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Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT)

 TNNT3_RAT               Reviewed;         259 AA.
P09739; P09740; Q304F4; Q4PPA0;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
10-MAY-2017, entry version 126.
RecName: Full=Troponin T, fast skeletal muscle;
Short=TnTf;
AltName: Full=Fast skeletal muscle troponin T;
Short=fTnT;
Name=Tnnt3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
PubMed=3735424; DOI=10.1016/0022-2836(86)90157-9;
Breitbart R.E., Nadal-Ginard B.;
"Complete nucleotide sequence of the fast skeletal troponin T gene.
Alternatively spliced exons exhibit unusual interspecies divergence.";
J. Mol. Biol. 188:313-324(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
PubMed=2986851; DOI=10.1016/0092-8674(85)90062-5;
Breitbart R.E., Nguyen H.T., Medford R.M., Destree A.T., Mahdavi V.,
Nadal-Ginard B.;
"Intricate combinatorial patterns of exon splicing generate multiple
regulated troponin T isoforms from a single gene.";
Cell 41:67-82(1985).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND FUNCTION.
STRAIN=Sprague-Dawley; TISSUE=Fast-twitch skeletal muscle;
PubMed=16839517; DOI=10.1016/j.abb.2006.06.008;
Gallon C.E., Tschirgi M.L., Chandra M.;
"Differences in myofilament calcium sensitivity in rat psoas fibers
reconstituted with troponin T isoforms containing the alpha- and beta-
exons.";
Arch. Biochem. Biophys. 456:127-134(2006).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-78; SER-149;
SER-156; SER-157; SER-193 AND TYR-209, PHOSPHORYLATION [LARGE SCALE
ANALYSIS] AT SER-2 (ISOFORMS 3; 6 AND 7), AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Troponin T is the tropomyosin-binding subunit of
troponin, the thin filament regulatory complex which confers
calcium-sensitivity to striated muscle actomyosin ATPase activity.
{ECO:0000269|PubMed:16839517}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=7;
Comment=Combinatorial alternative splicing of 5 short exons in
the 5' region of this gene may generate up to 32 distinct
N-terminal isoforms. These N-terminal isoforms may be further
combined with one of two mutually exclusive C-terminal exons
(alpha or beta) to produce up to 64 distinct isoforms. For
simplicity, only individual splice events are explicitly
described here. {ECO:0000269|PubMed:2986851,
ECO:0000269|PubMed:3735424};
Name=1; Synonyms=Beta;
IsoId=P09739-1; Sequence=Displayed;
Name=2; Synonyms=Alpha;
IsoId=P09739-2; Sequence=VSP_006664;
Note=Increased calcium sensitivity of myofilaments relative to
isoform 1.;
Name=3; Synonyms=Ia-2;
IsoId=P09739-3; Sequence=VSP_006658;
Note=Lacks exon 4. Contains a phosphoserine at position 2.
{ECO:0000244|PubMed:22673903};
Name=4; Synonyms=Ib-1;
IsoId=P09739-4; Sequence=VSP_006659;
Note=Lacks exon 5.;
Name=5; Synonyms=Ic-1;
IsoId=P09739-5; Sequence=VSP_006660;
Note=Lacks exon 6.;
Name=6; Synonyms=IIa-1;
IsoId=P09739-6; Sequence=VSP_006661;
Note=Lacks exon 7. Contains a phosphoserine at position 2.
{ECO:0000244|PubMed:22673903};
Name=7; Synonyms=IVb;
IsoId=P09739-7; Sequence=VSP_006663;
Note=Lacks exon 8. Contains a phosphoserine at position 2.
{ECO:0000244|PubMed:22673903};
-!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M15202; AAA96440.1; -; Genomic_DNA.
EMBL; M15202; AAA96441.1; -; Genomic_DNA.
EMBL; M15202; AAA96442.1; -; Genomic_DNA.
EMBL; M15202; AAA96443.1; -; Genomic_DNA.
EMBL; M15202; AAA96444.1; -; Genomic_DNA.
EMBL; M15202; AAA96445.1; -; Genomic_DNA.
EMBL; M15202; AAA96446.1; -; Genomic_DNA.
