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Tumor necrosis factor ligand superfamily member 8 (CD30 ligand) (CD30-L) (CD antigen CD153)

 TNFL8_HUMAN             Reviewed;         234 AA.
P32971; O43404;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
27-SEP-2017, entry version 132.
RecName: Full=Tumor necrosis factor ligand superfamily member 8;
AltName: Full=CD30 ligand;
Short=CD30-L;
AltName: CD_antigen=CD153;
Name=TNFSF8; Synonyms=CD30L, CD30LG;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8391931; DOI=10.1016/0092-8674(93)90361-S;
Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E.,
Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A.,
Grabstein K.H., Gliniak B., McAlister I.B., Fanslow W., Alderson M.,
Falk B., Gimpsel S., Gillis S., Din W.S., Goodwin R.G., Armitage R.J.;
"CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose
ligand defines an emerging family of cytokines with homology to TNF.";
Cell 73:1349-1360(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9349718; DOI=10.1016/S0167-4781(97)00108-5;
Croager E.J., Abraham L.J.;
"Characterisation of the human CD30 ligand gene structure.";
Biochim. Biophys. Acta 1353:231-235(1997).
-!- FUNCTION: Cytokine that binds to TNFRSF8/CD30. Induces
proliferation of T-cells.
-!- SUBUNIT: Homotrimer. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
protein.
-!- SIMILARITY: Belongs to the tumor necrosis factor family.
{ECO:0000305}.
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EMBL; L09753; AAA74594.1; -; mRNA.
EMBL; AF006384; AAB97877.1; -; Genomic_DNA.
EMBL; AF006381; AAB97877.1; JOINED; Genomic_DNA.
EMBL; AF006382; AAB97877.1; JOINED; Genomic_DNA.
EMBL; AF006383; AAB97877.1; JOINED; Genomic_DNA.
CCDS; CCDS6810.1; -.
PIR; A40710; A40710.
RefSeq; NP_001235.1; NM_001244.3.
UniGene; Hs.494901; -.
UniGene; Hs.654445; -.
ProteinModelPortal; P32971; -.
BioGrid; 107382; 41.
DIP; DIP-2929N; -.
IntAct; P32971; 2.
STRING; 9606.ENSP00000223795; -.
iPTMnet; P32971; -.
PhosphoSitePlus; P32971; -.
BioMuta; TNFSF8; -.
DMDM; 416777; -.
PaxDb; P32971; -.
PeptideAtlas; P32971; -.
PRIDE; P32971; -.
Ensembl; ENST00000223795; ENSP00000223795; ENSG00000106952.
GeneID; 944; -.
KEGG; hsa:944; -.
CTD; 944; -.
DisGeNET; 944; -.
EuPathDB; HostDB:ENSG00000106952.7; -.
GeneCards; TNFSF8; -.
HGNC; HGNC:11938; TNFSF8.
MIM; 603875; gene.
neXtProt; NX_P32971; -.
OpenTargets; ENSG00000106952; -.
PharmGKB; PA36628; -.
eggNOG; ENOG410IHE9; Eukaryota.
eggNOG; ENOG4111CQK; LUCA.
GeneTree; ENSGT00390000011719; -.
HOGENOM; HOG000136320; -.
HOVERGEN; HBG055267; -.
InParanoid; P32971; -.
KO; K05471; -.
OMA; WAYLQVS; -.
OrthoDB; EOG091G0HNM; -.
PhylomeDB; P32971; -.
TreeFam; TF335780; -.
Reactome; R-HSA-5669034; TNFs bind their physiological receptors.
GenomeRNAi; 944; -.
PMAP-CutDB; P32971; -.
PRO; PR:P32971; -.
Proteomes; UP000005640; Chromosome 9.
Bgee; ENSG00000106952; -.
CleanEx; HS_TNFSF8; -.
ExpressionAtlas; P32971; baseline and differential.
Genevisible; P32971; HS.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005102; F:receptor binding; TAS:ProtInc.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
GO; GO:0043374; P:CD8-positive, alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR021185; TNF_CD30_ligand_type.
InterPro; IPR021184; TNF_CS.
InterPro; IPR006052; TNF_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
Pfam; PF00229; TNF; 1.
PIRSF; PIRSF019548; TNF_CD30_ligand_type; 1.
SMART; SM00207; TNF; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS00251; TNF_1; 1.
PROSITE; PS50049; TNF_2; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Membrane;
Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
CHAIN 1 234 Tumor necrosis factor ligand superfamily
member 8.
/FTId=PRO_0000185499.
TOPO_DOM 1 37 Cytoplasmic. {ECO:0000255}.
TRANSMEM 38 62 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 63 234 Extracellular. {ECO:0000255}.
CARBOHYD 81 81 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 109 109 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 153 153 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 189 189 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 201 201 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 151 177 {ECO:0000255}.
SEQUENCE 234 AA; 26017 MW; C653615682305B1B CRC64;
MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL VFTVATIMVL
VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA YLQVAKHLNK TKLSWNKDGI
LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ CPNNSVDLKL ELLINKHIKK QALVTVCESG
MQTKHVYQNL SQFLLDYLQV NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD


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