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Transcriptional regulator CBF1

 CBF1_CANAL              Reviewed;         251 AA.
Q5A1E3; A0A1D8PML4;
16-APR-2014, integrated into UniProtKB/Swiss-Prot.
15-MAR-2017, sequence version 2.
23-MAY-2018, entry version 94.
RecName: Full=Transcriptional regulator CBF1;
Name=CBF1; OrderedLocusNames=CAALFM_C406580WA;
ORFNames=CaO19.10394, CaO19.2876;
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
Candida/Lodderomyces clade; Candida.
NCBI_TaxID=237561;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=15123810; DOI=10.1073/pnas.0401648101;
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
[2]
GENOME REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
Chibana H., Nantel A., Magee P.T.;
"Assembly of the Candida albicans genome into sixteen supercontigs
aligned on the eight chromosomes.";
Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
"Assembly of a phased diploid Candida albicans genome facilitates
allele-specific measurements and provides a simple model for repeat
and indel structure.";
Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
[4]
IDENTIFICATION, AND FUNCTION.
PubMed=11481675; DOI=10.1002/yea.757;
Eck R., Stoyan T., Kunkel W.;
"The centromere-binding factor Cbf1p from Candida albicans complements
the methionine auxotrophic phenotype of Saccharomyces cerevisiae.";
Yeast 18:1047-1052(2001).
[5]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=14659878; DOI=10.1016/j.gene.2003.09.005;
Biswas K., Rieger K.J., Morschhauser J.;
"Functional characterization of CaCBF1, the Candida albicans homolog
of centromere binding factor 1.";
Gene 323:43-55(2003).
[6]
FUNCTION, AND DNA-BINDING.
PubMed=18342603; DOI=10.1016/j.molcel.2008.02.006;
Hogues H., Lavoie H., Sellam A., Mangos M., Roemer T., Purisima E.,
Nantel A., Whiteway M.;
"Transcription factor substitution during the evolution of fungal
ribosome regulation.";
Mol. Cell 29:552-562(2008).
[7]
INDUCTION.
PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
"A recently evolved transcriptional network controls biofilm
development in Candida albicans.";
Cell 148:126-138(2012).
-!- FUNCTION: Transcription factor that binds ribosomal protein gene
promoters and rDNA locus with TBF1. Necessary for the expression
of genes involved in assimilation of inorganic sulfate. Also
required for the expression of respiratory genes and glycolytic
genes. Does not bind to centromeres and is not necessary for
efficient chromosome segregationas as does S.cerevisiae CBF1.
{ECO:0000269|PubMed:11481675, ECO:0000269|PubMed:14659878,
ECO:0000269|PubMed:18342603}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P17106}.
-!- INDUCTION: Repressed during biofilm formation.
{ECO:0000269|PubMed:22265407}.
-!- DISRUPTION PHENOTYPE: Leads to auxotrophy for sulfur amino acids.
{ECO:0000269|PubMed:14659878}.
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EMBL; CP017626; AOW29381.1; -; Genomic_DNA.
RefSeq; XP_019330942.1; XM_019475397.1.
ProteinModelPortal; Q5A1E3; -.
SMR; Q5A1E3; -.
EnsemblFungi; AOW29381; AOW29381; CAALFM_C406580WA.
GeneID; 3642779; -.
KEGG; cal:CAALFM_C406580WA; -.
CGD; CAL0000186329; CBF1.
InParanoid; Q5A1E3; -.
KO; K22484; -.
OMA; SEEWHRQ; -.
OrthoDB; EOG092C3RR5; -.
PRO; PR:Q5A1E3; -.
Proteomes; UP000000559; Chromosome 4.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003700; F:DNA binding transcription factor activity; IGI:CGD.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:CGD.
GO; GO:0007059; P:chromosome segregation; IGI:CGD.
GO; GO:0009086; P:methionine biosynthetic process; IGI:CGD.
GO; GO:0009303; P:rRNA transcription; IMP:CGD.
GO; GO:0000103; P:sulfate assimilation; IMP:CGD.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
1: Evidence at protein level;
Coiled coil; Complete proteome; DNA-binding; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 251 Transcriptional regulator CBF1.
/FTId=PRO_0000426067.
DOMAIN 152 200 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COILED 190 223 {ECO:0000255}.
SEQUENCE 251 AA; 29153 MW; 5479B57AE244BD24 CRC64;
MVKSHKRTLE KDEEHQEKKK ANKISKDDME IDAELLTQQA SDSAHTDTAT AAVAAVNNEQ
GKELEQTESS TNQTSALDKD DKETKDNLNP REETQSSHQE IDIPKDQLTN QQNLADQHQQ
YQYHQQLAQT NFKTEPTNSA KPPHGSEEWH RQRRENHKEV ERKRRESINT GIRELARLIP
TTDTNKAQIL QRAVEYIKRL KENENNNIEK WTLEKLLTEQ AVSELSASNE KLKHELESAY
REIEQLKRGK K


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