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Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT)

 TNNT3_MOUSE             Reviewed;         272 AA.
Q9QZ47; A2A6H7; A2A6H8; A2A6H9; A2A6I1; A2A6I2; A2A6I4; A2A6I6;
A2A6I7; A2A6I9; O35575; O35576; O35577; O35578; O35579; O35580;
O35581; O35582; O35583; O35584; O35585; P97456; Q99L89; Q9QZ46;
04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
25-OCT-2017, entry version 121.
RecName: Full=Troponin T, fast skeletal muscle;
Short=TnTf;
AltName: Full=Fast skeletal muscle troponin T;
Short=fTnT;
Name=Tnnt3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY,
AND DEVELOPMENTAL STAGE.
STRAIN=129/SvJ; TISSUE=Skeletal muscle;
PubMed=9249073; DOI=10.1016/S0378-1119(97)00100-5;
Wang J., Jin J.-P.;
"Primary structure and developmental acidic to basic transition of 13
alternatively spliced mouse fast skeletal muscle troponin T
isoforms.";
Gene 193:105-114(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B3E17).
PubMed=9107680; DOI=10.1007/s003359900437;
Koch A., Juan T.S.-C., Jenkins N.A., Gilbert D.J., Copeland N.G.,
McNiece I.K., Fletcher F.A.;
"cDNA cloning and chromosomal mapping of mouse fast skeletal muscle
troponin T.";
Mamm. Genome 8:346-348(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-131.
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 14).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brown adipose tissue;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Troponin T is the tropomyosin-binding subunit of
troponin, the thin filament regulatory complex which confers
calcium-sensitivity to striated muscle actomyosin ATPase activity.
{ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=14;
Comment=Additional isoforms seem to exist. Isoforms A1e17,
A2e17, A3e17, A4e17, A5e17 and A6e17 are acidic while isoforms
B1e16, B2e17, B2e16, B3e17, B3e16, B4e17 and B4e16 are basic.;
Name=A1e17;
IsoId=Q9QZ47-1; Sequence=Displayed;
Name=A2e17;
IsoId=Q9QZ47-2; Sequence=VSP_050341;
Name=A3e17;
IsoId=Q9QZ47-3; Sequence=VSP_050339;
Name=A4e17;
IsoId=Q9QZ47-4; Sequence=VSP_050338, VSP_050341;
Name=A5e17;
IsoId=Q9QZ47-5; Sequence=VSP_050343;
Name=A6e17;
IsoId=Q9QZ47-6; Sequence=VSP_050341, VSP_050343;
Name=B1e16;
IsoId=Q9QZ47-7; Sequence=VSP_050342, VSP_050344;
Name=B2e17;
IsoId=Q9QZ47-8; Sequence=VSP_050339, VSP_050343;
Name=B2e16;
IsoId=Q9QZ47-9; Sequence=VSP_050339, VSP_050343, VSP_050344;
Name=B3e17; Synonyms=PTROPT;
IsoId=Q9QZ47-10; Sequence=VSP_050338, VSP_050342;
Name=B3e16;
IsoId=Q9QZ47-11; Sequence=VSP_050338, VSP_050342, VSP_050344;
Name=B4e17;
IsoId=Q9QZ47-12; Sequence=VSP_050338, VSP_050340;
Name=B4e16;
IsoId=Q9QZ47-13; Sequence=VSP_050338, VSP_050340, VSP_050344;
Name=14;
IsoId=Q9QZ47-14; Sequence=VSP_050344;
-!- TISSUE SPECIFICITY: Expressed predominantly in skeletal muscle.
{ECO:0000269|PubMed:9249073}.
-!- DEVELOPMENTAL STAGE: Embryo and neonate express predominantly
acidic isoforms while all adult isoforms are basic. Only one
isoform, B2e17, is found in both embryo/neonate and adult. A
transition from high to low molecular weight isoforms is also seen
during postnatal development. {ECO:0000269|PubMed:9249073}.
-!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L49466; AAB67290.1; -; mRNA.
EMBL; L49467; AAF01502.1; -; mRNA.
EMBL; L49468; AAF01503.1; -; mRNA.
