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Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)

 TRPV1_MOUSE             Reviewed;         839 AA.
Q704Y3; Q5SSE1; Q5SSE2; Q5SSE4; Q5WPV5; Q68SW0;
26-APR-2005, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
22-NOV-2017, entry version 128.
RecName: Full=Transient receptor potential cation channel subfamily V member 1;
Short=TrpV1;
AltName: Full=Osm-9-like TRP channel 1;
Short=OTRPC1;
AltName: Full=Vanilloid receptor 1;
Name=Trpv1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, AND
SUBCELLULAR LOCATION.
STRAIN=C57BL/6J;
PubMed=15194687; DOI=10.1074/jbc.M404164200;
Hu H.Z., Gu Q., Wang C., Colton C.K., Tang J., Kinoshita-Kawada M.,
Lee L.Y., Wood J.D., Zhu M.X.;
"2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2,
and TRPV3.";
J. Biol. Chem. 279:35741-35748(2004).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
McIntyre P.;
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=DBA;
Ogawa S., Sugiura A., Pang C., Shinjo K.;
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND SUBCELLULAR
LOCATION.
STRAIN=Swiss Webster;
PubMed=15489017; DOI=10.1016/j.neulet.2004.07.058;
Correll C.C., Phelps P.T., Greenfeder S.;
"Cloning and pharmacological characterization of mouse TRPV1.";
Neurosci. Lett. 370:55-60(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[6]
DISRUPTION PHENOTYPE, FUNCTION, AND TISSUE SPECIFICITY.
PubMed=10764638; DOI=10.1126/science.288.5464.306;
Caterina M.J., Leffler A., Malmberg A.B., Martin W.J., Trafton J.,
Petersen-Zeitz K.R., Koltzenburg M., Basbaum A.I., Julius D.;
"Impaired nociception and pain sensation in mice lacking the capsaicin
receptor.";
Science 288:306-313(2000).
[7]
ENZYME REGULATION, SUBCELLULAR LOCATION, AND INTERACTION WITH PIRT.
PubMed=18455988; DOI=10.1016/j.cell.2008.02.053;
Kim A.Y., Tang Z., Liu Q., Patel K.N., Maag D., Geng Y., Dong X.;
"Pirt, a phosphoinositide-binding protein, functions as a regulatory
subunit of TRPV1.";
Cell 133:475-485(2008).
[8]
INTERACTION WITH TMEM100.
PubMed=25640077; DOI=10.1016/j.neuron.2014.12.065;
Weng H.J., Patel K.N., Jeske N.A., Bierbower S.M., Zou W., Tiwari V.,
Zheng Q., Tang Z., Mo G.C., Wang Y., Geng Y., Zhang J., Guan Y.,
Akopian A.N., Dong X.;
"Tmem100 Is a regulator of TRPA1-TRPV1 complex and contributes to
persistent pain.";
Neuron 85:833-846(2015).
-!- FUNCTION: Ligand-activated non-selective calcium permeant cation
channel involved in detection of noxious chemical and thermal
stimuli (PubMed:15194687, PubMed:15489017). Seems to mediate
proton influx and may be involved in intracellular acidosis in
nociceptive neurons. Involved in mediation of inflammatory pain
and hyperalgesia (PubMed:10764638). Sensitized by a
phosphatidylinositol second messenger system activated by receptor
tyrosine kinases, which involves PKC isozymes and PCL. Activation
by vanilloids, like capsaicin, and temperatures higher than 42
degrees Celsius, exhibits a time- and Ca(2+)-dependent outward
rectification, followed by a long-lasting refractory state. Mild
extracellular acidic pH (6.5) potentiates channel activation by
noxious heat and vanilloids, whereas acidic conditions (pH <6)
directly activate the channel. Can be activated by endogenous
compounds, including 12-hydroperoxytetraenoic acid and bradykinin.
Acts as ionotropic endocannabinoid receptor with central
neuromodulatory effects. Triggers a form of long-term depression
(TRPV1-LTD) mediated by the endocannabinoid anandamine in the
hippocampus and nucleus accumbens by affecting AMPA receptors
endocytosis (By similarity). {ECO:0000250|UniProtKB:O35433,
ECO:0000269|PubMed:10764638, ECO:0000269|PubMed:15194687,
ECO:0000269|PubMed:15489017}.
