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Transcription initiation factor TFIID subunit 12 (TAFII30 alpha) (Transcription initiation factor TFIID 28-alpha kDa/22 kDa subunits) (p28-alpha/p22)

 TAF12_DROME             Reviewed;         196 AA.
P49905; A4V2Q1; Q26339; Q9VGK0;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
12-SEP-2018, entry version 158.
RecName: Full=Transcription initiation factor TFIID subunit 12;
AltName: Full=TAFII30 alpha;
AltName: Full=Transcription initiation factor TFIID 28-alpha kDa/22 kDa subunits;
AltName: Full=p28-alpha/p22;
Name=Taf12; Synonyms=TAF30-ALPHA; ORFNames=CG17358;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 22 KDA AND 28 KDA), ALTERNATIVE
INITIATION, AND PROTEIN SEQUENCE OF 147-173.
PubMed=7545910; DOI=10.1038/367484a0;
Kokubo T., Gong D.-W., Wootton J.C., Horikoshi M., Roeder R.G.,
Nakatani Y.;
"Molecular cloning of Drosophila TFIID subunits.";
Nature 367:484-487(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 28 KDA), AND INTERACTION WITH TBP;
TAF2 AND TAF4.
PubMed=8276241; DOI=10.1101/gad.7.12b.2587;
Yokomori K., Chen J.L., Admon A., Zhou S., Tjian R.;
"Molecular cloning and characterization of dTAFII30 alpha and dTAFII30
beta: two small subunits of Drosophila TFIID.";
Genes Dev. 7:2587-2597(1993).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4]
GENOME REANNOTATION, AND ALTERNATIVE INITIATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 28 KDA).
STRAIN=Berkeley; TISSUE=Embryo;
PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
-!- FUNCTION: TFIID is a multimeric protein complex that plays a
central role in mediating promoter responses to various activators
and repressors.
-!- SUBUNIT: Belongs to the TFIID complex which is composed of TATA
binding protein (Tbp) and a number of TBP-associated factors
(TAFs). Interacts with Tbp, Taf2 and Taf4.
{ECO:0000269|PubMed:8276241}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative initiation; Named isoforms=2;
Name=28 kDa; Synonyms=A, B;
IsoId=P49905-1; Sequence=Displayed;
Name=22 kDa; Synonyms=D;
IsoId=P49905-2; Sequence=VSP_018890;
-!- SIMILARITY: Belongs to the TAF12 family. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; U06450; AAC46479.1; -; mRNA.
EMBL; U06456; AAB19244.1; -; mRNA.
EMBL; S67741; AAB29540.1; -; mRNA.
EMBL; AE014297; AAF54677.1; -; Genomic_DNA.
EMBL; AE014297; AAF54678.1; -; Genomic_DNA.
EMBL; AE014297; AAF54679.2; -; Genomic_DNA.
EMBL; AY061435; AAL28983.1; -; mRNA.
PIR; A49453; A49453.
PIR; S42222; S42222.
RefSeq; NP_001262479.1; NM_001275550.1. [P49905-2]
RefSeq; NP_524320.1; NM_079596.3. [P49905-1]
RefSeq; NP_731616.1; NM_169420.2. [P49905-1]
RefSeq; NP_731617.2; NM_169421.3. [P49905-2]
UniGene; Dm.2806; -.
ProteinModelPortal; P49905; -.
SMR; P49905; -.
BioGrid; 66532; 53.
DIP; DIP-779N; -.
IntAct; P49905; 6.
STRING; 7227.FBpp0081916; -.
PaxDb; P49905; -.
PRIDE; P49905; -.
EnsemblMetazoa; FBtr0082440; FBpp0081916; FBgn0011290. [P49905-1]
EnsemblMetazoa; FBtr0082442; FBpp0081918; FBgn0011290. [P49905-1]
EnsemblMetazoa; FBtr0290205; FBpp0288644; FBgn0011290. [P49905-2]
EnsemblMetazoa; FBtr0335213; FBpp0307200; FBgn0011290. [P49905-2]
GeneID; 41406; -.
KEGG; dme:Dmel_CG17358; -.
CTD; 6883; -.
FlyBase; FBgn0011290; Taf12.
eggNOG; KOG1142; Eukaryota.
eggNOG; COG5624; LUCA.
GeneTree; ENSGT00390000002144; -.
InParanoid; P49905; -.
KO; K03126; -.
OrthoDB; EOG091G0Q1X; -.
PhylomeDB; P49905; -.
Reactome; R-DME-674695; RNA Polymerase II Pre-transcription Events.
Reactome; R-DME-73776; RNA Polymerase II Promoter Escape.
Reactome; R-DME-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
Reactome; R-DME-75953; RNA Polymerase II Transcription Initiation.
Reactome; R-DME-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
GenomeRNAi; 41406; -.
PRO; PR:P49905; -.
Proteomes; UP000000803; Chromosome 3R.
Bgee; FBgn0011290; Expressed in 31 organ(s), highest expression level in antenna.
ExpressionAtlas; P49905; baseline and differential.
Genevisible; P49905; DM.
GO; GO:0005634; C:nucleus; IDA:FlyBase.
GO; GO:0000124; C:SAGA complex; IDA:FlyBase.
GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
GO; GO:0005669; C:transcription factor TFIID complex; IDA:FlyBase.
GO; GO:0003677; F:DNA binding; IBA:GO_Central.
GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
GO; GO:0042803; F:protein homodimerization activity; IPI:FlyBase.
GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IBA:GO_Central.
GO; GO:0001129; F:RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly; IPI:FlyBase.
GO; GO:0017025; F:TBP-class protein binding; IBA:GO_Central.
GO; GO:0008134; F:transcription factor binding; IPI:FlyBase.
GO; GO:0043966; P:histone H3 acetylation; IDA:FlyBase.
GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISS:FlyBase.
CDD; cd07981; TAF12; 1.
Gene3D; 1.10.20.10; -; 1.
InterPro; IPR009072; Histone-fold.
InterPro; IPR037794; TAF12.
InterPro; IPR003228; TFIID_TAF12_dom.
PANTHER; PTHR12264; PTHR12264; 1.
Pfam; PF03847; TFIID_20kDa; 1.
ProDom; PD012998; PD012998; 1.
SUPFAM; SSF47113; SSF47113; 1.
1: Evidence at protein level;
Alternative initiation; Complete proteome; Direct protein sequencing;
Nucleus; Reference proteome; Transcription; Transcription regulation.
CHAIN 1 196 Transcription initiation factor TFIID
subunit 12.
/FTId=PRO_0000033584.
DOMAIN 93 160 Histone-fold. {ECO:0000255}.
VAR_SEQ 1 36 Missing (in isoform 22 kDa).
{ECO:0000303|PubMed:7545910}.
/FTId=VSP_018890.
CONFLICT 15 15 E -> R (in Ref. 2; AAB29540).
{ECO:0000305}.
CONFLICT 127 127 E -> R (in Ref. 2; AAB29540).
{ECO:0000305}.
SEQUENCE 196 AA; 21523 MW; 9D6AE98FB9AEC1EC CRC64;
MSDLFTTFDS NGVAEHHLHH NHNSTSSASG LLHDPPMASP SQHSPMTNNS NSSSQNGGPV
SGLGTGTGPI SGGSKSSNHT SSAAGSENTP MLTKPRLTEL VREVDTTTQL DEDVEELLLQ
IIDDFVEDTV KSTSAFAKHR KSNKIEVRDV QLHFERKYNM WIPGFGTDEL RPYKRAAVTE
AHKQRLALIR KTIKKY


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