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Transmembrane protein 106B

 T106B_BOVIN             Reviewed;         275 AA.
Q3ZC25;
27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
27-SEP-2005, sequence version 1.
22-NOV-2017, entry version 78.
RecName: Full=Transmembrane protein 106B;
Name=TMEM106B;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Involved in dendrite morphogenesis and maintenance by
regulating lysosomal trafficking via its interaction with MAP6.
May act by inhibiting retrograde transport of lysosomes along
dendrites. Required for dendrite branching (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Interacts with MAP6. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250};
Single-pass type II membrane protein. Lysosome membrane
{ECO:0000250}; Single-pass type II membrane protein. Membrane
{ECO:0000250|UniProtKB:Q9NUM4}; Lipid-anchor
{ECO:0000250|UniProtKB:Q9NUM4}.
-!- SIMILARITY: Belongs to the TMEM106 family. {ECO:0000305}.
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EMBL; BC102965; AAI02966.1; -; mRNA.
RefSeq; NP_001029509.1; NM_001034337.1.
RefSeq; XP_015323767.1; XM_015468281.1.
RefSeq; XP_015323769.1; XM_015468283.1.
UniGene; Bt.49435; -.
SMR; Q3ZC25; -.
STRING; 9913.ENSBTAP00000026319; -.
PaxDb; Q3ZC25; -.
PRIDE; Q3ZC25; -.
Ensembl; ENSBTAT00000026319; ENSBTAP00000026319; ENSBTAG00000019750.
GeneID; 508903; -.
KEGG; bta:508903; -.
CTD; 54664; -.
eggNOG; ENOG410IEC7; Eukaryota.
eggNOG; ENOG410ZX7B; LUCA.
GeneTree; ENSGT00390000013076; -.
HOGENOM; HOG000230966; -.
HOVERGEN; HBG055025; -.
InParanoid; Q3ZC25; -.
OMA; MKQIDYM; -.
OrthoDB; EOG091G0KDT; -.
TreeFam; TF328907; -.
Proteomes; UP000009136; Chromosome 4.
Bgee; ENSBTAG00000019750; -.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
GO; GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
GO; GO:0007041; P:lysosomal transport; IBA:GO_Central.
GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
GO; GO:0007040; P:lysosome organization; IBA:GO_Central.
GO; GO:1900006; P:positive regulation of dendrite development; IEA:Ensembl.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR009790; DUF1356_TMEM106.
InterPro; IPR013783; Ig-like_fold.
PANTHER; PTHR28556; PTHR28556; 1.
Pfam; PF07092; DUF1356; 1.
2: Evidence at transcript level;
Complete proteome; Endosome; Glycoprotein; Lipoprotein; Lysosome;
Membrane; Myristate; Reference proteome; Signal-anchor; Transmembrane;
Transmembrane helix; Transport.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q9NUM4}.
CHAIN 2 275 Transmembrane protein 106B.
/FTId=PRO_0000242649.
TOPO_DOM 2 97 Cytoplasmic. {ECO:0000255}.
TRANSMEM 98 118 Helical. {ECO:0000255}.
TOPO_DOM 119 275 Lumenal. {ECO:0000255}.
LIPID 2 2 N-myristoyl glycine.
{ECO:0000250|UniProtKB:Q9NUM4}.
CARBOHYD 146 146 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 152 152 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 165 165 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 184 184 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 257 257 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 275 AA; 31213 MW; 33EE73967C885A43 CRC64;
MGKSFSHLPL HSNKEDGYDG MTSTENIRNG LVNGEVHNED GRSGDVSQFP YVEFTGRDSV
TCPTCQGTGR IPRGQENQLV ALIPYSDQRL RPRRTKLYVM ASVFVCLLLS GLAVFFLFPR
SIDVKYIGVK SAYVSYDVQK RTIYLNITNT LNITNNNYYS VEVENITAQV QFSKTVIGKA
RLNNITSIGP LDMKQIDYTV PTVIAEEMSY MFDFCTLLTI KVHNIVLMMQ VTVTTTYFGH
SEQISQERYQ YVDCGRNTTY HLGQSEYLNV LQPQQ


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