EMBL; L49470; AAB67291.1; -; mRNA.
EMBL; L49471; AAB67292.1; -; mRNA.
EMBL; L49472; AAB67293.1; -; mRNA.
EMBL; L48988; AAB67283.1; -; mRNA.
EMBL; L48989; AAB67284.1; -; mRNA.
EMBL; L48990; AAB67285.1; -; mRNA.
EMBL; L48991; AAB67286.1; -; mRNA.
EMBL; L48992; AAB67287.1; -; mRNA.
EMBL; L48993; AAB67288.1; -; mRNA.
EMBL; L49018; AAB67289.1; -; mRNA.
EMBL; U77779; AAB39743.1; -; mRNA.
EMBL; AL603651; CAM23264.1; -; Genomic_DNA.
EMBL; AL603651; CAM23265.1; -; Genomic_DNA.
EMBL; AL603651; CAM23266.1; -; Genomic_DNA.
EMBL; AL603651; CAM23268.1; -; Genomic_DNA.
EMBL; AL603651; CAM23269.1; -; Genomic_DNA.
EMBL; AL603651; CAM23271.1; -; Genomic_DNA.
EMBL; AL603651; CAM23273.1; -; Genomic_DNA.
EMBL; AL603651; CAM23274.1; -; Genomic_DNA.
EMBL; AL603651; CAM23276.1; -; Genomic_DNA.
EMBL; BC003747; AAH03747.1; -; mRNA.
CCDS; CCDS22031.1; -. [Q9QZ47-10]
CCDS; CCDS52451.1; -. [Q9QZ47-14]
CCDS; CCDS52452.1; -. [Q9QZ47-1]
CCDS; CCDS52453.1; -. [Q9QZ47-5]
CCDS; CCDS52454.1; -. [Q9QZ47-2]
CCDS; CCDS52455.1; -. [Q9QZ47-6]
CCDS; CCDS52456.1; -. [Q9QZ47-3]
CCDS; CCDS85471.1; -. [Q9QZ47-7]
CCDS; CCDS85472.1; -. [Q9QZ47-9]
CCDS; CCDS85473.1; -. [Q9QZ47-8]
CCDS; CCDS85474.1; -. [Q9QZ47-11]
CCDS; CCDS85475.1; -. [Q9QZ47-4]
CCDS; CCDS85476.1; -. [Q9QZ47-13]
CCDS; CCDS85477.1; -. [Q9QZ47-12]
RefSeq; NP_001157137.1; NM_001163665.1.
RefSeq; NP_001157140.1; NM_001163668.1.
RefSeq; NP_001334476.1; NM_001347547.1.
RefSeq; NP_001334477.1; NM_001347548.1.
RefSeq; NP_001334478.1; NM_001347549.1.
RefSeq; NP_001334479.1; NM_001347550.1.
RefSeq; NP_001334480.1; NM_001347551.1.
RefSeq; NP_001334481.1; NM_001347552.1.
RefSeq; NP_035750.2; NM_011620.3.
UniGene; Mm.389992; -.
ProteinModelPortal; Q9QZ47; -.
SMR; Q9QZ47; -.
IntAct; Q9QZ47; 1.
STRING; 10090.ENSMUSP00000101578; -.
iPTMnet; Q9QZ47; -.
PhosphoSitePlus; Q9QZ47; -.
PaxDb; Q9QZ47; -.
PRIDE; Q9QZ47; -.
GeneID; 21957; -.
KEGG; mmu:21957; -.
UCSC; uc009knj.2; mouse. [Q9QZ47-10]
UCSC; uc009knp.2; mouse. [Q9QZ47-14]
CTD; 7140; -.
MGI; MGI:109550; Tnnt3.
eggNOG; KOG3634; Eukaryota.
eggNOG; ENOG410XS6A; LUCA.
HOVERGEN; HBG052790; -.
InParanoid; Q9QZ47; -.
KO; K12046; -.
PhylomeDB; Q9QZ47; -.
TreeFam; TF313321; -.
PRO; PR:Q9QZ47; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_TNNT3; -.
GO; GO:0005861; C:troponin complex; ISO:MGI.
