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Transforming growth factor beta-2 (TGF-beta-2) [Cleaved into: Latency-associated peptide (LAP)]

 TGFB2_CHICK             Reviewed;         412 AA.
P30371;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
20-JUN-2018, entry version 134.
RecName: Full=Transforming growth factor beta-2;
Short=TGF-beta-2;
Contains:
RecName: Full=Latency-associated peptide;
Short=LAP;
Flags: Precursor;
Name=TGFB2;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=White leghorn; TISSUE=Blood;
PubMed=1683775; DOI=10.1089/dna.1991.10.723;
Burt D.W., Paton I.R.;
"Molecular cloning and primary structure of the chicken transforming
growth factor-beta 2 gene.";
DNA Cell Biol. 10:723-734(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Chondrocyte;
PubMed=2340183;
Jakowlew S.B., Dillard P.J., Sporn M.B., Roberts A.B.;
"Complementary deoxyribonucleic acid cloning of an mRNA encoding
transforming growth factor-beta 2 from chicken embryo chondrocytes.";
Growth Factors 2:123-133(1990).
-!- FUNCTION: TGF-beta 2 has suppressive effects on interleukin-2
dependent T-cell growth.
-!- SUBUNIT: Homodimer; disulfide-linked.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: The precursor is cleaved into mature TGF-beta-2 and LAP,
which remains non-covalently linked to mature TGF-beta-2 rendering
it inactive. {ECO:0000250}.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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EMBL; X58071; CAA41101.1; -; Genomic_DNA.
EMBL; X59082; CAA41101.1; JOINED; Genomic_DNA.
EMBL; X59081; CAA41101.1; JOINED; Genomic_DNA.
EMBL; X59080; CAA41101.1; JOINED; Genomic_DNA.
PIR; A39489; A39489.
UniGene; Gga.8797; -.
ProteinModelPortal; P30371; -.
SMR; P30371; -.
STRING; 9031.ENSGALP00000015648; -.
PaxDb; P30371; -.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
HOGENOM; HOG000290198; -.
HOVERGEN; HBG074115; -.
InParanoid; P30371; -.
PhylomeDB; P30371; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0030424; C:axon; ISS:UniProtKB.
GO; GO:0031012; C:extracellular matrix; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:AgBase.
GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO; GO:0001540; F:amyloid-beta binding; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0005102; F:signaling receptor binding; ISS:UniProtKB.
GO; GO:0005160; F:transforming growth factor beta receptor binding; ISS:UniProtKB.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; ISS:UniProtKB.
GO; GO:0034714; F:type III transforming growth factor beta receptor binding; ISA:AgBase.
GO; GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.
GO; GO:0048513; P:animal organ development; TAS:AgBase.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; ISS:UniProtKB.
GO; GO:0060038; P:cardiac muscle cell proliferation; ISS:UniProtKB.
GO; GO:0010002; P:cardioblast differentiation; ISS:UniProtKB.
GO; GO:0051216; P:cartilage development; TAS:AgBase.
GO; GO:0007050; P:cell cycle arrest; ISS:UniProtKB.
GO; GO:0008219; P:cell death; ISS:UniProtKB.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0016477; P:cell migration; ISS:UniProtKB.
GO; GO:0000902; P:cell morphogenesis; ISS:UniProtKB.
GO; GO:0045216; P:cell-cell junction organization; ISS:UniProtKB.
GO; GO:0030199; P:collagen fibril organization; ISS:UniProtKB.
GO; GO:0042416; P:dopamine biosynthetic process; ISS:UniProtKB.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEP:AgBase.
GO; GO:0048566; P:embryonic digestive tract development; IEP:AgBase.
GO; GO:0048568; P:embryonic organ development; IEP:AgBase.
GO; GO:0042118; P:endothelial cell activation; NAS:AgBase.
GO; GO:0001837; P:epithelial to mesenchymal transition; ISS:UniProtKB.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; TAS:DFLAT.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISA:AgBase.
GO; GO:0001654; P:eye development; IEP:AgBase.
GO; GO:0008585; P:female gonad development; IEP:AgBase.
GO; GO:0008347; P:glial cell migration; ISS:UniProtKB.
GO; GO:0008406; P:gonad development; TAS:AgBase.
GO; GO:0007507; P:heart development; IEP:AgBase.
GO; GO:0003007; P:heart morphogenesis; ISS:UniProtKB.
GO; GO:0030097; P:hemopoiesis; ISS:UniProtKB.
GO; GO:0030324; P:lung development; IEP:AgBase.
GO; GO:0008584; P:male gonad development; IEP:AgBase.
GO; GO:0010693; P:negative regulation of alkaline phosphatase activity; ISS:UniProtKB.
GO; GO:0007162; P:negative regulation of cell adhesion; TAS:AgBase.
