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Truncated non-functional calcium-binding mitochondrial carrier SAL1-1 (Suppressor of AAC2 lethality)

 CMC1_YEAST              Reviewed;         494 AA.
D6W196; P48233; Q45TY5; Q6WV05; Q96US1;
30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
30-NOV-2010, sequence version 2.
28-FEB-2018, entry version 61.
RecName: Full=Truncated non-functional calcium-binding mitochondrial carrier SAL1-1;
AltName: Full=Suppressor of AAC2 lethality;
Name=SAL1; OrderedLocusNames=YNL083W; ORFNames=N2312;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=8740422;
DOI=10.1002/(SICI)1097-0061(199604)12:5<485::AID-YEA928>3.0.CO;2-U;
Soler-Mira A., Saiz J.E., Ballesta J.P.G., Remacha M.A.;
"The sequence of a 17,933 bp segment of Saccharomyces cerevisiae
chromosome XIV contains the RHO2, TOP2, MKT1 and END3 genes and five
new open reading frames.";
Yeast 12:485-491(1996).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=8701611;
DOI=10.1002/(SICI)1097-0061(19960330)12:4<391::AID-YEA921>3.3.CO;2-E;
Poehlmann R., Philippsen P.;
"Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV
reveals 12 new open reading frames (ORFs) and an ancient duplication
of six ORFs.";
Yeast 12:391-402(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169873;
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F.,
Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M.,
Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N.,
Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D.,
Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A.,
Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A.,
Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C.,
Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M.,
Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J.,
Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L.,
Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M.,
Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P.,
Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A.,
Wambutt R., Wedler H., Zollner A., Hani J.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV
and its evolutionary implications.";
Nature 387:93-98(1997).
[4]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 364-436.
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
Gates K., Gaffney T.D., Philippsen P.;
"Reinvestigation of the Saccharomyces cerevisiae genome annotation by
comparison to the genome of a related fungus: Ashbya gossypii.";
Genome Biol. 4:R45.1-R45.13(2003).
[6]
IDENTIFICATION OF PROBABLE FRAMESHIFT.
PubMed=9178508;
DOI=10.1002/(SICI)1097-0061(199705)13:6<573::AID-YEA107>3.0.CO;2-I;
el Moualij B., Duyckaerts C., Lamotte-Brasseur J., Sluse F.E.;
"Phylogenetic classification of the mitochondrial carrier family of
Saccharomyces cerevisiae.";
Yeast 13:573-581(1997).
[7]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[8]
FUNCTION, AND IDENTIFICATION OF FRAMESHIFT IN SAL1-1.
STRAIN=M2915-6A;
PubMed=15238515; DOI=10.1534/genetics.103.023655;
Chen X.J.;
"Sal1p, a calcium-dependent carrier protein that suppresses an
essential cellular function associated With the Aac2 isoform of
ADP/ATP translocase in Saccharomyces cerevisiae.";
Genetics 167:607-617(2004).
[9]
CONFIRMATION OF FRAMESHIFT IN SAL1-1.
STRAIN=ATCC 200879 / BY4716, and ATCC 204508 / S288c;
PubMed=19581448; DOI=10.1534/genetics.109.104497;
Dimitrov L.N., Brem R.B., Kruglyak L., Gottschling D.E.;
"Polymorphisms in multiple genes contribute to the spontaneous
mitochondrial genome instability of Saccharomyces cerevisiae S288C
strains.";
Genetics 183:365-383(2009).
-!- FUNCTION: Calcium-dependent mitochondrial solute carrier.
{ECO:0000269|PubMed:15238515}.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
Multi-pass membrane protein {ECO:0000305}.
-!- MISCELLANEOUS: Present with 1170 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
family. {ECO:0000305}.
-!- CAUTION: Strain S288c has a frameshift in position 403, which
disrupts the gene coding for this protein and produces the non-
functional allele sal1-1. A full-length functional allele can be
found in strain CG379 (AC P0CI40). {ECO:0000305}.
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EMBL; X89016; CAA61427.1; -; Genomic_DNA.
EMBL; Z71359; CAA95958.1; -; Genomic_DNA.
EMBL; AY268134; AAR26280.1; -; Genomic_DNA.
EMBL; BK006947; DAA10462.2; -; Genomic_DNA.
PIR; S57539; S57539.
RefSeq; NP_014316.3; NM_001182921.1.
ProteinModelPortal; D6W196; -.
SMR; D6W196; -.