-!- ENZYME REGULATION: The channel is sensitized by ATP binding.
Repeated stimulation with capsaicin gives rise to progressively
smaller responses, due to desensitization. This desensitization is
triggered by the influx of calcium ions and is inhibited by
elevated ATP levels. Ca(2+) and CALM displace ATP from its binding
site and trigger a conformation change that leads to a closed,
desensitized channel. The double-knot toxin (DkTx) from the
Chinese earth tiger tarantula activates the channel and traps it
in an open conformation (By similarity). Channel activity is
activated via the interaction with PIRT and phosphatidylinositol
4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to
activate channel activity. Intracellular PIP2 inhibits
desensitization (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homotetramer. May also form a heteromeric channel with
TRPV3 (By similarity). Interacts with CALM, PRKCM and CSK (By
similarity). Interacts with PRKCG and NTRK1, probably by forming a
trimeric complex (By similarity). Interacts with PIRT
(PubMed:18455988). Interacts with TMEM100 (PubMed:25640077).
{ECO:0000250|UniProtKB:O35433, ECO:0000250|UniProtKB:Q8NER1,
ECO:0000269|PubMed:18455988, ECO:0000269|PubMed:25640077}.
-!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
membrane {ECO:0000250|UniProtKB:O35433}; Multi-pass membrane
protein {ECO:0000250|UniProtKB:O35433}. Cell projection, dendritic
spine membrane {ECO:0000250|UniProtKB:O35433}; Multi-pass membrane
protein {ECO:0000250|UniProtKB:O35433}. Cell membrane
{ECO:0000250|UniProtKB:O35433}; Multi-pass membrane protein
{ECO:0000250|UniProtKB:O35433}. Note=Mostly, but not exclusively
expressed in postsynaptic dendritic spines.
{ECO:0000250|UniProtKB:O35433}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Alpha;
IsoId=Q704Y3-1; Sequence=Displayed;
Name=2; Synonyms=Beta;
IsoId=Q704Y3-2; Sequence=VSP_013430;
-!- TISSUE SPECIFICITY: Detected in neurons in the root ganglia (at
protein level). Detected in dorsal root ganglia.
{ECO:0000269|PubMed:10764638}.
-!- DOMAIN: The association domain (AD) is necessary for self-
association. {ECO:0000250}.
-!- PTM: Phosphorylation by PKA reverses capsaicin-induced
dephosphorylation at multiple sites probably including Ser-117 as
a major phosphorylation site. Phosphorylation by CAMKII seems to
regulate binding to vanilloids. Phosphorylated and modulated by
PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin
seems to lead to receptor desensitization and phosphorylation by
CAMKII recovers activity. {ECO:0000250|UniProtKB:O35433}.
-!- DISRUPTION PHENOTYPE: Mice are viable and fertile, but lack
behavorial and physiological responses to capsaicin and show
impaired responses to noxious heat stimuli. Their dorsal root
ganglion neurons do not display calcium channel activation in
response to capsaicin or resiniferatoxin. Likewise, their dorsal
root ganglion neurons do not display calcium channel activitation
in response to low extracellular pH.
{ECO:0000269|PubMed:10764638}.
-!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
TrpV subfamily. TRPV1 sub-subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAI24577.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAI24579.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAI24580.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; AY452083; AAS15574.1; -; mRNA.
EMBL; AY452084; AAS15575.1; -; mRNA.
EMBL; AJ620495; CAF05661.1; -; mRNA.
EMBL; AB180097; BAD20301.1; -; mRNA.
EMBL; AY445519; AAS01605.1; -; mRNA.
EMBL; AL663116; CAI24577.1; ALT_SEQ; Genomic_DNA.
EMBL; AL663116; CAI24578.1; -; Genomic_DNA.
EMBL; AL663116; CAI24579.1; ALT_SEQ; Genomic_DNA.
EMBL; AL663116; CAI24580.1; ALT_SEQ; Genomic_DNA.
