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Type IV pilus biogenesis and competence protein PilQ

 PILQ_NEIMB              Reviewed;         769 AA.
Q70M91; Q4W562;
29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
29-MAR-2005, sequence version 2.
28-MAR-2018, entry version 77.
RecName: Full=Type IV pilus biogenesis and competence protein PilQ;
Flags: Precursor;
Name=pilQ; OrderedLocusNames=NMB1812;
Neisseria meningitidis serogroup B (strain MC58).
Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
Neisseriaceae; Neisseria.
NCBI_TaxID=122586;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ELECTRON CRYOMICROSCOPY.
STRAIN=CCUG 37602 / M1080 / Serogroup B / Serotype 1;
PubMed=15254043; DOI=10.1074/jbc.M405971200;
Collins R.F., Frye S.A., Kitmitto A., Ford R.C., Toenjum T.,
Derrick J.P.;
"Structure of the Neisseria meningitidis outer membrane PilQ secretin
complex at 12 A resolution.";
J. Biol. Chem. 279:39750-39756(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MC58;
PubMed=10710307; DOI=10.1126/science.287.5459.1809;
Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C.,
Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F.,
Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D.,
Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D.,
Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E.,
Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M.,
Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M.,
Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R.,
Venter J.C.;
"Complete genome sequence of Neisseria meningitidis serogroup B strain
MC58.";
Science 287:1809-1815(2000).
[3]
SUBUNIT.
STRAIN=CCUG 37602 / M1080 / Serogroup B / Serotype 1;
PubMed=11395444; DOI=10.1128/JB.183.13.3825-3832.2001;
Collins R.F., Davidsen L., Derrick J.P., Ford R.C., Toenjum T.;
"Analysis of the PilQ secretin from Neisseria meningitidis by
transmission electron microscopy reveals a dodecameric quaternary
structure.";
J. Bacteriol. 183:3825-3832(2001).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=17038831; DOI=10.4161/hv.1.2.1651;
Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.;
"Characterization of the protein content of a meningococcal outer
membrane vesicle vaccine by polyacrylamide gel electrophoresis and
mass spectrometry.";
Hum. Vaccin. 1:80-84(2005).
-!- FUNCTION: Required for type IV pilus biogenesis and competence.
Could function as a pore for exit of the pilus but also as a
channel for entry of heme and antimicrobial agents and uptake of
transforming DNA (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homododecamer. Tetramer of trimer.
{ECO:0000269|PubMed:11395444}.
-!- SUBCELLULAR LOCATION: Cell outer membrane.
-!- MISCELLANEOUS: Present in outer membrane vesicle formulations
which are used as vaccines in human.
-!- SIMILARITY: Belongs to the GSP D family. {ECO:0000305}.
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EMBL; AJ564200; CAD91899.1; -; Genomic_DNA.
EMBL; AE002098; AAY52170.1; -; Genomic_DNA.
RefSeq; NP_274809.1; NC_003112.2.
RefSeq; WP_002225652.1; NC_003112.2.
PDB; 4AQZ; NMR; -; A=224-329.
PDB; 4AV2; EM; 26.00 A; A/B/C/D/E/F/G/H/I/J/K/L=25-769.
PDBsum; 4AQZ; -.
PDBsum; 4AV2; -.
SMR; Q70M91; -.
IntAct; Q70M91; 1.
STRING; 122586.NMB1812; -.
PaxDb; Q70M91; -.
EnsemblBacteria; AAY52170; AAY52170; NMB1812.
GeneID; 903122; -.
KEGG; nme:NMB1812; -.
PATRIC; fig|122586.8.peg.2302; -.
eggNOG; ENOG4105E4G; Bacteria.
eggNOG; COG4796; LUCA.
HOGENOM; HOG000255072; -.
KO; K02666; -.
OMA; QNVPWDQ; -.
OrthoDB; POG091H01XS; -.
BioCyc; NMEN122586:G1G1B-1763-MONOMER; -.
Proteomes; UP000000425; Chromosome.
GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
GO; GO:0008565; F:protein transporter activity; IEA:InterPro.
GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
GO; GO:0009306; P:protein secretion; IEA:InterPro.
Gene3D; 3.30.1370.120; -; 1.
InterPro; IPR021731; AMIN_dom.
