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Translationally-controlled tumor protein 1 (TCTP1)

 TCTP1_ARATH             Reviewed;         168 AA.
P31265; Q8L973; Q9LUS0;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
07-JUN-2017, entry version 138.
RecName: Full=Translationally-controlled tumor protein 1 {ECO:0000303|Ref.1};
Short=TCTP1 {ECO:0000303|Ref.1};
Name=TCTP1 {ECO:0000303|Ref.1}; Synonyms=TXTP;
OrderedLocusNames=At3g16640 {ECO:0000312|Araport:AT3G16640};
ORFNames=MGL6.10 {ECO:0000312|EMBL:BAB02755.1};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Kang J.-G., Park C.-M.;
"Isolation of cDNA clone encoding a putative translationally
controlled tumor protein homolog in Arabidopsis thaliana.";
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10819329; DOI=10.1093/dnares/7.2.131;
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
features of the regions of 4,504,864 bp covered by sixty P1 and TAC
clones.";
DNA Res. 7:131-135(2000).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-53.
STRAIN=cv. C24; TISSUE=Flower bud;
PubMed=8281187; DOI=10.1046/j.1365-313X.1993.04061051.x;
Hoefte H., Desprez T., Amselem J., Chiapello H., Rouze P., Caboche M.,
Moisan A., Jourjon M.-F., Charpenteau J.-L., Berthomieu P.,
Guerrier D., Giraudat J., Quigley F., Thomas F., Yu D.-Y., Mache R.,
Raynal M., Cooke R., Grellet F., Delseny M., Parmentier Y.,
de Marcillac G., Gigot C., Fleck J., Philipps G., Axelos M.,
Bardet C., Tremousaygue D., Lescure B.;
"An inventory of 1152 expressed sequence tags obtained by partial
sequencing of cDNAs from Arabidopsis thaliana.";
Plant J. 4:1051-1061(1993).
[7]
TISSUE SPECIFICITY.
PubMed=16902407; DOI=10.1038/sj.emboj.7601270;
Szecsi J., Joly C., Bordji K., Varaud E., Cock J.M., Dumas C.,
Bendahmane M.;
"BIGPETALp, a bHLH transcription factor is involved in the control of
Arabidopsis petal size.";
EMBO J. 25:3912-3920(2006).
[8]
FUNCTION, 3D-STRUCTURE MODELING, TISSUE SPECIFICITY, INDUCTION BY
LIGHT, AND DISRUPTION PHENOTYPE.
STRAIN=cv. Columbia;
PubMed=19060111; DOI=10.1105/tpc.108.061010;
Berkowitz O., Jost R., Pollmann S., Masle J.;
"Characterization of TCTP, the translationally controlled tumor
protein, from Arabidopsis thaliana.";
Plant Cell 20:3430-3447(2008).
[9]
FUNCTION, DISRUPTION PHENOTYPE, SUBUNIT, MUTAGENESIS OF GLU-12, AND
INTERACTION WITH RABA4A; RABA4B; RABF1 AND RABF2B.
PubMed=20736351; DOI=10.1073/pnas.1007926107;
Brioudes F., Thierry A.M., Chambrier P., Mollereau B., Bendahmane M.;
"Translationally controlled tumor protein is a conserved mitotic
growth integrator in animals and plants.";
Proc. Natl. Acad. Sci. U.S.A. 107:16384-16389(2010).
[10]
FUNCTION, TISSUE SPECIFICITY, INDUCTION BY ABSCISIC ACID, AND
INTERACTION WITH MICROTUBULES.
PubMed=22610367; DOI=10.1007/s10059-012-0080-8;
Kim Y.M., Han Y.J., Hwang O.J., Lee S.S., Shin A.Y., Kim S.Y.,
Kim J.I.;
"Overexpression of Arabidopsis translationally controlled tumor
protein gene AtTCTP enhances drought tolerance with rapid ABA-induced
stomatal closure.";
Mol. Cells 33:617-626(2012).
[11]
FUNCTION, CALCIUM-BINDING, AND SUBCELLULAR LOCATION.
PubMed=24040826; DOI=10.1186/1471-2229-13-135;
Hoepflinger M.C., Reitsamer J., Geretschlaeger A.M., Mehlmer N.,
Tenhaken R.;
"The effect of translationally controlled tumour protein (TCTP) on
programmed cell death in plants.";
BMC Plant Biol. 13:135-135(2013).
[12]
GENE FAMILY, AND 3D-STRUCTURE MODELING.
PubMed=25120549; DOI=10.3389/fpls.2014.00361;
Gutierrez-Galeano D.F., Toscano-Morales R., Calderon-Perez B.,
Xoconostle-Cazares B., Ruiz-Medrano R.;
"Structural divergence of plant TCTPs.";
Front. Plant Sci. 5:361-361(2014).
