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Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b)

 TNR1B_RAT               Reviewed;         474 AA.
Q80WY6; Q5YLP0;
09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
22-NOV-2017, entry version 98.
RecName: Full=Tumor necrosis factor receptor superfamily member 1B;
AltName: Full=Tumor necrosis factor receptor 2;
Short=TNF-R2;
AltName: Full=Tumor necrosis factor receptor type II;
Short=TNF-RII;
Short=TNFR-II;
AltName: Full=p75;
AltName: Full=p80 TNF-alpha receptor;
AltName: CD_antigen=CD120b;
Flags: Precursor;
Name=Tnfrsf1b; Synonyms=Tnfr2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Spleen;
Li Y., Ji A., Schafer M.K.;
"Molecular cloning and cellular expression of TNFR2 in rat dorsal root
ganglion.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Receptor with high affinity for TNFSF2/TNF-alpha and
approximately 5-fold lower affinity for homotrimeric
TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the
apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Binds to TRAF2. Interacts with BMX. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
membrane protein {ECO:0000250}.
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EMBL; AF498039; AAP33151.1; -; mRNA.
EMBL; AY191268; AAO61402.1; -; mRNA.
EMBL; AY191269; AAO61403.1; -; mRNA.
RefSeq; NP_569110.1; NM_130426.4.
UniGene; Rn.83633; -.
ProteinModelPortal; Q80WY6; -.
SMR; Q80WY6; -.
IntAct; Q80WY6; 1.
STRING; 10116.ENSRNOP00000022478; -.
PaxDb; Q80WY6; -.
PRIDE; Q80WY6; -.
Ensembl; ENSRNOT00000022478; ENSRNOP00000022478; ENSRNOG00000016575.
GeneID; 156767; -.
KEGG; rno:156767; -.
CTD; 7133; -.
RGD; 621238; Tnfrsf1b.
eggNOG; ENOG410IJ06; Eukaryota.
eggNOG; ENOG410YPQW; LUCA.
GeneTree; ENSGT00760000119204; -.
HOGENOM; HOG000132845; -.
HOVERGEN; HBG054237; -.
InParanoid; Q80WY6; -.
KO; K05141; -.
OMA; NCVIMTQ; -.
OrthoDB; EOG091G03XW; -.
PhylomeDB; Q80WY6; -.
TreeFam; TF331157; -.
Reactome; R-RNO-5668541; TNFR2 non-canonical NF-kB pathway.
Reactome; R-RNO-5669034; TNFs bind their physiological receptors.
Reactome; R-RNO-6798695; Neutrophil degranulation.
PRO; PR:Q80WY6; -.
Proteomes; UP000002494; Chromosome 5.
Bgee; ENSRNOG00000016575; -.
Genevisible; Q80WY6; RN.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0045121; C:membrane raft; ISO:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO; GO:0043196; C:varicosity; IDA:RGD.
GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IDA:RGD.
GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:RGD.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:RGD.
GO; GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:0006955; P:immune response; IDA:RGD.
GO; GO:0006954; P:inflammatory response; ISO:RGD.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; ISO:RGD.
GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; ISO:RGD.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
GO; GO:0050779; P:RNA destabilization; ISO:RGD.
CDD; cd10577; TNFRSF1B; 1.
InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
InterPro; IPR020411; TNFR_1B.
InterPro; IPR033996; TNFRSF1B_N.
Pfam; PF00020; TNFR_c6; 2.
PRINTS; PR01919; TNFACTORR1B.
SMART; SM00208; TNFR; 4.
PROSITE; PS00652; TNFR_NGFR_1; 2.
PROSITE; PS50050; TNFR_NGFR_2; 3.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Membrane;
Phosphoprotein; Receptor; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 22 {ECO:0000250}.
CHAIN 23 474 Tumor necrosis factor receptor
superfamily member 1B.
/FTId=PRO_0000034551.
TOPO_DOM 23 258 Extracellular. {ECO:0000255}.
TRANSMEM 259 288 Helical. {ECO:0000255}.
TOPO_DOM 289 474 Cytoplasmic. {ECO:0000255}.
REPEAT 39 77 TNFR-Cys 1.
REPEAT 78 119 TNFR-Cys 2.
REPEAT 120 164 TNFR-Cys 3.
REPEAT 165 203 TNFR-Cys 4.
MOD_RES 331 331 Phosphoserine.
{ECO:0000250|UniProtKB:P20333}.
CARBOHYD 30 30 O-linked (GalNAc...) threonine.
{ECO:0000250|UniProtKB:P20333}.
CARBOHYD 69 69 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 110 110 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 195 195 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 208 208 O-linked (GalNAc...) threonine.
{ECO:0000250|UniProtKB:P20333}.
CARBOHYD 224 224 O-linked (GalNAc...) threonine.
{ECO:0000250|UniProtKB:P20333}.
DISULFID 40 54 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 55 68 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 58 76 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 79 94 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 97 111 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 101 119 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 121 127 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 136 145 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 139 163 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 166 181 {ECO:0000255|PROSITE-ProRule:PRU00206}.
SEQUENCE 474 AA; 50148 MW; 298C6AB9E8C8D714 CRC64;
MAPAALWVAL VVELQLWATG HTVPAKVVLT PYKPEPGNQC QISQEYYDKK AQMCCAKCPP
GQYAKHFCNK TSDTVCADCA AGMFTQVWNH LHTCLSCSSS CSDDQVETHN CTKKQNRVCA
CNADSYCALK LHSGNCRQCM KLSKCGPGFG VARSRTSNGN VICSACAPGT FSDTTSSTDV
CRPHRICSIL AIPGNASTDA VCASESPTPS AVPRTIYVSQ PEPTRSQPMD QEPGPSQTPH
IPVSLGSTPI IEPSITGGIS LPIGLIVGLT TLGLLMLGLA NCFILVQRKK KPSCLQRETM
VPHLPDDKSQ DAIGLEQQHL LTTAPSSSSS SLESSASAGD RRAPPGGHPQ ARVTAEAQGS
QEACAGSRSS DSSHGSHGTH VNVTCIVNVC SSSDHSSQCS SQASTTVGDP DANPSGSPKD
EQVPFSQEEC PSQSQWETTE TLQNHDKPFP LGVPDVGMKP NQPGWYDQIA VKVP


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