InterPro; IPR001775; GspD/PilQ.
InterPro; IPR005644; NolW-like.
InterPro; IPR038591; NolW-like_sf.
InterPro; IPR013355; Pilus_4_PilQ.
InterPro; IPR011662; Secretin/TonB_short_N.
InterPro; IPR004846; T2SS/T3SS.
InterPro; IPR004845; T2SS_GspD_CS.
Pfam; PF11741; AMIN; 1.
Pfam; PF00263; Secretin; 1.
Pfam; PF03958; Secretin_N; 1.
Pfam; PF07660; STN; 1.
PRINTS; PR00811; BCTERIALGSPD.
SMART; SM00965; STN; 1.
TIGRFAMs; TIGR02515; IV_pilus_PilQ; 1.
PROSITE; PS00875; T2SP_D; 1.
1: Evidence at protein level;
3D-structure; Cell outer membrane; Competence; Complete proteome;
Membrane; Protein transport; Reference proteome; Signal; Transport.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 769 Type IV pilus biogenesis and competence
protein PilQ.
/FTId=PRO_0000013117.
VARIANT 203 203 A -> T (in strain: CCUG 37602).
VARIANT 218 225 Missing (in strain: CCUG 37602).
VARIANT 428 428 L -> F (in strain: CCUG 37602).
VARIANT 461 461 R -> A (in strain: CCUG 37602).
VARIANT 475 475 I -> V (in strain: CCUG 37602).
VARIANT 607 607 T -> P (in strain: CCUG 37602).
STRAND 227 233 {ECO:0000244|PDB:4AQZ}.
TURN 234 236 {ECO:0000244|PDB:4AQZ}.
STRAND 237 243 {ECO:0000244|PDB:4AQZ}.
STRAND 252 255 {ECO:0000244|PDB:4AQZ}.
STRAND 257 264 {ECO:0000244|PDB:4AQZ}.
TURN 271 273 {ECO:0000244|PDB:4AQZ}.
STRAND 282 293 {ECO:0000244|PDB:4AQZ}.
STRAND 295 304 {ECO:0000244|PDB:4AQZ}.
STRAND 306 316 {ECO:0000244|PDB:4AQZ}.
STRAND 319 326 {ECO:0000244|PDB:4AQZ}.
SEQUENCE 769 AA; 82473 MW; 1CC24EF102DC4BC9 CRC64;
MNTKLTKIIS GLFVATAAFQ TASAGNITDI KVSSLPNKQK IVKVSFDKEI VNPTGFVTSS
PARIALDFEQ TGISMDQQVL EYADPLLSKI SAAQNSSRAR LVLNLNKPGQ YNTEVRGNKV
WIFINESDDT VSAPARPAVK AAPAAPAKQQ AAAPSTKSAV SVSEPFTPAK QQAAAPFTES
VVSVSAPFSP AKQQAAASAK QQAAAPAKQQ AAAPAKQQAA APAKQTNIDF RKDGKNAGII
ELAALGFAGQ PDISQQHDHI IVTLKNHTLP TTLQRSLDVA DFKTPVQKVT LKRLNNDTQL
IITTAGNWEL VNKSAAPGYF TFQVLPKKQN LESGGVNNAP KTFTGRKISL DFQDVEIRTI
LQILAKESGM NIVASDSVNG KMTLSLKDVP WDQALDLVMQ ARNLDMRQQG NIVNIAPRDE
LLAKDKALLQ AEKDIADLGA LYSQNFQLKY KNVEEFRSIL RLDNADTTGN RNTLISGRGS
VLIDPATNTL IVTDTRSVIE KFRKLIDELD VPAQQVMIEA RIVEAADGFS RDLGVKFGAT
GKKKLKNDTS AFGWGVNSGF GGDDKWGAET KINLPITAAA NSISLVRAIS SGALNLELSA
SESLSKTKTL ANPRVLTQNR KEAKIESGYE IPFTVTSIAN GGSSTNTELK KAVLGLTVTP
NITPDGQIIM TVKINKDSPA QCASGNQTIL CISTKNLNTQ AMVENGGTLI VGGIYEEDNG
NTLTKVPLLG DIPVIGNLFK TRGKKTDRRE LLIFITPRIM GTAGNSLRY


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