[13]
MUTAGENESIS OF 35-TRP--ALA-47, AND 3D-STRUCTURE MODELING.
STRAIN=cv. Columbia;
PubMed=26191065; DOI=10.3389/fpls.2015.00468;
Toscano-Morales R., Xoconostle-Cazares B., Cabrera-Ponce J.L.,
Hinojosa-Moya J., Ruiz-Salas J.L., Galvan-Gordillo S.V.,
Guevara-Gonzalez R.G., Ruiz-Medrano R.;
"AtTCTP2, an Arabidopsis thaliana homolog of Translationally
Controlled Tumor Protein, enhances in vitro plant regeneration.";
Front. Plant Sci. 6:468-468(2015).
[14]
INDUCTION BY MOMILACTONE B.
PubMed=26058145;
Kato-Noguchi H., Kitajima S.;
"Momilactone sensitive proteins in Arabidopsis thaliana.";
Nat. Prod. Commun. 10:729-732(2015).
-!- FUNCTION: General regulator required for the development of the
entire plant. Regulates the duration of cell cycle
(PubMed:20736351). Probable activator of Rab GTPases and upstream
regulator of the cell growth-regulating TOR (target of rapamycin)
network (PubMed:19060111, PubMed:20736351). Might also control
spatial growth in pollen tubes or root hairs via the TORC2
signaling branch (PubMed:19060111). Involved in the regulation of
abscisic acid- and calcium-mediated stomatal closure, but not in
light or H(+)-pumping induced stomatal opening. May regulate
microtubules depolymerization (PubMed:22610367). Binds calcium and
has a cytoprotective function (PubMed:24040826).
{ECO:0000269|PubMed:19060111, ECO:0000269|PubMed:20736351,
ECO:0000269|PubMed:22610367, ECO:0000269|PubMed:24040826}.
-!- SUBUNIT: Homodimer. Interacts with the Rab GTPases RABA4A, RABA4B,
RABF1 and RABF2B (PubMed:20736351). Interacts with microtubules
and heterodimers of alpha- and beta-tubulins. Cytosolic calcium
positively regulates this interaction (PubMed:22610367).
{ECO:0000269|PubMed:20736351, ECO:0000269|PubMed:22610367}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
{ECO:0000269|PubMed:24040826}.
-!- TISSUE SPECIFICITY: Expressed in flowers, leaves and stems
(PubMed:16902407, PubMed:19060111). Expressed in roots and
siliques. Detected in seeds. Highest expression in actively
dividing and differentiating cell types, such as the meristematic
and division zones of the root, the embryo or the elongating tube
of germinating pollen (PubMed:19060111). Expressed in cotyledons,
leaves, hypocotyls and roots. Detected in mitotically active
tissues such as shoot apical meristems, root tips, lateral root
initiation regions and anthers, and in guard cells
(PubMed:22610367). {ECO:0000269|PubMed:16902407,
ECO:0000269|PubMed:19060111, ECO:0000269|PubMed:22610367}.
-!- INDUCTION: Up-regulated by momilactone B (PubMed:26058145). Not
regulated by light (PubMed:19060111). Up-regulated by abscisic
acid (PubMed:22610367). {ECO:0000269|PubMed:19060111,
ECO:0000269|PubMed:22610367, ECO:0000269|PubMed:26058145}.
-!- DISRUPTION PHENOTYPE: Male gametophytic phenotype with normal
pollen formation and germination but impaired pollen tube growth
(PubMed:19060111). Embryonic lethality when homozygous due to a
retarded development of the embryos that eventually collapse at
the silique dehiscence stage (PubMed:20736351).
{ECO:0000269|PubMed:19060111, ECO:0000269|PubMed:20736351}.
-!- MISCELLANEOUS: Knockdown mutants have retarded growth due to
decreased cell size. {ECO:0000269|PubMed:19060111}.
-!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
ProRule:PRU01133}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF215897; AAG44002.1; -; mRNA.
EMBL; AB022217; BAB02755.1; -; Genomic_DNA.
EMBL; CP002686; AEE75847.1; -; Genomic_DNA.
EMBL; AF361815; AAK32828.1; -; mRNA.
EMBL; AY045802; AAK76476.1; -; mRNA.
EMBL; AY056065; AAL06965.1; -; mRNA.
EMBL; AY072337; AAL61944.1; -; mRNA.
EMBL; AY079333; AAL85064.1; -; mRNA.
EMBL; AY114601; AAM47920.1; -; mRNA.
EMBL; AY088605; AAM66134.1; -; mRNA.
EMBL; Z18387; CAA79177.1; -; mRNA.
RefSeq; NP_188286.1; NM_112537.4.
UniGene; At.34389; -.
UniGene; At.47256; -.
UniGene; At.74193; -.
ProteinModelPortal; P31265; -.
SMR; P31265; -.
