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Tribbles homolog 3 (TRB-3)

 TRIB3_BOVIN             Reviewed;         357 AA.
Q0VCE3;
17-APR-2007, integrated into UniProtKB/Swiss-Prot.
05-SEP-2006, sequence version 1.
12-SEP-2018, entry version 101.
RecName: Full=Tribbles homolog 3;
Short=TRB-3;
Name=TRIB3;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Placenta;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Disrupts insulin signaling by binding directly to Akt
kinases and blocking their activation. May bind directly to and
mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and
inhibits its transcriptional activation activity. Interacts with
the NF-kappa-B transactivator p65 RELA and inhibits its
phosphorylation and thus its transcriptional activation activity.
Interacts with MAPK kinases and regulates activation of MAP
kinases. May play a role in programmed neuronal cell death but
does not appear to affect non-neuronal cells. Does not display
kinase activity (By similarity). Inhibits the transcriptional
activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent
cell death during ER stress (By similarity). Can inhibit APOBEC3A
editing of nuclear DNA (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7.
Interacts with DDIT3/CHOP and inhibits its interaction with
EP300/P300. Interacts (via N-terminus) with APOBEC3A. Interacts
with APOBEC3C. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- DOMAIN: The protein kinase domain is predicted to be catalytically
inactive.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK
Ser/Thr protein kinase family. Tribbles subfamily. {ECO:0000305}.
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EMBL; BC120209; AAI20210.1; -; mRNA.
RefSeq; NP_001069571.1; NM_001076103.1.
RefSeq; XP_005214869.1; XM_005214812.3.
UniGene; Bt.45499; -.
ProteinModelPortal; Q0VCE3; -.
SMR; Q0VCE3; -.
STRING; 9913.ENSBTAP00000022616; -.
PaxDb; Q0VCE3; -.
PRIDE; Q0VCE3; -.
Ensembl; ENSBTAT00000022616; ENSBTAP00000022616; ENSBTAG00000017007.
GeneID; 538465; -.
KEGG; bta:538465; -.
CTD; 57761; -.
VGNC; VGNC:36310; TRIB3.
eggNOG; KOG0583; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00900000140868; -.
HOGENOM; HOG000231872; -.
HOVERGEN; HBG067729; -.
InParanoid; Q0VCE3; -.
KO; K19518; -.
OMA; YTCKVYP; -.
OrthoDB; EOG091G07JM; -.
TreeFam; TF329785; -.
Reactome; R-BTA-1257604; PIP3 activates AKT signaling.
Reactome; R-BTA-165158; Activation of AKT2.
Reactome; R-BTA-199418; Negative regulation of the PI3K/AKT network.
Reactome; R-BTA-389357; CD28 dependent PI3K/Akt signaling.
Reactome; R-BTA-5218920; VEGFR2 mediated vascular permeability.
Proteomes; UP000009136; Chromosome 13.
Bgee; ENSBTAG00000017007; Expressed in 7 organ(s), highest expression level in liver.
GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0031434; F:mitogen-activated protein kinase kinase binding; IBA:GO_Central.
GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0055106; F:ubiquitin-protein transferase regulator activity; IEA:Ensembl.
GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; ISS:UniProtKB.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO; GO:0010827; P:regulation of glucose transmembrane transport; IEA:Ensembl.
GO; GO:0043405; P:regulation of MAP kinase activity; IBA:GO_Central.
GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR024104; Tribbles/Ser_Thr_kinase_40.
InterPro; IPR024106; Tribbles_TRB3.
PANTHER; PTHR22961; PTHR22961; 1.
PANTHER; PTHR22961:SF14; PTHR22961:SF14; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
2: Evidence at transcript level;
Apoptosis; Complete proteome; Nucleus; Protein kinase inhibitor;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 357 Tribbles homolog 3.
/FTId=PRO_0000284059.
DOMAIN 68 316 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 1 127 Interaction with DDIT3/CHOP.
{ECO:0000250}.
SEQUENCE 357 AA; 39657 MW; 18B65E01109CAB6E CRC64;
MRASPLAVPA NAPSRKKRLE LDDDLDTECP SQKQARSGPQ PRLPSCPLTL NPPPAPVHAP
DVTTPSRLGP YVLLEPEEGS RTYRALHCPT GTEYICKVYP ACERLAVLEP YWRLPHHGHV
ARPAEVLAGT QLLYAFFLRP HGDMHSLVRR RRRLPEPEAA ALFRQMAAAL AHCHQHGLVL
RDLKLRRFVF TDRERTKLVL ENLEDACVLT GPDDSLWDKH ACPAYVGPEI LSSRASYSGK
AADVWSLGVA LFTMLAGHYP FQDSEPALLF GKIRRGAFAL PEGLSAPARC LVRCLLRREP
TERLTASGIL LHPWLRENAI PAALPRSRHC EADQVVPEGP GLEEAEEEGE RDMGLYG


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