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Type IV inositol polyphosphate 5-phosphatase 6 (At5PTase6) (EC 3.1.3.36) (EC 3.1.3.86) (Protein COTYLEDON VASCULAR PATTERN 2)

 IP5P6_ARATH             Reviewed;         617 AA.
Q9LR47;
07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
22-SEP-2009, sequence version 2.
20-DEC-2017, entry version 110.
RecName: Full=Type IV inositol polyphosphate 5-phosphatase 6 {ECO:0000305};
Short=At5PTase6 {ECO:0000305};
EC=3.1.3.36 {ECO:0000269|PubMed:19473324};
EC=3.1.3.86 {ECO:0000269|PubMed:19473324};
AltName: Full=Protein COTYLEDON VASCULAR PATTERN 2 {ECO:0000303|PubMed:10559439};
Name=IP5P6 {ECO:0000305}; Synonyms=CVP2 {ECO:0000303|PubMed:10559439};
OrderedLocusNames=At1g05470 {ECO:0000312|Araport:AT1G05470};
ORFNames=T25N20.12 {ECO:0000312|EMBL:AAF79735.1};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130712; DOI=10.1038/35048500;
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana.";
Nature 408:816-820(2000).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=cv. Columbia;
PubMed=14993207; DOI=10.1101/gr.1515604;
Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G.,
Caboche M., Weissenbach J., Salanoubat M.;
"Whole genome sequence comparisons and 'full-length' cDNA sequences: a
combined approach to evaluate and improve Arabidopsis genome
annotation.";
Genome Res. 14:406-413(2004).
[4]
FUNCTION, AND MUTANT CVP2-1.
PubMed=10559439; DOI=10.1105/tpc.11.11.2123;
Carland F.M., Berg B.L., FitzGerald J.N., Jinamornphongs S.,
Nelson T., Keith B.;
"Genetic regulation of vascular tissue patterning in Arabidopsis.";
Plant Cell 11:2123-2137(1999).
[5]
GENE FAMILY.
PubMed=11402208; DOI=10.1104/pp.126.2.801;
Berdy S.E., Kudla J., Gruissem W., Gillaspy G.E.;
"Molecular characterization of At5PTase1, an inositol phosphatase
capable of terminating inositol trisphosphate signaling.";
Plant Physiol. 126:801-810(2001).
[6]
FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND MUTAGENESIS OF
ALA-543 AND GLY-575.
PubMed=15100402; DOI=10.1105/tpc.021030;
Carland F.M., Nelson T.;
"COTYLEDON VASCULAR PATTERN2-mediated inositol (1,4,5) triphosphate
signal transduction is essential for closed venation patterns of
Arabidopsis foliar organs.";
Plant Cell 16:1263-1275(2004).
[7]
FUNCTION.
PubMed=19363154; DOI=10.1242/dev.030098;
Naramoto S., Sawa S., Koizumi K., Uemura T., Ueda T., Friml J.,
Nakano A., Fukuda H.;
"Phosphoinositide-dependent regulation of VAN3 ARF-GAP localization
and activity essential for vascular tissue continuity in plants.";
Development 136:1529-1538(2009).
[8]
FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND CATALYTIC
ACTIVITY.
PubMed=19473324; DOI=10.1111/j.1365-313X.2009.03920.x;
Carland F., Nelson T.;
"CVP2- and CVL1-mediated phosphoinositide signaling as a regulator of
the ARF GAP SFC/VAN3 in establishment of foliar vein patterns.";
Plant J. 59:895-907(2009).
[9]
FUNCTION.
PubMed=25813544; DOI=10.1242/dev.118364;
Rodriguez-Villalon A., Gujas B., van Wijk R., Munnik T., Hardtke C.S.;
"Primary root protophloem differentiation requires balanced
phosphatidylinositol-4,5-biphosphate levels and systemically affects
root branching.";
Development 142:1437-1446(2015).
-!- FUNCTION: Has phosphatase activity toward PtdIns(4,5)P2 and
PtdIns(3,4,5)P3 (PubMed:19473324). Required for the patterning of
procambium and during the differentiation of vascular tissues.
