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Transforming growth factor beta 1

 G1SV95_RABIT            Unreviewed;       387 AA.
G1SV95;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
25-OCT-2017, entry version 47.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000007334};
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000007334, ECO:0000313|Proteomes:UP000001811};
[1] {ECO:0000313|Proteomes:UP000001811}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
The Genome Sequencing Platform;
The Genome Assembly Team;
Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.;
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Proteomes:UP000001811}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
The Genome Sequencing Platform;
The Assembly Computation and Development Core Team;
Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S.,
Lindblad-Toh K.;
"Version 2 of The Genome Sequence of Oryctolagus cuniculus (European
rabbit).";
Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSOCUP00000007334}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000007334};
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29
mammals.";
Nature 478:476-482(2011).
[4] {ECO:0000313|Ensembl:ENSOCUP00000007334}
IDENTIFICATION.
STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000007334};
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000007334}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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ProteinModelPortal; G1SV95; -.
STRING; 9986.ENSOCUP00000007334; -.
Ensembl; ENSOCUT00000008484; ENSOCUP00000007334; ENSOCUG00000008485.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00760000119112; -.
InParanoid; G1SV95; -.
OMA; WINSKEA; -.
OrthoDB; EOG091G0BMM; -.
TreeFam; TF318514; -.
Proteomes; UP000001811; Unplaced.
Bgee; ENSOCUG00000008485; -.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:Ensembl.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:Ensembl.
GO; GO:0002460; P:adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; IEA:Ensembl.
GO; GO:0060751; P:branch elongation involved in mammary gland duct branching; IEA:Ensembl.
GO; GO:0016049; P:cell growth; IEA:InterPro.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:1990402; P:embryonic liver development; IEA:Ensembl.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0085029; P:extracellular matrix assembly; IEA:Ensembl.
GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
GO; GO:0008354; P:germ cell migration; IEA:Ensembl.
GO; GO:0003179; P:heart valve morphogenesis; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0070306; P:lens fiber cell differentiation; IEA:Ensembl.
GO; GO:0048535; P:lymph node development; IEA:Ensembl.
GO; GO:0060744; P:mammary gland branching involved in thelarche; IEA:Ensembl.
GO; GO:0032943; P:mononuclear cell proliferation; IEA:Ensembl.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0030279; P:negative regulation of ossification; IEA:Ensembl.
GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl.
GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0071158; P:positive regulation of cell cycle arrest; IEA:Ensembl.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0010763; P:positive regulation of fibroblast migration; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0035066; P:positive regulation of histone acetylation; IEA:Ensembl.
GO; GO:0031065; P:positive regulation of histone deacetylation; IEA:Ensembl.
GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0042482; P:positive regulation of odontogenesis; IEA:Ensembl.
GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
GO; GO:1903911; P:positive regulation of receptor clustering; IEA:Ensembl.
GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:2000249; P:regulation of actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
GO; GO:0061035; P:regulation of cartilage development; IEA:Ensembl.
GO; GO:0051101; P:regulation of DNA binding; IEA:Ensembl.
GO; GO:0032667; P:regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0042306; P:regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0002028; P:regulation of sodium ion transport; IEA:Ensembl.
GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
GO; GO:0045066; P:regulatory T cell differentiation; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
GO; GO:0002513; P:tolerance induction to self antigen; IEA:Ensembl.
GO; GO:1905313; P:transforming growth factor beta receptor signaling pathway involved in heart development; IEA:Ensembl.
GO; GO:0001657; P:ureteric bud development; IEA:Ensembl.
GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR016319; TGF-beta.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR003939; TGFb1.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PIRSF; PIRSF001787; TGF-beta; 1.
PRINTS; PR01423; TGFBETA.
PRINTS; PR01424; TGFBETA1.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000001811};
Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
Growth factor {ECO:0000256|RuleBase:RU000354,
ECO:0000256|SAAS:SAAS00516085};
Reference proteome {ECO:0000313|Proteomes:UP000001811};
Secreted {ECO:0000256|SAAS:SAAS00516087};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 26 {ECO:0000256|SAM:SignalP}.
CHAIN 27 387 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003422616.
DOMAIN 272 387 TGF_BETA_2.
{ECO:0000259|PROSITE:PS51362}.
SEQUENCE 387 AA; 44293 MW; 6E87E33E88D79C19 CRC64;
MLPSGMRLLL PLLWLLVLSP ARPAVGTLSR NNTHMELLRQ QHIQAVGALI LAKLGLSSPP
SDDEVPTGPV PEDILALYNR TRDQVSGERA KQKPQPDSGF FGKEITSVPM LDSNHEIYQK
YKESRHSVYM FFNTSELRQA VPKPVLLSHA ELRLQVLKLQ QEQQVELYQK CSNDSWRYHR
RRKLTPSDTD EWLSFTVTWI VRQWLRGGEE IEGFRLSAHC SCDNKDNVLQ VDINGISSGR
RGDLATIHSM NRPFLLLMAT PLERAQHLHS SRHRRALDTN YCFSSTEKNC CVRQLYIDFR
KDLGWKWIHE PKGYHANFCL GPCPYIWSLD TQYSKVLALY NQHNPGASAA PCCVPQALEP
LPIVYYVGRK PKVEQLSNMI VRSCKCS


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