GO; GO:0048306; F:calcium-dependent protein binding; ISO:MGI.
GO; GO:0005523; F:tropomyosin binding; ISO:MGI.
GO; GO:0030172; F:troponin C binding; ISO:MGI.
GO; GO:0031013; F:troponin I binding; ISO:MGI.
GO; GO:0043462; P:regulation of ATPase activity; ISO:MGI.
GO; GO:0006942; P:regulation of striated muscle contraction; ISO:MGI.
GO; GO:0003009; P:skeletal muscle contraction; ISO:MGI.
InterPro; IPR027707; TNNT.
InterPro; IPR027708; Tnnt3.
InterPro; IPR001978; Troponin.
PANTHER; PTHR11521; PTHR11521; 1.
PANTHER; PTHR11521:SF4; PTHR11521:SF4; 1.
Pfam; PF00992; Troponin; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Complete proteome; Muscle protein;
Phosphoprotein; Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P02641}.
CHAIN 2 272 Troponin T, fast skeletal muscle.
/FTId=PRO_0000186179.
MOD_RES 2 2 N-acetylserine.
{ECO:0000250|UniProtKB:P02641}.
MOD_RES 2 2 Phosphoserine.
{ECO:0000250|UniProtKB:P09739}.
MOD_RES 91 91 Phosphoserine.
{ECO:0000250|UniProtKB:P09739}.
MOD_RES 162 162 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 169 169 Phosphoserine.
{ECO:0000250|UniProtKB:P09739}.
MOD_RES 170 170 Phosphoserine.
{ECO:0000250|UniProtKB:P09739}.
MOD_RES 206 206 Phosphoserine.
{ECO:0000250|UniProtKB:P09739}.
MOD_RES 222 222 Phosphotyrosine.
{ECO:0000250|UniProtKB:P09739}.
VAR_SEQ 11 16 Missing (in isoform A4e17, isoform B3e17,
isoform B3e16, isoform B4e17 and isoform
B4e16). {ECO:0000303|PubMed:9107680}.
/FTId=VSP_050338.
VAR_SEQ 23 49 Missing (in isoform B4e17 and isoform
B4e16). {ECO:0000305}.
/FTId=VSP_050340.
VAR_SEQ 23 31 Missing (in isoform A3e17, isoform B2e17
and isoform B2e16). {ECO:0000305}.
/FTId=VSP_050339.
VAR_SEQ 28 31 Missing (in isoform A2e17, isoform A4e17
and isoform A6e17). {ECO:0000305}.
/FTId=VSP_050341.
VAR_SEQ 32 49 Missing (in isoform B1e16, isoform B3e17
and isoform B3e16).
{ECO:0000303|PubMed:9107680}.
/FTId=VSP_050342.
VAR_SEQ 37 49 Missing (in isoform A5e17, isoform A6e17,
isoform B2e17 and isoform B2e16).
{ECO:0000305}.
/FTId=VSP_050343.
VAR_SEQ 243 255 TTLRSRIDQAQKH -> MTVRARVEMLAKF (in
isoform B1e16, isoform B2e16, isoform
B3e16, isoform B4e16 and isoform 14).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_050344.
VARIANT 131 131 P -> R. {ECO:0000269|PubMed:19468303}.
CONFLICT 252 252 A -> T (in Ref. 2; AAB39743).
{ECO:0000305}.
SEQUENCE 272 AA; 32241 MW; 5AF24573DD6A9529 CRC64;
MSDEETEQVE EQYEEEEEAQ EEEVQEEAPE PEEVQEDAVA EEEREEDEEE EKPRPKLTAP
KIPEGEKVDF DDIQKKRQNK DLMELQALID SHFEARKKEE EELIALKERI EKRRAERAEQ
QRIRAEKERE PQNRLAEEKA RREEEDAKRR AEDDMKKKKA LSSMGANYSS YLAKADQKRG
KKQTAREMKK KILAERRKPL NIDHLSDDKL RDKAKELWDT LYQLETDKFE FGEKLKRQKY
DITTLRSRID QAQKHSKKAG ATAKGKVGGR WK


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