Complete DNA sequence of yeast chromosome II.";
EMBO J. 13:5795-5809(1994).
[5]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[6]
IDENTIFICATION IN TFIIIC.
PubMed=2180956;
Parsons M.C., Weil P.A.;
"Purification and characterization of Saccharomyces cerevisiae
transcription factor TFIIIC. Polypeptide composition defined with
polyclonal antibodies.";
J. Biol. Chem. 265:5095-5103(1990).
[7]
FUNCTION, INTERACTION WITH TFC3; TFC4 AND TFC6, AND PHOSPHORYLATION.
PubMed=7688737;
Conesa C., Swanson R.N., Schultz P., Oudet P., Sentenac A.;
"On the subunit composition, stoichiometry, and phosphorylation of the
yeast transcription factor TFIIIC/tau.";
J. Biol. Chem. 268:18047-18052(1993).
[8]
IDENTIFICATION.
PubMed=9335584;
Lussier M., White A.-M., Sheraton J., di Paolo T., Treadwell J.,
Southard S.B., Horenstein C.I., Chen-Weiner J., Ram A.F.J.,
Kapteyn J.C., Roemer T.W., Vo D.H., Bondoc D.C., Hall J., Zhong W.-W.,
Sdicu A.-M., Davies J., Klis F.M., Robbins P.W., Bussey H.;
"Large scale identification of genes involved in cell surface
biosynthesis and architecture in Saccharomyces cerevisiae.";
Genetics 147:435-450(1997).
[9]
FUNCTION, INTERACTION WITH TFC3 AND TFC6, AND MUTAGENESIS OF GLU-447.
PubMed=12533520; DOI=10.1074/jbc.M213310200;
Jourdain S., Acker J., Ducrot C., Sentenac A., Lefebvre O.;
"The tau95 subunit of yeast TFIIIC influences upstream and downstream
functions of TFIIIC.DNA complexes.";
J. Biol. Chem. 278:10450-10457(2003).
[10]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[11]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=18407956; DOI=10.1074/mcp.M700468-MCP200;
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth
phosphoproteome analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
-!- FUNCTION: TFIIIC mediates tRNA and 5S RNA gene activation by
binding to intragenic promoter elements. Upstream of the
transcription start site, TFIIIC assembles the initiation complex
TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III
recruitment and function. Part of the tauA domain of TFIIIC that
binds boxA DNA promoter sites of tRNA and similar genes.
Participates in the interconnection of tauA with tauB via its
contacts with TFC3 and TFC6. Serves as a scaffold critical for
tauA-DNA spatial configuration and tauB-DNA stability.
{ECO:0000269|PubMed:12533520, ECO:0000269|PubMed:7688737}.
-!- SUBUNIT: Component of the TFIIIC complex composed of TFC1, TFC3,
TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two
globular domains, tauA and tauB, connected by a proteolysis-
sensitive and flexible linker. Interacts with TFC3, TFC4 and TFC6.
{ECO:0000269|PubMed:12533520, ECO:0000269|PubMed:2180956,
ECO:0000269|PubMed:7688737}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
-!- MISCELLANEOUS: Present with 15800 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the TFIIIC subunit 5 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; M63385; AAA35144.1; -; Genomic_DNA.
EMBL; M80922; AAA35142.1; -; Genomic_DNA.
EMBL; X78993; CAA55625.1; -; Genomic_DNA.
EMBL; Z35992; CAA85080.1; -; Genomic_DNA.
EMBL; BK006936; DAA07241.1; -; Genomic_DNA.
PIR; A39711; A39711.
RefSeq; NP_009681.3; NM_001178471.3.
ProteinModelPortal; P32367; -.
BioGrid; 32825; 197.
ComplexPortal; CPX-1656; Transcription factor TFIIIC complex.
DIP; DIP-2235N; -.
IntAct; P32367; 13.
MINT; P32367; -.
STRING; 4932.YBR123C; -.
iPTMnet; P32367; -.
MaxQB; P32367; -.
PaxDb; P32367; -.
PRIDE; P32367; -.
EnsemblFungi; YBR123C; YBR123C; YBR123C.
GeneID; 852421; -.
KEGG; sce:YBR123C; -.
EuPathDB; FungiDB:YBR123C; -.
SGD; S000000327; TFC1.
HOGENOM; HOG000142016; -.
InParanoid; P32367; -.
KO; K15202; -.
OMA; PPEYFVR; -.
OrthoDB; EOG092C3J9Y; -.
