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Transforming growth factor beta 1

 E5LDB9_MARMO            Unreviewed;       390 AA.
E5LDB9;
08-FEB-2011, integrated into UniProtKB/TrEMBL.
08-FEB-2011, sequence version 1.
27-SEP-2017, entry version 25.
SubName: Full=Transforming growth factor beta 1 {ECO:0000313|EMBL:ADP44690.1};
Name=TGF-beta 1 {ECO:0000313|EMBL:ADP44690.1};
Marmota monax (Woodchuck).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
Sciuridae; Xerinae; Marmotini; Marmota.
NCBI_TaxID=9995 {ECO:0000313|EMBL:ADP44690.1};
[1] {ECO:0000313|EMBL:ADP44690.1}
NUCLEOTIDE SEQUENCE.
Otano I., Gonzalez G., Menne S., Riezu J.I.;
"Treatment of chronic viral hepatitis in woodchucks by prolonged
intrahepatic expression of interleukin-12.";
Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
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EMBL; HQ433224; ADP44690.1; -; mRNA.
GO; GO:0072562; C:blood microparticle; ISS:AgBase.
GO; GO:0009986; C:cell surface; ISS:AgBase.
GO; GO:0005737; C:cytoplasm; ISS:AgBase.
GO; GO:0005615; C:extracellular space; ISS:AgBase.
GO; GO:0005634; C:nucleus; ISS:AgBase.
GO; GO:0003823; F:antigen binding; ISS:AgBase.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0034713; F:type I transforming growth factor beta receptor binding; ISS:AgBase.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; ISS:AgBase.
GO; GO:0034714; F:type III transforming growth factor beta receptor binding; ISS:AgBase.
GO; GO:0006754; P:ATP biosynthetic process; ISS:AgBase.
GO; GO:0007050; P:cell cycle arrest; ISS:AgBase.
GO; GO:0016049; P:cell growth; IEA:InterPro.
GO; GO:0045216; P:cell-cell junction organization; ISS:AgBase.
GO; GO:0071407; P:cellular response to organic cyclic compound; ISS:AgBase.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISS:AgBase.
GO; GO:0002062; P:chondrocyte differentiation; ISS:AgBase.
GO; GO:0007182; P:common-partner SMAD protein phosphorylation; ISS:AgBase.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; ISS:AgBase.
GO; GO:0019049; P:evasion or tolerance of host defenses by virus; ISS:AgBase.
GO; GO:0085029; P:extracellular matrix assembly; ISS:AgBase.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:AgBase.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:AgBase.
GO; GO:0030214; P:hyaluronan catabolic process; ISS:AgBase.
GO; GO:0006954; P:inflammatory response; ISS:AgBase.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:AgBase.
GO; GO:0000165; P:MAPK cascade; ISS:AgBase.
GO; GO:0007093; P:mitotic cell cycle checkpoint; ISS:AgBase.
GO; GO:0043537; P:negative regulation of blood vessel endothelial cell migration; ISS:AgBase.
GO; GO:0045786; P:negative regulation of cell cycle; ISS:AgBase.
GO; GO:0030308; P:negative regulation of cell growth; ISS:AgBase.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:AgBase.
GO; GO:0022408; P:negative regulation of cell-cell adhesion; ISS:AgBase.
GO; GO:0008156; P:negative regulation of DNA replication; ISS:AgBase.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:AgBase.
GO; GO:0045599; P:negative regulation of fat cell differentiation; ISS:AgBase.
GO; GO:0010629; P:negative regulation of gene expression; ISS:BHF-UCL.
GO; GO:0060965; P:negative regulation of gene silencing by miRNA; ISS:BHF-UCL.
GO; GO:1900126; P:negative regulation of hyaluronan biosynthetic process; ISS:AgBase.
GO; GO:0010936; P:negative regulation of macrophage cytokine production; ISS:AgBase.
GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISS:AgBase.
GO; GO:0045662; P:negative regulation of myoblast differentiation; ISS:AgBase.
GO; GO:0001933; P:negative regulation of protein phosphorylation; ISS:AgBase.
GO; GO:0048642; P:negative regulation of skeletal muscle tissue development; ISS:AgBase.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:AgBase.
