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Transcriptional regulator SarA (Staphylococcal accessory regulator A)

 SARA_STAAU              Reviewed;         124 AA.
P0C1U6; Q200K0; Q53600; Q53777;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
07-NOV-2018, entry version 73.
RecName: Full=Transcriptional regulator SarA;
AltName: Full=Staphylococcal accessory regulator A;
Name=sarA;
Staphylococcus aureus.
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
Staphylococcus.
NCBI_TaxID=1280;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Shawcross S.G., Edwards-Jones V., Dawson M.M., Foster H.A.;
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-113.
STRAIN=C101, C2, C437, C640, C720, D17, D22, D274, D365, D456, D470,
D535, D547, D97, EMRSA3, EMRSA4, EMRSA9, H116, H19, H295, H402, H417,
H466, H512, H560, H591, H707, H783, and H831;
PubMed=16622047; DOI=10.1099/mic.0.28620-0;
Cooper J.E., Feil E.J.;
"The phylogeny of Staphylococcus aureus -- which genes make the best
intra-species markers?";
Microbiology 152:1297-1305(2006).
[3]
SUBUNIT.
STRAIN=DB;
PubMed=10411747; DOI=10.1046/j.1365-2958.1999.01474.x;
Rechtin T.M., Gillaspy A.F., Schumacher M.A., Brennan R.G.,
Smeltzer M.S., Hurlburt B.K.;
"Characterization of the SarA virulence gene regulator of
Staphylococcus aureus.";
Mol. Microbiol. 33:307-316(1999).
[4]
STRAIN-DEPENDENT DIFFERENCES IN REGULATORY FUNCTION.
STRAIN=Various isolates;
PubMed=11796572; DOI=10.1128/IAI.70.2.470-480.2002;
Blevins J.S., Beenken K.E., Elasri M.O., Hurlburt B.K., Smeltzer M.S.;
"Strain-dependent differences in the regulatory roles of sarA and agr
in Staphylococcus aureus.";
Infect. Immun. 70:470-480(2002).
[5]
FUNCTION IN BIOFILM DEVELOPMENT.
STRAIN=Isolate 15981;
PubMed=12753197; DOI=10.1046/j.1365-2958.2003.03493.x;
Valle J., Toledo-Arana A., Berasain C., Ghigo J.-M., Amorena B.,
Penades J.R., Lasa I.;
"SarA and not sigmaB is essential for biofilm development by
Staphylococcus aureus.";
Mol. Microbiol. 48:1075-1087(2003).
[6]
IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=Phillips;
PubMed=15822900; DOI=10.1021/pr049866k;
Nandakumar R., Nandakumar M.P., Marten M.R., Ross J.M.;
"Proteome analysis of membrane and cell wall associated proteins from
Staphylococcus aureus.";
J. Proteome Res. 4:250-257(2005).
[7]
X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) IN COMPLEX WITH DNA.
STRAIN=DB;
PubMed=11196648; DOI=10.1038/35051623;
Schumacher M.A., Hurlburt B.K., Brennan R.G.;
"Crystal structures of SarA, a pleiotropic regulator of virulence
genes in S. aureus.";
Nature 409:215-219(2001).
-!- FUNCTION: Global regulator with both positive and negative effects
that controls expression of several virulence factors and biofilm
formation process in a cell density-dependent manner. In a strain-
dependent manner plays a role in multidrug resistance mechanism.
Is required for transcription of primary transcripts RNAII and
RNAIII generated by agr (virulence accessory gene regulator)
locus. Acts as a transcriptional activator of the genes encoding,
among others, for fibronectin binding proteins (fnbA and fnbB),
hemolysins (hla, hld, hlgB and hlgC), serine proteases (splA,
splB, splD and splF) and of the bap gene, which is essential for
biofilm development in some strains. Negatively regulates the
expression of the genes for protein A (spa), lipase (lip),
thermonuclease (nuc), immunodominant staphylococcal antigen B
(isaB), staphylococcal serine and cysteine proteases (sspA and
sspB), staphostatin B (sspC), metalloprotease aureolysin (aur) and
collagen adhesin (cna). Probably activates the development of
biofilm by both enhancing the ica operon transcription and
suppressing the transcription of either a protein involved in the
turnover of PIA/PNAG or a repressor of its synthesis, whose
expression would be sigma-B-dependent.
{ECO:0000269|PubMed:12753197}.
-!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:10411747,
ECO:0000269|PubMed:11196648}.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- INDUCTION: Expressed at the exponential growth phase and maximally
induced during the transition from late exponential phase to
stationary phase. Repressed by SarR and activated by two-component
regulatory system ArlS/ArlR. Activated by SigB in strains
harboring an intact sigB operon (rsbU, rsbV, rsbW, and sigB).
Transcription is also attenuated by MsrR.
-!- MISCELLANEOUS: Can regulate transcription of some virulence
factors (hemolysins, staphylococcal serine and cysteine proteases,
lipase, protein A and metalloprotease aureolysin) via either agr-
dependent and/or agr-independent pathway. Agr and SarA have
opposing effects on the expression of sspA, sspB, sspC, lip and
aur.
-!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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EMBL; AF515775; AAM74164.1; -; Genomic_DNA.
EMBL; DQ414117; ABD73686.1; -; Genomic_DNA.
EMBL; DQ414116; ABD73685.1; -; Genomic_DNA.
EMBL; DQ414115; ABD73684.1; -; Genomic_DNA.
EMBL; DQ414114; ABD73683.1; -; Genomic_DNA.
EMBL; DQ414113; ABD73682.1; -; Genomic_DNA.
EMBL; DQ414112; ABD73681.1; -; Genomic_DNA.
EMBL; DQ414111; ABD73680.1; -; Genomic_DNA.
EMBL; DQ414110; ABD73679.1; -; Genomic_DNA.
EMBL; DQ414109; ABD73678.1; -; Genomic_DNA.
EMBL; DQ414108; ABD73677.1; -; Genomic_DNA.
EMBL; DQ414107; ABD73676.1; -; Genomic_DNA.
EMBL; DQ414106; ABD73675.1; -; Genomic_DNA.
EMBL; DQ414105; ABD73674.1; -; Genomic_DNA.
EMBL; DQ414104; ABD73673.1; -; Genomic_DNA.
EMBL; DQ414103; ABD73672.1; -; Genomic_DNA.
EMBL; DQ414102; ABD73671.1; -; Genomic_DNA.
EMBL; DQ414101; ABD73670.1; -; Genomic_DNA.
EMBL; DQ414100; ABD73669.1; -; Genomic_DNA.
EMBL; DQ414099; ABD73668.1; -; Genomic_DNA.
EMBL; DQ414098; ABD73667.1; -; Genomic_DNA.
EMBL; DQ414097; ABD73666.1; -; Genomic_DNA.
EMBL; DQ414096; ABD73665.1; -; Genomic_DNA.
EMBL; DQ414095; ABD73664.1; -; Genomic_DNA.
EMBL; DQ414094; ABD73663.1; -; Genomic_DNA.
EMBL; DQ414093; ABD73662.1; -; Genomic_DNA.
EMBL; DQ414092; ABD73661.1; -; Genomic_DNA.
EMBL; DQ414091; ABD73660.1; -; Genomic_DNA.
EMBL; DQ414090; ABD73659.1; -; Genomic_DNA.
EMBL; DQ414089; ABD73658.1; -; Genomic_DNA.
RefSeq; WP_001018677.1; NZ_UHEH01000001.1.
PDB; 1FZP; X-ray; 2.95 A; B/D=2-124.
PDBsum; 1FZP; -.
ProteinModelPortal; P0C1U6; -.
SMR; P0C1U6; -.
eggNOG; COG1846; LUCA.
EvolutionaryTrace; P0C1U6; -.
PRO; PR:P0C1U6; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
GO; GO:0090609; P:single-species submerged biofilm formation; IMP:CACAO.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR010166; SarA/Rot.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
SUPFAM; SSF46785; SSF46785; 1.
TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
1: Evidence at protein level;
3D-structure; Activator; Cytoplasm; DNA-binding; Metal-binding;
Repressor; Transcription; Transcription regulation; Virulence.
INIT_MET 1 1 Removed. {ECO:0000250}.
CHAIN 2 124 Transcriptional regulator SarA.
/FTId=PRO_0000219576.
METAL 7 7 Divalent metal cation. {ECO:0000250}.
METAL 8 8 Divalent metal cation. {ECO:0000250}.
METAL 11 11 Divalent metal cation. {ECO:0000250}.
HELIX 10 13 {ECO:0000244|PDB:1FZP}.
HELIX 15 29 {ECO:0000244|PDB:1FZP}.
HELIX 33 39 {ECO:0000244|PDB:1FZP}.
HELIX 40 42 {ECO:0000244|PDB:1FZP}.
HELIX 45 47 {ECO:0000244|PDB:1FZP}.
HELIX 48 54 {ECO:0000244|PDB:1FZP}.
HELIX 68 87 {ECO:0000244|PDB:1FZP}.
TURN 88 91 {ECO:0000244|PDB:1FZP}.
HELIX 92 110 {ECO:0000244|PDB:1FZP}.
SEQUENCE 124 AA; 14718 MW; DB9A16E806C10661 CRC64;
MAITKINDCF ELLSMVTYAD KLKSLIKKEF SISFEEFAVL TYISENKEKE YYLKDIINHL
NYKQPQVVKA VKILSQEDYF DKKRNEHDER TVLILVNAQQ RKKIESLLSR VNKRITEANN
EIEL


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