Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Tubulin beta chain (Beta-tubulin)

 TBB_SCHPO               Reviewed;         448 AA.
P05219; O74206; Q9UQZ0;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
28-FEB-2018, entry version 157.
RecName: Full=Tubulin beta chain;
AltName: Full=Beta-tubulin;
Name=nda3; Synonyms=alp12; ORFNames=SPBC26H8.07c;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTAGENESIS OF ILE-100.
PubMed=6094012; DOI=10.1016/0092-8674(84)90013-8;
Hiraoka Y., Toda T., Yanagida M.;
"The NDA3 gene of fission yeast encodes beta-tubulin: a cold-sensitive
nda3 mutation reversibly blocks spindle formation and chromosome
movement in mitosis.";
Cell 39:349-358(1984).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTAGENESIS OF TYR-422.
STRAIN=972 / ATCC 24843;
PubMed=9658169; DOI=10.1091/mbc.9.7.1757;
Radcliffe P., Hirata D., Childs D., Vardy L., Toda T.;
"Identification of novel temperature-sensitive lethal alleles in
essential beta-tubulin and nonessential alpha 2-tubulin genes as
fission yeast polarity mutants.";
Mol. Biol. Cell 9:1757-1771(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[4]
ANTIBIOTIC RESISTANCE TO RHIZOXIN.
PubMed=2274023; DOI=10.1007/BF00633814;
Takahashi M., Matsumoto S., Iwasaki S., Yahara I.;
"Molecular basis for determining the sensitivity of eucaryotes to the
antimitotic drug rhizoxin.";
Mol. Gen. Genet. 222:169-175(1990).
-!- FUNCTION: Tubulin is the major constituent of microtubules. It
binds two moles of GTP, one at an exchangeable site on the beta
chain and one at a non-exchangeable site on the alpha chain.
-!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is
a hollow water-filled tube with an outer diameter of 25 nm and an
inner diameter of 15 nM. Alpha-beta heterodimers associate head-
to-tail to form protofilaments running lengthwise along the
microtubule wall with the beta-tubulin subunit facing the
microtubule plus end conferring a structural polarity.
Microtubules usually have 13 protofilaments but different
protofilament numbers can be found in some organisms and
specialized cells.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
-!- MISCELLANEOUS: A cold-sensitive nda3 mutation reversibly blocks
spindle formation and chromosome movement in mitosis.
-!- MISCELLANEOUS: Rhizoxin, an antibiotic that exhibits potent anti-
mitotic activity against most eukaryotic cells except for yeasts,
binds to beta tubulin.
-!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M10347; AAA35352.1; -; Genomic_DNA.
EMBL; CU329671; CAA21099.1; -; Genomic_DNA.
EMBL; AF042827; AAC21454.1; -; Genomic_DNA.
EMBL; AF042828; AAC21455.1; -; Genomic_DNA.
PIR; A21649; A21649.
PIR; T40019; T40019.
PIR; T43624; T43624.
RefSeq; NP_596650.1; NM_001022572.2.
PDB; 5MJS; EM; 4.60 A; A/B/C/J=1-429.
PDBsum; 5MJS; -.
ProteinModelPortal; P05219; -.
SMR; P05219; -.
BioGrid; 277108; 32.
DIP; DIP-46363N; -.
IntAct; P05219; 2.
STRING; 4896.SPBC26H8.07c.1; -.
iPTMnet; P05219; -.
MaxQB; P05219; -.
PaxDb; P05219; -.
PRIDE; P05219; -.
EnsemblFungi; SPBC26H8.07c.1; SPBC26H8.07c.1:pep; SPBC26H8.07c.
GeneID; 2540582; -.
KEGG; spo:SPBC26H8.07c; -.
EuPathDB; FungiDB:SPBC26H8.07c; -.
PomBase; SPBC26H8.07c; nda3.
HOGENOM; HOG000165710; -.
InParanoid; P05219; -.
KO; K07375; -.
OMA; AVFRGPM; -.
OrthoDB; EOG092C2U1W; -.
PhylomeDB; P05219; -.
Reactome; R-SPO-6798695; Neutrophil degranulation.
PRO; PR:P05219; -.
Proteomes; UP000002485; Chromosome II.
GO; GO:0000235; C:astral microtubule; NAS:PomBase.
