Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (CD antigen CD71)

 TFR1_PONAB              Reviewed;         760 AA.
Q5RDH6;
30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
12-SEP-2018, entry version 87.
RecName: Full=Transferrin receptor protein 1;
Short=TR;
Short=TfR;
Short=TfR1;
Short=Trfr;
AltName: CD_antigen=CD71;
Name=TFRC;
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Cellular uptake of iron occurs via receptor-mediated
endocytosis of ligand-occupied transferrin receptor into
specialized endosomes. Endosomal acidification leads to iron
release. The apotransferrin-receptor complex is then recycled to
the cell surface with a return to neutral pH and the concomitant
loss of affinity of apotransferrin for its receptor. Transferrin
receptor is necessary for development of erythrocytes and the
nervous system (By similarity). Positively regulates T and B cell
proliferation through iron uptake (By similarity). {ECO:0000250,
ECO:0000250|UniProtKB:P02786}.
-!- SUBUNIT: Homodimer; disulfide-linked. Binds one transferrin or HFE
molecule per subunit. Interacts with SH3BP4 (By similarity).
Interacts with STEAP3; facilitates TFRC endocytosis in erythroid
precursor cells (By similarity). {ECO:0000250,
ECO:0000250|UniProtKB:P02786}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P02786}; Single-pass type II membrane
protein {ECO:0000250|UniProtKB:P02786}. Melanosome
{ECO:0000250|UniProtKB:P02786}.
-!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; CR857934; CAH90181.1; -; mRNA.
RefSeq; NP_001125063.1; NM_001131591.1.
UniGene; Pab.323; -.
ProteinModelPortal; Q5RDH6; -.
SMR; Q5RDH6; -.
STRING; 9601.ENSPPYP00000016144; -.
MEROPS; M28.972; -.
PRIDE; Q5RDH6; -.
Ensembl; ENSPPYT00000016790; ENSPPYP00000016144; ENSPPYG00000014434.
GeneID; 100171944; -.
KEGG; pon:100171944; -.
CTD; 7037; -.
eggNOG; KOG2195; Eukaryota.
eggNOG; COG2234; LUCA.
GeneTree; ENSGT00550000074421; -.
HOVERGEN; HBG023177; -.
InParanoid; Q5RDH6; -.
KO; K06503; -.
OMA; DNSHVEM; -.
OrthoDB; EOG091G02ZM; -.
TreeFam; TF312981; -.
Proteomes; UP000001595; Chromosome 3.
GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
GO; GO:0005769; C:early endosome; IEA:Ensembl.
GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0004998; F:transferrin receptor activity; ISS:UniProtKB.
GO; GO:0033570; F:transferrin transmembrane transporter activity; IEA:InterPro.
GO; GO:0006879; P:cellular iron ion homeostasis; IEA:Ensembl.
GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
GO; GO:0097286; P:iron ion import; IEA:Ensembl.
GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
GO; GO:0045830; P:positive regulation of isotype switching; ISS:UniProtKB.
GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
GO; GO:0031623; P:receptor internalization; ISS:UniProtKB.
GO; GO:0033572; P:transferrin transport; ISS:UniProtKB.
CDD; cd02128; PA_TfR; 1.
Gene3D; 1.20.930.40; -; 1.
InterPro; IPR003137; PA_domain.
InterPro; IPR007484; Peptidase_M28.
InterPro; IPR039373; Peptidase_M28B.
InterPro; IPR029513; TfR.
InterPro; IPR007365; TFR-like_dimer_dom.
InterPro; IPR036757; TFR-like_dimer_dom_sf.
InterPro; IPR037324; TfR1/2_PA.
PANTHER; PTHR10404; PTHR10404; 1.
PANTHER; PTHR10404:SF26; PTHR10404:SF26; 1.
Pfam; PF02225; PA; 1.
Pfam; PF04389; Peptidase_M28; 1.
Pfam; PF04253; TFR_dimer; 1.
SUPFAM; SSF47672; SSF47672; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Endocytosis;
Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein;
Receptor; Reference proteome; Signal-anchor; Transmembrane;
Transmembrane helix.
CHAIN 1 760 Transferrin receptor protein 1.
/FTId=PRO_0000237617.
TOPO_DOM 1 65 Cytoplasmic. {ECO:0000255}.
TRANSMEM 66 86 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 87 760 Extracellular. {ECO:0000255}.
DOMAIN 223 313 PA.
REGION 1 67 Mediates interaction with SH3BP4.
{ECO:0000250}.
REGION 569 760 Ligand-binding. {ECO:0000250}.
MOTIF 20 23 Endocytosis signal.
MOTIF 58 61 Stop-transfer sequence.
MOTIF 646 648 Cell attachment site. {ECO:0000255}.
MOD_RES 10 10 Phosphoserine.
{ECO:0000250|UniProtKB:P02786}.
MOD_RES 19 19 Phosphoserine.
{ECO:0000250|UniProtKB:Q62351}.
MOD_RES 20 20 Phosphotyrosine.
{ECO:0000250|UniProtKB:P02786}.
MOD_RES 21 21 Phosphothreonine.
{ECO:0000250|UniProtKB:P02786}.
MOD_RES 24 24 Phosphoserine.
{ECO:0000250|UniProtKB:P02786}.
LIPID 62 62 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 67 67 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 251 251 N-linked (GlcNAc...) asparagine.
{ECO:0000250|UniProtKB:P02786}.
CARBOHYD 317 317 N-linked (GlcNAc...) asparagine.
{ECO:0000250|UniProtKB:P02786}.
CARBOHYD 722 722 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 727 727 N-linked (GlcNAc...) asparagine.
{ECO:0000250|UniProtKB:P02786}.
DISULFID 89 89 Interchain. {ECO:0000250}.
DISULFID 98 98 Interchain. {ECO:0000250}.
SEQUENCE 760 AA; 84817 MW; A94E6F82FE856918 CRC64;
MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL AVDEEENADN NTKANVTKPK
RCGGSICYGT IAVIIFFLIG FMIGYLGYCK GVEPKTECER LAGTESPVRE EPEEDFPAAP
RLYWDDLKKK LSEKLDTTDF TSTIKLLNEN SYVPREAGSQ KDENLALYVE NQFREFKLSK
VWRDQHFVKI QVKDSAQNSV IIVDKNGRLV YLVENPGGYV AYSKAATVTG KLVHANFGTK
KDFEDLDTPV NGSIVIVRAG KITFAEKVAN AESLNAIGVL IYMDQTKFPI VNAELSFFGH
AHLGTGDPYT PGFPSFNHTQ FPPSRSSGLP NIPVQTISRA AAEKLFGNME GDCPSDWKTD
STCRMVTSES KNVKLTVSNV LKEIKILNIF GVIKGFVEPD HYVVVGAQRD AWGPGAAKSG
VGTALLLKLA EMFSDMVLKD GFQPSRSIIF ASWSAGDFGS VGATEWLEGY LSSLHLKAFT
YINLDKAVLG TSNFKVSASP LLYTLIEKTM QNVKHPVTGQ SLYQDSNWAS KVEKLTLDNA
AFPFLAYSGI PAVSFCFCED TDYPYLGTTM DTYKELTERI PELNKVARAA AEVAGQFMIK
LTHDVELNLD YERYNSQLLS FVRDLNQYRA DIKEMGLSLQ WLYSARGDFF RATSRLTTDF
GNAEKTDRFV MKKLNDRVMR VEYHFLSPYV SPKESPFRHV FWGSGSHTLS ALLENLKLRK
QNNSAFNETL FRNQLALATW TIQGAANALS GDVWDIDNEF


