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Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (T-cell antigen 4-1BB) (CD antigen CD137)

 TNR9_MOUSE              Reviewed;         256 AA.
P20334;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 1.
23-MAY-2018, entry version 155.
RecName: Full=Tumor necrosis factor receptor superfamily member 9;
AltName: Full=4-1BB ligand receptor;
AltName: Full=T-cell antigen 4-1BB;
AltName: CD_antigen=CD137;
Flags: Precursor;
Name=Tnfrsf9; Synonyms=Cd137, Ila, Ly63;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2784565; DOI=10.1073/pnas.86.6.1963;
Kwon B.S., Weissman S.M.;
"cDNA sequences of two inducible T-cell genes.";
Proc. Natl. Acad. Sci. U.S.A. 86:1963-1967(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=BALB/cJ;
PubMed=8133039;
Kwon B.S., Kozak C.A., Kim K.K., Pickard R.T.;
"Genomic organization and chromosomal localization of the T-cell
antigen 4-1BB.";
J. Immunol. 152:2256-2262(1994).
[3]
CHARACTERIZATION, AND PROTEIN SEQUENCE OF 24-29.
PubMed=7678621;
Pollok K.E., Kim Y.-J., Zhou Z., Hurtado J., Kin K.K., Pickard R.T.,
Kwon B.S.;
"Inducible T cell antigen 4-1BB. Analysis of expression and
function.";
J. Immunol. 150:771-781(1993).
-!- FUNCTION: Receptor for TNFSF9/4-1BBL. Possibly active during T
cell activation.
-!- SUBUNIT: Principally a homodimer, but also found as a monomer.
Associates with p56-LCK. Interacts with TRAF1, TRAF2 and TRAF3 (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- TISSUE SPECIFICITY: Expressed on the surface of activated T-cells.
-!- INDUCTION: Optimal by PMA and ionomycin.
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EMBL; J04492; AAA40167.1; -; mRNA.
EMBL; U02567; AAA93113.1; -; Genomic_DNA.
CCDS; CCDS18976.1; -.
PIR; B32393; B32393.
RefSeq; NP_001070977.1; NM_001077509.1.
RefSeq; NP_035742.1; NM_011612.2.
RefSeq; XP_011248530.1; XM_011250228.2.
UniGene; Mm.244187; -.
PDB; 1D0J; X-ray; 2.50 A; G/H/I/J/K=231-236.
PDB; 5WI8; X-ray; 2.95 A; A/B/C/D=24-160.
PDB; 5WIW; X-ray; 2.30 A; A/B=24-160.
PDB; 5WJF; X-ray; 2.60 A; A/B=24-160.
PDBsum; 1D0J; -.
PDBsum; 5WI8; -.
PDBsum; 5WIW; -.
PDBsum; 5WJF; -.
ProteinModelPortal; P20334; -.
SMR; P20334; -.
BioGrid; 204254; 1.
DIP; DIP-1154N; -.
IntAct; P20334; 5.
MINT; P20334; -.
STRING; 10090.ENSMUSP00000030808; -.
PhosphoSitePlus; P20334; -.
EPD; P20334; -.
PaxDb; P20334; -.
PeptideAtlas; P20334; -.
PRIDE; P20334; -.
Ensembl; ENSMUST00000030808; ENSMUSP00000030808; ENSMUSG00000028965.
Ensembl; ENSMUST00000105671; ENSMUSP00000101296; ENSMUSG00000028965.
Ensembl; ENSMUST00000116257; ENSMUSP00000111961; ENSMUSG00000028965.
GeneID; 21942; -.
KEGG; mmu:21942; -.
UCSC; uc008vya.1; mouse.
CTD; 3604; -.
MGI; MGI:1101059; Tnfrsf9.
eggNOG; ENOG410IW3N; Eukaryota.
eggNOG; ENOG41129F9; LUCA.
GeneTree; ENSGT00730000111279; -.
HOGENOM; HOG000033708; -.
HOVERGEN; HBG000021; -.
InParanoid; P20334; -.
KO; K05146; -.
OMA; FKQPFMR; -.
OrthoDB; EOG091G03XW; -.
PhylomeDB; P20334; -.
TreeFam; TF336151; -.
Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
ChiTaRS; Tnfrsf9; mouse.
EvolutionaryTrace; P20334; -.