GO; GO:0043932; P:ossification involved in bone remodeling; ISS:AgBase.
GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; ISS:AgBase.
GO; GO:0006796; P:phosphate-containing compound metabolic process; ISS:AgBase.
GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISS:AgBase.
GO; GO:0030501; P:positive regulation of bone mineralization; ISS:AgBase.
GO; GO:0030335; P:positive regulation of cell migration; ISS:BHF-UCL.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:AgBase.
GO; GO:0032270; P:positive regulation of cellular protein metabolic process; ISS:AgBase.
GO; GO:0050921; P:positive regulation of chemotaxis; ISS:AgBase.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISS:AgBase.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0010763; P:positive regulation of fibroblast migration; ISS:AgBase.
GO; GO:0032740; P:positive regulation of interleukin-17 production; ISS:AgBase.
GO; GO:0048298; P:positive regulation of isotype switching to IgA isotypes; ISS:AgBase.
GO; GO:0043406; P:positive regulation of MAP kinase activity; ISS:AgBase.
GO; GO:1901666; P:positive regulation of NAD+ ADP-ribosyltransferase activity; ISS:AgBase.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISS:AgBase.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:AgBase.
GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; ISS:AgBase.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISS:AgBase.
GO; GO:0031334; P:positive regulation of protein complex assembly; ISS:AgBase.
GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISS:AgBase.
GO; GO:0042307; P:positive regulation of protein import into nucleus; ISS:AgBase.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:AgBase.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:AgBase.
GO; GO:0060391; P:positive regulation of SMAD protein import into nucleus; ISS:AgBase.
GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:AgBase.
GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; ISS:AgBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:AgBase.
GO; GO:0006611; P:protein export from nucleus; ISS:AgBase.
GO; GO:0000060; P:protein import into nucleus, translocation; ISS:AgBase.
GO; GO:0043491; P:protein kinase B signaling; ISS:AgBase.
GO; GO:0032801; P:receptor catabolic process; ISS:AgBase.
GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; ISS:AgBase.
GO; GO:0070723; P:response to cholesterol; ISS:AgBase.
GO; GO:0032355; P:response to estradiol; ISS:AgBase.
GO; GO:0032570; P:response to progesterone; ISS:AgBase.
GO; GO:0009611; P:response to wounding; ISS:AgBase.
GO; GO:0007435; P:salivary gland morphogenesis; ISS:AgBase.
GO; GO:0007183; P:SMAD protein complex assembly; ISS:AgBase.
GO; GO:0007184; P:SMAD protein import into nucleus; ISS:AgBase.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:AgBase.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR016319; TGF-beta.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR003939; TGFb1.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PIRSF; PIRSF001787; TGF-beta; 1.
PRINTS; PR01423; TGFBETA.
PRINTS; PR01424; TGFBETA1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
Growth factor {ECO:0000256|RuleBase:RU000354,
ECO:0000256|SAAS:SAAS00516085};
Secreted {ECO:0000256|SAAS:SAAS00516087};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 29 {ECO:0000256|SAM:SignalP}.
CHAIN 30 390 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003196465.
DOMAIN 275 390 TGF_BETA_2.
{ECO:0000259|PROSITE:PS51362}.
COILED 150 177 {ECO:0000256|SAM:Coils}.
SEQUENCE 390 AA; 44420 MW; B571160C7AC20D9A CRC64;
MPPSGLRLLP LLLPLLWLLV LTPGRPVAGL STCKTIDMEL VKRKRIEAIR GQILSKLRLA
SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESAEPEPEPE ADYYAKEVTR VLMVESTNKI
YEKTKDISHS VYMFFNTSEL REAVPDPLLL SRAELRLQRL KVKAEQHVEL YQKYSNNSWR
YLSNRLLTPS NTQEWLSFDV TGVVRQWLSQ GEEIEGFRFS AHCSCDSKDN VLQVDINGIG
PRRRGDLAAI HDMNRPFLLL MATPLERAQH LHSSRHRRAL DTNYCFSSTE KNCCVRQLYI
DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SASPCCVPQA
LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS


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