BioGrid; 6250; 3.
IntAct; P31265; 4.
STRING; 3702.AT3G16640.1; -.
iPTMnet; P31265; -.
PaxDb; P31265; -.
PRIDE; P31265; -.
EnsemblPlants; AT3G16640.1; AT3G16640.1; AT3G16640.
GeneID; 820916; -.
Gramene; AT3G16640.1; AT3G16640.1; AT3G16640.
KEGG; ath:AT3G16640; -.
Araport; AT3G16640; -.
TAIR; locus:2089378; AT3G16640.
eggNOG; KOG1727; Eukaryota.
eggNOG; ENOG4111FVP; LUCA.
HOGENOM; HOG000203361; -.
InParanoid; P31265; -.
OMA; MVVLLNY; -.
OrthoDB; EOG09360P0R; -.
PhylomeDB; P31265; -.
PRO; PR:P31265; -.
Proteomes; UP000006548; Chromosome 3.
Genevisible; P31265; AT.
GO; GO:0048046; C:apoplast; IDA:TAIR.
GO; GO:0009507; C:chloroplast; IDA:TAIR.
GO; GO:0005829; C:cytosol; IDA:TAIR.
GO; GO:0005794; C:Golgi apparatus; IDA:TAIR.
GO; GO:0005634; C:nucleus; IDA:TAIR.
GO; GO:0005886; C:plasma membrane; IDA:TAIR.
GO; GO:0009506; C:plasmodesma; IDA:TAIR.
GO; GO:0090406; C:pollen tube; IDA:TAIR.
GO; GO:0009579; C:thylakoid; IDA:TAIR.
GO; GO:0005774; C:vacuolar membrane; IDA:TAIR.
GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
GO; GO:0008017; F:microtubule binding; IDA:TAIR.
GO; GO:0019904; F:protein domain specific binding; IPI:CAFA.
GO; GO:0010252; P:auxin homeostasis; IMP:TAIR.
GO; GO:0008283; P:cell proliferation; IMP:TAIR.
GO; GO:0042742; P:defense response to bacterium; IEP:TAIR.
GO; GO:0009819; P:drought recovery; IMP:TAIR.
GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
GO; GO:0048527; P:lateral root development; IMP:TAIR.
GO; GO:0009860; P:pollen tube growth; IMP:TAIR.
GO; GO:0031117; P:positive regulation of microtubule depolymerization; IMP:TAIR.
GO; GO:0009791; P:post-embryonic development; IMP:TAIR.
GO; GO:0001558; P:regulation of cell growth; IMP:TAIR.
GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:TAIR.
GO; GO:0040014; P:regulation of multicellular organism growth; IMP:TAIR.
GO; GO:0090333; P:regulation of stomatal closure; IMP:TAIR.
GO; GO:0046686; P:response to cadmium ion; IEP:TAIR.
GO; GO:0009735; P:response to cytokinin; IDA:TAIR.
GO; GO:0048364; P:root development; IMP:TAIR.
GO; GO:0048768; P:root hair cell tip growth; IMP:TAIR.
InterPro; IPR011057; Mss4-like.
InterPro; IPR034737; TCTP.
InterPro; IPR018103; Translation_control_tumour_CS.
InterPro; IPR018105; Translational_control_tumour_p.
PANTHER; PTHR11991; PTHR11991; 1.
Pfam; PF00838; TCTP; 1.
PRINTS; PR01653; TCTPROTEIN.
SUPFAM; SSF51316; SSF51316; 1.
PROSITE; PS01002; TCTP_1; 1.
PROSITE; PS01003; TCTP_2; 1.
PROSITE; PS51797; TCTP_3; 1.
1: Evidence at protein level;
Calcium; Complete proteome; Cytoplasm; Reference proteome.
CHAIN 1 168 Translationally-controlled tumor protein
1.
/FTId=PRO_0000211297.
DOMAIN 1 168 TCTP. {ECO:0000255|PROSITE-
ProRule:PRU01133}.
MUTAGEN 12 12 E->V: Loss of function.
{ECO:0000269|PubMed:20736351}.
MUTAGEN 35 47 Missing: Gain of regeneration capacity.
{ECO:0000269|PubMed:26191065}.
CONFLICT 64 64 T -> A (in Ref. 5; AAM66134).
{ECO:0000305}.
SEQUENCE 168 AA; 18910 MW; 3A86AB8DFEBBE166 CRC64;
MLVYQDLLTG DELLSDSFPY KEIENGILWE VEGKWVTVGA VDVNIGANPS AEEGGEDEGV
DDSTQKVVDI VDTFRLQEQP TYDKKGFIAY IKKYIKLLTP KLSEEDQAVF KKGIEGATKF
LLPRLSDFQF FVGEGMHDDS TLVFAYYKEG STNPTFLYFA HGLKEVKC


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