BioGrid; 35740; 52.
STRING; 4932.YNL083W; -.
iPTMnet; D6W196; -.
PaxDb; D6W196; -.
PRIDE; D6W196; -.
GeneID; 855641; -.
KEGG; sce:YNL083W; -.
EuPathDB; FungiDB:YNL083W; -.
SGD; S000005027; SAL1.
InParanoid; D6W196; -.
KO; K14684; -.
OrthoDB; EOG092C2RR5; -.
BioCyc; YEAST:G3O-33112-MONOMER; -.
PRO; PR:D6W196; -.
Proteomes; UP000002311; Chromosome XIV.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005743; C:mitochondrial inner membrane; ISS:SGD.
GO; GO:0005471; F:ATP:ADP antiporter activity; IMP:SGD.
GO; GO:0005509; F:calcium ion binding; IDA:SGD.
GO; GO:0015866; P:ADP transport; IMP:SGD.
GO; GO:0015867; P:ATP transport; IMP:SGD.
GO; GO:0006839; P:mitochondrial transport; IMP:SGD.
Gene3D; 1.50.40.10; -; 1.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR002048; EF_hand_dom.
InterPro; IPR002067; Mit_carrier.
InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
InterPro; IPR023395; Mt_carrier_dom_sf.
Pfam; PF13202; EF-hand_5; 1.
Pfam; PF13499; EF-hand_7; 1.
Pfam; PF00153; Mito_carr; 2.
PRINTS; PR00926; MITOCARRIER.
SUPFAM; SSF103506; SSF103506; 1.
SUPFAM; SSF47473; SSF47473; 2.
PROSITE; PS00018; EF_HAND_1; 1.
PROSITE; PS50222; EF_HAND_2; 3.
PROSITE; PS50920; SOLCAR; 2.
1: Evidence at protein level;
Calcium; Complete proteome; Membrane; Metal-binding; Mitochondrion;
Mitochondrion inner membrane; Reference proteome; Repeat;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 494 Truncated non-functional calcium-binding
mitochondrial carrier SAL1-1.
/FTId=PRO_0000402277.
TRANSMEM 231 248 Helical; Name=1. {ECO:0000255}.
TRANSMEM 307 326 Helical; Name=2. {ECO:0000255}.
TRANSMEM 355 368 Helical; Name=3. {ECO:0000255}.
TRANSMEM 409 428 Helical; Name=4. {ECO:0000255}.
TRANSMEM 458 475 Helical; Name=5. {ECO:0000255}.
DOMAIN 11 46 EF-hand 1. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 80 115 EF-hand 2. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 120 155 EF-hand 3. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
DOMAIN 156 191 EF-hand 4. {ECO:0000255|PROSITE-
ProRule:PRU00448}.
REPEAT 225 332 Solcar 1.
REPEAT 345 434 Solcar 2.
REPEAT 452 494 Solcar 3; truncated.
CA_BIND 59 70 1.
CA_BIND 93 104 2.
CA_BIND 155 166 3.
CONFLICT 131 131 V -> M (in Ref. 3; DAA10462).
{ECO:0000305}.
SEQUENCE 494 AA; 55715 MW; 0AB408E1CED63946 CRC64;
MLLKNCETDK QRDIRYACLF KELDVKGNGQ VTLDNLISAF EKNDHPLKGN DEAIKMLFTA
MDVNKDSVVD LSDFKKYASN AESQIWNGFQ RIDLDHDGKI GINEINRYLS DLDNQSICNN
ELNHELSNEK VNKFSRFFEW AFPKRKANIA LRGQASHKKN TDNDRSKKTT DSDLYVTYDQ
WRDFLLLVPR KQGSRLHTAY SYFYLFNEDV DLSSEGDVTL INDFIRGFGF FIAGGISGVI
SRTCTAPFDR LKVFLIARTD LSSILLNSKT DLLAKNPNAD INKISSPLAK AVKSLYRQGG
IKAFYVGNGL NVIKVFPESS IKFGSFEVTK KIMTKLEGCR DTKDLSKFST YIAGGLAGMA
AQFSVYPIDT LKFRVQCAPL DTKLKGNNLL FQTAKDMFRE GGGQIILQRC HSRYSGHISL
CCIRFGDFFC LKKMVYCQTG KDPEPTTRSG HSKQPGCTSN GCIQWNCRSF CCLSNQSFKN
KTTSPRNICT SLCV


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