CCDS; CCDS25003.1; -. [Q704Y3-1]
RefSeq; NP_001001445.1; NM_001001445.2. [Q704Y3-1]
UniGene; Mm.447485; -.
ProteinModelPortal; Q704Y3; -.
SMR; Q704Y3; -.
BioGrid; 228724; 4.
DIP; DIP-59791N; -.
STRING; 10090.ENSMUSP00000099585; -.
BindingDB; Q704Y3; -.
ChEMBL; CHEMBL1781864; -.
GuidetoPHARMACOLOGY; 507; -.
iPTMnet; Q704Y3; -.
PhosphoSitePlus; Q704Y3; -.
PaxDb; Q704Y3; -.
PRIDE; Q704Y3; -.
DNASU; 193034; -.
Ensembl; ENSMUST00000102526; ENSMUSP00000099585; ENSMUSG00000005952. [Q704Y3-1]
GeneID; 193034; -.
KEGG; mmu:193034; -.
UCSC; uc007kah.2; mouse. [Q704Y3-1]
UCSC; uc011xyq.2; mouse. [Q704Y3-2]
CTD; 7442; -.
MGI; MGI:1341787; Trpv1.
eggNOG; KOG3676; Eukaryota.
eggNOG; ENOG4110DG4; LUCA.
GeneTree; ENSGT00550000074425; -.
HOGENOM; HOG000234630; -.
HOVERGEN; HBG054085; -.
InParanoid; Q704Y3; -.
KO; K05222; -.
OMA; VEEVNWN; -.
OrthoDB; EOG091G01LY; -.
PhylomeDB; Q704Y3; -.
TreeFam; TF314711; -.
Reactome; R-MMU-3295583; TRP channels.
PRO; PR:Q704Y3; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000005952; -.
ExpressionAtlas; Q704Y3; baseline and differential.
Genevisible; Q704Y3; MM.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
GO; GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
GO; GO:0016020; C:membrane; ISA:MGI.
GO; GO:0043005; C:neuron projection; IDA:MGI.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
GO; GO:0005262; F:calcium channel activity; IMP:MGI.
GO; GO:0015278; F:calcium-release channel activity; ISS:UniProtKB.
GO; GO:0005516; F:calmodulin binding; ISS:UniProtKB.
GO; GO:0005261; F:cation channel activity; ISA:MGI.
GO; GO:0008324; F:cation transmembrane transporter activity; ISO:MGI.
GO; GO:0017081; F:chloride channel regulator activity; IEA:Ensembl.
GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; ISS:UniProtKB.
GO; GO:0005230; F:extracellular ligand-gated ion channel activity; ISS:UniProtKB.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0005216; F:ion channel activity; IDA:MGI.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.
GO; GO:0051219; F:phosphoprotein binding; ISO:MGI.
GO; GO:0097603; F:temperature-gated ion channel activity; IDA:MGI.
GO; GO:0004888; F:transmembrane signaling receptor activity; ISS:UniProtKB.
GO; GO:0048266; P:behavioral response to pain; IDA:MGI.
GO; GO:0098703; P:calcium ion import across plasma membrane; ISS:UniProtKB.
GO; GO:0070588; P:calcium ion transmembrane transport; ISS:UniProtKB.
GO; GO:0006816; P:calcium ion transport; IDA:MGI.
GO; GO:0006812; P:cation transport; ISA:MGI.
GO; GO:0071468; P:cellular response to acidic pH; ISS:UniProtKB.
GO; GO:0071312; P:cellular response to alkaloid; ISS:UniProtKB.
GO; GO:0071318; P:cellular response to ATP; ISS:UniProtKB.
GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO; GO:0071502; P:cellular response to temperature stimulus; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0050968; P:detection of chemical stimulus involved in sensory perception of pain; IDA:MGI.
GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:UniProtKB.
GO; GO:0050960; P:detection of temperature stimulus involved in thermoception; IDA:MGI.
GO; GO:0002024; P:diet induced thermogenesis; IMP:MGI.
GO; GO:0001660; P:fever generation; IMP:MGI.
GO; GO:0014047; P:glutamate secretion; IEA:Ensembl.
GO; GO:0034220; P:ion transmembrane transport; IMP:UniProtKB.
GO; GO:0006629; P:lipid metabolic process; IMP:MGI.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0090212; P:negative regulation of establishment of blood-brain barrier; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO; GO:0002790; P:peptide secretion; IMP:MGI.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0060454; P:positive regulation of gastric acid secretion; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
GO; GO:1901594; P:response to capsazepine; ISS:UniProtKB.
GO; GO:0009408; P:response to heat; IMP:MGI.
GO; GO:0010243; P:response to organonitrogen compound; IMP:MGI.
GO; GO:0048265; P:response to pain; IDA:MGI.
GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
GO; GO:0009268; P:response to pH; IMP:MGI.
GO; GO:0050954; P:sensory perception of mechanical stimulus; IMP:MGI.
GO; GO:0019233; P:sensory perception of pain; IMP:MGI.
GO; GO:0060083; P:smooth muscle contraction involved in micturition; IMP:MGI.
GO; GO:0001659; P:temperature homeostasis; IMP:MGI.
GO; GO:0014832; P:urinary bladder smooth muscle contraction; IMP:MGI.
CDD; cd00204; ANK; 1.
Gene3D; 1.25.40.20; -; 2.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR004729; TRP_channel.
InterPro; IPR024862; TRPV.
InterPro; IPR024863; TRPV1.
InterPro; IPR008347; TRPV1-4_channel.
PANTHER; PTHR10582; PTHR10582; 1.
PANTHER; PTHR10582:SF17; PTHR10582:SF17; 1.
Pfam; PF12796; Ank_2; 1.
Pfam; PF00520; Ion_trans; 1.
PRINTS; PR01768; TRPVRECEPTOR.
SMART; SM00248; ANK; 4.
SUPFAM; SSF48403; SSF48403; 1.
TIGRFAMs; TIGR00870; trp; 1.
PROSITE; PS50297; ANK_REP_REGION; 1.
PROSITE; PS50088; ANK_REPEAT; 1.
1: Evidence at protein level;
Alternative splicing; ANK repeat; ATP-binding; Calcium;
Calcium channel; Calcium transport; Calmodulin-binding; Cell junction;
Cell membrane; Cell projection; Complete proteome; Glycoprotein;
Ion channel; Ion transport; Membrane; Metal-binding;
Nucleotide-binding; Phosphoprotein; Postsynaptic cell membrane;
Reference proteome; Repeat; Synapse; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 839 Transient receptor potential cation
channel subfamily V member 1.
/FTId=PRO_0000215339.
TOPO_DOM 1 433 Cytoplasmic.
{ECO:0000250|UniProtKB:O35433}.
TRANSMEM 434 454 Helical. {ECO:0000250|UniProtKB:O35433}.
TOPO_DOM 455 472 Extracellular.
{ECO:0000250|UniProtKB:O35433}.
TRANSMEM 473 498 Helical. {ECO:0000250|UniProtKB:O35433}.
TOPO_DOM 499 511 Cytoplasmic.
{ECO:0000250|UniProtKB:O35433}.
TRANSMEM 512 532 Helical. {ECO:0000250|UniProtKB:O35433}.
TOPO_DOM 533 536 Extracellular.
{ECO:0000250|UniProtKB:O35433}.
TRANSMEM 537 557 Helical. {ECO:0000250|UniProtKB:O35433}.
TOPO_DOM 558 572 Cytoplasmic.
{ECO:0000250|UniProtKB:O35433}.
TRANSMEM 573 600 Helical. {ECO:0000250|UniProtKB:O35433}.
TOPO_DOM 601 658 Extracellular.
{ECO:0000250|UniProtKB:O35433}.
TRANSMEM 659 687 Helical. {ECO:0000250|UniProtKB:O35433}.
TOPO_DOM 688 839 Cytoplasmic.
{ECO:0000250|UniProtKB:O35433}.
REPEAT 111 153 ANK 1.
REPEAT 154 200 ANK 2.
REPEAT 201 247 ANK 3.
REPEAT 248 283 ANK 4.
REPEAT 284 332 ANK 5.
REPEAT 333 359 ANK 6.
NP_BIND 200 203 ATP. {ECO:0000250|UniProtKB:O35433}.
NP_BIND 211 212 ATP. {ECO:0000250|UniProtKB:O35433}.
REGION 115 116 Important for channel activation by
agonists and heat.
{ECO:0000250|UniProtKB:O35433}.
REGION 685 713 AD. {ECO:0000250}.
REGION 768 802 Interaction with calmodulin.
{ECO:0000250|UniProtKB:O35433}.
REGION 778 793 Required for PIP2-mediated channel
inhibition. {ECO:0000250}.
MOTIF 644 647 Selectivity filter.
{ECO:0000250|UniProtKB:O35433}.
METAL 647 647 Calcium; shared with neighboring
subunits. {ECO:0000250|UniProtKB:Q9R186}.
BINDING 116 116 ATP. {ECO:0000250|UniProtKB:O35433}.
BINDING 156 156 ATP. {ECO:0000250|UniProtKB:O35433}.
BINDING 161 161 ATP. {ECO:0000250|UniProtKB:O35433}.
BINDING 165 165 ATP. {ECO:0000250|UniProtKB:O35433}.
BINDING 513 513 Agonist. {ECO:0000250|UniProtKB:O35433}.
BINDING 551 551 Agonist. {ECO:0000250|UniProtKB:O35433}.
SITE 558 558 Important for agonist binding.
{ECO:0000250|UniProtKB:O35433}.
MOD_RES 117 117 Phosphoserine; by PKA and PKD.
{ECO:0000250|UniProtKB:O35433}.
MOD_RES 145 145 Phosphothreonine; by PKA; in vitro.
{ECO:0000250|UniProtKB:O35433}.
MOD_RES 371 371 Phosphothreonine; by PKA; in vitro.
{ECO:0000250|UniProtKB:O35433}.
MOD_RES 503 503 Phosphoserine; by PKC/PRKCE.
{ECO:0000250|UniProtKB:O35433}.
MOD_RES 705 705 Phosphothreonine.
{ECO:0000250|UniProtKB:O35433}.
MOD_RES 775 775 Phosphoserine.
{ECO:0000250|UniProtKB:O35433}.
MOD_RES 801 801 Phosphoserine; by PKC/PRKCE and
PKC/PRKCZ.
{ECO:0000250|UniProtKB:O35433}.
MOD_RES 821 821 Phosphoserine.
{ECO:0000250|UniProtKB:O35433}.
CARBOHYD 605 605 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
VAR_SEQ 399 408 Missing (in isoform 2).
{ECO:0000303|PubMed:15194687}.
/FTId=VSP_013430.
CONFLICT 734 734 D -> E (in Ref. 4; AAS01605).
{ECO:0000305}.
SEQUENCE 839 AA; 94976 MW; EB50780E9281C2B7 CRC64;
MEKWASLDSD ESEPPAQENS CPDPPDRDPN SKPPPAKPHI FATRSRTRLF GKGDSEEASP
MDCPYEEGGL ASCPIITVSS VVTLQRSVDG PTCLRQTSQD SVSTGVETPP RLYDRRSIFD
AVAQSNCQEL ESLLSFLQKS KKRLTDSEFK DPETGKTCLL KAMLNLHNGQ NDTIALLLDI
ARKTDSLKQF VNASYTDSYY KGQTALHIAI ERRNMALVTL LVENGADVQA AANGDFFKKT
KGRPGFYFGE LPLSLAACTN QLAIVKFLLQ NSWQPADISA RDSVGNTVLH ALVEVADNTA
DNTKFVTNMY NEILILGAKL HPTLKLEELT NKKGLTPLAL AASSGKIGVL AYILQREIHE
PECRHLSRKF TEWAYGPVHS SLYDLSCIDT CEKNSVLEVI AYSSSETPNR HDMLLVEPLN
RLLQDKWDRF VKRIFYFNFF VYCLYMIIFT TAAYYRPVEG LPPYKLNNTV GDYFRVTGEI
LSVSGGVYFF FRGIQYFLQR RPSLKSLFVD SYSEILFFVQ SLFMLVSVVL YFSHRKEYVA
SMVFSLAMGW TNMLYYTRGF QQMGIYAVMI EKMILRDLCR FMFVYLVFLF GFSTAVVTLI
EDGKNNSLPV ESPPHKCRGS ACRPGNSYNS LYSTCLELFK FTIGMGDLEF TENYDFKAVF
IILLLAYVIL TYILLLNMLI ALMGETVNKI AQESKNIWKL QRAITILDTE KSFLKCMRKA
FRSGKLLQVG FTPDGKDDFR WCFRVDEVNW TTWNTNVGII NEDPGNCEGV KRTLSFSLRS
GRVSGRNWKN FALVPLLRDA STRDRHSTQP EEVQLKHYTG SLKPEDAEVF KDSMAPGEK


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EIAAB44116 Canis familiaris,Canis lupus familiaris,Dog,Osm-9-like TRP channel 1,OTRPC1,Transient receptor potential cation channel subfamily V member 1,TrpV1,TRPV1,Vanilloid receptor 1