Acts before the acquisition of preprocambial identity. Seems to be
also involved in the abscisic acid (ABA) signaling pathway
(PubMed:10559439, PubMed:15100402). Acts redundantly with CVL1 for
maintaining vascular continuity (PubMed:19363154,
PubMed:25813544). Regulates phosphoinositide-dependent VAN3
localization (PubMed:19473324). {ECO:0000269|PubMed:10559439,
ECO:0000269|PubMed:15100402, ECO:0000269|PubMed:19363154,
ECO:0000269|PubMed:19473324, ECO:0000269|PubMed:25813544}.
-!- CATALYTIC ACTIVITY: 1-phosphatidyl-1D-myo-inositol 4,5-
bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate
+ phosphate. {ECO:0000269|PubMed:19473324}.
-!- CATALYTIC ACTIVITY: 1-phosphatidyl-1D-myo-inositol 3,4,5-
triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-
diphosphate + phosphate. {ECO:0000269|PubMed:19473324}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9LR47-1; Sequence=Displayed;
Name=2;
IsoId=Q9LR47-2; Sequence=VSP_037992, VSP_037993;
Note=May be due to a competing donor splice site. No
experimental confirmation available.;
-!- TISSUE SPECIFICITY: Broadly expressed in emerging organs. Mostly
localized in procambium of growing organs. Restricted to vascular
differentiating cells of young organs.
{ECO:0000269|PubMed:15100402, ECO:0000269|PubMed:19473324}.
-!- DEVELOPMENTAL STAGE: During early stages of embryogenesis, broadly
expressed throughout globular and torpedo stages. At late torpedo
stage, strongly expressed in developing vascular cells and weakly
expressed in surrounding cells. By the walking-stick stage,
restricted to incipient vascular cells of the apical loop, the
midvein of the cotyledon and the root vasculature. In emerging
leaves, strongly expressed in procambium and weakly expressed in
areole cells. Limited to developing vascular cells in later stage
of leaf development. In roots, expressed in procambium of the
elongating zone and in immature vascular cells of the root
differentiation zone. During inflorescence development, broadly
expressed in young floral buds, and gradually restricted to
procambium of cauline leaves, sepals, petals, gynoecia and
anthers. {ECO:0000269|PubMed:15100402,
ECO:0000269|PubMed:19473324}.
-!- MISCELLANEOUS: CVP2 overexpression impairs protophloeme sieve
element differentiation and overall root growth. Cvp1 and cvp2
double mutant displays high PtdIns(4,5)P2 levels.
{ECO:0000269|PubMed:25813544}.
-!- SIMILARITY: Belongs to the inositol polyphosphate 5-phosphatase
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAF79735.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=BX816898; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AC005106; AAF79735.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002684; AEE27844.1; -; Genomic_DNA.
EMBL; CP002684; ANM59756.1; -; Genomic_DNA.
EMBL; BX816898; -; NOT_ANNOTATED_CDS; mRNA.
RefSeq; NP_001322092.1; NM_001331550.1. [Q9LR47-1]
RefSeq; NP_172038.4; NM_100426.5. [Q9LR47-1]
UniGene; At.42397; -.
ProteinModelPortal; Q9LR47; -.
SMR; Q9LR47; -.
BioGrid; 22290; 1.
STRING; 3702.AT1G05470.1; -.
PaxDb; Q9LR47; -.
PRIDE; Q9LR47; -.
EnsemblPlants; AT1G05470.1; AT1G05470.1; AT1G05470. [Q9LR47-1]
EnsemblPlants; AT1G05470.2; AT1G05470.2; AT1G05470. [Q9LR47-1]
GeneID; 837048; -.
Gramene; AT1G05470.1; AT1G05470.1; AT1G05470. [Q9LR47-1]
Gramene; AT1G05470.2; AT1G05470.2; AT1G05470. [Q9LR47-1]
KEGG; ath:AT1G05470; -.
Araport; AT1G05470; -.
TAIR; locus:2201016; AT1G05470.
eggNOG; KOG0565; Eukaryota.
eggNOG; COG5411; LUCA.
HOGENOM; HOG000241161; -.
InParanoid; Q9LR47; -.
OMA; SAHNRLK; -.
OrthoDB; EOG0936064A; -.
PhylomeDB; Q9LR47; -.
BioCyc; ARA:AT1G05470-MONOMER; -.
