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Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) (CD antigen CD40)

 TNR5_HORSE              Reviewed;         280 AA.
Q3ZTK5;
17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
27-SEP-2005, sequence version 1.
28-MAR-2018, entry version 79.
RecName: Full=Tumor necrosis factor receptor superfamily member 5;
AltName: Full=B-cell surface antigen CD40;
AltName: Full=CD40L receptor;
AltName: CD_antigen=CD40;
Flags: Precursor;
Name=CD40; Synonyms=TNFRSF5;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Wagner B., Antczak D.F.;
"The CD40 gene of the horse.";
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Receptor for TNFSF5/CD40LG. Transduces TRAF6- and
MAP3K8-mediated signals that activate ERK in macrophages and B
cells, leading to induction of immunoglobulin secretion (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer and homodimer. Interacts with TRAF1, TRAF2,
TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the
interaction is required for ERK activation (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
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EMBL; AY514017; AAS82955.1; -; mRNA.
RefSeq; NP_001075371.1; NM_001081902.1.
UniGene; Eca.12610; -.
ProteinModelPortal; Q3ZTK5; -.
SMR; Q3ZTK5; -.
STRING; 9796.ENSECAP00000014907; -.
PaxDb; Q3ZTK5; -.
Ensembl; ENSECAT00000018286; ENSECAP00000014907; ENSECAG00000016998.
GeneID; 100034049; -.
KEGG; ecb:100034049; -.
CTD; 958; -.
VGNC; VGNC:16268; CD40.
eggNOG; ENOG410IY0H; Eukaryota.
eggNOG; ENOG4112DB5; LUCA.
GeneTree; ENSGT00760000119204; -.
HOGENOM; HOG000136317; -.
HOVERGEN; HBG005117; -.
InParanoid; Q3ZTK5; -.
KO; K03160; -.
OMA; CHPWTSC; -.
OrthoDB; EOG091G03XW; -.
TreeFam; TF331157; -.
Proteomes; UP000002281; Chromosome 22.
Bgee; ENSECAG00000016998; -.
GO; GO:0035631; C:CD40 receptor complex; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IBA:GO_Central.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0042113; P:B cell activation; IEA:Ensembl.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Ensembl.
GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0051023; P:regulation of immunoglobulin secretion; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
CDD; cd13407; TNFRSF5; 1.
InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
InterPro; IPR020435; TNFR_5.
InterPro; IPR034021; TNFRSF5_N.
Pfam; PF00020; TNFR_c6; 1.
PRINTS; PR01922; TNFACTORR5.
SMART; SM00208; TNFR; 4.
PROSITE; PS00652; TNFR_NGFR_1; 1.
PROSITE; PS50050; TNFR_NGFR_2; 3.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane;
Receptor; Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 280 Tumor necrosis factor receptor
superfamily member 5.
/FTId=PRO_0000252695.
TOPO_DOM 21 194 Extracellular. {ECO:0000255}.
TRANSMEM 195 215 Helical. {ECO:0000255}.
TOPO_DOM 216 280 Cytoplasmic. {ECO:0000255}.
REPEAT 25 60 TNFR-Cys 1.
REPEAT 61 103 TNFR-Cys 2.
REPEAT 104 144 TNFR-Cys 3.
REPEAT 145 187 TNFR-Cys 4.
CARBOHYD 180 180 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 26 37 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 38 51 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 41 59 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 62 77 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 83 103 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 105 119 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 111 116 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 125 143 {ECO:0000255|PROSITE-ProRule:PRU00206}.
SEQUENCE 280 AA; 30279 MW; 1667919F81D60D68 CRC64;
MVRLPLQCLL WGCLLTPVHP EQATACKGNQ YLSGSHCCDL CPPGKKLVND CTGITETECS
PCGAGEFLDT WNRESRCHQH KYCDPNLGLQ VQGTGTSTTD ATCICHEGQH CSSDACESCI
LHSPCAPGLG VKQLATGVSD TVCEPCPVGF FSKVSSALEK CHPWTSCDTK GLVELQAGTN
KTDAVCGFRN RMRALVVIPI TMGVLFAVLL LSACIRKVAK EPENKALHRK VGWQDPVETV
YPDDFPGPHS IAPVQETLHG CQPVTQEDGK ESRISVQERQ


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