Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Transmembrane emp24 domain-containing protein 2 (COPI-coated vesicle membrane protein p24) (Membrane protein p24A) (Sid 394) (p24 family protein beta-1) (p24beta1)

 TMED2_MOUSE             Reviewed;         201 AA.
Q9R0Q3;
24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
25-OCT-2017, entry version 145.
RecName: Full=Transmembrane emp24 domain-containing protein 2;
AltName: Full=COPI-coated vesicle membrane protein p24;
AltName: Full=Membrane protein p24A;
AltName: Full=Sid 394;
AltName: Full=p24 family protein beta-1;
Short=p24beta1;
Flags: Precursor;
Name=Tmed2; Synonyms=Rnp24, Sid394;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Saito T.;
"Mouse mRNA for transmembrane protein.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N-3; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[4]
FUNCTION, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF LEU-15.
PubMed=20178780; DOI=10.1016/j.ydbio.2010.02.019;
Jerome-Majewska L.A., Achkar T., Luo L., Lupu F., Lacy E.;
"The trafficking protein Tmed2/p24beta(1) is required for
morphogenesis of the mouse embryo and placenta.";
Dev. Biol. 341:154-166(2010).
-!- FUNCTION: Involved in vesicular protein trafficking. Mainly
functions in the early secretory pathway but also in post-Golgi
membranes. Thought to act as cargo receptor at the lumenal side
for incorporation of secretory cargo molecules into transport
vesicles and to be involved in vesicle coat formation at the
cytoplasmic side. In COPII vesicle-mediated anterograde transport
involved in the transport of GPI-anchored proteins and proposed to
act together with TMED10 as their cargo receptor; the function
specifically implies SEC24C and SEC24D of the COPII vesicle coat
and lipid raft-like microdomains of the ER. Recognizes GPI anchors
structural remodeled in the ER by PGAP1 and MPPE1. In COPI
vesicle-mediated retrograde transport inhibits the GTPase-
activating activity of ARFGAP1 towards ARF1 thus preventing
immature uncoating and allowing cargo selection to take place.
Involved in trafficking of G protein-coupled receptors (GPCRs).
Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the
Golgi to the plasma membrane thus contributing to receptor
resensitization. Facilitates CASR maturation and stabilization in
the early secretory pathway and increases CASR plasma membrane
targeting. Proposed to be involved in organization of
intracellular membranes such as the maintenance of the Golgi
apparatus. May also play a role in the biosynthesis of secreted
cargo such as eventual processing (By similarity). Required for
morphogenesis of embryo and placenta. {ECO:0000250,
ECO:0000269|PubMed:20178780}.
-!- SUBUNIT: Monomer and homodimer in the endoplasmic reticulum,
endoplasmic reticulum-Golgi intermediate compartment and Golgi.
Probably oligomerizes with other members of the EMP24/GP25L family
such as TMED7, TMED9 and TMED10. Interacts (via GOLD domain) with
TMED10 (via GOLD domain). Associates with the COPI vesicle coat
(coatomer); TMED10:TMED2 heterotetramers are proposed to be
involved in coatomer association. Interacts (via C-terminus) with
COPG1; the interaction involves dimeric TMED2. Interacts with
SEC23A; indicative for an association of TMED2 with the COPII
vesicle coat. Interacts with ARF1 and ARFGAP1. Interacts with
CD59, SEC24A, SEC24B, SEC24C, SEC24D and ATLA1. Interacts with
KDELR1; the interaction is decreased by KDEL ligand. Interacts
with F2RL1; the interaction occurs at the Golgi apparatus.
Interacts with CASR (immaturely glycosylated form); the
interaction occurs in the endoplasmic reticulum-Golgi intermediate
compartment or cis-Golgi. Interacts with F2RL1; the interaction
occurs at the Golgi apparatus. Interacts with GORASP1 and GORASP2.