PRO; PR:P20334; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000028965; -.
ExpressionAtlas; P20334; baseline and differential.
Genevisible; P20334; MM.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0019955; F:cytokine binding; IPI:MGI.
GO; GO:0038023; F:signaling receptor activity; IPI:MGI.
GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IBA:GO_Central.
GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:InterPro.
GO; GO:2001180; P:negative regulation of interleukin-10 secretion; IMP:MGI.
GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IMP:MGI.
GO; GO:0070207; P:protein homotrimerization; IDA:MGI.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0042127; P:regulation of cell proliferation; IDA:MGI.
GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
CDD; cd13410; TNFRSF9; 1.
InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
InterPro; IPR020413; TNFR_9.
InterPro; IPR034020; TNFRSF9_N.
PANTHER; PTHR23097:SF136; PTHR23097:SF136; 1.
Pfam; PF00020; TNFR_c6; 1.
PRINTS; PR01924; TNFACTORR9.
SMART; SM00208; TNFR; 2.
PROSITE; PS00652; TNFR_NGFR_1; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Direct protein sequencing;
Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
Repeat; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 23 {ECO:0000269|PubMed:7678621}.
CHAIN 24 256 Tumor necrosis factor receptor
superfamily member 9.
/FTId=PRO_0000034578.
TOPO_DOM 24 187 Extracellular. {ECO:0000255}.
TRANSMEM 188 208 Helical. {ECO:0000255}.
TOPO_DOM 209 256 Cytoplasmic. {ECO:0000255}.
REPEAT 24 45 TNFR-Cys 1.
REPEAT 46 85 TNFR-Cys 2.
REPEAT 86 117 TNFR-Cys 3.
REPEAT 118 159 TNFR-Cys 4.
CARBOHYD 128 128 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 138 138 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 28 37 {ECO:0000250}.
DISULFID 31 44 {ECO:0000250}.
DISULFID 47 61 {ECO:0000250}.
DISULFID 64 77 {ECO:0000250}.
DISULFID 67 85 {ECO:0000250}.
DISULFID 87 93 {ECO:0000250}.
DISULFID 98 105 {ECO:0000250}.
DISULFID 101 116 {ECO:0000250}.
DISULFID 119 133 {ECO:0000250}.
DISULFID 139 158 {ECO:0000250}.
HELIX 28 30 {ECO:0000244|PDB:5WJF}.
STRAND 35 38 {ECO:0000244|PDB:5WJF}.
STRAND 41 46 {ECO:0000244|PDB:5WJF}.
STRAND 54 56 {ECO:0000244|PDB:5WJF}.
STRAND 58 60 {ECO:0000244|PDB:5WJF}.
STRAND 71 75 {ECO:0000244|PDB:5WIW}.
STRAND 79 81 {ECO:0000244|PDB:5WIW}.
STRAND 84 87 {ECO:0000244|PDB:5WIW}.
STRAND 91 95 {ECO:0000244|PDB:5WIW}.
STRAND 100 103 {ECO:0000244|PDB:5WIW}.
STRAND 109 112 {ECO:0000244|PDB:5WIW}.
STRAND 115 118 {ECO:0000244|PDB:5WIW}.
STRAND 127 130 {ECO:0000244|PDB:5WIW}.
TURN 139 143 {ECO:0000244|PDB:5WIW}.
STRAND 144 148 {ECO:0000244|PDB:5WIW}.
STRAND 152 154 {ECO:0000244|PDB:5WIW}.
STRAND 157 160 {ECO:0000244|PDB:5WIW}.
SEQUENCE 256 AA; 27598 MW; 93A10D03C60813C4 CRC64;
MGNNCYNVVV IVLLLVGCEK VGAVQNSCDN CQPGTFCRKY NPVCKSCPPS TFSSIGGQPN
CNICRVCAGY FRFKKFCSST HNAECECIEG FHCLGPQCTR CEKDCRPGQE LTKQGCKTCS
LGTFNDQNGT GVCRPWTNCS LDGRSVLKTG TTEKDVVCGP PVVSFSPSTT ISVTPEGGPG
GHSLQVLTLF LALTSALLLA LIFITLLFSV LKWIRKKFPH IFKQPFKKTT GAAQEEDACS
CRCPQEEEGG GGGYEL


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