GO; GO:0005881; C:cytoplasmic microtubule; IMP:PomBase.
GO; GO:0005829; C:cytosol; HDA:PomBase.
GO; GO:0005634; C:nucleus; IC:PomBase.
GO; GO:0005876; C:spindle microtubule; IDA:PomBase.
GO; GO:0005525; F:GTP binding; IC:PomBase.
GO; GO:0003924; F:GTPase activity; IEA:InterPro.
GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
GO; GO:0031122; P:cytoplasmic microtubule organization; IMP:PomBase.
GO; GO:0071963; P:establishment or maintenance of cell polarity regulating cell shape; IMP:PomBase.
GO; GO:0048312; P:intracellular distribution of mitochondria; IMP:PomBase.
GO; GO:1903087; P:mitotic spindle pole body duplication; IMP:PomBase.
GO; GO:0098863; P:nuclear migration by microtubule mediated pushing forces; IDA:PomBase.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
Gene3D; 1.10.287.600; -; 1.
Gene3D; 3.30.1330.20; -; 1.
Gene3D; 3.40.50.1440; -; 1.
InterPro; IPR013838; Beta-tubulin_BS.
InterPro; IPR002453; Beta_tubulin.
InterPro; IPR008280; Tub_FtsZ_C.
InterPro; IPR000217; Tubulin.
InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
InterPro; IPR037103; Tubulin/FtsZ_C_sf.
InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
InterPro; IPR023123; Tubulin_C.
InterPro; IPR017975; Tubulin_CS.
InterPro; IPR003008; Tubulin_FtsZ_GTPase.
PANTHER; PTHR11588; PTHR11588; 1.
PANTHER; PTHR11588:SF256; PTHR11588:SF256; 1.
Pfam; PF00091; Tubulin; 1.
Pfam; PF03953; Tubulin_C; 1.
PRINTS; PR01163; BETATUBULIN.
PRINTS; PR01161; TUBULIN.
SMART; SM00864; Tubulin; 1.
SMART; SM00865; Tubulin_C; 1.
SUPFAM; SSF52490; SSF52490; 1.
SUPFAM; SSF55307; SSF55307; 1.
PROSITE; PS00227; TUBULIN; 1.
PROSITE; PS00228; TUBULIN_B_AUTOREG; 1.
1: Evidence at protein level;
3D-structure; Antibiotic resistance; Complete proteome; Cytoplasm;
Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding;
Reference proteome.
CHAIN 1 448 Tubulin beta chain.
/FTId=PRO_0000048430.
NP_BIND 140 146 GTP. {ECO:0000255}.
MUTAGEN 100 100 I->N: Becomes sensitive to rhizoxin.
{ECO:0000269|PubMed:6094012}.
MUTAGEN 422 422 Y->H: Temperature sensitive.
{ECO:0000269|PubMed:9658169}.
CONFLICT 6 6 H -> L (in Ref. 1; AAA35352).
{ECO:0000305}.
CONFLICT 114 114 D -> V (in Ref. 1; AAA35352).
{ECO:0000305}.
CONFLICT 211 211 F -> I (in Ref. 1; AAA35352).
{ECO:0000305}.
CONFLICT 392 392 K -> N (in Ref. 1; AAA35352).
{ECO:0000305}.
CONFLICT 447 447 E -> D (in Ref. 1; AAA35352).
{ECO:0000305}.