Found in a complex composed at least of SURF4, TMED2 and TMED10
(By similarity). {ECO:0000250|UniProtKB:Q15363,
ECO:0000250|UniProtKB:Q63524}.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
{ECO:0000250|UniProtKB:Q15363}; Single-pass type I membrane
protein {ECO:0000255}. Cytoplasmic vesicle, COPI-coated vesicle
membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass type I
membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network
membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass type I
membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack
membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass type I
membrane protein {ECO:0000255}. Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:Q15363}; Single-pass type I membrane
protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate
compartment membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass
type I membrane protein {ECO:0000255}. Note=Cycles between
compartments of the early secretatory pathway.
{ECO:0000250|UniProtKB:Q15363}.
-!- DEVELOPMENTAL STAGE: Expressed during embryonal and placental
development. {ECO:0000269|PubMed:20178780}.
-!- MISCELLANEOUS: Embryonic lethal for homozygotes with Glu-15 in the
signal peptide. Animals do not show Tmed2 protein expression and
also have reduced protein levels of Tmed7 and Tmed10. Prior to
death at mid-gestation, embryos exhibit developmental delay,
abnormal rostral-caudal elongation, randomized heart looping, and
absence of the labyrinth layer of the placenta.
-!- SIMILARITY: Belongs to the EMP24/GP25L family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB025218; BAA84689.1; -; mRNA.
EMBL; BC083140; AAH83140.1; -; mRNA.
CCDS; CCDS19679.1; -.
RefSeq; NP_062744.1; NM_019770.2.
RefSeq; XP_003945495.1; XM_003945446.4.
UniGene; Mm.325307; -.
UniGene; Mm.425279; -.
ProteinModelPortal; Q9R0Q3; -.
SMR; Q9R0Q3; -.
BioGrid; 207909; 116.
IntAct; Q9R0Q3; 120.
MINT; MINT-1863429; -.
STRING; 10090.ENSMUSP00000054834; -.
iPTMnet; Q9R0Q3; -.
PhosphoSitePlus; Q9R0Q3; -.
EPD; Q9R0Q3; -.
MaxQB; Q9R0Q3; -.
PaxDb; Q9R0Q3; -.
PeptideAtlas; Q9R0Q3; -.
PRIDE; Q9R0Q3; -.
Ensembl; ENSMUST00000060226; ENSMUSP00000054834; ENSMUSG00000029390.
GeneID; 100862175; -.
GeneID; 56334; -.
KEGG; mmu:100862175; -.
KEGG; mmu:56334; -.
UCSC; uc008zqa.1; mouse.
CTD; 10959; -.
MGI; MGI:1929269; Tmed2.
eggNOG; KOG1692; Eukaryota.
eggNOG; ENOG410XQCK; LUCA.
GeneTree; ENSGT00670000097656; -.
HOGENOM; HOG000160229; -.
HOVERGEN; HBG105106; -.
InParanoid; Q9R0Q3; -.
KO; K20347; -.
OMA; YTYCFGN; -.
OrthoDB; EOG091G0L5D; -.
PhylomeDB; Q9R0Q3; -.
TreeFam; TF313000; -.
Reactome; R-MMU-1912420; Pre-NOTCH Processing in Golgi.
Reactome; R-MMU-204005; COPII (Coat Protein 2) Mediated Vesicle Transport.
Reactome; R-MMU-5694530; Cargo concentration in the ER.
Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
Reactome; R-MMU-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
PRO; PR:Q9R0Q3; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000029390; -.
CleanEx; MM_TMED2; -.
ExpressionAtlas; Q9R0Q3; baseline and differential.
Genevisible; Q9R0Q3; MM.
GO; GO:0030137; C:COPI-coated vesicle; ISS:UniProtKB.
GO; GO:0030663; C:COPI-coated vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; ISS:HGNC.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
GO; GO:0042589; C:zymogen granule membrane; ISS:HGNC.
GO; GO:0048598; P:embryonic morphogenesis; IMP:UniProtKB.
GO; GO:0001892; P:embryonic placenta development; IMP:MGI.
GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
GO; GO:0001947; P:heart looping; IMP:MGI.
GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
GO; GO:0060716; P:labyrinthine layer blood vessel development; IMP:CACAO.
GO; GO:0001893; P:maternal placenta development; IMP:UniProtKB.
GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
GO; GO:0034260; P:negative regulation of GTPase activity; ISS:UniProtKB.
GO; GO:0001843; P:neural tube closure; IMP:MGI.
GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI.
GO; GO:0036342; P:post-anal tail morphogenesis; IMP:MGI.
GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
GO; GO:0032525; P:somite rostral/caudal axis specification; IMP:MGI.
GO; GO:0001756; P:somitogenesis; IMP:MGI.
GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
InterPro; IPR009038; GOLD_dom.
InterPro; IPR036598; GOLD_dom_sf.
InterPro; IPR015720; TMP21-related.
PANTHER; PTHR22811; PTHR22811; 1.
Pfam; PF01105; EMP24_GP25L; 1.
SMART; SM01190; EMP24_GP25L; 1.
SUPFAM; SSF101576; SSF101576; 1.
PROSITE; PS50866; GOLD; 1.
1: Evidence at protein level;
Coiled coil; Complete proteome; Cytoplasmic vesicle;
Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
Protein transport; Reference proteome; Signal; Transmembrane;
Transmembrane helix; Transport.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 201 Transmembrane emp24 domain-containing
protein 2.
/FTId=PRO_0000010382.
TOPO_DOM 21 168 Lumenal. {ECO:0000255}.
TRANSMEM 169 189 Helical. {ECO:0000255}.
TOPO_DOM 190 201 Cytoplasmic. {ECO:0000255}.
DOMAIN 30 112 GOLD. {ECO:0000255|PROSITE-
ProRule:PRU00096}.
REGION 1 181 Interaction with F2RL1. {ECO:0000250}.
REGION 118 157 Required for TMED10 and TMED2 cis-Golgi
network localization. {ECO:0000250}.
COILED 117 167 {ECO:0000255}.
MOTIF 194 201 COPI vesicle coat-binding. {ECO:0000255}.
MOTIF 194 195 COPII vesicle coat-binding.
{ECO:0000255}.
MUTAGEN 15 15 L->E: Embryonic lethal.
{ECO:0000269|PubMed:20178780}.
SEQUENCE 201 AA; 22705 MW; F5DE259FC419CF85 CRC64;
MVTLAELLAL LAALLATASG YFVSIDAHAE ECFFERVTSG TKMGLIFEVA EGGFLDIDVE
ITGPDNKGIY KGDRESSGKY TFAAHMDGTY KFCFSNRMST MTPKIVMFTI DIGEAPKGQD
METEAHQNKL EEMINELAVA MTAVKHEQEY MEVRERIHRA INDNTNSRVV LWSFFEALVL
VAMTLGQIYY LKRFFEVRRV V


Related products :

Catalog number Product name Quantity
EIAAB43013 Membrane protein p24A,Rat,Rattus norvegicus,RNP21.4,Rnp24,Tmed2,Transmembrane emp24 domain-containing protein 2
EIAAB43012 Membrane protein p24A,Mouse,Mus musculus,Rnp24,Sid 394,Sid394,Tmed2,Transmembrane emp24 domain-containing protein 2
EIAAB43011 Homo sapiens,Human,Membrane protein p24A,RNP24,TMED2,Transmembrane emp24 domain-containing protein 2
EIAAB43035 21 kDa transmembrane-trafficking protein,Integral membrane protein p23,Oryctolagus cuniculus,Rabbit,TMED10,TMP21,Transmembrane emp24 domain-containing protein 10,Transmembrane protein Tmp21
EIAAB43015 C15orf22,Homo sapiens,Human,Membrane protein p24B,TMED3,Transmembrane emp24 domain-containing protein 3,UNQ5357_PRO1078
20-272-191029 Clathrin - Membrane Vesicle Marker - Mouse monoclonal [1.BB.763] to Clathrin - Membrane Vesicle Marker; Adapter-related protein complex 1 beta-1 subunit; Beta-adaptin 1; Adaptor protein complex AP-1 b 0.025 mg