Reactome; R-ATH-1660499; Synthesis of PIPs at the plasma membrane.
Reactome; R-ATH-1855183; Synthesis of IP2, IP, and Ins in the cytosol.
Reactome; R-ATH-1855204; Synthesis of IP3 and IP4 in the cytosol.
PRO; PR:Q9LR47; -.
Proteomes; UP000006548; Chromosome 1.
ExpressionAtlas; Q9LR47; baseline and differential.
Genevisible; Q9LR47; AT.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0046030; F:inositol trisphosphate phosphatase activity; IMP:TAIR.
GO; GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.
GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:UniProtKB.
GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0010588; P:cotyledon vascular tissue pattern formation; IMP:TAIR.
GO; GO:0046855; P:inositol phosphate dephosphorylation; IMP:TAIR.
GO; GO:0048016; P:inositol phosphate-mediated signaling; IC:TAIR.
GO; GO:0032957; P:inositol trisphosphate metabolic process; IMP:TAIR.
GO; GO:0010305; P:leaf vascular tissue pattern formation; IMP:TAIR.
GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.
GO; GO:0010067; P:procambium histogenesis; IMP:TAIR.
GO; GO:0009737; P:response to abscisic acid; IMP:TAIR.
GO; GO:0010051; P:xylem and phloem pattern formation; IMP:TAIR.
Gene3D; 3.60.10.10; -; 1.
InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
InterPro; IPR000300; IPPc.
SMART; SM00128; IPPc; 1.
SUPFAM; SSF56219; SSF56219; 2.
1: Evidence at protein level;
Abscisic acid signaling pathway; Alternative splicing;
Complete proteome; Differentiation; Hydrolase; Reference proteome.
CHAIN 1 617 Type IV inositol polyphosphate 5-
phosphatase 6.
/FTId=PRO_0000209724.
REGION 458 473 Catalytic 1.
{ECO:0000250|UniProtKB:Q84MA2}.
REGION 538 553 Catalytic 2.
{ECO:0000250|UniProtKB:Q84MA2}.
COMPBIAS 236 333 Ser-rich.
VAR_SEQ 1 111 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_037992.
VAR_SEQ 112 128 LDEWLHSSAPADIYVLG -> MSGFIHQLLLISMYSGI
(in isoform 2). {ECO:0000305}.
/FTId=VSP_037993.
MUTAGEN 543 543 A->V: In cvp2-2; induces an open vein
network. {ECO:0000269|PubMed:15100402}.
MUTAGEN 575 575 G->D: In cvp2-1; induces an open vein
network. {ECO:0000269|PubMed:15100402}.
SEQUENCE 617 AA; 70853 MW; B4325EA5F3FE915C CRC64;
MREEKSKTNK LAWSKKMVRK WFNIKSKTEE FQADDPSSAG IEVEHRSSFS AEKAPSTIKN
TKTEKLSKNW EQQARQRRMN YENPRIIDVQ NYSIFVATWN VAGRSPPSDL NLDEWLHSSA
PADIYVLGFQ EIVPLNAGNV LGAEDNGPAQ KWLSLIRKTL NNRPGTSGTS GYHTPSPIPV
PMAELDADFS GSTRQKNSTF FHRRSFQTPS STWNDPSIPQ PGLDRRFSVC DRVFFSHRPS
DFDPSFRGSS SSHRPSDYSR RPSDYSRRPS DYSRRPSDYS RRPSDSRPSD YSRPSDYYSR
PSDYSRPSDF SRSSDDDNGL GDSPSTVLYS PGSAANENGY RIPWNSSQYC LVASKQMVGV
FLTIWVKSEL REHVKNMKVS CVGRGLMGYL GNKGSISISM LLHQTSFCFV CTHLTSGQKE
GDELKRNSDV MEILKKTRFP RVKSSEEEKS PENILQHDRV IWLGDLNYRI ALSYRSAKAL
VEMQNWRALL ENDQLRIEQK RGHVFKGWNE GKIYFPPTYK YSRNSDRYSG DDLHPKEKRR
TPAWCDRILW FGEGLHQLSY VRGESRFSDH RPVYGIFCAE VESAHNRIKR TTSYSASRVQ
AEELLPYSRG YTELSFF


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