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Transcriptional regulator WAR1 (Weak acid resistance protein 1)

 WAR1_CANAL              Reviewed;         947 AA.
Q59VQ8; A0A1D8PD27; Q59VV4;
16-APR-2014, integrated into UniProtKB/Swiss-Prot.
15-MAR-2017, sequence version 2.
22-NOV-2017, entry version 74.
RecName: Full=Transcriptional regulator WAR1;
AltName: Full=Weak acid resistance protein 1;
Name=WAR1; OrderedLocusNames=CAALFM_C103740WA;
ORFNames=CaO19.1035, CaO19.8637;
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
Candida/Lodderomyces clade; Candida.
NCBI_TaxID=237561;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=15123810; DOI=10.1073/pnas.0401648101;
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
[2]
GENOME REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
Chibana H., Nantel A., Magee P.T.;
"Assembly of the Candida albicans genome into sixteen supercontigs
aligned on the eight chromosomes.";
Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
"Assembly of a phased diploid Candida albicans genome facilitates
allele-specific measurements and provides a simple model for repeat
and indel structure.";
Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
[4]
IDENTIFICATION.
PubMed=18629206; DOI=10.1002/cfg.492;
Maicas S., Moreno I., Nieto A., Gomez M., Sentandreu R., Valentin E.;
"In silico analysis for transcription factors with Zn(II)(2)C(6)
binuclear cluster DNA-binding domains in Candida albicans.";
Comp. Funct. Genomics 6:345-356(2005).
[5]
IDENTIFICATION.
PubMed=16959962; DOI=10.1128/MMBR.00015-06;
MacPherson S., Larochelle M., Turcotte B.;
"A fungal family of transcriptional regulators: the zinc cluster
proteins.";
Microbiol. Mol. Biol. Rev. 70:583-604(2006).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=16544288; DOI=10.1002/yea.1346;
Lebel K., MacPherson S., Turcotte B.;
"New tools for phenotypic analysis in Candida albicans: the WAR1 gene
confers resistance to sorbate.";
Yeast 23:249-259(2006).
[7]
FUNCTION, AND DNA-BINDING.
PubMed=18083829; DOI=10.1128/EC.00240-07;
Chiranand W., McLeod I., Zhou H., Lynn J.J., Vega L.A., Myers H.,
Yates J.R. III, Lorenz M.C., Gustin M.C.;
"CTA4 transcription factor mediates induction of nitrosative stress
response in Candida albicans.";
Eukaryot. Cell 7:268-278(2008).
[8]
INDUCTION.
PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
"A recently evolved transcriptional network controls biofilm
development in Candida albicans.";
Cell 148:126-138(2012).
[9]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=22359502; DOI=10.1371/journal.ppat.1002525;
Finkel J.S., Xu W., Huang D., Hill E.M., Desai J.V., Woolford C.A.,
Nett J.E., Taff H., Norice C.T., Andes D.R., Lanni F., Mitchell A.P.;
"Portrait of Candida albicans adherence regulators.";
PLoS Pathog. 8:E1002525-E1002525(2012).
-!- FUNCTION: Transcription factor required for yeast cell adherence
to silicone substrate. Plays a role in resistance to weak organic
acids such as acetate and sorbate. Binds in vitro to a nitric
oxide-responsive element (NORE) but seems not to be involved in
response to nitrosative stress. {ECO:0000269|PubMed:16544288,
ECO:0000269|PubMed:18083829, ECO:0000269|PubMed:22359502}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00227}.
-!- INDUCTION: Expression is induced in biofilm.
{ECO:0000269|PubMed:22265407}.
-!- DISRUPTION PHENOTYPE: Leads to sensitivity to weak organic acids
and decreases cell adherence to silicone substrate.
{ECO:0000269|PubMed:16544288, ECO:0000269|PubMed:22359502}.
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EMBL; CP017623; AOW26051.1; -; Genomic_DNA.