SEQUENCE 448 AA; 49472 MW; B0A08C9AF23A3846 CRC64;
MREIVHIQAG QCGNQVGAAF WSTIADEHGL DSAGIYHGTS EAQHERLNVY FNEAAGGKYV
PRAVLVDLEP GTMDAVKSGK FGNLFRPDNI IYGQSGAGNI WAKGHYTEGA ELADAVLDVV
RREAEACDAL QGFQLTHSLG GGTGSGMGTL LLSKIREEYP DRMMATFSVA PAPKSSDTVV
EPYNATLSMH QLVENSDETF CIDNEALSSI FANTLKIKSP SYDDLNHLVS AVMAGVTTSF
RFPGELNSDL RKLAVNMVPF PRLHFFMVGF APLAAIGSSS FQAVSVPELT QQMFDANNMM
VAADPRHGRY LTVAALFRGK VSMKEVDEQI RSVQTKNSAY FVEWIPDNVL KAVCSVPPKD
LKMSATFIGN STSIQEIFRR LGDQFSAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
EYQQYQEAGI DEGDEDYEIE EEKEPLEY


Related products :

Catalog number Product name Quantity
AS10 681 Antibody: Tubulin beta chain, Immunogen: KLH-conjugated peptide derived from available tubulin beta chain sequences (located at a surface loop) including all Arabidopsis thaliana tubulin beta-2_beta-3 100
U1638h CLIA Homo sapiens,Human,TUBB3,TUBB4,Tubulin beta-3 chain,Tubulin beta-4 chain,Tubulin beta-III 96T
E1638h ELISA Homo sapiens,Human,TUBB3,TUBB4,Tubulin beta-3 chain,Tubulin beta-4 chain,Tubulin beta-III 96T
E1638h ELISA kit Homo sapiens,Human,TUBB3,TUBB4,Tubulin beta-3 chain,Tubulin beta-4 chain,Tubulin beta-III 96T
E1870h ELISA kit Homo sapiens,Human,OK_SW-cl.56,TUBB,TUBB5,Tubulin beta chain,Tubulin beta-5 chain 96T
U1870h CLIA kit Homo sapiens,Human,OK_SW-cl.56,TUBB,TUBB5,Tubulin beta chain,Tubulin beta-5 chain 96T
E1870h ELISA Homo sapiens,Human,OK_SW-cl.56,TUBB,TUBB5,Tubulin beta chain,Tubulin beta-5 chain 96T
U1870h CLIA Homo sapiens,Human,OK_SW-cl.56,TUBB,TUBB5,Tubulin beta chain,Tubulin beta-5 chain 96T
20-272-191335 beta Tubulin - Mouse monoclonal [DM1B] to beta Tubulin; Tubulin beta-5 chain Monoclonal 0.5 ml
E1638r ELISA Neuron-specific class III beta-tubulin,Rat,Rattus norvegicus,Tubb3,Tubulin beta-3 chain 96T
U1638r CLIA Neuron-specific class III beta-tubulin,Rat,Rattus norvegicus,Tubb3,Tubulin beta-3 chain 96T
E1638r ELISA kit Neuron-specific class III beta-tubulin,Rat,Rattus norvegicus,Tubb3,Tubulin beta-3 chain 96T
E1870p ELISA Pig,Sus scrofa,TUBB,TUBB5,Tubulin beta chain,Tubulin beta-5 chain 96T
EIAAB41459 Homo sapiens,Human,TUBB2C,Tubulin beta-2 chain,Tubulin beta-2C chain
U1870p CLIA Pig,Sus scrofa,TUBB,TUBB5,Tubulin beta chain,Tubulin beta-5 chain 96T
U1870p CLIA kit Pig,Sus scrofa,TUBB,TUBB5,Tubulin beta chain,Tubulin beta-5 chain 96T
E1870p ELISA kit Pig,Sus scrofa,TUBB,TUBB5,Tubulin beta chain,Tubulin beta-5 chain 96T
EIAAB41463 Homo sapiens,Human,TUBB4,TUBB5,Tubulin 5 beta,Tubulin beta-4 chain
20-272-190440 beta Tubulin - Mouse monoclonal [D66] to beta Tubulin; Tubulin beta-5 chain Monoclonal 0.1 ml
20-272-190441 beta Tubulin - Mouse monoclonal [TUB 2.1] to beta Tubulin; Tubulin beta-5 chain Monoclonal 0.2 ml
18-272-196478 beta Tubulin - Rabbit polyclonal to beta Tubulin; Tubulin beta-5 chain Polyclonal 0.5 ml
20-272-190444 beta Tubulin - Mouse monoclonal [2 - 28 - 33] to beta Tubulin; Tubulin beta-5 chain Monoclonal 0.2 ml
20-272-190445 beta I Tubulin - Mouse monoclonal [SAP.4G5] to beta I Tubulin; Tubulin beta-5 chain Monoclonal 0.1 ml
20-272-190442 beta Tubulin ( Cy3 ) - Mouse monoclonal [TUB 2.1] to beta Tubulin ( Cy3 ); Tubulin beta-5 chain Monoclonal 0.2 ml
18-272-196694 beta Tubulin - Rabbit polyclonal to beta Tubulin; Tubulin beta-5 chain Polyclonal 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur