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Troponin C, skeletal muscle

 TNNC2_HUMAN             Reviewed;         160 AA.
P02585; Q6FH92;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
25-OCT-2017, entry version 168.
RecName: Full=Troponin C, skeletal muscle;
Name=TNNC2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3166492; DOI=10.1016/0022-2836(88)90145-3;
Gahlmann R., Wade R., Gunning R., Kedes L.;
"Differential expression of slow and fast skeletal muscle troponin C.
Slow skeletal muscle troponin C is expressed in human fibroblasts.";
J. Mol. Biol. 201:379-391(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2373703;
Gahlmann R., Kedes L.;
"Cloning, structural analysis, and expression of the human fast twitch
skeletal muscle troponin C gene.";
J. Biol. Chem. 265:12520-12528(1990).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Muscle;
Wu Q.L.;
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Tongue;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
PROTEIN SEQUENCE OF 2-160, AND ACETYLATION AT THR-2.
TISSUE=Skeletal muscle;
PubMed=978749; DOI=10.1007/BF01730999;
Romero-Herrera A.E., Castillo O., Lehmann H.;
"Human skeletal muscle proteins. The primary structure of troponin
C.";
J. Mol. Evol. 8:251-270(1976).
-!- FUNCTION: Troponin is the central regulatory protein of striated
muscle contraction. Tn consists of three components: Tn-I which is
the inhibitor of actomyosin ATPase, Tn-T which contains the
binding site for tropomyosin and Tn-C. The binding of calcium to
Tn-C abolishes the inhibitory action of Tn on actin filaments.
-!- INTERACTION:
P19429:TNNI3; NbExp=3; IntAct=EBI-10249681, EBI-704146;
Q6FGX2:TNNI3; NbExp=3; IntAct=EBI-10249681, EBI-10249686;
-!- MISCELLANEOUS: Skeletal muscle troponin C binds four calcium ions.
-!- SIMILARITY: Belongs to the troponin C family. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; X07898; CAA30737.1; -; mRNA.
EMBL; M33772; AAA61197.1; -; Genomic_DNA.
EMBL; M33771; AAA61197.1; JOINED; Genomic_DNA.
EMBL; M22307; AAA91854.1; -; mRNA.
EMBL; AK291323; BAF84012.1; -; mRNA.
EMBL; CR541864; CAG46662.1; -; mRNA.
EMBL; CR541884; CAG46682.1; -; mRNA.
EMBL; CH471077; EAW75803.1; -; Genomic_DNA.
EMBL; AL050348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC005323; AAH05323.1; -; mRNA.
CCDS; CCDS13375.1; -.
PIR; A36574; TPHUCS.
RefSeq; NP_003270.1; NM_003279.2.
UniGene; Hs.182421; -.
ProteinModelPortal; P02585; -.
SMR; P02585; -.
BioGrid; 112980; 39.
IntAct; P02585; 5.
STRING; 9606.ENSP00000361636; -.
ChEMBL; CHEMBL3831282; -.
DrugBank; DB01373; Calcium.
DrugBank; DB01023; Felodipine.
DrugBank; DB04682; Octylphenoxy polyethoxyethanol.
iPTMnet; P02585; -.
PhosphoSitePlus; P02585; -.
BioMuta; TNNC2; -.
DMDM; 136043; -.
PaxDb; P02585; -.
PeptideAtlas; P02585; -.
PRIDE; P02585; -.
DNASU; 7125; -.
Ensembl; ENST00000372555; ENSP00000361636; ENSG00000101470.
GeneID; 7125; -.
KEGG; hsa:7125; -.
UCSC; uc002xpr.4; human.
CTD; 7125; -.
EuPathDB; HostDB:ENSG00000101470.9; -.
GeneCards; TNNC2; -.
HGNC; HGNC:11944; TNNC2.
HPA; HPA043174; -.
HPA; HPA058481; -.
MIM; 191039; gene.
neXtProt; NX_P02585; -.
OpenTargets; ENSG00000101470; -.
PharmGKB; PA36633; -.
eggNOG; KOG0027; Eukaryota.
eggNOG; COG5126; LUCA.
GeneTree; ENSGT00760000118901; -.
HOGENOM; HOG000233018; -.
HOVERGEN; HBG012180; -.
InParanoid; P02585; -.
KO; K12042; -.
OMA; VETWEVD; -.
OrthoDB; EOG091G0QHM; -.
PhylomeDB; P02585; -.
TreeFam; TF318191; -.
Reactome; R-HSA-390522; Striated Muscle Contraction.
SIGNOR; P02585; -.
ChiTaRS; TNNC2; human.
GeneWiki; TNNC2; -.
GenomeRNAi; 7125; -.
PRO; PR:P02585; -.
Proteomes; UP000005640; Chromosome 20.
Bgee; ENSG00000101470; -.
CleanEx; HS_TNNC2; -.
ExpressionAtlas; P02585; baseline and differential.
Genevisible; P02585; HS.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005861; C:troponin complex; IDA:UniProtKB.
GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
GO; GO:0030049; P:muscle filament sliding; TAS:Reactome.
GO; GO:0006937; P:regulation of muscle contraction; TAS:ProtInc.
GO; GO:0003009; P:skeletal muscle contraction; IDA:UniProtKB.
CDD; cd00051; EFh; 2.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR002048; EF_hand_dom.
Pfam; PF13499; EF-hand_7; 1.
Pfam; PF13833; EF-hand_8; 1.
SMART; SM00054; EFh; 4.
SUPFAM; SSF47473; SSF47473; 1.
PROSITE; PS00018; EF_HAND_1; 4.
PROSITE; PS50222; EF_HAND_2; 4.
1: Evidence at protein level;
Acetylation; Calcium; Complete proteome; Direct protein sequencing;
Metal-binding; Muscle protein; Reference proteome; Repeat.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:978749}.
CHAIN 2 160 Troponin C, skeletal muscle.
/FTId=PRO_0000073703.
DOMAIN 15 50 EF-hand 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 51 86 EF-hand 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 91 126 EF-hand 3. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 127 160 EF-hand 4. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
CA_BIND 28 39 1.
CA_BIND 64 75 2.
CA_BIND 104 115 3.
CA_BIND 140 151 4.
MOD_RES 2 2 N-acetylthreonine.
{ECO:0000269|PubMed:978749}.
CONFLICT 2 3 TD -> DT (in Ref. 9; AA sequence).
{ECO:0000305}.
CONFLICT 114 114 E -> G (in Ref. 3; AAA91854).
{ECO:0000305}.
SEQUENCE 160 AA; 18122 MW; EA93729732A0F916 CRC64;
MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT PTKEELDAII
EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF RIFDRNADGY IDPEELAEIF
RASGEHVTDE EIESLMKDGD KNNDGRIDFD EFLKMMEGVQ


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