RefSeq; XP_713640.2; XM_708547.2.
PRIDE; Q59VQ8; -.
EnsemblFungi; AOW26051; AOW26051; CAALFM_C103740WA.
GeneID; 3644691; -.
KEGG; cal:CAALFM_C103740WA; -.
CGD; CAL0000177698; WAR1.
InParanoid; Q59VQ8; -.
OrthoDB; EOG092C0DOI; -.
PRO; PR:Q59VQ8; -.
Proteomes; UP000000559; Chromosome 1.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0000982; F:transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISO:CGD.
GO; GO:0044212; F:transcription regulatory region DNA binding; IBA:GO_Central.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0071311; P:cellular response to acetate; IMP:CGD.
GO; GO:1900189; P:positive regulation of cell adhesion involved in single-species biofilm formation; IMP:CGD.
GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IMP:CGD.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:CGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:CGD.
GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00067; GAL4; 1.
Gene3D; 4.10.240.10; -; 1.
InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
SMART; SM00066; GAL4; 1.
SUPFAM; SSF57701; SSF57701; 1.
PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
1: Evidence at protein level;
Cell adhesion; Complete proteome; DNA-binding; Metal-binding; Nucleus;
Reference proteome; Stress response; Transcription;
Transcription regulation; Zinc.
CHAIN 1 947 Transcriptional regulator WAR1.
/FTId=PRO_0000426087.
DNA_BIND 54 86 Zn(2)-C6 fungal-type.
{ECO:0000255|PROSITE-ProRule:PRU00227}.
SEQUENCE 947 AA; 105854 MW; 9DAA645E36D94C01 CRC64;
MSDTTPEKGS VDSVSPSASN GSNTNNPLNN SSPQPLKSNE SDKKPKVTRR SVACKSCHSL
KVKCTPSDPN NPSAPCVRCI NANRICEIDL NQTRKRRKKS EILEAKRQAG QSLPEHKKEK
NTPTQSGYNS SENYSSSINN ANDSSLTSRY QSPMTFDPTS PMVFRPQASS AVPPISSNLN
PQSAAPTPIP TSGIPPQLPS PHESAILRGN TTSPTSKDDE INQLKQRVRF LETELANKRL
LANKKGFSND SPTDLQSPPF VSKFDLESEI SILAESSARL TDLTNQLNEA ASRRIQLVSA
KKPVDLISKG VITVAEAEER LKLYREQIYG RHPLIAIPDN MHAIEFSQSQ PFLFNSIMSA
CNLITKNADK DVVLAIDNEA MTSVAVEVMV VGTKSVELVK AFSVLCLYYN SPELFKQRRY
HMLNTICVSL LHDVGIFARP TYSYNQADGT LKQDASSKDK GNDEYRELVL ITYFVTVSTC
LVLRRSIYAR WTPYVEECCS LLENSSQEKH RRLALFARMN NKLDKIHHIV HAPEMPGQKS
GVSQYVIQEL QRLLSDLKLK IKDNQYSLLS YYYSIEAYLH EPILTKVFKS DTELDGKAMK
SIRYCTSSCL NALDEYSKLT PDQIALLPFP FGSRIMYTAG MLLRLRYLIL SLPSHIDKEL
VPKRAVTSIQ CVSKLVEQAN ILNPHNHYLT KMRLVLQLFI QTYATQVLEL LSKNGNTPQN
FKPDESETQQ LRALAREYND IRKVSKVSLV SDTRSAEPLD VLSYAATFRR ENNDKPSAVA
GSLRKSFSEN DQAIKTPSQC GQFVSANNTP VPQVINSPPI SQTNVPVLHQ SQSIINGNNR
NSAPLAFNNT TTPSLHQFGD VLPPSSMPQP DYRQFRLPSI SNTVHYSSNP RLNANLANPD
QLENSYQVLN DEFWSNLLST DSTDRINFTS NNFNGNTSND EVFFMNN


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