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Transcriptional regulator SarA (Staphylococcal accessory regulator A)

 SARA_STAAB              Reviewed;         124 AA.
Q2YSV9;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
20-DEC-2005, sequence version 1.
28-MAR-2018, entry version 80.
RecName: Full=Transcriptional regulator SarA;
AltName: Full=Staphylococcal accessory regulator A;
Name=sarA; OrderedLocusNames=SAB0569c;
Staphylococcus aureus (strain bovine RF122 / ET3-1).
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
Staphylococcus.
NCBI_TaxID=273036;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=bovine RF122 / ET3-1;
PubMed=17971880; DOI=10.1371/journal.pone.0001120;
Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
"Molecular correlates of host specialization in Staphylococcus
aureus.";
PLoS ONE 2:E1120-E1120(2007).
-!- FUNCTION: Global regulator with both positive and negative effects
that controls the expression of several virulence factors and the
biofilm formation process in a cell density-dependent manner.
{ECO:0000250}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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EMBL; AJ938182; CAI80257.1; -; Genomic_DNA.
RefSeq; WP_001018677.1; NC_007622.1.
ProteinModelPortal; Q2YSV9; -.
SMR; Q2YSV9; -.
EnsemblBacteria; CAI80257; CAI80257; SAB0569c.
KEGG; sab:SAB0569c; -.
HOGENOM; HOG000279851; -.
OMA; AMITYAD; -.
PRO; PR:Q2YSV9; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR010166; SarA/Rot.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
SUPFAM; SSF46785; SSF46785; 1.
TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
3: Inferred from homology;
Activator; Cytoplasm; DNA-binding; Metal-binding; Repressor;
Transcription; Transcription regulation; Virulence.
INIT_MET 1 1 Removed. {ECO:0000250}.
CHAIN 2 124 Transcriptional regulator SarA.
/FTId=PRO_0000295625.
METAL 7 7 Divalent metal cation. {ECO:0000250}.
METAL 8 8 Divalent metal cation. {ECO:0000250}.
METAL 11 11 Divalent metal cation. {ECO:0000250}.
SEQUENCE 124 AA; 14718 MW; DB9A16E806C10661 CRC64;
MAITKINDCF ELLSMVTYAD KLKSLIKKEF SISFEEFAVL TYISENKEKE YYLKDIINHL
NYKQPQVVKA VKILSQEDYF DKKRNEHDER TVLILVNAQQ RKKIESLLSR VNKRITEANN
EIEL


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