Related products :

Catalog number Product name Quantity
15-288-22459A Transferrin receptor protein 1 - TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Polyclonal 0.05 mg
15-288-22459A Transferrin receptor protein 1 - TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Polyclonal 0.1 mg
20-272-192007 Transferrin Receptor - Mouse monoclonal [DF1513] to Transferrin Receptor; TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.2 mg
20-272-190159 Transferrin Receptor - Mouse monoclonal [10D2] to Transferrin Receptor; TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-190160 Transferrin Receptor - Mouse monoclonal [11F5] to Transferrin Receptor; TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-190161 Transferrin Receptor - Mouse monoclonal [13E4] to Transferrin Receptor; TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-190162 Transferrin Receptor - Mouse monoclonal [23D10 ] to Transferrin Receptor; TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-190164 Transferrin Receptor - Mouse monoclonal [5B11] to Transferrin Receptor; TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-190166 Transferrin Receptor - Mouse monoclonal [7 - 1] to Transferrin Receptor; TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-190165 Transferrin Receptor - Mouse monoclonal [7F8] to Transferrin Receptor; TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-190163 Transferrin Receptor - Mouse monoclonal [2B6] to Transferrin Receptor; TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-192191 Transferrin Receptor - Mouse monoclonal [MEM - 189] to Transferrin Receptor; TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-191918 Transferrin Receptor (Biotin) - Mouse monoclonal [T56_14] to Transferrin Receptor (Biotin); TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-191924 Transferrin Receptor (Phycoerythrin) - Mouse monoclonal [T56_14] to Transferrin Receptor (Phycoerythrin); TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 0.1 mg
20-272-191668 Transferrin Receptor (Phycoerythrin) - Mouse monoclonal [MEM-75] to Transferrin Receptor (Phycoerythrin); TfR1; TR; TfR; Trfr; CD71 antigen; T9; p90 Monoclonal 100 TESTS
U0809r CLIA Rat,Rattus norvegicus,TfR,TfR1,Tfrc,TR,Transferrin receptor protein 1,Trfr,Trfr 96T
E0809r ELISA kit Rat,Rattus norvegicus,TfR,TfR1,Tfrc,TR,Transferrin receptor protein 1,Trfr,Trfr 96T
E0809r ELISA Rat,Rattus norvegicus,TfR,TfR1,Tfrc,TR,Transferrin receptor protein 1,Trfr,Trfr 96T
E0809m ELISA Mouse,Mus musculus,TfR,TfR1,Tfrc,TR,Transferrin receptor protein 1,Trfr,Trfr 96T
E0809m ELISA kit Mouse,Mus musculus,TfR,TfR1,Tfrc,TR,Transferrin receptor protein 1,Trfr,Trfr 96T
U0809m CLIA Mouse,Mus musculus,TfR,TfR1,Tfrc,TR,Transferrin receptor protein 1,Trfr,Trfr 96T
101-M685 Transferrin R Anti-Human Host: Mouse TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR 100
101-M685 Transferrin R, Host: Mouse, Species: Anti-Human, Synonyms: TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR 100 ug
U0809p CLIA Pig,Sus scrofa,TfR,TfR1,TFRC,TR,Transferrin receptor protein 1,Trfr 96T
E0809p ELISA Pig,Sus scrofa,TfR,TfR1,TFRC,TR,Transferrin receptor protein 1,Trfr 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur