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Translation initiation factor eIF-2B subunit beta (GCD complex subunit GCD7) (Guanine nucleotide exchange factor subunit GCD7) (eIF-2B GDP-GTP exchange factor subunit beta)

 EI2BB_YEAST             Reviewed;         381 AA.
P32502; D6VYT7;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
25-OCT-2017, entry version 143.
RecName: Full=Translation initiation factor eIF-2B subunit beta;
AltName: Full=GCD complex subunit GCD7;
AltName: Full=Guanine nucleotide exchange factor subunit GCD7;
AltName: Full=eIF-2B GDP-GTP exchange factor subunit beta;
Name=GCD7; Synonyms=TIF222; OrderedLocusNames=YLR291C;
ORFNames=L8003.17;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8441423; DOI=10.1128/MCB.13.3.1920;
Bushman J.L., Asuru A.I., Matts R.L., Hinnebusch A.G.;
"Evidence that GCD6 and GCD7, translational regulators of GCN4, are
subunits of the guanine nucleotide exchange factor for eIF-2 in
Saccharomyces cerevisiae.";
Mol. Cell. Biol. 13:1920-1932(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169871;
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B.,
Ansorge W., Benes V., Brueckner M., Delius H., Dubois E.,
Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U.,
Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K.,
Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T.,
Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E.,
Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M.,
Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C.,
Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M.,
Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H.,
Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A.,
Hani J., Hoheisel J.D.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
Nature 387:87-90(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
IDENTIFICATION IN THE EIF2-B COMPLEX, AND FUNCTION OF THE EIF2-B
COMPLEX.
PubMed=8506384; DOI=10.1073/pnas.90.11.5350;
Cigan A.M., Bushman J.L., Boal T.R., Hinnebusch A.G.;
"A protein complex of translational regulators of GCN4 mRNA is the
guanine nucleotide-exchange factor for translation initiation factor 2
in yeast.";
Proc. Natl. Acad. Sci. U.S.A. 90:5350-5354(1993).
[5]
FUNCTION, AND IDENTIFICATION IN A EIF2-B SUBCOMPLEX.
PubMed=9472020; DOI=10.1101/gad.12.4.514;
Pavitt G.D., Ramaiah K.V., Kimball S.R., Hinnebusch A.G.;
"eIF2 independently binds two distinct eIF2B subcomplexes that
catalyze and regulate guanine-nucleotide exchange.";
Genes Dev. 12:514-526(1998).
[6]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
-!- FUNCTION: Acts as a regulatory component of the translation
initiation factor 2B (eIF2-B or GCD complex), which catalyzes the
exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for
GTP and is regulated by phosphorylated eIF-2. It activates the
synthesis of GCN4 in yeast under amino acid starvation conditions
by suppressing the inhibitory effects of multiple AUG codons
present in the leader of GCN4 mRNA. It may promote either
repression or activation of GCN4 expression depending on amino
acid availability. GCD6 and GCD7 repress GCN4 expression at the
translational level by ensuring that ribosomes which have
translated UORF1 will reinitiate at UORF2, -3, or -4 and thus fail
to reach the GCN4 start site. {ECO:0000269|PubMed:8506384,
ECO:0000269|PubMed:9472020}.
-!- SUBUNIT: Translation initiation factor 2B (eIF2-B) is composed of
five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1),
delta (GCD2) and epsilon (GCD6). A regulatory subcomplex
comprising GCN3, GCD7 and GCD2 interacts preferentially with
phosphorylated eIF-2 and has no exchange activity in vitro.
{ECO:0000269|PubMed:8506384, ECO:0000269|PubMed:9472020}.
-!- INTERACTION:
P12754:GCD2; NbExp=10; IntAct=EBI-6260, EBI-6265;
P14741:GCN3; NbExp=10; IntAct=EBI-6260, EBI-6253;
-!- MISCELLANEOUS: Present with 6650 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L07116; AAA34634.1; -; Genomic_DNA.
EMBL; U17243; AAB67337.1; -; Genomic_DNA.
EMBL; BK006945; DAA09603.1; -; Genomic_DNA.
PIR; B48156; B48156.
RefSeq; NP_013394.1; NM_001182179.1.
ProteinModelPortal; P32502; -.
SMR; P32502; -.
BioGrid; 31557; 302.
DIP; DIP-1185N; -.
IntAct; P32502; 156.
MINT; MINT-401217; -.
STRING; 4932.YLR291C; -.
MaxQB; P32502; -.
PRIDE; P32502; -.
EnsemblFungi; YLR291C; YLR291C; YLR291C.
GeneID; 850998; -.
KEGG; sce:YLR291C; -.
EuPathDB; FungiDB:YLR291C; -.
SGD; S000004282; GCD7.
GeneTree; ENSGT00550000074908; -.
HOGENOM; HOG000208487; -.
InParanoid; P32502; -.
KO; K03754; -.
OMA; SNAGELM; -.
OrthoDB; EOG092C3UWH; -.
BioCyc; YEAST:G3O-32386-MONOMER; -.
Reactome; R-SCE-72731; Recycling of eIF2:GDP.
PRO; PR:P32502; -.
Proteomes; UP000002311; Chromosome XII.
GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:SGD.
GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:SGD.
GO; GO:0030234; F:enzyme regulator activity; IMP:SGD.
GO; GO:0003743; F:translation initiation factor activity; IGI:SGD.
GO; GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
GO; GO:0006446; P:regulation of translational initiation; IDA:SGD.
Gene3D; 1.20.120.420; -; 1.
InterPro; IPR000649; IF-2B-related.
InterPro; IPR027363; M1Pi_N.
Pfam; PF01008; IF-2B; 1.
1: Evidence at protein level;
Complete proteome; Initiation factor; Protein biosynthesis;
Reference proteome; Translation regulation.
CHAIN 1 381 Translation initiation factor eIF-2B
subunit beta.
/FTId=PRO_0000156066.
SEQUENCE 381 AA; 42570 MW; A5409FAF1594854C CRC64;
MSSQAFTSVH PNAATSDVNV TIDTFVAKLK RRQVQGSYAI ALETLQLLMR FISAARWNHV
NDLIEQIRDL GNSLEKAHPT AFSCGNVIRR ILAVLRDEVE EDTMSTTVTS TSVAEPLISS
MFNLLQKPEQ PHQNRKNSSG SSSMKTKTDY RQVAIQGIKD LIDEIKNIDE GIQQIAIDLI
HDHEILLTPT PDSKTVLKFL ITARERSNRT FTVLVTEGFP NNTKNAHEFA KKLAQHNIET
LVVPDSAVFA LMSRVGKVII GTKAVFVNGG TISSNSGVSS VCECAREFRT PVFAVAGLYK
LSPLYPFDVE KFVEFGGSQR ILPRMDPRKR LDTVNQITDY VPPENIDIYI TNVGGFNPSF
IYRIAWDNYK QIDVHLDKNK A


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