EMBL; M15202; AAA96447.1; -; Genomic_DNA.
EMBL; M15202; AAA96448.1; -; Genomic_DNA.
EMBL; M15202; AAA96449.1; -; Genomic_DNA.
EMBL; M15202; AAA96450.1; -; Genomic_DNA.
EMBL; M15202; AAA96451.1; -; Genomic_DNA.
EMBL; M15202; AAA96452.1; -; Genomic_DNA.
EMBL; M15202; AAA96453.1; -; Genomic_DNA.
EMBL; M15202; AAA96454.1; -; Genomic_DNA.
EMBL; M15202; AAA96455.1; -; Genomic_DNA.
EMBL; M15202; AAA96456.1; -; Genomic_DNA.
EMBL; M15202; AAA96457.1; -; Genomic_DNA.
EMBL; M15202; AAA96458.1; -; Genomic_DNA.
EMBL; M15202; AAA96459.1; -; Genomic_DNA.
EMBL; M15202; AAA96460.1; -; Genomic_DNA.
EMBL; M15202; AAA96461.1; -; Genomic_DNA.
EMBL; M15202; AAA96462.1; -; Genomic_DNA.
EMBL; M15202; AAA96463.1; -; Genomic_DNA.
EMBL; M15202; AAA96464.1; -; Genomic_DNA.
EMBL; M15202; AAA96465.1; -; Genomic_DNA.
EMBL; M15202; AAA96466.1; -; Genomic_DNA.
EMBL; M15202; AAA96467.1; -; Genomic_DNA.
EMBL; M15202; AAA96468.1; -; Genomic_DNA.
EMBL; M15202; AAA96469.1; -; Genomic_DNA.
EMBL; M15202; AAA96470.1; -; Genomic_DNA.
EMBL; M15202; AAA96471.1; -; Genomic_DNA.
EMBL; M15202; AAA96472.1; -; Genomic_DNA.
EMBL; M15202; AAA96473.1; -; Genomic_DNA.
EMBL; M15202; AAA96474.1; -; Genomic_DNA.
EMBL; M15202; AAA96475.1; -; Genomic_DNA.
EMBL; M15202; AAA96476.1; -; Genomic_DNA.
EMBL; M15202; AAA96477.1; -; Genomic_DNA.
EMBL; M15202; AAA96478.1; -; Genomic_DNA.
EMBL; M15202; AAA96479.1; -; Genomic_DNA.
EMBL; M15202; AAA96480.1; -; Genomic_DNA.
EMBL; M15202; AAA96481.1; -; Genomic_DNA.
EMBL; M15202; AAA96482.1; -; Genomic_DNA.
EMBL; M15202; AAA96483.1; -; Genomic_DNA.
EMBL; DQ062204; AAY59901.1; -; mRNA.
EMBL; DQ273678; ABB51539.1; -; mRNA.
PIR; A24824; A24824.
RefSeq; NP_001257593.1; NM_001270664.1.
RefSeq; NP_001257594.1; NM_001270665.1. [P09739-1]
RefSeq; NP_001257595.1; NM_001270666.1.
RefSeq; NP_001257597.1; NM_001270668.1.
RefSeq; NP_001257599.1; NM_001270670.1.
RefSeq; NP_001257600.1; NM_001270671.1. [P09739-3]
RefSeq; NP_001257602.1; NM_001270673.1. [P09739-7]
RefSeq; NP_001257605.1; NM_001270676.1.
RefSeq; NP_001257607.1; NM_001270678.1.
RefSeq; NP_113720.1; NM_031532.2. [P09739-6]
RefSeq; XP_006230743.1; XM_006230681.3.
RefSeq; XP_006230745.1; XM_006230683.3.
RefSeq; XP_006230747.1; XM_006230685.3.
RefSeq; XP_006230748.1; XM_006230686.3.
RefSeq; XP_017444281.1; XM_017588792.1. [P09739-5]
RefSeq; XP_017444282.1; XM_017588793.1.
RefSeq; XP_017444283.1; XM_017588794.1.
UniGene; Rn.15488; -.
ProteinModelPortal; P09739; -.
SMR; P09739; -.
BioGrid; 246956; 1.
STRING; 10116.ENSRNOP00000062653; -.
iPTMnet; P09739; -.
PhosphoSitePlus; P09739; -.
PaxDb; P09739; -.
PRIDE; P09739; -.
Ensembl; ENSRNOT00000063918; ENSRNOP00000062891; ENSRNOG00000020332. [P09739-6]
Ensembl; ENSRNOT00000066135; ENSRNOP00000062653; ENSRNOG00000020332. [P09739-1]
Ensembl; ENSRNOT00000066896; ENSRNOP00000059829; ENSRNOG00000020332. [P09739-7]
GeneID; 24838; -.
KEGG; rno:24838; -.
UCSC; RGD:3883; rat. [P09739-1]
CTD; 7140; -.
RGD; 3883; Tnnt3.
eggNOG; KOG3634; Eukaryota.
eggNOG; ENOG410XS6A; LUCA.
GeneTree; ENSGT00390000013611; -.
HOGENOM; HOG000231049; -.
HOVERGEN; HBG052790; -.
InParanoid; P09739; -.
KO; K12046; -.
OrthoDB; EOG091G0U67; -.
PhylomeDB; P09739; -.
Reactome; R-RNO-390522; Striated Muscle Contraction.
PRO; PR:P09739; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000020332; -.
ExpressionAtlas; P09739; baseline and differential.
Genevisible; P09739; RN.
GO; GO:0005861; C:troponin complex; IDA:RGD.
GO; GO:0031014; F:troponin T binding; NAS:RGD.
GO; GO:0006936; P:muscle contraction; TAS:RGD.
GO; GO:0006937; P:regulation of muscle contraction; IDA:RGD.
GO; GO:0006942; P:regulation of striated muscle contraction; IMP:RGD.
InterPro; IPR027707; TNNT.
InterPro; IPR027708; Tnnt3.
InterPro; IPR001978; Troponin.
PANTHER; PTHR11521; PTHR11521; 1.
PANTHER; PTHR11521:SF18; PTHR11521:SF18; 1.
Pfam; PF00992; Troponin; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Complete proteome; Muscle protein;
Phosphoprotein; Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P02641}.
CHAIN 2 259 Troponin T, fast skeletal muscle.
/FTId=PRO_0000186181.
MOD_RES 2 2 N-acetylserine.
{ECO:0000250|UniProtKB:P02641}.
MOD_RES 2 2 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 78 78 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 149 149 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 156 156 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 157 157 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 193 193 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 209 209 Phosphotyrosine.
{ECO:0000244|PubMed:22673903}.
VAR_SEQ 10 15 Missing (in isoform 3). {ECO:0000305}.
/FTId=VSP_006658.
VAR_SEQ 16 21 Missing (in isoform 4). {ECO:0000305}.
/FTId=VSP_006659.
VAR_SEQ 22 26 Missing (in isoform 5). {ECO:0000305}.
/FTId=VSP_006660.
VAR_SEQ 28 31 Missing (in isoform 6). {ECO:0000305}.
/FTId=VSP_006661.
VAR_SEQ 32 36 Missing (in isoform 7). {ECO:0000305}.
/FTId=VSP_006663.
VAR_SEQ 230 242 TTLRSRIDQAQKH -> MNVRARVEMLAKF (in
isoform 2).
{ECO:0000303|PubMed:16839517}.
/FTId=VSP_006664.
SEQUENCE 259 AA; 30750 MW; 37BDCF3394F2B5B7 CRC64;
MSDEETEQVE EQYEEEEEAQ EEEVQEEAPE PEEVQEEEKP RPKLTAPKIP EGEKVDFDDI
QKKRQNKDLM ELQALIDSHF EARKKEEEEL IALKERIEKR RAERAEQQRI RAEKERERQN
RLAEEKARRE EEDAKRRAED DLKKKKALSS MGANYSSYLA KADQKRGKKQ TAREMKKKIL
AERRKPLNID HLSDDKLRDK AKELWDTLYQ LETDKFEFGE KLKRQKYDIT TLRSRIDQAQ
KHSKKAGATA KGKVGGRWK


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