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Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)

 TNR6_PIG                Reviewed;         332 AA.
O77736;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
23-MAY-2018, entry version 112.
RecName: Full=Tumor necrosis factor receptor superfamily member 6;
AltName: Full=Apo-1 antigen;
AltName: Full=Apoptosis-mediating surface antigen FAS;
AltName: Full=FASLG receptor;
AltName: CD_antigen=CD95;
Flags: Precursor;
Name=FAS; Synonyms=APT1, TNFRSF6;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Bartling B., Hoffmann J., Holtz J., Schulz R., Heusch G., Darmer D.;
"Expression of apoptosis-associated genes in hibernating and stunned
myocardium of pig.";
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Receptor for TNFSF6/FASLG. The adapter molecule FADD
recruits caspase-8 to the activated receptor. The resulting death-
inducing signaling complex (DISC) performs caspase-8 proteolytic
activation which initiates the subsequent cascade of caspases
(aspartate-specific cysteine proteases) mediating apoptosis. FAS-
mediated apoptosis may have a role in the induction of peripheral
tolerance, in the antigen-stimulated suicide of mature T-cells, or
both (By similarity). {ECO:0000250}.
-!- SUBUNIT: Binds DAXX. Interacts with HIPK3. Part of a complex
containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2.
Interacts with BABAM2 and FEM1B. Interacts with FADD (By
similarity). Interacts directly (via DED domain) with NOL3 (via
CARD domain); inhibits death-inducing signaling complex (DISC)
assembly by inhibiting the increase in FAS-FADD binding induced by
FAS activation (By similarity). Interacts with CALM (By
similarity). {ECO:0000250|UniProtKB:P25445,
ECO:0000250|UniProtKB:Q63199}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- DOMAIN: Contains a death domain involved in the binding of FADD,
and maybe to other cytosolic adapter proteins.
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EMBL; AJ001202; CAA04596.1; -; mRNA.
RefSeq; NP_999004.1; NM_213839.1.
UniGene; Ssc.14497; -.
ProteinModelPortal; O77736; -.
SMR; O77736; -.
STRING; 9823.ENSSSCP00000011136; -.
PaxDb; O77736; -.
PeptideAtlas; O77736; -.
PRIDE; O77736; -.
GeneID; 396826; -.
KEGG; ssc:396826; -.
CTD; 355; -.
eggNOG; ENOG410J23A; Eukaryota.
eggNOG; ENOG4112ADB; LUCA.
HOGENOM; HOG000139681; -.
HOVERGEN; HBG004091; -.
InParanoid; O77736; -.
KO; K04390; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
GO; GO:0005516; F:calmodulin binding; ISS:UniProtKB.
GO; GO:0043120; F:tumor necrosis factor binding; IBA:GO_Central.
GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IBA:GO_Central.
GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
CDD; cd08316; Death_FAS_TNFRSF6; 1.
CDD; cd10579; TNFRSF6; 1.
InterPro; IPR011029; DEATH-like_dom_sf.
InterPro; IPR000488; Death_domain.
InterPro; IPR008063; Fas_rcpt.
InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
InterPro; IPR033998; TNFRSF6_death.
InterPro; IPR033999; TNFRSF6_N.
PANTHER; PTHR23097:SF114; PTHR23097:SF114; 2.
Pfam; PF00531; Death; 1.
Pfam; PF00020; TNFR_c6; 2.
PRINTS; PR01680; TNFACTORR6.
SMART; SM00005; DEATH; 1.
SMART; SM00208; TNFR; 3.
SUPFAM; SSF47986; SSF47986; 1.
PROSITE; PS50017; DEATH_DOMAIN; 1.
PROSITE; PS00652; TNFR_NGFR_1; 2.
PROSITE; PS50050; TNFR_NGFR_2; 2.
2: Evidence at transcript level;
Apoptosis; Calmodulin-binding; Complete proteome; Disulfide bond;
Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
Repeat; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 16 {ECO:0000255}.
CHAIN 17 332 Tumor necrosis factor receptor
superfamily member 6.
/FTId=PRO_0000034568.
TOPO_DOM 17 175 Extracellular. {ECO:0000255}.
TRANSMEM 176 192 Helical. {ECO:0000255}.
TOPO_DOM 193 332 Cytoplasmic. {ECO:0000255}.
REPEAT 45 81 TNFR-Cys 1.
REPEAT 82 125 TNFR-Cys 2.
REPEAT 126 164 TNFR-Cys 3.
DOMAIN 227 311 Death. {ECO:0000255|PROSITE-
ProRule:PRU00064}.
REGION 210 314 Interaction with HIPK3. {ECO:0000250}.
REGION 227 251 Interaction with CALM.
{ECO:0000250|UniProtKB:P25445}.
MOD_RES 212 212 Phosphothreonine.
{ECO:0000250|UniProtKB:P25446}.
CARBOHYD 38 38 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 116 116 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 46 57 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 58 71 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 61 80 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 83 99 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 102 117 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 105 125 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 127 141 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 144 155 {ECO:0000255|PROSITE-ProRule:PRU00206}.
DISULFID 147 163 {ECO:0000255|PROSITE-ProRule:PRU00206}.
SEQUENCE 332 AA; 37593 MW; 5B8B03682756BF1B CRC64;
MSGIWVLLSL VFTCIAGPLS KGDDAQVTDP DSEMVKLNIT KRESECPEGQ HREGQFCCQP
CPPGKRKHAD CTSPGGAPQC VPCSEGEDYT DKNHHSSKCR RCRVCDGEHG LEVEKNCTRT
QNTKCRCKPN FFCHTSQCEH CNPCTTCEHG VIENCTPTSN TKCREVFQSA GSRSNLHWLW
ALLILIPVPA LVYREVKRRC RRKENGYQKP ITSNAEEVPM IKDVDLGKYI TRIAEQMKIT
EVKDFVRKNG IEETKIDEIM HDNPKDTAEQ KVQLLRNWYL YHGKKDAYCT LIQGLRKAKL
SALADKINDI VQKDVTSEQE NANSQNENES LT


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