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Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL)

 TNFL9_HUMAN             Reviewed;         254 AA.
P41273; Q2M3S2;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
27-SEP-2017, entry version 131.
RecName: Full=Tumor necrosis factor ligand superfamily member 9;
AltName: Full=4-1BB ligand;
Short=4-1BBL;
Name=TNFSF9;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8088337; DOI=10.1002/eji.1830240943;
Alderson M.R., Smith C.A., Tough T.W., Davis-Smith T., Armitage R.J.,
Falk B., Roux E., Baker E., Sutherland G.R., Din W.S., Goodwin R.G.;
"Molecular and biological characterization of human 4-1BB and its
ligand.";
Eur. J. Immunol. 24:2219-2227(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 80-246, FUNCTION, AND
SUBUNIT.
PubMed=20032458; DOI=10.1074/jbc.M109.084442;
Won E.Y., Cha K., Byun J.S., Kim D.U., Shin S., Ahn B., Kim Y.H.,
Rice A.J., Walz T., Kwon B.S., Cho H.S.;
"The structure of the trimer of human 4-1BB ligand is unique among
members of the tumor necrosis factor superfamily.";
J. Biol. Chem. 285:9202-9210(2010).
-!- FUNCTION: Cytokine that binds to TNFRSF9. Induces the
proliferation of activated peripheral blood T-cells. May have a
role in activation-induced cell death (AICD). May play a role in
cognate interactions between T-cells and B-cells/macrophages.
{ECO:0000269|PubMed:20032458}.
-!- SUBUNIT: Homotrimer. {ECO:0000269|PubMed:20032458}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
protein.
-!- TISSUE SPECIFICITY: Expressed in brain, placenta, lung, skeletal
muscle and kidney.
-!- SIMILARITY: Belongs to the tumor necrosis factor family.
{ECO:0000305}.
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EMBL; U03398; AAA53134.1; -; mRNA.
EMBL; BC104805; AAI04806.1; -; mRNA.
EMBL; BC104807; AAI04808.1; -; mRNA.
CCDS; CCDS12169.1; -.
PIR; I38427; I38427.
RefSeq; NP_003802.1; NM_003811.3.
UniGene; Hs.1524; -.
PDB; 2X29; X-ray; 2.30 A; A=80-246.
PDBsum; 2X29; -.
ProteinModelPortal; P41273; -.
SMR; P41273; -.
BioGrid; 114281; 45.
DIP; DIP-3020N; -.
STRING; 9606.ENSP00000245817; -.
iPTMnet; P41273; -.
PhosphoSitePlus; P41273; -.
BioMuta; TNFSF9; -.
DMDM; 728739; -.
EPD; P41273; -.
MaxQB; P41273; -.
PaxDb; P41273; -.
PeptideAtlas; P41273; -.
PRIDE; P41273; -.
DNASU; 8744; -.
Ensembl; ENST00000245817; ENSP00000245817; ENSG00000125657.
GeneID; 8744; -.
KEGG; hsa:8744; -.
UCSC; uc002mfh.2; human.
CTD; 8744; -.
DisGeNET; 8744; -.
EuPathDB; HostDB:ENSG00000125657.4; -.
GeneCards; TNFSF9; -.
HGNC; HGNC:11939; TNFSF9.
HPA; HPA059857; -.
MIM; 606182; gene.
neXtProt; NX_P41273; -.
OpenTargets; ENSG00000125657; -.
PharmGKB; PA36629; -.
eggNOG; ENOG410J4ZC; Eukaryota.
eggNOG; ENOG4111EDT; LUCA.
GeneTree; ENSGT00390000006244; -.
HOGENOM; HOG000154658; -.
HOVERGEN; HBG079273; -.
InParanoid; P41273; -.
KO; K05472; -.
OMA; WQLTQGA; -.
OrthoDB; EOG091G0GL6; -.
PhylomeDB; P41273; -.
TreeFam; TF338523; -.
Reactome; R-HSA-5669034; TNFs bind their physiological receptors.
ChiTaRS; TNFSF9; human.
EvolutionaryTrace; P41273; -.
GenomeRNAi; 8744; -.
PRO; PR:P41273; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000125657; -.
CleanEx; HS_TNFSF9; -.
ExpressionAtlas; P41273; baseline and differential.
Genevisible; P41273; HS.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005102; F:receptor binding; TAS:ProtInc.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
GO; GO:0032813; F:tumor necrosis factor receptor superfamily binding; IBA:GO_Central.
GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IBA:GO_Central.
GO; GO:0045585; P:positive regulation of cytotoxic T cell differentiation; IBA:GO_Central.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR021184; TNF_CS.
InterPro; IPR006052; TNF_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
Pfam; PF00229; TNF; 1.
SMART; SM00207; TNF; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS00251; TNF_1; 1.
PROSITE; PS50049; TNF_2; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytokine; Membrane; Polymorphism;
Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
CHAIN 1 254 Tumor necrosis factor ligand superfamily
member 9.
/FTId=PRO_0000185501.
TOPO_DOM 1 28 Cytoplasmic. {ECO:0000255}.
TRANSMEM 29 49 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 50 254 Extracellular. {ECO:0000255}.
COMPBIAS 35 41 Poly-Leu.
VARIANT 17 17 P -> A (in dbSNP:rs442511).
/FTId=VAR_011928.
STRAND 83 85 {ECO:0000244|PDB:2X29}.
STRAND 92 97 {ECO:0000244|PDB:2X29}.
STRAND 104 106 {ECO:0000244|PDB:2X29}.
STRAND 115 117 {ECO:0000244|PDB:2X29}.
STRAND 121 123 {ECO:0000244|PDB:2X29}.
STRAND 133 135 {ECO:0000244|PDB:2X29}.
STRAND 139 151 {ECO:0000244|PDB:2X29}.
STRAND 159 168 {ECO:0000244|PDB:2X29}.
STRAND 178 185 {ECO:0000244|PDB:2X29}.
STRAND 195 206 {ECO:0000244|PDB:2X29}.
STRAND 210 217 {ECO:0000244|PDB:2X29}.
HELIX 220 223 {ECO:0000244|PDB:2X29}.
STRAND 226 228 {ECO:0000244|PDB:2X29}.
STRAND 234 239 {ECO:0000244|PDB:2X29}.
SEQUENCE 254 AA; 26625 MW; 827551F34563E508 CRC64;
MEYASDASLD PEAPWPPAPR ARACRVLPWA LVAGLLLLLL LAAACAVFLA CPWAVSGARA
SPGSAASPRL REGPELSPDD PAGLLDLRQG MFAQLVAQNV LLIDGPLSWY SDPGLAGVSL
TGGLSYKEDT KELVVAKAGV YYVFFQLELR RVVAGEGSGS VSLALHLQPL RSAAGAAALA
LTVDLPPASS EARNSAFGFQ GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV
TPEIPAGLPS PRSE


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