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Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL)

 TNFL9_MOUSE             Reviewed;         309 AA.
P41274;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
20-JUN-2018, entry version 118.
RecName: Full=Tumor necrosis factor ligand superfamily member 9;
AltName: Full=4-1BB ligand;
Short=4-1BBL;
Name=Tnfsf9; Synonyms=Cd137l, Cd157l, Ly63l;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=T-cell;
PubMed=8405064; DOI=10.1002/eji.1830231037;
Goodwin R.G., Din W.S., Davis-Smith T., Anderson D.M., Gimpel S.D.,
Sato T.A., Maliszewski C.R., Brannan C.I., Copeland N.G.,
Jenkins N.A., Farrah T., Armitage R.J., Fanslow W.C., Smith C.A.;
"Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a
member of an emerging family of cytokines with homology to tumor
necrosis factor.";
Eur. J. Immunol. 23:2631-2641(1993).
-!- FUNCTION: Cytokine that binds to TNFRSF9. Induces the
proliferation of activated peripheral blood T-cells. May have a
role in activation-induced cell death (AICD). May play a role in
cognate interactions between T-cells and B-cells/macrophages.
-!- SUBUNIT: Homotrimer. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
protein.
-!- SIMILARITY: Belongs to the tumor necrosis factor family.
{ECO:0000305}.
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EMBL; L15435; AAA39435.1; -; Genomic_DNA.
CCDS; CCDS28926.1; -.
PIR; I53384; I53384.
RefSeq; NP_033430.1; NM_009404.3.
UniGene; Mm.41171; -.
ProteinModelPortal; P41274; -.
BioGrid; 204262; 1.
DIP; DIP-1153N; -.
STRING; 10090.ENSMUSP00000040412; -.
iPTMnet; P41274; -.
PhosphoSitePlus; P41274; -.
SwissPalm; P41274; -.
PaxDb; P41274; -.
PeptideAtlas; P41274; -.
PRIDE; P41274; -.
Ensembl; ENSMUST00000039490; ENSMUSP00000040412; ENSMUSG00000035678.
GeneID; 21950; -.
KEGG; mmu:21950; -.
UCSC; uc008ded.1; mouse.
CTD; 8744; -.
MGI; MGI:1101058; Tnfsf9.
eggNOG; ENOG410J4ZC; Eukaryota.
eggNOG; ENOG4111EDT; LUCA.
GeneTree; ENSGT00390000006244; -.
HOVERGEN; HBG067183; -.
InParanoid; P41274; -.
KO; K05472; -.
OMA; YYVFLEL; -.
OrthoDB; EOG091G0GL6; -.
PhylomeDB; P41274; -.
TreeFam; TF338523; -.
Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
PRO; PR:P41274; -.
Proteomes; UP000000589; Chromosome 17.
Bgee; ENSMUSG00000035678; -.
ExpressionAtlas; P41274; baseline and differential.
Genevisible; P41274; MM.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005102; F:signaling receptor binding; IPI:MGI.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
GO; GO:0032813; F:tumor necrosis factor receptor superfamily binding; IPI:MGI.
GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0043011; P:myeloid dendritic cell differentiation; ISO:MGI.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISO:MGI.
GO; GO:0045585; P:positive regulation of cytotoxic T cell differentiation; ISO:MGI.
GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:MGI.
GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:MGI.
GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:MGI.
GO; GO:0042127; P:regulation of cell proliferation; IDA:MGI.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR021184; TNF_CS.
InterPro; IPR006052; TNF_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
Pfam; PF00229; TNF; 1.
SMART; SM00207; TNF; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS00251; TNF_1; 1.
PROSITE; PS50049; TNF_2; 1.
3: Inferred from homology;
Complete proteome; Cytokine; Glycoprotein; Membrane;
Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
CHAIN 1 309 Tumor necrosis factor ligand superfamily
member 9.
/FTId=PRO_0000185502.
TOPO_DOM 1 82 Cytoplasmic. {ECO:0000255}.
TRANSMEM 83 103 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 104 309 Extracellular. {ECO:0000255}.
CARBOHYD 139 139 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 293 293 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 309 AA; 33853 MW; 2A425829AD6B89C0 CRC64;
MDQHTLDVED TADARHPAGT SCPSDAALLR DTGLLADAAL LSDTVRPTNA ALPTDAAYPA
VNVRDREAAW PPALNFCSRH PKLYGLVALV LLLLIAACVP IFTRTEPRPA LTITTSPNLG
TRENNADQVT PVSHIGCPNT TQQGSPVFAK LLAKNQASLC NTTLNWHSQD GAGSSYLSQG
LRYEEDKKEL VVDSPGLYYV FLELKLSPTF TNTGHKVQGW VSLVLQAKPQ VDDFDNLALT
VELFPCSMEN KLVDRSWSQL LLLKAGHRLS VGLRAYLHGA QDAYRDWELS YPNTTSFGLF
LVKPDNPWE


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