BioCyc; YEAST:G3O-29080-MONOMER; -.
PRO; PR:P32367; -.
Proteomes; UP000002311; Chromosome II.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0000127; C:transcription factor TFIIIC complex; IDA:SGD.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0042791; P:5S class rRNA transcription by RNA polymerase III; IDA:SGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006383; P:transcription by RNA polymerase III; IDA:SGD.
InterPro; IPR019136; TF_IIIC_su-5.
PANTHER; PTHR13230; PTHR13230; 1.
Pfam; PF09734; Tau95; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; DNA-binding; Nucleus;
Phosphoprotein; Reference proteome; Repeat; Transcription;
Transcription regulation.
CHAIN 1 649 Transcription factor tau 95 kDa subunit.
/FTId=PRO_0000209717.
REPEAT 221 239 1.
REPEAT 400 419 2.
REGION 221 419 2 X repeats, Pro-rich.
MOTIF 296 300 Nuclear localization signal.
{ECO:0000255}.
COMPBIAS 510 620 Asp/Glu-rich (acidic).
MOD_RES 617 617 Phosphoserine.
{ECO:0000244|PubMed:18407956}.
MUTAGEN 447 447 E->K: Temperature-sensitive. TFCIII-DNA
complexes present a shift in their 5'
border, generate slow-migrating TFIIIB-
DNA complexes upon stripping TFIIIC by
heparin or heat treatment, and allow
initiation at downstream sites. TFIIIC-
DNA complexes highly unstable at high
temperatures.
{ECO:0000269|PubMed:12533520}.
SEQUENCE 649 AA; 73554 MW; FD39EB5E2ED4D8C6 CRC64;
MPVEEPLATL SSIPDSSADQ APPLIADEFT LDLPRIPSLE LPLNVSTKHS SIQKAIKMCG
GIEKVKEAFK EHGPIESQHG LQLYLNDDTD SDGSKSYFNE HPVIGKRVPF RDESVILKVT
MPKGTLSKNN NSVKDSIKSL KDSNKLRVTP VSIVDNTIKF REMSDFQIKL DNVPSAREFK
SSFGSLEWNN FKSFVNSVPD NDSQPQENIG NLILDRSVKI PSTDFQLPPP PKLSMVGFPL
LYKYKANPFA KKKKNGVTEV KGTYIKNYQL FVHDLSDKTV IPSQAHEQVL YDFEVAKKTK
VYPGTKSDSK FYESLEECLK ILRELFARRP IWVKRHLDGI VPKKIHHTMK IALALISYRF
TMGPWRNTYI KFGIDPRSSV EYAQYQTEYF KIERKLLSSP IVKKNVPKPP PLVFESDTPG
GIDSRFKFDG KRIPWYLMLQ IDLLIGEPNI AEVFHNVEYL DKANELTGWF KELDLVKIRR
IVKYELGCMV QGNYEYNKYK LKYFKTMLFV KESMVPENKN SEEGMGVNTN KDADGDINMD
AGSQMSSNAI EEDKGIAAGD DFDDNGAITE EPDDAALENE EMDTDQNLKV PASIDDDVDD
VDADEEEQES FDVKTASFQD IINKIAKLDP KTAETMKSEL KGFVDEVDL


Related products :

Catalog number Product name Quantity
EIAAB42065 General transcription factor 3C polypeptide 1,GTF3C1,Homo sapiens,Human,TF3C-alpha,TFIIIC 220 kDa subunit,TFIIIC box B-binding subunit,TFIIIC220,Transcription factor IIIC 220 kDa subunit,Transcription
EIAAB42066 General transcription factor 3C polypeptide 1,Gtf3c1,Mouse,Mus musculus,TF3C-alpha,TFIIIC 220 kDa subunit,TFIIIC box B-binding subunit,TFIIIC220,Transcription factor IIIC 220 kDa subunit,Transcription
EIAAB42064 General transcription factor 3C polypeptide 1,Gtf3c1,Rat,Rattus norvegicus,TF3C-alpha,TFIIIC 220 kDa subunit,TFIIIC box B-binding subunit,TFIIIC220,Transcription factor IIIC 220 kDa subunit,Transcript
EIAAB42075 C6orf51,CDA020,General transcription factor 3C polypeptide 6,GTF3C6,Homo sapiens,Human,NPD020,TFIIIC 35 kDa subunit,TFIIIC35,Transcription factor IIIC 35 kDa subunit,Transcription factor IIIC subunit
EIAAB42073 CDABP0017,General transcription factor 3C polypeptide 5,GTF3C5,Homo sapiens,Human,TF3C-epsilon,TFIIIC 63 kDa subunit,TFIIIC63,Transcription factor IIIC 63 kDa subunit,Transcription factor IIIC subunit
EIAAB42068 General transcription factor 3C polypeptide 2,GTF3C2,Homo sapiens,Human,KIAA0011,TF3C-beta,TFIIIC 110 kDa subunit,TFIIIC110,Transcription factor IIIC 110 kDa subunit,Transcription factor IIIC subunit