EIAAB43033 21 kDa transmembrane-trafficking protein,Homo sapiens,Human,p23,p24delta,S31I125,S31III125,TMED10,TMP21,Tmp-21-I,Transmembrane emp24 domain-containing protein 10,Transmembrane protein Tmp21
EIAAB07951 Acam,Adipocyte adhesion molecule,Adipocyte-specific protein 5,Asam,Asp5,CAR-like membrane protein,Clmp,Coxsackie- and adenovirus receptor-like membrane protein,CXADR-like membrane protein,Mouse,Mus mu
EIAAB07950 Acam,Adipocyte adhesion molecule,Asam,CAR-like membrane protein,Clmp,Coxsackie- and adenovirus receptor-like membrane protein,CXADR-like membrane protein,Rat,Rattus norvegicus
EIAAB43637 Gpr175,Integral membrane protein GPR175,Rat,Rattus norvegicus,Tpra1,TPRA40,Tpra40,Transmembrane domain protein of 40 kDa regulated in adipocytes,Transmembrane protein adipocyte-associated 1
EIAAB43635 Gpr175,Integral membrane protein GPR175,Mouse,Mus musculus,Tpra1,TPRA40,Tpra40,Transmembrane domain protein of 40 kDa regulated in adipocytes,Transmembrane protein adipocyte-associated 1
EIAAB07952 ACAM,Adipocyte adhesion molecule,ASAM,CAR-like membrane protein,CLMP,Coxsackie- and adenovirus receptor-like membrane protein,CXADR-like membrane protein,Homo sapiens,Human,UNQ318_PRO363
EIAAB43034 21 kDa transmembrane-trafficking protein,Rat,Rattus norvegicus,Tmed10,Tmp21,Transmembrane emp24 domain-containing protein 10,Transmembrane protein Tmp21
EIAAB43036 21 kDa transmembrane-trafficking protein,Mouse,Mus musculus,Tmed10,Tmp21,Transmembrane emp24 domain-containing protein 10,Transmembrane protein Tmp21
EIAAB43032 21 kDa transmembrane-trafficking protein,Bos taurus,Bovine,TMED10,TMP21,Transmembrane emp24 domain-containing protein 10,Transmembrane protein Tmp21
26-039 ITGB8 is a member of the integrin beta chain family and is a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit 0.05 mg
EIAAB45850 Mouse,Mus musculus,NF-E2-inducible protein 2,Protein ni-2,Tmem49,Transmembrane protein 49,Vacuole membrane protein 1,Vmp1
26-176 SYNGR4 is an integral membrane protein. The gene belongs to the synaptogyrin gene family. Like other members of the family the protein contains four transmembrane regions. The exact function of this p 0.05 mg
EIAAB06474 CDCP1,CUB domain-containing protein 1,Homo sapiens,Human,Membrane glycoprotein gp140,SIMA135,Subtractive immunization M plus HEp3-associated 135 kDa protein,Transmembrane and associated with src kinas
EIAAB31872 ANKRD4,Ankyrin repeat domain-containing protein 4,CAAX box protein TIMAP,Homo sapiens,hTIMAP,Human,KIAA0823,PPP1R16B,Protein phosphatase 1 regulatory inhibitor subunit 16B,TGF-beta-inhibited membrane-
EIAAB41003 Fasting-inducible integral membrane protein TM6P1,Rat,Rattus norvegicus,Tm6p1,Tmem150,Tmem150a,Transmembrane protein 150,Transmembrane protein 150A
PE048044h Recombinant human Transmembrane emp24 domain-containing protein 9 protein 1mg
PE048044h Recombinant human Transmembrane emp24 domain-containing protein 9 protein 50ug
PE048044h Recombinant human Transmembrane emp24 domain-containing protein 9 protein 5mg
PE048044h Recombinant human Transmembrane emp24 domain-containing protein 9 protein 200ug


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur