GENTAUR Molecular Products.

 A0A074JY95_9RHOB        Unreviewed;       258 AA.
 A0A074JY95;
 01-OCT-2014, integrated into UniProtKB/TrEMBL.
 01-OCT-2014, sequence version 1.
 27-SEP-2017, entry version 18.
 RecName: Full=Type III pantothenate kinase {ECO:0000256|HAMAP-Rule:MF_01274};
          EC=2.7.1.33 {ECO:0000256|HAMAP-Rule:MF_01274};
 AltName: Full=PanK-III {ECO:0000256|HAMAP-Rule:MF_01274};
 AltName: Full=Pantothenic acid kinase {ECO:0000256|HAMAP-Rule:MF_01274};
 Name=coaX {ECO:0000256|HAMAP-Rule:MF_01274};
 ORFNames=DT23_00430 {ECO:0000313|EMBL:KEO61464.1};
 Thioclava indica.
 Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
 Rhodobacteraceae; Thioclava.
 NCBI_TaxID=1353528 {ECO:0000313|EMBL:KEO61464.1, ECO:0000313|Proteomes:UP000027471};
 [1] {ECO:0000313|EMBL:KEO61464.1, ECO:0000313|Proteomes:UP000027471}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=DT23-4 {ECO:0000313|EMBL:KEO61464.1,
 ECO:0000313|Proteomes:UP000027471};
 PubMed=25361528; DOI=10.1007/s10482-014-0320-3;
 Liu Y., Lai Q., Du J., Xu H., Jiang L., Shao Z.;
 "Thioclava indica sp. nov., isolated from surface seawater of the
 Indian Ocean.";
 Antonie Van Leeuwenhoek 107:297-304(2015).
 -!- FUNCTION: Catalyzes the phosphorylation of pantothenate (Pan), the
     first step in CoA biosynthesis. {ECO:0000256|HAMAP-Rule:MF_01274,
     ECO:0000256|SAAS:SAAS00384421}.
 -!- CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'-
     phosphopantothenate. {ECO:0000256|HAMAP-Rule:MF_01274,
     ECO:0000256|SAAS:SAAS00384435}.
 -!- COFACTOR:
     Name=K(+); Xref=ChEBI:CHEBI:29103;
       Evidence={ECO:0000256|SAAS:SAAS00611758};
 -!- COFACTOR:
     Name=NH4(+); Xref=ChEBI:CHEBI:28938;
       Evidence={ECO:0000256|HAMAP-Rule:MF_01274};
     Name=K(+); Xref=ChEBI:CHEBI:29103;
       Evidence={ECO:0000256|HAMAP-Rule:MF_01274};
     Note=A monovalent cation. Ammonium or potassium.
     {ECO:0000256|HAMAP-Rule:MF_01274};
 -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from
     (R)-pantothenate: step 1/5. {ECO:0000256|HAMAP-Rule:MF_01274,
     ECO:0000256|SAAS:SAAS00384485}.
 -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01274,
     ECO:0000256|SAAS:SAAS00701620}.
 -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01274,
     ECO:0000256|SAAS:SAAS00384519}.
 -!- SIMILARITY: Belongs to the type III pantothenate kinase family.
     {ECO:0000256|HAMAP-Rule:MF_01274, ECO:0000256|SAAS:SAAS00701623}.
 -!- CAUTION: Lacks conserved residue(s) required for the propagation
     of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01274}.
 -!- CAUTION: The sequence shown here is derived from an
     EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
     preliminary data. {ECO:0000313|EMBL:KEO61464.1}.
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 EMBL; AUNB01000001; KEO61464.1; -; Genomic_DNA.
 RefSeq; WP_038127091.1; NZ_AUNB01000001.1.
 EnsemblBacteria; KEO61464; KEO61464; DT23_00430.
 UniPathway; UPA00241; UER00352.
 Proteomes; UP000027471; Unassembled WGS sequence.
 GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
 GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO; GO:0004594; F:pantothenate kinase activity; IEA:UniProtKB-UniRule.
 GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
 HAMAP; MF_01274; Pantothen_kinase_3; 1.
 InterPro; IPR004619; Type_III_PanK.
 PANTHER; PTHR34265; PTHR34265; 1.
 Pfam; PF03309; Pan_kinase; 1.
 TIGRFAMs; TIGR00671; baf; 1.
 3: Inferred from homology;
 ATP-binding {ECO:0000256|HAMAP-Rule:MF_01274,
 ECO:0000256|SAAS:SAAS00088442};
 Coenzyme A biosynthesis {ECO:0000256|HAMAP-Rule:MF_01274,
 ECO:0000256|SAAS:SAAS00088444};
 Complete proteome {ECO:0000313|Proteomes:UP000027471};
 Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01274,
 ECO:0000256|SAAS:SAAS00088451};
 Kinase {ECO:0000256|HAMAP-Rule:MF_01274,
 ECO:0000256|SAAS:SAAS00088438, ECO:0000313|EMBL:KEO61464.1};
 Metal-binding {ECO:0000256|HAMAP-Rule:MF_01274};
 Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01274,
 ECO:0000256|SAAS:SAAS00088442};
 Potassium {ECO:0000256|HAMAP-Rule:MF_01274,
 ECO:0000256|SAAS:SAAS00461364};
 Reference proteome {ECO:0000313|Proteomes:UP000027471};
 Transferase {ECO:0000256|HAMAP-Rule:MF_01274,
 ECO:0000256|SAAS:SAAS00088438, ECO:0000313|EMBL:KEO61464.1}.
 NP_BIND       6     13       ATP. {ECO:0000256|HAMAP-Rule:MF_01274}.
 REGION      107    110       Substrate binding. {ECO:0000256|HAMAP-
                              Rule:MF_01274}.
 ACT_SITE    109    109       Proton acceptor. {ECO:0000256|HAMAP-
                              Rule:MF_01274}.
 METAL       129    129       Monovalent cation. {ECO:0000256|HAMAP-
                              Rule:MF_01274}.
 BINDING     132    132       ATP. {ECO:0000256|HAMAP-Rule:MF_01274}.
 BINDING     184    184       Substrate. {ECO:0000256|HAMAP-
                              Rule:MF_01274}.
 SEQUENCE   258 AA;  28253 MW;  7F40CCFAF5EDCF5E CRC64;
 MLLCIDCGNT NTVFSIWDGN AFLSTWRMET NHKRTADEYF VWLQGLMRLH GIEAKISETI
 ISSTVPRVVF NLRVLCNRYF DCRPVVVGKP ECDLPVAPRV DEGTTVGPDR LVNAAAGFDR
 HGGDIIVVDF GTATTFDVVA RDGAYIGGVI APGVNLSLEA LHQSAAALPH VDITKPQAVI
 GTNTVACIQS GVFWGYIGLV EGIVRQIRVE RDRPMKVIAT GGLAPLFDQG FDLFDKVEED
 LTMHGLRLLY DYNKGLTA

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