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Type 4 prepilin-like proteins leader peptide-processing enzyme [Includes: Leader peptidase (EC 3.4.23.43) (Prepilin peptidase); N-methyltransferase (EC 2.1.1.-)]

 LEP4_LEGPN              Reviewed;         287 AA.
O68433;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
05-JUL-2017, entry version 76.
RecName: Full=Type 4 prepilin-like proteins leader peptide-processing enzyme;
Includes:
RecName: Full=Leader peptidase;
EC=3.4.23.43;
AltName: Full=Prepilin peptidase;
Includes:
RecName: Full=N-methyltransferase;
EC=2.1.1.-;
Name=pilD;
Legionella pneumophila.
Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
Legionellaceae; Legionella.
NCBI_TaxID=446;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=130b / Wadsworth / Serogroup 1;
PubMed=9529113;
Liles M.R., Viswanathan V.K., Cianciotto N.P.;
"Identification and temperature regulation of Legionella pneumophila
genes involved in type IV pilus biogenesis and type II protein
secretion.";
Infect. Immun. 66:1776-1782(1998).
-!- FUNCTION: Cleaves type-4 fimbrial leader sequence and methylates
the N-terminal (generally Phe) residue. Processes the TapA pilin
precursor during membrane translocation.
-!- CATALYTIC ACTIVITY: Typically cleaves a -Gly-|-Phe- bond to
release an N-terminal, basic peptide of 5-8 residues from type IV
prepilin, and then N-methylates the new N-terminal amino group,
the methyl donor being S-adenosyl-L-methionine.
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-
pass membrane protein {ECO:0000305}.
-!- SIMILARITY: Belongs to the peptidase A24 family. {ECO:0000305}.
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EMBL; AF038655; AAC12718.1; -; Genomic_DNA.
TCDB; 3.A.15.3.1; the outer membrane protein secreting main terminal branch (mtb) family.
eggNOG; ENOG4105EHH; Bacteria.
eggNOG; COG1989; LUCA.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
InterPro; IPR010627; Pept_A24A_N.
InterPro; IPR014032; Peptidase_A24A_bac.
InterPro; IPR000045; Prepilin_IV_endopep_pep.
Pfam; PF06750; DiS_P_DiS; 1.
Pfam; PF01478; Peptidase_A24; 1.
PRINTS; PR00864; PREPILNPTASE.
3: Inferred from homology;
Cell inner membrane; Cell membrane; Hydrolase; Membrane;
Methyltransferase; Multifunctional enzyme; Protease;
S-adenosyl-L-methionine; Transferase; Transmembrane;
Transmembrane helix.
CHAIN 1 287 Type 4 prepilin-like proteins leader
peptide-processing enzyme.
/FTId=PRO_0000192622.
TRANSMEM 12 32 Helical. {ECO:0000255}.
TRANSMEM 127 147 Helical. {ECO:0000255}.
TRANSMEM 158 178 Helical. {ECO:0000255}.
TRANSMEM 182 202 Helical. {ECO:0000255}.
TRANSMEM 215 235 Helical. {ECO:0000255}.
TRANSMEM 259 279 Helical. {ECO:0000255}.
SEQUENCE 287 AA; 32850 MW; 3DA1B1968498EB66 CRC64;
MINALIINYP WFMYLVVGLF SLAVGSLLNV IIYRLPIILQ EEWKEQCCEL FHFEQRKEKI
KLNLFLPRSF CPHCKAMVKA WQNIPLLAIL VLRGRCYQCD SPFSIRYPFV ETLTTVLSLY
ASWHFGFTIQ LLFALLAIWI LISLVFIDLD HQLLPDSLTL GLLWIGLIAN TQNVFVSLDV
AVLSCAGAYL ALWLFINLFY LMTCKVCMGH GDFKLFAAFG AWLGWMYLPI ILLISSITGA
IIGLIYLKIN GKSRDTAIPF GPFLCISGLI AMFWGDSIIN WYIGYWM


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