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Transcription factor unc-37 (Uncoordinated protein 37)

 UNC37_CAEEL             Reviewed;         612 AA.
O02482; P91912;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
05-DEC-2018, entry version 151.
RecName: Full=Transcription factor unc-37;
AltName: Full=Uncoordinated protein 37;
Name=unc-37; Synonyms=esg; ORFNames=W02D3.9;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
STRAIN=Bristol N2;
PubMed=9165118;
Pflugrad A., Meir J.Y.-J., Barnes T.M., Miller D.M. III;
"The Groucho-like transcription factor UNC-37 functions with the
neural specificity gene unc-4 to govern motor neuron identity in C.
elegans.";
Development 124:1699-1709(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=Bristol N2;
PubMed=9350340;
Sharief F.S., Tsoi S.C.M., Li S.S.-L.;
"cDNA cloning and genomic organization of enhancer of split groucho
gene from nematode Caenorhabditis elegans.";
Biochem. Mol. Biol. Int. 43:327-337(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[4]
INTERACTION WITH UNC-4.
PubMed=10557206; DOI=10.1101/gad.13.21.2774;
Winnier A.R., Meir J.Y.-J., Ross J.M., Tavernarakis N., Driscoll M.,
Ishihara T., Katsura I., Miller D.M. III;
"UNC-4/UNC-37-dependent repression of motor neuron-specific genes
controls synaptic choice in Caenorhabditis elegans.";
Genes Dev. 13:2774-2786(1999).
[5]
FUNCTION, INTERACTION WITH MLS-1, AND DISRUPTION PHENOTYPE.
PubMed=21852953; DOI=10.1371/journal.pgen.1002210;
Miller R.R., Okkema P.G.;
"The Caenorhabditis elegans T-box factor MLS-1 requires Groucho co-
repressor interaction for uterine muscle specification.";
PLoS Genet. 7:E1002210-E1002210(2011).
-!- FUNCTION: Transcriptional corepressor that functions with the
neural specificity gene unc-4 to govern motor neuron identity
(PubMed:9165118). May function with transcription factor mls-1 to
promote uterine muscle specification and formation
(PubMed:21852953). {ECO:0000269|PubMed:21852953,
ECO:0000269|PubMed:9165118}.
-!- SUBUNIT: Interacts with unc-4 (PubMed:10557206). May interact with
mls-1 (PubMed:21852953). {ECO:0000269|PubMed:10557206,
ECO:0000269|PubMed:21852953}.
-!- INTERACTION:
O62505:CELE_ZK1053.3; NbExp=4; IntAct=EBI-314716, EBI-326955;
G5ECN8:ces-1; NbExp=4; IntAct=EBI-314716, EBI-322161;
Q93616:lsy-22; NbExp=7; IntAct=EBI-314716, EBI-2005589;
Q9XVV3:nhr-67; NbExp=3; IntAct=EBI-314716, EBI-314697;
G5ED66:pax-3; NbExp=5; IntAct=EBI-314716, EBI-2416749;
Q10666:pop-1; NbExp=3; IntAct=EBI-314716, EBI-317870;
Q22678:sptf-2; NbExp=5; IntAct=EBI-314716, EBI-2420648;
Q18694:unc-130; NbExp=3; IntAct=EBI-314716, EBI-2414897;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- DISRUPTION PHENOTYPE: Maternal effect embryonic lethal. RNAi-
mediated knockdown results in reduced uterine cell specification.
{ECO:0000269|PubMed:21852953}.
-!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; U89245; AAB49459.1; -; mRNA.
EMBL; AF001271; AAB84234.1; -; mRNA.
EMBL; AF001272; AAB84235.1; -; Genomic_DNA.
EMBL; FO081084; CCD68992.1; -; Genomic_DNA.
PIR; T15211; T15211.
RefSeq; NP_491932.1; NM_059531.6.
UniGene; Cel.7359; -.
ProteinModelPortal; O02482; -.
SMR; O02482; -.
BioGrid; 37842; 9.
DIP; DIP-27333N; -.
IntAct; O02482; 48.
STRING; 6239.W02D3.9.2; -.
EPD; O02482; -.
PaxDb; O02482; -.
PeptideAtlas; O02482; -.
PRIDE; O02482; -.
EnsemblMetazoa; W02D3.9.1; W02D3.9.1; WBGene00006773.
EnsemblMetazoa; W02D3.9.2; W02D3.9.2; WBGene00006773.
GeneID; 172394; -.
KEGG; cel:CELE_W02D3.9; -.
