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Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266)

 TNR12_HUMAN             Reviewed;         129 AA.
Q9NP84; D3DUA6; Q9HCS0;
27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
20-JUN-2018, entry version 144.
RecName: Full=Tumor necrosis factor receptor superfamily member 12A;
AltName: Full=Fibroblast growth factor-inducible immediate-early response protein 14;
Short=FGF-inducible 14;
AltName: Full=Tweak-receptor;
Short=TweakR;
AltName: CD_antigen=CD266;
Flags: Precursor;
Name=TNFRSF12A; Synonyms=FN14;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Placenta;
PubMed=10751351; DOI=10.1016/S0002-9440(10)64996-6;
Feng S.-L.Y., Guo Y., Factor V.M., Thorgeirsson S.S., Bell D.W.,
Testa J.R., Peifley K.A., Winkles J.A.;
"The Fn14 immediate-early response gene is induced during liver
regeneration and highly expressed in both human and murine
hepatocellular carcinomas.";
Am. J. Pathol. 156:1253-1261(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tanaka S., Sugimachi K.;
"Human homologue of Fn14.";
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Uterus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION.
PubMed=11728344; DOI=10.1016/S1074-7613(01)00232-1;
Wiley S.R., Cassiano L., Lofton T., Davis-Smith T., Winkles J.A.,
Lindner V., Liu H., Daniel T.O., Smith C.A., Fanslow W.C.;
"A novel TNF receptor family member binds TWEAK and is implicated in
angiogenesis.";
Immunity 15:837-846(2001).
[6]
STRUCTURE BY NMR OF 26-70.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the STN_TNFRSF12A_TNFR domain of tumor necrosis
factor receptor superfamily member 12A precursor.";
Submitted (APR-2008) to the PDB data bank.
[7]
STRUCTURE BY NMR OF 26-70, AND DISULFIDE BONDS.
PubMed=19241374; DOI=10.1002/pro.49;
He F., Dang W., Saito K., Watanabe S., Kobayashi N., Guntert P.,
Kigawa T., Tanaka A., Muto Y., Yokoyama S.;
"Solution structure of the cysteine-rich domain in Fn14, a member of
the tumor necrosis factor receptor superfamily.";
Protein Sci. 18:650-656(2009).
-!- FUNCTION: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in
some cell types. Promotes angiogenesis and the proliferation of
endothelial cells. May modulate cellular adhesion to matrix
proteins. {ECO:0000269|PubMed:11728344}.
-!- SUBUNIT: Associates with TRAF1 and TRAF2, and probably also with
TRAF3.
-!- INTERACTION:
Q13490:BIRC2; NbExp=2; IntAct=EBI-2851995, EBI-514538;
Q9BRI3:SLC30A2; NbExp=5; IntAct=EBI-2851995, EBI-8644112;
O43508:TNFSF12; NbExp=2; IntAct=EBI-2851995, EBI-6932080;
Q12933:TRAF2; NbExp=3; IntAct=EBI-2851995, EBI-355744;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9NP84-1; Sequence=Displayed;
Name=2;
IsoId=Q9NP84-2; Sequence=VSP_006519;
-!- TISSUE SPECIFICITY: Highly expressed in heart, placenta and
kidney. Intermediate expression in lung, skeletal muscle and
pancreas.
-!- INDUCTION: By FGF1 and phorbol ester.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF191148; AAF69108.1; -; mRNA.
EMBL; AB035480; BAA94792.1; -; mRNA.
EMBL; AB035481; BAB17850.1; -; mRNA.
EMBL; CH471112; EAW85429.1; -; Genomic_DNA.
EMBL; CH471112; EAW85430.1; -; Genomic_DNA.
EMBL; BC002718; AAH02718.1; -; mRNA.
CCDS; CCDS10489.1; -. [Q9NP84-1]
RefSeq; NP_057723.1; NM_016639.2. [Q9NP84-1]
UniGene; Hs.355899; -.
PDB; 2EQP; NMR; -; A=28-70.
PDB; 2KMZ; NMR; -; A=28-80.
PDB; 2RPJ; NMR; -; A=28-70.
PDBsum; 2EQP; -.
PDBsum; 2KMZ; -.
PDBsum; 2RPJ; -.
ProteinModelPortal; Q9NP84; -.
SMR; Q9NP84; -.
BioGrid; 119478; 4.
IntAct; Q9NP84; 6.
MINT; Q9NP84; -.
STRING; 9606.ENSP00000326737; -.
ChEMBL; CHEMBL3712850; -.
PhosphoSitePlus; Q9NP84; -.
SwissPalm; Q9NP84; -.
BioMuta; TNFRSF12A; -.
DMDM; 21263626; -.
EPD; Q9NP84; -.
MaxQB; Q9NP84; -.
PaxDb; Q9NP84; -.
PeptideAtlas; Q9NP84; -.
PRIDE; Q9NP84; -.
ProteomicsDB; 81927; -.
ProteomicsDB; 81928; -. [Q9NP84-2]
DNASU; 51330; -.
Ensembl; ENST00000326577; ENSP00000326737; ENSG00000006327. [Q9NP84-1]
Ensembl; ENST00000341627; ENSP00000343894; ENSG00000006327. [Q9NP84-2]
GeneID; 51330; -.
KEGG; hsa:51330; -.
UCSC; uc002csv.5; human. [Q9NP84-1]
CTD; 51330; -.
DisGeNET; 51330; -.
EuPathDB; HostDB:ENSG00000006327.13; -.
GeneCards; TNFRSF12A; -.
HGNC; HGNC:18152; TNFRSF12A.
HPA; HPA007853; -.
MIM; 605914; gene.
neXtProt; NX_Q9NP84; -.
OpenTargets; ENSG00000006327; -.
PharmGKB; PA134976874; -.
eggNOG; ENOG410IYHX; Eukaryota.
eggNOG; ENOG41116AK; LUCA.
GeneTree; ENSGT00390000001948; -.
HOGENOM; HOG000154660; -.
HOVERGEN; HBG031553; -.
InParanoid; Q9NP84; -.
KO; K05149; -.
OMA; MDCASCP; -.
PhylomeDB; Q9NP84; -.
TreeFam; TF337901; -.
Reactome; R-HSA-5668541; TNFR2 non-canonical NF-kB pathway.
Reactome; R-HSA-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
SIGNOR; Q9NP84; -.
ChiTaRS; TNFRSF12A; human.
EvolutionaryTrace; Q9NP84; -.
GeneWiki; TNFRSF12A; -.
GenomeRNAi; 51330; -.
PRO; PR:Q9NP84; -.
Proteomes; UP000005640; Chromosome 16.
Bgee; ENSG00000006327; -.
CleanEx; HS_TNFRSF12A; -.
ExpressionAtlas; Q9NP84; baseline and differential.
Genevisible; Q9NP84; HS.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0001726; C:ruffle; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO; GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO; GO:0045765; P:regulation of angiogenesis; IEA:Ensembl.
GO; GO:0061041; P:regulation of wound healing; IDA:UniProtKB.
GO; GO:0006931; P:substrate-dependent cell migration, cell attachment to substrate; IEA:Ensembl.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome.
CDD; cd13413; TNFRSF12A; 1.
InterPro; IPR022316; TNFR_12.
PANTHER; PTHR32037; PTHR32037; 1.
Pfam; PF12191; stn_TNFRSF12A; 1.
PRINTS; PR01962; TNFACTORR12.
ProDom; PD336131; TNFR_12; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Angiogenesis; Apoptosis;
Cell adhesion; Complete proteome; Developmental protein;
Differentiation; Disulfide bond; Membrane; Receptor;
Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 27 {ECO:0000255}.
CHAIN 28 129 Tumor necrosis factor receptor
superfamily member 12A.
/FTId=PRO_0000034611.
TOPO_DOM 28 80 Extracellular. {ECO:0000255}.
TRANSMEM 81 101 Helical. {ECO:0000255}.
TOPO_DOM 102 129 Cytoplasmic. {ECO:0000255}.
REPEAT 36 67 TNFR-Cys; atypical.
DISULFID 36 49 {ECO:0000269|PubMed:19241374}.
DISULFID 52 67 {ECO:0000269|PubMed:19241374}.
DISULFID 55 64 {ECO:0000269|PubMed:19241374}.
VAR_SEQ 33 67 Missing (in isoform 2).
{ECO:0000303|Ref.2}.
/FTId=VSP_006519.
HELIX 30 33 {ECO:0000244|PDB:2EQP}.
STRAND 41 43 {ECO:0000244|PDB:2EQP}.
TURN 44 47 {ECO:0000244|PDB:2EQP}.
STRAND 48 50 {ECO:0000244|PDB:2EQP}.
HELIX 52 57 {ECO:0000244|PDB:2EQP}.
HELIX 62 65 {ECO:0000244|PDB:2EQP}.
SEQUENCE 129 AA; 13911 MW; BF3FDFB9C1E1C448 CRC64;
MARGSLRRLL RLLVLGLWLA LLRSVAGEQA PGTAPCSRGS SWSADLDKCM DCASCRARPH
SDFCLGCAAA PPAPFRLLWP ILGGALSLTF VLGLLSGFLV WRRCRRREKF TTPIEETGGE
GCPAVALIQ


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