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Tumor necrosis factor receptor superfamily member 4 (MRC OX40) (OX40 antigen) (OX40L receptor) (CD antigen CD134)

 TNR4_RAT                Reviewed;         271 AA.
P15725;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 1.
12-SEP-2018, entry version 137.
RecName: Full=Tumor necrosis factor receptor superfamily member 4;
AltName: Full=MRC OX40;
AltName: Full=OX40 antigen;
AltName: Full=OX40L receptor;
AltName: CD_antigen=CD134;
Flags: Precursor;
Name=Tnfrsf4; Synonyms=Ox40, Txgp1l;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=T-cell;
PubMed=2157591;
Mallett S., Fossum S., Barclay A.N.;
"Characterization of the MRC OX40 antigen of activated CD4 positive T
lymphocytes -- a molecule related to nerve growth factor receptor.";
EMBO J. 9:1063-1068(1990).
-!- FUNCTION: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory
molecule implicated in long-term T-cell immunity (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Interacts with TRAF2, TRAF3 and TRAF5. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- TISSUE SPECIFICITY: Activated T-cells.
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EMBL; X17037; CAA34897.1; -; mRNA.
PIR; S12783; S12783.
RefSeq; NP_037181.1; NM_013049.1.
UniGene; Rn.48883; -.
ProteinModelPortal; P15725; -.
SMR; P15725; -.
IntAct; P15725; 1.
STRING; 10116.ENSRNOP00000027251; -.
PaxDb; P15725; -.
PRIDE; P15725; -.
Ensembl; ENSRNOT00000027251; ENSRNOP00000027251; ENSRNOG00000020106.
GeneID; 25572; -.
KEGG; rno:25572; -.
CTD; 7293; -.
RGD; 3920; Tnfrsf4.
eggNOG; ENOG410J0US; Eukaryota.
eggNOG; ENOG4111DUJ; LUCA.
GeneTree; ENSGT00730000111452; -.
HOGENOM; HOG000049154; -.
HOVERGEN; HBG005031; -.
InParanoid; P15725; -.
KO; K05142; -.
OMA; PIQEEHA; -.
OrthoDB; EOG091G03XW; -.
PhylomeDB; P15725; -.
TreeFam; TF330135; -.
Reactome; R-RNO-5669034; TNFs bind their physiological receptors.
PRO; PR:P15725; -.
Proteomes; UP000002494; Chromosome 5.
Bgee; ENSRNOG00000020106; Expressed in 9 organ(s), highest expression level in colon.
Genevisible; P15725; RN.
GO; GO:0009986; C:cell surface; IMP:BHF-UCL.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; TAS:RGD.
GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0006968; P:cellular defense response; TAS:RGD.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
GO; GO:0042098; P:T cell proliferation; IMP:BHF-UCL.
CDD; cd13406; TNFRSF4; 1.
InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
InterPro; IPR020445; TNFR_4.
InterPro; IPR034022; TNFRSF4_N.
Pfam; PF00020; TNFR_c6; 3.
PRINTS; PR01921; TNFACTORR4.
SMART; SM00208; TNFR; 3.
PROSITE; PS00652; TNFR_NGFR_1; 2.
PROSITE; PS50050; TNFR_NGFR_2; 2.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor;
Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 271 Tumor necrosis factor receptor
superfamily member 4.
/FTId=PRO_0000034556.
TOPO_DOM 20 210 Extracellular. {ECO:0000255}.
TRANSMEM 211 235 Helical. {ECO:0000255}.
TOPO_DOM 236 271 Cytoplasmic. {ECO:0000255}.
REPEAT 25 60 TNFR-Cys 1.
REPEAT 61 102 TNFR-Cys 2.
REPEAT 103 123 TNFR-Cys 3; truncated.
REPEAT 124 164 TNFR-Cys 4.
CARBOHYD 143 143 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 26 37 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 38 51 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 41 59 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 62 76 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 79 94 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 82 102 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 104 122 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 125 138 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 144 163 {ECO:0000255|PROSITE-ProRule:PRU00206}.
SEQUENCE 271 AA; 29895 MW; C06465136B16E821 CRC64;
MYVWVQQPTA FLLLGLSLGV TVKLNCVKDT YPSGHKCCRE CQPGHGMVSR CDHTRDTVCH
PCEPGFYNEA VNYDTCKQCT QCNHRSGSEL KQNCTPTEDT VCQCRPGTQP RQDSSHKLGV
DCVPCPPGHF SPGSNQACKP WTNCTLSGKQ IRHPASNSLD TVCEDRSLLA TLLWETQRTT
FRPTTVPSTT VWPRTSQLPS TPTLVAPEGP AFAVILGLGL GLLAPLTVLL ALYLLRKAWR
SPNTPKPCWG NSFRTPIQEE QTDTHFTLAK I


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