UCSC; W02D3.9.2; c. elegans.
CTD; 172394; -.
WormBase; W02D3.9; CE14434; WBGene00006773; unc-37.
eggNOG; KOG0639; Eukaryota.
eggNOG; ENOG410XPX3; LUCA.
GeneTree; ENSGT00940000153368; -.
HOGENOM; HOG000293211; -.
InParanoid; O02482; -.
OMA; PDNKLCF; -.
OrthoDB; EOG091G181Y; -.
PhylomeDB; O02482; -.
Reactome; R-CEL-3769402; Deactivation of the beta-catenin transactivating complex.
Reactome; R-CEL-4641265; Repression of WNT target genes.
SignaLink; O02482; -.
PRO; PR:O02482; -.
Proteomes; UP000001940; Chromosome I.
Bgee; WBGene00006773; Expressed in 5 organ(s), highest expression level in multi-cellular organism.
GO; GO:0005634; C:nucleus; IDA:WormBase.
GO; GO:0005667; C:transcription factor complex; IBA:GO_Central.
GO; GO:0070491; F:repressing transcription factor binding; IBA:GO_Central.
GO; GO:0003714; F:transcription corepressor activity; ISS:WormBase.
GO; GO:0008134; F:transcription factor binding; IPI:WormBase.
GO; GO:0007268; P:chemical synaptic transmission; IMP:WormBase.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:WormBase.
GO; GO:0050770; P:regulation of axonogenesis; IMP:WormBase.
GO; GO:0001505; P:regulation of neurotransmitter levels; IDA:WormBase.
GO; GO:0050803; P:regulation of synapse structure or activity; IMP:WormBase.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR005617; Groucho/TLE_N.
InterPro; IPR009146; Groucho_enhance.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
PANTHER; PTHR10814; PTHR10814; 2.
Pfam; PF03920; TLE_N; 1.
Pfam; PF00400; WD40; 2.
PRINTS; PR01850; GROUCHOFAMLY.
SMART; SM00320; WD40; 7.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS50082; WD_REPEATS_2; 2.
PROSITE; PS50294; WD_REPEATS_REGION; 2.
1: Evidence at protein level;
Complete proteome; Developmental protein; Nucleus; Reference proteome;
Repeat; Transcription; Transcription regulation; WD repeat.
CHAIN 1 612 Transcription factor unc-37.
/FTId=PRO_0000051316.
REPEAT 308 339 WD 1.
REPEAT 372 402 WD 2.
REPEAT 414 444 WD 3.
REPEAT 456 486 WD 4.
REPEAT 538 568 WD 5.
REPEAT 579 609 WD 6.
REGION 153 196 CCN domain.
COMPBIAS 1 102 Gln-rich.
COMPBIAS 102 152 Gly/Pro-rich.
COMPBIAS 196 287 Pro/Ser-rich.
COMPBIAS 225 228 Poly-Gln.
CONFLICT 66 66 K -> T (in Ref. 1; AAB49459).
{ECO:0000305}.
SEQUENCE 612 AA; 65617 MW; D3AFF39E526F8249 CRC64;
MKASYLETLD RIKDEHAEMS KHVNQQRSDI EKVALEKENM NRSYMTYAEV SNTLRSDLRK
AEEINKRLQE FIMQSLAPQL SQDNQANCLA ALEAFKTASP RENGNGAPAL PPGFPPGAAG
MLGMMPNMPF GMSPAMSQLF NQFASPHVNG GDGAGGSSGG ASEAKKAKLE DPDDGELEID
VTNDDHPSTA SNGGAANKNG RDSTNSVASS GASTPSIASN SRARQQQQPL AGLQGLEQMN
FLAGFNPNLL RQASAAGGFN FLNDPHAQAR LAAAIGQIGS RPAYSFKIVD GGVPTPTSFP
PDAQKGPGIP TGLKKKMELN HGEVVCAATI SRDNSRVYTG GKGCVKIWDV KESDISGATV
VNRPPIASLD CLKENYIRSC KLFEDGNTLL IGGEASTVAL WDLTTETKTL DLETDSQACY
ALAMSPDEKL LFACLADGNI LIYDIHNKVK VGTLPGHQDG ASCLDLSKDG TKLWSGGLDN
SVRCWDLAQR KEVAKHDFAS QVFSLGCCPN DEWVAVGMEN NYVEVLSTTG KEKYQLTQHE
SCVLSLKFAH SGKFFISTGK DNALNAWRTP YGASLFQLKE NSSVLSCDIS FDDSLIVTGS
GEKKATLYAV EY


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