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Tubby protein homolog 1

 TUB1_CAEEL              Reviewed;         426 AA.
Q09306; Q9UB22;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
02-AUG-2002, sequence version 3.
10-MAY-2017, entry version 108.
RecName: Full=Tubby protein homolog 1;
Name=tub-1 {ECO:0000312|WormBase:F10B5.4};
ORFNames=F10B5.4 {ECO:0000312|WormBase:F10B5.4};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Bristol N2;
Nelson L., Basson M., Spoerke J., Liu L.X., Yan G., North M.A.,
Johnson C.D.;
"A tubby family member in Caenorhabditis elegans is required for
normal sensory behavior.";
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
IDENTIFICATION.
PubMed=2592410; DOI=10.1083/jcb.109.6.2993;
Driscoll M., Dean E., Reilly E., Bergholz E., Chalfie M.;
"Genetic and molecular analysis of a Caenorhabditis elegans beta-
tubulin that conveys benzimidazole sensitivity.";
J. Cell Biol. 109:2993-3003(1989).
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=12529643; DOI=10.1038/nature01279;
Ashrafi K., Chang F.Y., Watts J.L., Fraser A.G., Kamath R.S.,
Ahringer J., Ruvkun G.;
"Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory
genes.";
Nature 421:268-272(2003).
[5]
FUNCTION, INTERACTION WITH RGB-3, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=16054097; DOI=10.1016/j.cmet.2005.06.004;
Mukhopadhyay A., Deplancke B., Walhout A.J., Tissenbaum H.A.;
"C. elegans tubby regulates life span and fat storage by two
independent mechanisms.";
Cell Metab. 2:35-42(2005).
[6]
FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=15790967; DOI=10.1242/dev.01775;
Efimenko E., Bubb K., Mak H.Y., Holzman T., Leroux M.R., Ruvkun G.,
Thomas J.H., Swoboda P.;
"Analysis of xbx genes in C. elegans.";
Development 132:1923-1934(2005).
[7]
FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=16462744; DOI=10.1038/ng1739;
Mak H.Y., Nelson L.S., Basson M., Johnson C.D., Ruvkun G.;
"Polygenic control of Caenorhabditis elegans fat storage.";
Nat. Genet. 38:363-368(2006).
[8]
FUNCTION.
PubMed=17762880; DOI=10.1038/sj.embor.7401055;
Mukhopadhyay A., Pan X., Lambright D.G., Tissenbaum H.A.;
"An endocytic pathway as a target of tubby for regulation of fat
storage.";
EMBO Rep. 8:931-938(2007).
-!- FUNCTION: Has a role in fat regulation independent of daf-16.
Implicated in ciliar sensory function which is required for normal
sensory behavior such as chemotaxis. Functions in life span
control via the insulin/IGF-1 pathway. Thought to be involved in
neuronal trafficking. {ECO:0000269|PubMed:12529643,
ECO:0000269|PubMed:15790967, ECO:0000269|PubMed:16054097,
ECO:0000269|PubMed:16462744, ECO:0000269|PubMed:17762880}.
-!- SUBUNIT: Interacts with rgb-3. {ECO:0000269|PubMed:16054097}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15790967,
ECO:0000269|PubMed:16054097}. Cell projection, axon
{ECO:0000269|PubMed:16462744}. Cell projection, dendrite
{ECO:0000269|PubMed:16462744}. Cell projection, cilium
{ECO:0000269|PubMed:16462744}.
-!- TISSUE SPECIFICITY: Expressed in ciliated sensory neurons.
{ECO:0000269|PubMed:15790967, ECO:0000269|PubMed:16054097,
ECO:0000269|PubMed:16462744}.
-!- DISRUPTION PHENOTYPE: Twofold increase in fat content. Extension
in life span. Defective in chemotaxis.
{ECO:0000269|PubMed:12529643}.
-!- SIMILARITY: Belongs to the TUB family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF143297; AAD33902.1; -; mRNA.
EMBL; Z48334; CAB61010.2; -; Genomic_DNA.
RefSeq; NP_495710.1; NM_063309.4.
UniGene; Cel.19577; -.
ProteinModelPortal; Q09306; -.
SMR; Q09306; -.
BioGrid; 39641; 2.
IntAct; Q09306; 1.
MINT; MINT-1064833; -.
STRING; 6239.F10B5.4; -.
EPD; Q09306; -.
PaxDb; Q09306; -.
PeptideAtlas; Q09306; -.
PRIDE; Q09306; -.
EnsemblMetazoa; F10B5.4; F10B5.4; WBGene00006655.
GeneID; 174312; -.
KEGG; cel:CELE_F10B5.4; -.
UCSC; F10B5.4; c. elegans.
CTD; 174312; -.
WormBase; F10B5.4; CE29091; WBGene00006655; tub-1.
eggNOG; KOG2502; Eukaryota.
eggNOG; ENOG410XQFT; LUCA.
GeneTree; ENSGT00610000085970; -.
HOGENOM; HOG000016044; -.
InParanoid; Q09306; -.
OMA; KSPQWND; -.
OrthoDB; EOG091G04TF; -.
PhylomeDB; Q09306; -.
Reactome; R-CEL-5610787; Hedgehog 'off' state.
PRO; PR:Q09306; -.
Proteomes; UP000001940; Chromosome II.
Bgee; WBGene00006655; -.
GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
GO; GO:0005929; C:cilium; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
GO; GO:0051015; F:actin filament binding; IEA:InterPro.
GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
GO; GO:0006909; P:phagocytosis; IEA:InterPro.
GO; GO:0097500; P:receptor localization to non-motile cilium; IMP:WormBase.
Gene3D; 3.20.90.10; -; 1.
InterPro; IPR000007; Tubby_C.
InterPro; IPR025659; Tubby_C-like.
InterPro; IPR018066; Tubby_C_CS.
InterPro; IPR033018; TULP1.
PANTHER; PTHR16517:SF64; PTHR16517:SF64; 1.
Pfam; PF01167; Tub; 1.
PRINTS; PR01573; SUPERTUBBY.
SUPFAM; SSF54518; SSF54518; 1.
PROSITE; PS01200; TUB_1; 1.
PROSITE; PS01201; TUB_2; 1.
1: Evidence at protein level;
Cell projection; Chemotaxis; Coiled coil; Complete proteome;
Cytoplasm; Lipid metabolism; Reference proteome; Sensory transduction.
CHAIN 1 426 Tubby protein homolog 1.
/FTId=PRO_0000186474.
SEQUENCE 426 AA; 48454 MW; F907CA1191E011D3 CRC64;
MTDTNSQWIE MNLQRQRKML EDKQKQKRHQ SAGSVRTTST AMSMNSMKDY PTFDNSLPFS
ISDNSSVSVS MNTPLIPTQD PIAQPRMQSM PRQQPQQVQE SLISIGDYPD NDINAKLSKV
NLTSCVVSDD EDEDKRSYAD SPWNTDVVAD RIPSEVLPDY NFIKNNLAKF VEDPAVEHCL
YKCSITRQKS GVDKGMFPTY FLHLEEFDTD KRQKIFLLAA RKRKKSTTAN YLLSTDPTNL
SREGEGYCAK VRSNALGTQF TVYDSGQNPK KTTNHAAIRQ ELAAVIYETN VLGFKGPRKM
TIVMPGIEPP TENRPAVRCP VRPIQDKHTL LERYRLNDLD SLKILSNKSP QWNDETQSYV
LNFHGRVTQA SVKNFQIIHQ SSPEYIVMQF GRISDDEFTM DFRYPLSAVQ AFGIAMTSFH
GKLACE


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