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Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1)

 TPH1_RAT                Reviewed;         444 AA.
P09810;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 2.
22-NOV-2017, entry version 153.
RecName: Full=Tryptophan 5-hydroxylase 1;
EC=1.14.16.4;
AltName: Full=Tryptophan 5-monooxygenase 1;
Name=Tph1; Synonyms=Tph;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Pineal gland;
PubMed=3379411; DOI=10.1111/j.1471-4159.1988.tb04871.x;
Darmon M.C., Guibert B., Leviel V., Ehret M., Maitre M., Mallet J.;
"Sequence of two mRNAs encoding active rat tryptophan hydroxylase.";
J. Neurochem. 51:312-316(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1645430; DOI=10.1016/0169-328X(91)90073-7;
Kim K.S., Wessel T.C., Stone D.M., Carver C.H., Joh T.H., Park D.H.;
"Molecular cloning and characterization of cDNA encoding tryptophan
hydroxylase from rat central serotonergic neurons.";
Brain Res. Mol. Brain Res. 9:277-283(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 167-261.
PubMed=2875901; DOI=10.1016/0014-5793(86)81337-0;
Darmon M.C., Grima B., Cash C.D., Maitre M., Mallet J.;
"Isolation of a rat pineal gland cDNA clone homologous to tyrosine and
phenylalanine hydroxylases.";
FEBS Lett. 206:43-46(1986).
-!- CATALYTIC ACTIVITY: L-tryptophan + tetrahydrobiopterin + O(2) = 5-
hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
-!- COFACTOR:
Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
-!- PATHWAY: Aromatic compound metabolism; serotonin biosynthesis;
serotonin from L-tryptophan: step 1/2.
-!- SUBUNIT: Homotetramer.
-!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
hydroxylase family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M28000; AAA42262.1; -; mRNA.
EMBL; X53501; CAA37579.1; -; mRNA.
PIR; JL0034; WHRTW.
RefSeq; NP_001094104.1; NM_001100634.2.
RefSeq; XP_006229281.1; XM_006229219.2.
UniGene; Rn.94788; -.
ProteinModelPortal; P09810; -.
SMR; P09810; -.
STRING; 10116.ENSRNOP00000052959; -.
BindingDB; P09810; -.
ChEMBL; CHEMBL4809; -.
iPTMnet; P09810; -.
PhosphoSitePlus; P09810; -.
PaxDb; P09810; -.
PRIDE; P09810; -.
Ensembl; ENSRNOT00000056109; ENSRNOP00000052959; ENSRNOG00000011672.
GeneID; 24848; -.
KEGG; rno:24848; -.
UCSC; RGD:3895; rat.
CTD; 7166; -.
RGD; 3895; Tph1.
eggNOG; KOG3820; Eukaryota.
eggNOG; COG3186; LUCA.
GeneTree; ENSGT00390000010268; -.
HOGENOM; HOG000233373; -.
HOVERGEN; HBG006841; -.
InParanoid; P09810; -.
KO; K00502; -.
OMA; MENWPEL; -.
OrthoDB; EOG091G05MZ; -.
PhylomeDB; P09810; -.
TreeFam; TF313327; -.
Reactome; R-RNO-209931; Serotonin and melatonin biosynthesis.
SABIO-RK; P09810; -.
UniPathway; UPA00846; UER00799.
PRO; PR:P09810; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000011672; -.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0043005; C:neuron projection; IDA:RGD.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0004510; F:tryptophan 5-monooxygenase activity; IDA:RGD.
GO; GO:0046849; P:bone remodeling; ISO:RGD.
GO; GO:0007623; P:circadian rhythm; IEP:RGD.
GO; GO:0060749; P:mammary gland alveolus development; ISO:RGD.
GO; GO:0030279; P:negative regulation of ossification; IMP:RGD.
GO; GO:0045600; P:positive regulation of fat cell differentiation; ISO:RGD.
GO; GO:0035902; P:response to immobilization stress; IEP:RGD.
GO; GO:0006587; P:serotonin biosynthetic process from tryptophan; TAS:RGD.
Gene3D; 1.10.800.10; -; 1.
InterPro; IPR002912; ACT_dom.
InterPro; IPR001273; ArAA_hydroxylase.
InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
InterPro; IPR036951; ArAA_hydroxylase_sf.
InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
InterPro; IPR005963; Trp_5_mOase.
InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
PANTHER; PTHR11473; PTHR11473; 1.
Pfam; PF00351; Biopterin_H; 1.
PIRSF; PIRSF000336; TH; 1.
PRINTS; PR00372; FYWHYDRXLASE.
SUPFAM; SSF56534; SSF56534; 1.
TIGRFAMs; TIGR01270; Trp_5_monoox; 1.
PROSITE; PS51671; ACT; 1.
PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
2: Evidence at transcript level;
Complete proteome; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
Phosphoprotein; Reference proteome; Serotonin biosynthesis.
CHAIN 1 444 Tryptophan 5-hydroxylase 1.
/FTId=PRO_0000205571.
DOMAIN 19 94 ACT. {ECO:0000255|PROSITE-
ProRule:PRU01007}.
METAL 272 272 Iron. {ECO:0000250}.
METAL 277 277 Iron. {ECO:0000250}.
METAL 317 317 Iron. {ECO:0000250}.
BINDING 235 235 Tryptophan. {ECO:0000250}.
BINDING 257 257 Tryptophan. {ECO:0000250}.
BINDING 265 265 Tryptophan. {ECO:0000250}.
BINDING 336 336 Tryptophan. {ECO:0000250}.
BINDING 366 366 Tryptophan; via carbonyl oxygen.
{ECO:0000250}.
MOD_RES 58 58 Phosphoserine; by PKA. {ECO:0000255}.
SEQUENCE 444 AA; 51068 MW; C3CF5245727CC825 CRC64;
MIEDNKENKD HSSERGRVTL IFSLKNEVGG LIKALKIFQE NHVNLLHIES RKSKRRNSEF
EIFVDCDINR EQLNDIFPLL KSHTTVLSVD SPDQLPEKED VMETVPWFPK KISDLDFCAN
RVLLYGSELD ADHPGFKDNV YRRRRKYFAE LAMNYKHGDP IPKIEFTEEE IKTWGTIFRE
LNKLYPTHAC REYLRNLPLL SKYCGYREDN VPQLEDVSNF LKERTGFSIR PVAGYLSPRD
FLSGLAFRVF HCTQYVRHSS DPLYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA
SEETVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LRHALSGHAK VKPFDPKVAC
KQECLITSFQ DVYFVSESFE DAKEKMREFA KTVKRPFGVK YNPYTQSIQV LRDSKSITSA
MNELRHDLDV VNDALARVSR WPSV


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