EIAAB42067 General transcription factor 3C polypeptide 2,Gtf3c2,Kiaa0011,Mouse,Mus musculus,TF3C-beta,TFIIIC 110 kDa subunit,TFIIIC110,Transcription factor IIIC 110 kDa subunit,Transcription factor IIIC subunit
EIAAB42074 General transcription factor 3C polypeptide 6,Gtf3c6,Mouse,Mus musculus,TFIIIC 35 kDa subunit,TFIIIC35,Transcription factor IIIC 35 kDa subunit,Transcription factor IIIC subunit 6
EIAAB42071 General transcription factor 3C polypeptide 4,GTF3C4,Homo sapiens,Human,TF3C-delta,TFIIIC 90 kDa subunit,TFIIIC90,Transcription factor IIIC 90 kDa subunit,Transcription factor IIIC subunit delta
EIAAB42069 General transcription factor 3C polypeptide 3,GTF3C3,Homo sapiens,Human,TF3C-gamma,TFIIIC 102 kDa subunit,TFIIIC102,Transcription factor IIIC 102 kDa subunit,Transcription factor IIIC subunit gamma
EIAAB42070 General transcription factor 3C polypeptide 4,Gtf3c4,Mouse,Mus musculus,TF3C-delta,TFIIIC 90 kDa subunit,TFIIIC90,Transcription factor IIIC 90 kDa subunit,Transcription factor IIIC subunit delta
EIAAB42072 General transcription factor 3C polypeptide 5,Gtf3c5,Mouse,Mus musculus,TF3C-epsilon,TFIIIC 63 kDa subunit,TFIIIC63,Transcription factor IIIC 63 kDa subunit,Transcription factor IIIC subunit epsilon
EIAAB27113 CAAT box DNA-binding protein subunit C,CBF-C,CCAAT-binding transcription factor subunit C,Nfyc,NF-YC,Nuclear transcription factor Y subunit C,Nuclear transcription factor Y subunit gamma,Rat,Rattus no
EIAAB27109 CAAT box DNA-binding protein subunit B,CBF-A,CCAAT-binding transcription factor subunit A,Nfyb,NF-YB,Nuclear transcription factor Y subunit B,Nuclear transcription factor Y subunit beta,Rat,Rattus nor
EIAAB27106 CAAT box DNA-binding protein subunit A,CBF-B,CCAAT-binding transcription factor subunit B,Nfya,NF-YA,Nuclear transcription factor Y subunit A,Nuclear transcription factor Y subunit alpha,Rat,Rattus no
EIAAB41099 General transcription factor IIF 74 kDa subunit,General transcription factor IIF subunit 1,GTF2F1,Homo sapiens,Human,RAP74,TFIIF-alpha,Transcription initiation factor IIF subunit alpha,Transcription i
EIAAB42045 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,GTF2H3,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42050 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,GTF2H4,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42048 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,Gtf2h3,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42039 Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,General transcription factor IIH subunit 1,Gtf2h1,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42049 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,Gtf2h4,Mouse,Mus musculus,TFIIH basal transcription facto
15-288-22005B TFIIH basal transcription factor complex p62 subunit - Basic transcription factor 62 kDa subunit; BTF2-p62; General transcription factor IIH polypeptide 1 Polyclonal 0.1 mg
15-288-22005A TFIIH basal transcription factor complex p62 subunit - Basic transcription factor 62 kDa subunit; BTF2-p62; General transcription factor IIH polypeptide 1 Polyclonal 0.05 mg
15-288-22005B TFIIH basal transcription factor complex p62 subunit - Basic transcription factor 62 kDa subunit; BTF2-p62; General transcription factor IIH polypeptide 1 Polyclonal 0.05 mg
18-003-42051 TFIIH basal transcription factor complex p34 subunit - Basic transcription factor 2 34 kDa subunit; BTF2-p34; General transcription factor IIH polypeptide 3 Polyclonal 0.05 mg Aff Pur


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur