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Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)

 TNNT2_RABIT             Reviewed;         301 AA.
P09741; P09742;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
30-AUG-2017, entry version 101.
RecName: Full=Troponin T, cardiac muscle;
Short=TnTc;
AltName: Full=Cardiac muscle troponin T;
Short=cTnT;
Name=TNNT2;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
PubMed=8261593; DOI=10.1161/01.RES.74.1.41;
Greig A., Hirschberg Y., Anderson P.A.W., Hainsworth C., Malouf N.N.,
Oakeley A.E., Kay B.K.;
"Molecular basis of cardiac troponin T isoform heterogeneity in rabbit
heart.";
Circ. Res. 74:41-47(1994).
[2]
PROTEIN SEQUENCE OF 2-301, AND ACETYLATION AT SER-2.
TISSUE=Heart;
PubMed=3782144;
Pearlstone J.R., Carpenter M.R., Smillie L.B.;
"Amino acid sequence of rabbit cardiac troponin T.";
J. Biol. Chem. 261:16795-16810(1986).
[3]
PHOSPHORYLATION AT SER-2.
PubMed=7458911; DOI=10.1042/bj1890219;
Gusev N.B., Dobrovolskii A.B., Severin S.E.;
"Isolation and some properties of troponin T kinase from rabbit
skeletal muscle.";
Biochem. J. 189:219-226(1980).
-!- FUNCTION: Troponin T is the tropomyosin-binding subunit of
troponin, the thin filament regulatory complex which confers
calcium-sensitivity to striated muscle actomyosin ATPase activity.
-!- SUBUNIT: Binds with troponins I and C to make the thin-filament
regulatory complex, troponin.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=CTNT1;
IsoId=P09741-1; Sequence=Displayed;
Name=CTNT2;
IsoId=P09741-2; Sequence=VSP_006651;
Name=CTNT3;
IsoId=P09741-3; Sequence=VSP_006652;
Name=CTNT4;
IsoId=P09741-4; Sequence=VSP_006651, VSP_006652;
-!- TISSUE SPECIFICITY: The major isoform in adult heart is CTNT4.
-!- PTM: Phosphorylation at Thr-216 by PRKCA induces significant
reduction in myofilament calcium sensitivity and actomyosin ATPase
activity. {ECO:0000250}.
-!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAB51160.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; L40178; AAB51160.1; ALT_INIT; mRNA.
PIR; A25345; A25345.
PIR; A61032; A61032.
PIR; B25345; B25345.
PIR; I46903; I46903.
UniGene; Ocu.2129; -.
ProteinModelPortal; P09741; -.
SMR; P09741; -.
iPTMnet; P09741; -.
HOGENOM; HOG000231049; -.
HOVERGEN; HBG052790; -.
InParanoid; P09741; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0005865; C:striated muscle thin filament; ISS:UniProtKB.
GO; GO:0005861; C:troponin complex; ISS:UniProtKB.
GO; GO:0003779; F:actin binding; ISS:UniProtKB.
GO; GO:0005523; F:tropomyosin binding; ISS:UniProtKB.
GO; GO:0030172; F:troponin C binding; ISS:UniProtKB.
GO; GO:0031013; F:troponin I binding; ISS:UniProtKB.
GO; GO:0030049; P:muscle filament sliding; ISS:UniProtKB.
GO; GO:0032780; P:negative regulation of ATPase activity; ISS:UniProtKB.
GO; GO:0032781; P:positive regulation of ATPase activity; ISS:UniProtKB.
GO; GO:0008016; P:regulation of heart contraction; ISS:UniProtKB.
GO; GO:0006937; P:regulation of muscle contraction; IEA:InterPro.
GO; GO:0051592; P:response to calcium ion; ISS:UniProtKB.
GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; ISS:UniProtKB.
InterPro; IPR027707; TNNT.
InterPro; IPR001978; Troponin.
PANTHER; PTHR11521; PTHR11521; 1.
Pfam; PF00992; Troponin; 2.
1: Evidence at protein level;
Acetylation; Alternative splicing; Complete proteome;
Direct protein sequencing; Muscle protein; Phosphoprotein;
Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:3782144}.
CHAIN 2 301 Troponin T, cardiac muscle.
/FTId=PRO_0000186175.
MOD_RES 2 2 N-acetylserine.
{ECO:0000269|PubMed:3782144}.
MOD_RES 2 2 Phosphoserine; by CK2.
{ECO:0000269|PubMed:7458911}.
MOD_RES 207 207 Phosphothreonine; by PKC/PRKCA.
{ECO:0000250|UniProtKB:P50752}.
MOD_RES 211 211 Phosphoserine; by PKC/PRKCA.
{ECO:0000250|UniProtKB:P50752}.
MOD_RES 216 216 Phosphothreonine; by PKC/PRKCA and RAF1.
{ECO:0000250}.
MOD_RES 297 297 Phosphothreonine; by PKC/PRKCA.
{ECO:0000250|UniProtKB:P50752}.
VAR_SEQ 17 22 Missing (in isoform CTNT2 and isoform
CTNT4). {ECO:0000305}.
/FTId=VSP_006651.
VAR_SEQ 24 33 Missing (in isoform CTNT3 and isoform
CTNT4). {ECO:0000305}.
/FTId=VSP_006652.
CONFLICT 14 33 EQEAEEAAAEEEDWREDEDE -> QQAG (in Ref. 2;
AA sequence). {ECO:0000305}.
CONFLICT 17 32 Missing (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 38 41 EEEE -> AGGG (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 46 46 R -> A (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 139 139 D -> E (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 147 147 D -> ER (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 184 184 E -> D (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 206 214 Missing (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 301 AA; 35876 MW; 88777671C9F35541 CRC64;
MSDLEEVVEE YEEEQEAEEA AAEEEDWRED EDEQEAGEEE EAGGGREAEA ETEETQAEED
GQEEEDKEDE DGPVEESKPK PRPFMPNLVP PKIPDGERVD FDDIHRKRME KDLNELQTLI
EAHFENRKKE EEELVSLKDR IEKRRADAEQ LRIRAEREKE RQNRLAEERA RREEEESRRK
AEDEARKKKA LSNMMHFGGY IQKQAQTERK SGKRQTEREK KKKILAERRK VLAIDHLNED
QLREKAKELW QSIYNLEAEK FDLQEKFKQQ KYEINVLRNR INDNQKVSKT RGKAKVTGRW
K


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