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Transient receptor potential cation channel, subfamily C, member 5

 Q2KHN9_MOUSE            Unreviewed;       975 AA.
Q2KHN9;
07-MAR-2006, integrated into UniProtKB/TrEMBL.
07-MAR-2006, sequence version 1.
25-OCT-2017, entry version 105.
SubName: Full=Transient receptor potential cation channel, subfamily C, member 5 {ECO:0000313|EMBL:AAI12973.1};
Name=Trpc5 {ECO:0000313|EMBL:AAI12973.1, ECO:0000313|MGI:MGI:109524};
ORFNames=mCG_3695 {ECO:0000313|EMBL:EDL14721.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI12973.1};
[1] {ECO:0000313|EMBL:EDL14721.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL14721.1};
PubMed=12040188; DOI=10.1126/science.1069193;
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
"A comparison of whole-genome shotgun-derived mouse chromosome 16 and
the human genome.";
Science 296:1661-1671(2002).
[2] {ECO:0000313|EMBL:AAI12973.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI12973.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3] {ECO:0000313|EMBL:EDL14721.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL14721.1};
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
-!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
{ECO:0000256|SAAS:SAAS00933551}.
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EMBL; BC112972; AAI12973.1; -; mRNA.
EMBL; CH466610; EDL14721.1; -; Genomic_DNA.
RefSeq; NP_033454.1; NM_009428.3.
UniGene; Mm.328378; -.
UniGene; Mm.82621; -.
GeneID; 22067; -.
KEGG; mmu:22067; -.
CTD; 7224; -.
MGI; MGI:109524; Trpc5.
eggNOG; KOG3609; Eukaryota.
eggNOG; ENOG410XQ0Y; LUCA.
HOVERGEN; HBG068337; -.
KO; K04968; -.
OMA; GFNEYVH; -.
OrthoDB; EOG091G029I; -.
Bgee; ENSMUSG00000041710; -.
GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0030426; C:growth cone; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0003779; F:actin binding; IEA:Ensembl.
GO; GO:0042805; F:actinin binding; IEA:Ensembl.
GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
GO; GO:0030276; F:clathrin binding; IEA:Ensembl.
GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
GO; GO:0050774; P:negative regulation of dendrite morphogenesis; IEA:Ensembl.
GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
GO; GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:1902630; P:regulation of membrane hyperpolarization; IEA:Ensembl.
CDD; cd00204; ANK; 1.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR004729; TRP_channel.
InterPro; IPR013555; TRP_dom.
InterPro; IPR005461; TRPC5_channel.
InterPro; IPR002153; TRPC_channel.
PANTHER; PTHR10117; PTHR10117; 1.
PANTHER; PTHR10117:SF24; PTHR10117:SF24; 1.
Pfam; PF12796; Ank_2; 1.
Pfam; PF00520; Ion_trans; 1.
Pfam; PF08344; TRP_2; 1.
PRINTS; PR01097; TRNSRECEPTRP.
PRINTS; PR01646; TRPCHANNEL5.
SMART; SM00248; ANK; 2.
SUPFAM; SSF48403; SSF48403; 1.
TIGRFAMs; TIGR00870; trp; 1.
2: Evidence at transcript level;
ANK repeat {ECO:0000256|SAAS:SAAS00933366};
Ion channel {ECO:0000256|SAAS:SAAS00931870};
Ion transport {ECO:0000256|SAAS:SAAS00931870};
Membrane {ECO:0000256|SAM:Phobius};
Receptor {ECO:0000313|EMBL:AAI12973.1};
Repeat {ECO:0000256|SAAS:SAAS00931009};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius};
Transport {ECO:0000256|SAAS:SAAS00931870}.
TRANSMEM 327 351 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 363 382 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 402 419 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 440 460 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 480 499 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 520 542 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 599 621 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 38 118 ANK_REP_REGION.
{ECO:0000259|Pfam:PF12796}.
DOMAIN 176 238 TRP_2. {ECO:0000259|Pfam:PF08344}.
DOMAIN 376 635 Ion_trans. {ECO:0000259|Pfam:PF00520}.
SEQUENCE 975 AA; 111458 MW; DF9248168D3D2D62 CRC64;
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLSAV EKGDYATVKQ ALQEAEIYYN
VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL LYAIRKEVVG AVELLLSYRK
PSGEKQVPTL MMDTQFSEFT PDITPIMLAA HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE
CVSSSEVDSL RHSRSRLNIY KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE
YEELSQQCKL FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI SPRSNLGLFI
KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP TVVEWMILPW VLGFIWGEIK
EMWDGGFTEY IHDWWNLMDF AMNSLYLATI SLKIVAYVKY NGSRPREEWE MWHPTLIAEA
LFAISNILSS LRLISLFTAN SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF
YYETRAIDEP NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY FDEGGTLPPP
FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRHNLRSFT ERHADSLIQN QHYQEVIRNL
VKRYVAAMIR NSKTNEGLTE ENFKELKQDI SSFRYEVLDL LGNRKHPRRS LSTSSADFSQ
RDDTNDGSGG ARAKSKSVSF NVGCKKKACH GAPLIRTVPR ASGAQGKPKS ESSSKRSFMG
PSFKKLGLFF SKFNGQTSEP TSEPMYTISD GIAQQHCMWQ DIRYSQMEKG KAEACSQSQM
NLGEVELGEI RGAAARSSEC PLACSSSLHC ASGICSSNSK LLDSSEDVFE TWGEACDLLM
HKWGDGQEEQ VTTRL


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