GO; GO:0030308; P:negative regulation of cell growth; ISA:AgBase.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:UniProtKB.
GO; GO:0010936; P:negative regulation of macrophage cytokine production; ISS:UniProtKB.
GO; GO:0007399; P:nervous system development; TAS:AgBase.
GO; GO:0021915; P:neural tube development; IEP:AgBase.
GO; GO:0048666; P:neuron development; ISS:UniProtKB.
GO; GO:0030593; P:neutrophil chemotaxis; ISS:UniProtKB.
GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB.
GO; GO:0051891; P:positive regulation of cardioblast differentiation; ISS:UniProtKB.
GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; ISS:UniProtKB.
GO; GO:0045787; P:positive regulation of cell cycle; ISS:UniProtKB.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0010634; P:positive regulation of epithelial cell migration; ISS:UniProtKB.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISS:UniProtKB.
GO; GO:0045823; P:positive regulation of heart contraction; ISS:UniProtKB.
GO; GO:0050778; P:positive regulation of immune response; ISS:UniProtKB.
GO; GO:0045726; P:positive regulation of integrin biosynthetic process; ISS:UniProtKB.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO; GO:0045778; P:positive regulation of ossification; ISA:AgBase.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO; GO:0050714; P:positive regulation of protein secretion; ISS:UniProtKB.
GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO; GO:0051795; P:positive regulation of timing of catagen; ISS:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0045595; P:regulation of cell differentiation; NAS:AgBase.
GO; GO:0042127; P:regulation of cell proliferation; TAS:AgBase.
GO; GO:1903659; P:regulation of complement-dependent cytotoxicity; ISA:AgBase.
GO; GO:0040008; P:regulation of growth; NAS:AgBase.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0060390; P:regulation of SMAD protein signal transduction; ISA:AgBase.
GO; GO:0032909; P:regulation of transforming growth factor beta2 production; ISS:UniProtKB.
GO; GO:0042493; P:response to drug; ISS:UniProtKB.
GO; GO:0060416; P:response to growth hormone; IEP:AgBase.
GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
GO; GO:0032570; P:response to progesterone; ISS:UniProtKB.
GO; GO:0009615; P:response to virus; IDA:AgBase.
GO; GO:0009611; P:response to wounding; ISA:AgBase.
GO; GO:0007435; P:salivary gland morphogenesis; ISA:AgBase.
GO; GO:0023014; P:signal transduction by protein phosphorylation; ISA:AgBase.
GO; GO:0007519; P:skeletal muscle tissue development; IEP:AgBase.
GO; GO:0060395; P:SMAD protein signal transduction; ISS:BHF-UCL.
GO; GO:0048103; P:somatic stem cell division; ISS:UniProtKB.
GO; GO:0001756; P:somitogenesis; IEP:AgBase.
GO; GO:0048536; P:spleen development; IEP:AgBase.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
GO; GO:0042060; P:wound healing; ISS:UniProtKB.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR016319; TGF-beta.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR003940; TGFb2.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
PANTHER; PTHR11848:SF141; PTHR11848:SF141; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PIRSF; PIRSF001787; TGF-beta; 1.
PRINTS; PR01423; TGFBETA.
PRINTS; PR01425; TGFBETA2.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
3: Inferred from homology;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Glycoprotein; Growth factor; Mitogen; Reference proteome; Secreted;
Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 300 Latency-associated peptide.
/FTId=PRO_0000033792.
CHAIN 301 412 Transforming growth factor beta-2.
/FTId=PRO_0000033793.
CARBOHYD 72 72 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 139 139 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 240 240 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 307 316 {ECO:0000250}.
DISULFID 315 378 {ECO:0000250}.
DISULFID 344 409 {ECO:0000250}.
DISULFID 348 411 {ECO:0000250}.
DISULFID 377 377 Interchain. {ECO:0000250}.
CONFLICT 95 95 D -> G (in Ref. 2). {ECO:0000305}.
CONFLICT 245 245 P -> L (in Ref. 2). {ECO:0000305}.
SEQUENCE 412 AA; 47606 MW; 93E759BF1BD958DC CRC64;
MHCYLLSVFL TLDLAAVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL TSPPDEYPEP
EEVPPEVISI YNSTRDLLQE KANHRAATCE RERSDEEYYA KEVYKIDMQP FYPENAIPPS
YYSLYFRIVR FDVSAMEKNA SNLVKAEFRV FRLQNSKARV SEQRIELYQV LKSKELSSPG
QRYIDSKVVK TRAEGEWLSF DVTEAVHEWL HHRDRNLGFK ISLHCPCCTF VPSNNYIIPN
KSEEPEARFA GIDDYTYSSG DVKALKSNRK KYSGKTPHLL LMLLPSYRLE SQQPSRRKKR
ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYH ANFCAGACPY LWSSDTQHSR
VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS


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