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Transient receptor potential cation channel subfamily C member 5

 H2QZ06_PANTR            Unreviewed;       919 AA.
H2QZ06;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
25-OCT-2017, entry version 35.
SubName: Full=Transient receptor potential cation channel subfamily C member 5 {ECO:0000313|Ensembl:ENSPTRP00000038200};
Name=TRPC5 {ECO:0000313|Ensembl:ENSPTRP00000038200};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000038200, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000038200, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136134; DOI=10.1038/nature04101;
Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
Rozen S., Wilson R.K., Page D.C.;
"Conservation of Y-linked genes during human evolution revealed by
comparative sequencing in chimpanzee.";
Nature 437:100-103(2005).
[3] {ECO:0000313|Ensembl:ENSPTRP00000038200}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
{ECO:0000256|SAAS:SAAS00933551}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000038200}.
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EMBL; AACZ03136925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03136926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03136927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03136928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03136929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03136930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03136931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03136932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03136933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03136934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9598.ENSPTRP00000038200; -.
PaxDb; H2QZ06; -.
Ensembl; ENSPTRT00000041355; ENSPTRP00000038200; ENSPTRG00000022192.
eggNOG; KOG3609; Eukaryota.
eggNOG; ENOG410XQ0Y; LUCA.
GeneTree; ENSGT00760000119180; -.
InParanoid; H2QZ06; -.
OMA; GFNEYVH; -.
OrthoDB; EOG091G029I; -.
TreeFam; TF313147; -.
Proteomes; UP000002277; Chromosome X.
Bgee; ENSPTRG00000022192; -.
GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
CDD; cd00204; ANK; 1.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR004729; TRP_channel.
InterPro; IPR005461; TRPC5_channel.
InterPro; IPR002153; TRPC_channel.
PANTHER; PTHR10117; PTHR10117; 2.
PANTHER; PTHR10117:SF24; PTHR10117:SF24; 2.
Pfam; PF12796; Ank_2; 1.
Pfam; PF00520; Ion_trans; 1.
PRINTS; PR01097; TRNSRECEPTRP.
PRINTS; PR01646; TRPCHANNEL5.
SMART; SM00248; ANK; 2.
SUPFAM; SSF48403; SSF48403; 1.
TIGRFAMs; TIGR00870; trp; 1.
3: Inferred from homology;
ANK repeat {ECO:0000256|SAAS:SAAS00933366};
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Ion channel {ECO:0000256|SAAS:SAAS00931870};
Ion transport {ECO:0000256|SAAS:SAAS00931870};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Repeat {ECO:0000256|SAAS:SAAS00931009};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius};
Transport {ECO:0000256|SAAS:SAAS00931870}.
TRANSMEM 273 297 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 309 328 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 348 365 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 386 406 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 426 445 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 466 488 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 545 567 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 38 118 ANK_REP_REGION.
{ECO:0000259|Pfam:PF12796}.
DOMAIN 322 581 Ion_trans. {ECO:0000259|Pfam:PF00520}.
SEQUENCE 919 AA; 105405 MW; 5F06103DE179910E CRC64;
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLNAV EKGDYATVKQ ALQEAEIYYN
VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL LYAIRKEVVG AVELLLSYRR
PSGEKQVPTL MMDTQFSEFT PDITPIMLAA HTNNYEIIKL LVQKRVTILG WELKELSKVE
NEFKAEYEEL SQQCKLFAKD LLDQARSSRE LEIILNHRDD HSEELDPQKY HDLAKLKVAI
KYHQKEFVAQ PNCQQLLATL WYDGFPGWRR KHWVVKLLTC MTIGFLFPML SIAYLISPRS
NLGLFIKKPF IKFICHTASY LTFLFMLLLA SQHIVRTDLH VQGPPPTVVE WMILPWVLGF
IWGEIKEMWD GGFTEYIHDW WNLMDFAMNS LYLATISLKI VAYVKYNGSR PREEWEMWHP
TLIAEALFAI SNILSSLRLI SLFTANSHLG PLQISLGRML LDILKFLFIY CLVLLAFANG
LNQLYFYYET RAIDEPNNCK GIRCEKQNNA FSTLFETLQS LFWSVFGLLN LYVTNVKARH
EFTEFVGATM FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFDEG
GTLPPPFNII PSPKSFLYLG NWFNNTFCPK RDPDGRRRRR NLRSFTERNA DSLIQNQHYQ
EVIRNLVKRY VAAMIRNSKT HEGLTEENFK ELKQDISSFR YEVLDLLGNR KHPRSFSTSS
TELSQRDDNN DGSGGARAKS KSVSFNLGCK KKTCHGPPLI RTMPRSSGAQ GKSKAESSSK
RSFMGPSLKK LGLLFSKFNG HMSEPSSEPM YTISDGIVQQ HCMWQDIRYS QMEKGKAEAC
SQSEINLSEV ELGEVQGAAQ SSECPLACSS SLHCASSICS SNSKLLDSSE DVFETWGEAC
DLLMHKWGDG QEEQVTTRL


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