EIAAB44124 Homo sapiens,Human,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential cation channel subfamily V member 4,Transient receptor potential protein 12,TRP12,TrpV4,TRPV4,Vanilloid receptor-like ch
EIAAB44125 Osm-9-like TRP channel 4,OTRPC4,Rat,Rattus norvegicus,Transient receptor potential cation channel subfamily V member 4,TrpV4,Trpv4,Vanilloid receptor-related osmotically-activated channel,Vroac,VR-OAC
EIAAB44120 Osm-9-like TRP channel 2,OTRPC2,Rat,Rattus norvegicus,Sac2b,Stretch-activated channel 2B,Transient receptor potential cation channel subfamily V member 2,TrpV2,Trpv2,Vanilloid receptor-like protein 1,
EIAAB44123 Mouse,Mus musculus,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential cation channel subfamily V member 4,Transient receptor potential protein 12,TRP12,Trp12,TrpV4,Trpv4,Vanilloid receptor-l
TRPV1 TRPV1 Gene transient receptor potential cation channel, subfamily V, member 1
DL-TRPV1-Mu Mouse Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) ELISA Kit 96T
DL-TRPV1-Hu Human Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) ELISA Kit 96T
EIAAB44104 Chak,Channel-kinase 1,Long transient receptor potential channel 7,LTrpC7,Ltrpc7,LTrpC-7,Mouse,Mus musculus,Transient receptor potential cation channel subfamily M member 7,Transient receptor potential
EIAAB44103 Long transient receptor potential channel 7,LTrpC7,LTrpC-7,Rat,Rattus norvegicus,Transient receptor potential cation channel subfamily M member 7,Transient receptor potential-phospholipase C-interacti
EIAAB44095 Calcium-activated non-selective cation channel 1,Long transient receptor potential channel 4,LTrpC4,Ltrpc4,LTrpC-4,Mouse,Mus musculus,Transient receptor potential cation channel subfamily M member 4,T
EIAAB44119 Homo sapiens,Human,Osm-9-like TRP channel 2,OTRPC2,Transient receptor potential cation channel subfamily V member 2,TrpV2,TRPV2,Vanilloid receptor-like protein 1,VRL,VRL-1
18-783-75531 RABBIT ANTI Trpv2 (N-TERMINAL) - TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL. SUBFAMILY V. MEMBER 2; TrpV2; osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1 Polyclonal 0.05 mg
201-11-1194 Rat Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1)ELISA Kit 96T
E95839Hu ELISA Kit for Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) 96T/Kit
CSB-EL025093RA Rat Transient receptor potential cation channel subfamily V member 1(TRPV1) ELISA kit 96T
UB-E10451 Rat Transient Receptor Potential Cation Channel Subfamily V, Member 1(TRPV1)ELISA Kit 96T
CSB-EL025093DO Dog Transient receptor potential cation channel subfamily V member 1(TRPV1) ELISA kit 96T
H7783 Transient receptor potential cation channel subfamily V member 1 (TRPV1), Dog, ELISA Kit 96T
201-11-1194 Rat Transient Receptor Potential Cation Channel Subfamily V, Member 1(TRPV1)ELISA Kit 96T
E95839Mu ELISA Kit for Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) 96T/Kit


 

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