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Transferrin receptor (Transferrin receptor 1) (Transferrin receptor protein 1)

 F6UX47_MACMU            Unreviewed;       760 AA.
F6UX47;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
12-SEP-2018, entry version 58.
SubName: Full=Transferrin receptor protein 1 {ECO:0000313|EMBL:AFH30253.1};
Name=TFRC {ECO:0000313|EMBL:AFH30253.1,
ECO:0000313|Ensembl:ENSMMUP00000002816};
Synonyms=Tfrc {ECO:0000313|EMBL:AFD18260.1};
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002816, ECO:0000313|Proteomes:UP000006718};
[1] {ECO:0000313|Ensembl:ENSMMUP00000002816, ECO:0000313|Proteomes:UP000006718}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002816,
ECO:0000313|Proteomes:UP000006718};
PubMed=17431167; DOI=10.1126/science.1139247;
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
Zwieg A.S.;
"Evolutionary and biomedical insights from the rhesus macaque
genome.";
Science 316:222-234(2007).
[2] {ECO:0000313|Ensembl:ENSMMUP00000002816}
IDENTIFICATION.
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002816};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[3] {ECO:0000313|EMBL:AFD18260.1}
NUCLEOTIDE SEQUENCE.
PubMed=22278244; DOI=10.1128/JVI.06397-11;
Helguera G., Jemielity S., Abraham J., Cordo S.M., Martinez M.G.,
Rodriguez J.A., Bregni C., Wang J.J., Farzan M., Penichet M.L.,
Candurra N.A., Choe H.;
"An antibody recognizing the apical domain of human transferrin
receptor 1 efficiently inhibits the entry of all new world hemorrhagic
Fever arenaviruses.";
J. Virol. 86:4024-4028(2012).
[4] {ECO:0000313|EMBL:AFH30253.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Thymus {ECO:0000313|EMBL:AFH30253.1};
PubMed=25319552; DOI=10.1186/1745-6150-9-20;
Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X.,
Pandey S., Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P.,
Tharp G.K., Marcais G., Roberts M., Ferguson B., Fox H.S.,
Treangen T., Salzberg S.L., Yorke J.A., Norgren R.B.Jr.;
"A new rhesus macaque assembly and annotation for next-generation
sequencing analyses.";
Biol. Direct 9:20-20(2014).
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EMBL; JSUE03025254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; JQ014204; AFD18260.1; -; mRNA.
EMBL; JU473449; AFH30253.1; -; mRNA.
EMBL; JU473450; AFH30254.1; -; mRNA.
RefSeq; NP_001244232.1; NM_001257303.1.
RefSeq; XP_014988039.1; XM_015132553.1.
UniGene; Mmu.861; -.
STRING; 9544.ENSMMUP00000002816; -.
MEROPS; M28.972; -.
Ensembl; ENSMMUT00000002982; ENSMMUP00000002816; ENSMMUG00000002114.
GeneID; 711568; -.
KEGG; mcc:711568; -.
CTD; 7037; -.
eggNOG; KOG2195; Eukaryota.
eggNOG; COG2234; LUCA.
GeneTree; ENSGT00550000074421; -.
KO; K06503; -.
OMA; DNSHVEM; -.
OrthoDB; EOG091G02ZM; -.
TreeFam; TF312981; -.
Proteomes; UP000006718; Chromosome 2.
Bgee; ENSMMUG00000002114; Expressed in 14 organ(s), highest expression level in colon.
GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
GO; GO:0005769; C:early endosome; IEA:Ensembl.
GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0004998; F:transferrin receptor activity; IEA:Ensembl.
GO; GO:0033570; F:transferrin transmembrane transporter activity; IEA:InterPro.
GO; GO:0006879; P:cellular iron ion homeostasis; IEA:Ensembl.
GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
GO; GO:0097286; P:iron ion import; IEA:Ensembl.
GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
GO; GO:0045830; P:positive regulation of isotype switching; IEA:Ensembl.
GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
CDD; cd02128; PA_TfR; 1.
Gene3D; 1.20.930.40; -; 1.
InterPro; IPR003137; PA_domain.
InterPro; IPR007484; Peptidase_M28.
InterPro; IPR039373; Peptidase_M28B.
InterPro; IPR029513; TfR.
InterPro; IPR007365; TFR-like_dimer_dom.
InterPro; IPR036757; TFR-like_dimer_dom_sf.
InterPro; IPR037324; TfR1/2_PA.
PANTHER; PTHR10404; PTHR10404; 1.
PANTHER; PTHR10404:SF26; PTHR10404:SF26; 1.
Pfam; PF02225; PA; 1.
Pfam; PF04389; Peptidase_M28; 1.
Pfam; PF04253; TFR_dimer; 1.
SUPFAM; SSF47672; SSF47672; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000006718};
Membrane {ECO:0000256|SAM:Phobius};
Receptor {ECO:0000313|EMBL:AFD18260.1};
Reference proteome {ECO:0000313|Proteomes:UP000006718};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 66 88 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 228 345 PA. {ECO:0000259|Pfam:PF02225}.
DOMAIN 388 576 Peptidase_M28.
{ECO:0000259|Pfam:PF04389}.
DOMAIN 637 749 TFR_dimer. {ECO:0000259|Pfam:PF04253}.
SEQUENCE 760 AA; 84908 MW; 26002F7B4EB22A22 CRC64;
MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL GVDEEENTDN NTKPNGTKPK
RCGGNICYGT IAVIIFFLIG FMIGYLGYCK GVEPKTECER LAGTESPARE EPEEDFPAAP
RLYWDDLKRK LSEKLDTTDF TSTIKLLNEN LYVPREAGSQ KDENLALYIE NQFREFKLSK
VWRDQHFVKI QVKDSAQNSV IIVDKNGGLV YLVENPGGYV AYSKAATVTG KLVHANFGTK
KDFEDLDSPV NGSIVIVRAG KITFAEKVAN AESLNAIGVL IYMDQTKFPI VKADLSFFGH
AHLGTGDPYT PGFPSFNHTQ FPPSQSSGLP NIPVQTISRA AAEKLFGNME GDCPSDWKTD
STCKMVTSEN KSVKLTVSNV LKETKILNIF GVIKGFVEPD HYVVVGAQRD AWGPGAAKSS
VGTALLLKLA QMFSDMVLKD GFQPSRSIIF ASWSAGDFGS VGATEWLEGY LSSLHLKAFT
YINLDKAVLG TSNFKVSASP LLYTLIEKTM QDVKHPVTGR SLYQDSNWAS KVEKLTLDNA
AFPFLAYSGI PAVSFCFCED TDYPYLGTTM DTYKELVERI PELNKVARAA AEVAGQFVIK
LTHDTELNLD YERYNSQLLL FLRDLNQYRA DVKEMGLSLQ WLYSARGDFF RATSRLTTDF
RNAEKRDKFV MKKLNDRVMR VEYYFLSPYV SPKESPFRHV FWGSGSHTLS ALLESLKLRR
QNNSAFNETL FRNQLALATW TIQGAANALS GDVWDIDNEF


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