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Troponin I, cardiac muscle (Cardiac troponin I)

 TNNI3_BOVIN             Reviewed;         212 AA.
P08057; Q5ZG22;
01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
30-AUG-2017, entry version 106.
RecName: Full=Troponin I, cardiac muscle;
AltName: Full=Cardiac troponin I;
Name=TNNI3;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Peripheral blood;
Guziewicz K.;
"Bovine dilated cardiomyopathy: evidence for a major gene on BTA18.";
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
[2]
PROTEIN SEQUENCE OF 2-212, AND ACETYLATION AT ALA-2.
PubMed=3042023; DOI=10.1021/bi00408a024;
Leszyk J., Dumaswala R., Potter J.D., Collins J.H.;
"Amino acid sequence of bovine cardiac troponin I.";
Biochemistry 27:2821-2827(1988).
[3]
PROTEIN SEQUENCE OF 2-212.
PubMed=2967699; DOI=10.1016/S0006-291X(88)80426-1;
Creutz C.E., Snyder S.L., Husted L.D., Beggerly L.K., Fox J.W.;
"Pattern of repeating aromatic residues in synexin. Similarity to the
cytoplasmic domain of synaptophysin.";
Biochem. Biophys. Res. Commun. 152:1298-1303(1988).
-!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the
thin filament regulatory complex which confers calcium-sensitivity
to striated muscle actomyosin ATPase activity.
-!- SUBUNIT: Interacts with TRIM63 (By similarity). Binds to actin and
tropomyosin. Interacts with STK4/MST1 (By similarity).
{ECO:0000250}.
-!- PTM: Phosphorylated at Ser-24 and Ser-25 by PRKD1; phosphorylation
reduces myofilament calcium sensitivity. Phosphorylated
preferentially at Thr-33. Phosphorylation by STK4/MST1 alters its
binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).
Phosphorylated at Ser-44 and Ser-46 by PRKCE; phosphorylation
increases myocardium contractile dysfunction (By similarity).
{ECO:0000250}.
-!- SIMILARITY: Belongs to the troponin I family. {ECO:0000305}.
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EMBL; AJ842179; CAH57016.1; -; Genomic_DNA.
PIR; A29994; A29994.
RefSeq; NP_001035607.1; NM_001040517.1.
UniGene; Bt.11438; -.
ProteinModelPortal; P08057; -.
SMR; P08057; -.
IntAct; P08057; 1.
STRING; 9913.ENSBTAP00000008425; -.
iPTMnet; P08057; -.
PaxDb; P08057; -.
PRIDE; P08057; -.
Ensembl; ENSBTAT00000008425; ENSBTAP00000008425; ENSBTAG00000006424.
GeneID; 511094; -.
KEGG; bta:511094; -.
CTD; 7137; -.
eggNOG; KOG3977; Eukaryota.
eggNOG; ENOG410Y9IX; LUCA.
GeneTree; ENSGT00390000002746; -.
HOGENOM; HOG000293300; -.
HOVERGEN; HBG052737; -.
InParanoid; P08057; -.
KO; K12044; -.
OMA; KMFDTGG; -.
OrthoDB; EOG091G0NOD; -.
TreeFam; TF313374; -.
Reactome; R-BTA-390522; Striated Muscle Contraction.
Reactome; R-BTA-5578775; Ion homeostasis.
Proteomes; UP000009136; Chromosome 18.
Bgee; ENSBTAG00000006424; -.
GO; GO:0097512; C:cardiac myofibril; IDA:CAFA.
GO; GO:1990584; C:cardiac Troponin complex; IDA:CAFA.
GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IDA:CAFA.
GO; GO:0016887; F:ATPase activity; IDA:CAFA.
GO; GO:0019855; F:calcium channel inhibitor activity; IEA:Ensembl.
GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
GO; GO:0000287; F:magnesium ion binding; IDA:CAFA.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0030172; F:troponin C binding; IPI:CAFA.
GO; GO:0031014; F:troponin T binding; IEA:Ensembl.
GO; GO:0060048; P:cardiac muscle contraction; IBA:GO_Central.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0032780; P:negative regulation of ATPase activity; IEA:Ensembl.
GO; GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IEA:Ensembl.
GO; GO:0001980; P:regulation of systemic arterial blood pressure by ischemic conditions; IEA:Ensembl.
GO; GO:0003009; P:skeletal muscle contraction; IBA:GO_Central.
GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
InterPro; IPR001978; Troponin.
InterPro; IPR021666; Troponin-I_N.
Pfam; PF00992; Troponin; 1.
Pfam; PF11636; Troponin-I_N; 1.
1: Evidence at protein level;
Acetylation; Actin-binding; Calcium; Complete proteome;
Direct protein sequencing; Metal-binding; Muscle protein;
Phosphoprotein; Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:2967699,
ECO:0000269|PubMed:3042023}.
CHAIN 2 212 Troponin I, cardiac muscle.
/FTId=PRO_0000186149.
CA_BIND 139 150 {ECO:0000250}.
REGION 34 81 Involved in binding TNC.
REGION 131 151 Involved in binding TNC and actin.
SITE 82 82 Involved in TNI-TNT interactions.
SITE 99 99 Involved in TNI-TNT interactions.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000269|PubMed:3042023}.
MOD_RES 5 5 Phosphoserine.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 24 24 Phosphoserine; by PKA and PKD/PRKD1.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 25 25 Phosphoserine; by PKA and PKD/PRKD1.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 28 28 Phosphotyrosine.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 33 33 Phosphothreonine; by STK4/MST1.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 44 44 Phosphoserine; by PKC/PRKCE.
{ECO:0000250|UniProtKB:P48787}.
MOD_RES 46 46 Phosphoserine; by PKC/PRKCE.
{ECO:0000250|UniProtKB:P48787}.
MOD_RES 53 53 Phosphothreonine; by STK4/MST1.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 79 79 Phosphoserine.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 80 80 Phosphothreonine.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 145 145 Phosphothreonine; by STK4/MST1.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 152 152 Phosphoserine; by PAK3.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 183 183 Phosphothreonine.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 201 201 Phosphoserine.
{ECO:0000250|UniProtKB:P19429}.
CONFLICT 17 17 P -> M (in Ref. 3; AA sequence).
{ECO:0000305}.
SEQUENCE 212 AA; 24054 MW; B4B15DCCA7BA2B5E CRC64;
MADRSGGSTA GDTVPAPPPV RRRSSANYRA YATEPHAKKK SKISASRKLQ LKTLMLQIAK
QELEREAEER RGEKGRALST RCQPLELAGL GFAELQDLCR QLHARVDKVD EERYDVEAKV
TKNITEIADL NQKIFDLRGK FKRPTLRRVR ISADAMMQAL LGARAKETLD LRAHLKQVKK
EDTEKENREV GDWRKNIDAL SGMEGRKKKF EG


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