Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)

 PURA_MOUSE              Reviewed;         321 AA.
P42669;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
20-DEC-2017, entry version 143.
RecName: Full=Transcriptional activator protein Pur-alpha;
AltName: Full=Purine-rich single-stranded DNA-binding protein alpha;
Name=Pura;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7959008; DOI=10.1016/0378-1119(94)90167-8;
Ma Z.-W., Bergemann A.D., Johnson E.M.;
"Conservation in human and mouse Pur alpha of a motif common to
several proteins involved in initiation of DNA replication.";
Gene 149:311-314(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6 X CBA; TISSUE=Lung;
PubMed=9334258; DOI=10.1074/jbc.272.42.26727;
Kelm R.J. Jr., Elder P.K., Strauch A.R., Getz M.J.;
"Sequence of cDNAs encoding components of vascular actin single-
stranded DNA-binding factor 2 establish identity to Puralpha and
Purbeta.";
J. Biol. Chem. 272:26727-26733(1997).
[3]
PROTEIN SEQUENCE OF 176-198 AND 204-228, AND IDENTIFICATION BY MASS
SPECTROMETRY.
STRAIN=OF1; TISSUE=Hippocampus;
Lubec G., Sunyer B., Chen W.-Q.;
Submitted (JAN-2009) to UniProtKB.
[4]
SUBUNIT.
PubMed=10318844; DOI=10.1074/jbc.274.20.14238;
Kelm R.J. Jr., Cogan J.G., Elder P.K., Strauch A.R., Getz M.J.;
"Molecular interactions between single-stranded DNA-binding proteins
associated with an essential MCAT element in the mouse smooth muscle
alpha-actin promoter.";
J. Biol. Chem. 274:14238-14245(1999).
[5]
INTERACTION WITH FMR1.
PubMed=12147688; DOI=10.1074/jbc.M203608200;
Ohashi S., Koike K., Omori A., Ichinose S., Ohara S., Kobayashi S.,
Sato T.A., Anzai K.;
"Identification of mRNA/protein (mRNP) complexes containing Puralpha,
mStaufen, fragile X protein, and myosin Va and their association with
rough endoplasmic reticulum equipped with a kinesin motor.";
J. Biol. Chem. 277:37804-37810(2002).
[6]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: This is a probable transcription activator that
specifically binds the purine-rich single strand of the PUR
element located upstream of the c-Myc gene. May play a role in the
initiation of DNA replication and in recombination.
-!- SUBUNIT: Homodimer, heterodimer with PURB and heterotrimer with
PURB and YBX1/Y-box protein 1 (PubMed:10318844). Interacts with
FMR1; this interaction occurs in association with polyribosome
(PubMed:12147688). {ECO:0000269|PubMed:10318844,
ECO:0000269|PubMed:12147688}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the PUR DNA-binding protein family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U02098; AAA64630.1; -; mRNA.
EMBL; AF017631; AAB71860.1; -; mRNA.
CCDS; CCDS29151.1; -.
RefSeq; NP_033015.1; NM_008989.3.
RefSeq; XP_006525787.1; XM_006525724.3.
RefSeq; XP_011245162.1; XM_011246860.2.
UniGene; Mm.231802; -.
UniGene; Mm.482241; -.
ProteinModelPortal; P42669; -.
SMR; P42669; -.
BioGrid; 202515; 22.
IntAct; P42669; 5.
MINT; MINT-243159; -.
STRING; 10090.ENSMUSP00000059404; -.
iPTMnet; P42669; -.
PhosphoSitePlus; P42669; -.
SwissPalm; P42669; -.
UCD-2DPAGE; P42669; -.
EPD; P42669; -.
MaxQB; P42669; -.
PaxDb; P42669; -.
PeptideAtlas; P42669; -.
PRIDE; P42669; -.
DNASU; 19290; -.
Ensembl; ENSMUST00000051301; ENSMUSP00000059404; ENSMUSG00000043991.
GeneID; 19290; -.
KEGG; mmu:19290; -.
UCSC; uc008enh.2; mouse.
CTD; 5813; -.
MGI; MGI:103079; Pura.
eggNOG; KOG3074; Eukaryota.
eggNOG; ENOG410ZKKR; LUCA.
GeneTree; ENSGT00390000015406; -.
HOGENOM; HOG000232132; -.
HOVERGEN; HBG006888; -.
InParanoid; P42669; -.
KO; K21772; -.
OMA; VPYKVWS; -.
OrthoDB; EOG091G0JS7; -.
PhylomeDB; P42669; -.
TreeFam; TF313701; -.
PRO; PR:P42669; -.
Proteomes; UP000000589; Chromosome 18.
Bgee; ENSMUSG00000043991; -.
CleanEx; MM_PURA; -.
Genevisible; P42669; MM.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0030425; C:dendrite; IDA:MGI.
GO; GO:0005662; C:DNA replication factor A complex; IDA:UniProtKB.
GO; GO:0043025; C:neuronal cell body; IDA:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0003690; F:double-stranded DNA binding; IDA:MGI.
GO; GO:0003691; F:double-stranded telomeric DNA binding; ISO:MGI.
GO; GO:0032422; F:purine-rich negative regulatory element binding; IDA:HGNC.
GO; GO:0003723; F:RNA binding; ISO:MGI.
GO; GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO; GO:0046332; F:SMAD binding; IDA:MGI.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:MGI.
GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO; GO:0000900; F:translation repressor activity, nucleic acid binding; IDA:HGNC.
GO; GO:0006915; P:apoptotic process; NAS:UniProtKB.
GO; GO:0030154; P:cell differentiation; NAS:UniProtKB.
GO; GO:0008283; P:cell proliferation; NAS:UniProtKB.
GO; GO:0006268; P:DNA unwinding involved in DNA replication; ISO:MGI.
GO; GO:0007093; P:mitotic cell cycle checkpoint; NAS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:HGNC.
GO; GO:0007399; P:nervous system development; IMP:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR006628; PUR-bd_fam.
InterPro; IPR030500; PURalpha.
PANTHER; PTHR12611; PTHR12611; 1.
PANTHER; PTHR12611:SF2; PTHR12611:SF2; 1.
Pfam; PF04845; PurA; 1.
SMART; SM00712; PUR; 3.
1: Evidence at protein level;
Acetylation; Activator; Complete proteome; Direct protein sequencing;
DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
Transcription; Transcription regulation.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:17242355}.
CHAIN 2 321 Transcriptional activator protein Pur-
alpha.
/FTId=PRO_0000097108.
COMPBIAS 11 52 Gly-rich.
COMPBIAS 292 321 Gln/Glu-rich (part of the transcriptional
activation domain).
MOD_RES 2 2 N-acetylalanine.
{ECO:0000244|PubMed:17242355}.
MOD_RES 181 181 Phosphoserine.
{ECO:0000250|UniProtKB:Q00577}.
SEQUENCE 321 AA; 34884 MW; 0379DBD96D47DCEA CRC64;
MADRDSGSEQ GGAALGSGGS LGHPGSGSGS GGGGGGGGGG GGSGGGGGAP GGLQHETQEL
ASKRVDIQNK RFYLDVKQNA KGRFLKIAEV GAGGNKSRLT LSMSVAVEFR DYLGDFIEHY
AQLGPSQPPD LAQAQDEPRR ALKSEFLVRE NRKYYMDLKE NQRGRFLRIR QTVNRGPGLG
STQGQTIALP AQGLIEFRDA LAKLIDDYGV EEEPAELPEG TSLTVDNKRF FFDVGSNKYG
VFMRVSEVKP TYRNSITVPY KVWAKFGHTF CKYSEEMKKI QEKQREKRAA CEQLHQQQQQ
QQEETTAATL LLQGEEEGEE D


Related products :

Catalog number Product name Quantity
EIAAB33180 Pura,Purine-rich single-stranded DNA-binding protein alpha,Rat,Rattus norvegicus,Transcriptional activator protein Pur-alpha
EIAAB33179 Mouse,Mus musculus,Pura,Purine-rich single-stranded DNA-binding protein alpha,Transcriptional activator protein Pur-alpha
EIAAB33181 Homo sapiens,Human,PUR1,PURA,Purine-rich single-stranded DNA-binding protein alpha,Transcriptional activator protein Pur-alpha
EIAAB33191 Mouse,Mus musculus,Purb,Purine-rich element-binding protein B,Transcriptional activator protein Pur-beta,Vascular actin single-stranded DNA-binding factor 2 p44 component
25-124 PURA is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in 0.05 mg
25-445 PURA is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in 0.05 mg
EIAAB33193 Purb,Purine-rich element-binding protein B,Rat,Rattus norvegicus,Transcriptional activator protein Pur-beta
EIAAB33192 Homo sapiens,Human,PURB,Purine-rich element-binding protein B,Transcriptional activator protein Pur-beta
26-521 The exact function of PURG is not known, however, it is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of 0.05 mg
EIAAB40016 Rat,Rattus norvegicus,Sequence-specific single-stranded-DNA-binding protein,Single-stranded DNA-binding protein 3,Ssbp3,Ssdp,Ssdp1,Ssdp3
EIAAB40014 Homo sapiens,Human,Sequence-specific single-stranded-DNA-binding protein,Single-stranded DNA-binding protein 3,SSBP3,SSDP,SSDP1
EIAAB40017 Last,Lck-associated signal transducer,Mouse,Mus musculus,Sequence-specific single-stranded-DNA-binding protein,Single-stranded DNA-binding protein 3,Ssbp3,Ssdp1
EIAAB40012 Homo sapiens,Human,Sequence-specific single-stranded-DNA-binding protein 2,Single-stranded DNA-binding protein 2,SSBP2,SSDP2
EIAAB40013 Mouse,Mus musculus,Sequence-specific single-stranded-DNA-binding protein 2,Single-stranded DNA-binding protein 2,Ssbp2,Ssdp2
EIAAB34030 C2orf12,Homo sapiens,Human,MSSP,MSSP1,RBMS1,RNA-binding motif, single-stranded-interacting protein 1,SCR2,Single-stranded DNA-binding protein MSSP-1,Suppressor of CDC2 with RNA-binding motif 2
18-003-44184 RNA-binding motif. single-stranded-interacting protein 1 - Single-stranded DNA-binding protein MSSP-1; Suppressor of CDC2 with RNA-binding motif 2 Polyclonal 0.1 mg Protein A
18-003-43583 RNA-binding motif. single-stranded-interacting protein 1 - Single-stranded DNA-binding protein MSSP-1; Suppressor of CDC2 with RNA-binding motif 2 Polyclonal 0.1 mg Protein A
EIAAB34029 Mouse,Mssp,Mssp1,Mus musculus,Rbms1,RNA-binding motif, single-stranded-interacting protein 1,Single-stranded DNA-binding protein MSSP-1
25-576 FOXK2 contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) pr 0.05 mg
31-177 FOXK2 contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) pr 0.1 mg
28-189 FOXK2 contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) pr 0.05 mg
18-003-42085 Single-stranded DNA-binding protein 2 - Sequence-specific single-stranded-DNA-binding protein 2 Polyclonal 0.05 mg Aff Pur
EIAAB40015 Chicken,Gallus gallus,Sequence-specific single-stranded-DNA-binding protein,Single-stranded DNA-binding protein 3,SSBP3,SSDP
20-272-191623 AP2 alpha - Mouse monoclonal [AP2a 8G8_5] to AP2 alpha; AP2-alpha; Activating enhancer-binding protein 2 alpha; AP-2 transcription factor; Activator protein 2; AP-2 Monoclonal 0.1 mg
18-272-195538 AP2 alpha - Rabbit polyclonal to AP2 alpha; AP2-alpha; Activating enhancer-binding protein 2 alpha; AP-2 transcription factor; Activator protein 2; AP-2 Polyclonal 0.1 ml


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur