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Type-1A angiotensin II receptor (Angiotensin II type-1A receptor) (AT1A)

 AGTRA_RAT               Reviewed;         359 AA.
P25095; Q9QVS5;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
01-MAY-1992, sequence version 1.
12-SEP-2018, entry version 159.
RecName: Full=Type-1A angiotensin II receptor;
AltName: Full=Angiotensin II type-1A receptor;
Short=AT1A;
Name=Agtr1; Synonyms=Agtr1a, At1a;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Vascular smooth muscle;
PubMed=2041570; DOI=10.1038/351233a0;
Murphy T.J., Alexander R.W., Griendling K.K., Runge M.S.,
Bernstein K.E.;
"Isolation of a cDNA encoding the vascular type-1 angiotensin II
receptor.";
Nature 351:233-236(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=2043116; DOI=10.1016/0006-291X(91)91982-I;
Iwai N., Yamano Y., Chaki S., Konishi F., Bardhan S., Tibbetts C.,
Sasaki K., Hasegawa M., Matsuda Y., Inagami T.;
"Rat angiotensin II receptor: cDNA sequence and regulation of the gene
expression.";
Biochem. Biophys. Res. Commun. 177:299-304(1991).
[3]
NUCLEOTIDE SEQUENCE.
PubMed=1533121; DOI=10.1016/S0006-291X(05)80293-1;
Langford K.G., Frenzel K., Martin B.M., Bernstein K.E.;
"The genomic organization of the rat AT1 angiotensin receptor.";
Biochem. Biophys. Res. Commun. 183:1025-1032(1992).
[4]
NUCLEOTIDE SEQUENCE.
TISSUE=Adrenal gland;
PubMed=1544458; DOI=10.1016/0014-5793(92)80071-N;
Iwai N., Inagami T.;
"Identification of two subtypes in the rat type I angiotensin II
receptor.";
FEBS Lett. 298:257-260(1992).
[5]
NUCLEOTIDE SEQUENCE.
PubMed=7713098; DOI=10.1093/eurheartj/15.suppl_D.104;
Inagami T., Iwai N., Sasaki K., Yamano Y., Bardhan S., Chaki S.,
Guo D.F., Furuta H., Ohyama K., Kambayashi Y., Takahashi K.,
Ichiki T.;
"Cloning, expression and regulation of angiotensin II receptors.";
Eur. Heart J. 15:104-107(1994).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE OF 84-259.
TISSUE=Kidney;
PubMed=1599457; DOI=10.1016/S0006-291X(05)80976-3;
Ye M.Q., Healy D.P.;
"Characterization of an angiotensin type-1 receptor partial cDNA from
rat kidney: evidence for a novel AT1B receptor subtype.";
Biochem. Biophys. Res. Commun. 185:204-210(1992).
[8]
INTERACTION WITH ARRB1.
PubMed=11579203; DOI=10.1210/mend.15.10.0714;
Qian H., Pipolo L., Thomas W.G.;
"Association of beta-Arrestin 1 with the type 1A angiotensin II
receptor involves phosphorylation of the receptor carboxyl terminus
and correlates with receptor internalization.";
Mol. Endocrinol. 15:1706-1719(2001).
-!- FUNCTION: Receptor for angiotensin II. Mediates its action by
association with G proteins that activate a phosphatidylinositol-
calcium second messenger system.
-!- SUBUNIT: Interacts with MAS1 (By similarity). Interacts with ARRB1
(PubMed:11579203). Interacts with FLNA (via filamin repeat 21);
increases PKA-mediated phosphorylation of FLNA (By similarity).
{ECO:0000250|UniProtKB:P30556, ECO:0000269|PubMed:11579203}.
-!- INTERACTION:
P01019:AGT (xeno); NbExp=10; IntAct=EBI-764979, EBI-751728;
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Is expressed in the liver, kidney, aorta,
lung, uterus, ovary, spleen, heart, adrenal gland, and vascular
smooth muscle cell.
-!- PTM: C-terminal Ser or Thr residues may be phosphorylated.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
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EMBL; X62295; CAA44183.1; -; mRNA.
EMBL; M74054; AAA40738.1; -; mRNA.
EMBL; BC078810; AAH78810.1; -; mRNA.
EMBL; M86912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
PIR; JC2134; JC2134.
RefSeq; NP_112247.2; NM_030985.4.
RefSeq; XP_006253944.1; XM_006253882.3.
RefSeq; XP_008769816.1; XM_008771594.2.
UniGene; Rn.9814; -.
PDB; 2AC6; Model; -; A=1-359.
PDB; 2AH3; Model; -; A=1-359.
PDBsum; 2AC6; -.
PDBsum; 2AH3; -.
ProteinModelPortal; P25095; -.
SMR; P25095; -.
BioGrid; 246370; 8.
IntAct; P25095; 6.
MINT; P25095; -.
STRING; 10116.ENSRNOP00000034687; -.
BindingDB; P25095; -.
ChEMBL; CHEMBL329; -.
GuidetoPHARMACOLOGY; 34; -.
iPTMnet; P25095; -.
PhosphoSitePlus; P25095; -.
PaxDb; P25095; -.
PRIDE; P25095; -.
Ensembl; ENSRNOT00000038532; ENSRNOP00000034687; ENSRNOG00000018346.
GeneID; 24180; -.
KEGG; rno:24180; -.
UCSC; RGD:2070; rat.
CTD; 11607; -.
RGD; 2070; Agtr1a.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00760000119055; -.
HOGENOM; HOG000234122; -.
HOVERGEN; HBG104998; -.
InParanoid; P25095; -.
KO; K04166; -.
OMA; YTLIWKT; -.
OrthoDB; EOG091G0C1Y; -.
PhylomeDB; P25095; -.
TreeFam; TF330024; -.
Reactome; R-RNO-375276; Peptide ligand-binding receptors.
Reactome; R-RNO-416476; G alpha (q) signalling events.
Reactome; R-RNO-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-RNO-8856828; Clathrin-mediated endocytosis.
PRO; PR:P25095; -.
Proteomes; UP000002494; Chromosome 17.
Bgee; ENSRNOG00000018346; Expressed in 9 organ(s), highest expression level in liver.
Genevisible; P25095; RN.
GO; GO:0016323; C:basolateral plasma membrane; IDA:RGD.
GO; GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0012505; C:endomembrane system; IDA:RGD.
GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
GO; GO:0016021; C:integral component of membrane; TAS:RGD.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0031968; C:organelle outer membrane; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0055037; C:recycling endosome; IDA:RGD.
GO; GO:0031983; C:vesicle lumen; IDA:RGD.
GO; GO:0012506; C:vesicle membrane; IDA:RGD.
GO; GO:0001596; F:angiotensin type I receptor activity; IDA:RGD.
GO; GO:0004945; F:angiotensin type II receptor activity; IEA:InterPro.
GO; GO:0031748; F:D1 dopamine receptor binding; IPI:RGD.
GO; GO:0001965; F:G-protein alpha-subunit binding; IMP:RGD.
GO; GO:0017046; F:peptide hormone binding; IMP:RGD.
GO; GO:0019901; F:protein kinase binding; IPI:RGD.
GO; GO:0043621; F:protein self-association; IMP:RGD.
GO; GO:0042976; P:activation of Janus kinase activity; IMP:RGD.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0038166; P:angiotensin-activated signaling pathway; IMP:BHF-UCL.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0002035; P:brain renin-angiotensin system; IEA:Ensembl.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; IDA:UniProtKB.
GO; GO:0042416; P:dopamine biosynthetic process; IMP:RGD.
GO; GO:0042756; P:drinking behavior; IMP:RGD.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0034392; P:negative regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IDA:RGD.
GO; GO:0045777; P:positive regulation of blood pressure; IMP:BHF-UCL.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
GO; GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO; GO:0032930; P:positive regulation of superoxide anion generation; IMP:RGD.
GO; GO:0008217; P:regulation of blood pressure; TAS:RGD.
GO; GO:0006885; P:regulation of pH; IDA:RGD.
GO; GO:0002019; P:regulation of renal output by angiotensin; IEA:Ensembl.
GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
GO; GO:0002001; P:renin secretion into blood stream; IEA:Ensembl.
GO; GO:0002018; P:renin-angiotensin regulation of aldosterone production; IMP:RGD.
GO; GO:0014823; P:response to activity; IEP:RGD.
GO; GO:1990776; P:response to angiotensin; IEP:RGD.
GO; GO:0051412; P:response to corticosterone; IEP:RGD.
GO; GO:0043627; P:response to estrogen; IDA:RGD.
GO; GO:0009651; P:response to salt stress; IEP:RGD.
GO; GO:0042310; P:vasoconstriction; IMP:RGD.
CDD; cd15192; 7tmA_AT1R; 1.
InterPro; IPR000190; ATII_AT1_rcpt.
InterPro; IPR000248; ATII_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00241; ANGIOTENSINR.
PRINTS; PR00635; ANGIOTENSN1R.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
Palmitate; Phosphoprotein; Receptor; Reference proteome; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 359 Type-1A angiotensin II receptor.
/FTId=PRO_0000069160.
TOPO_DOM 1 27 Extracellular. {ECO:0000255}.
TRANSMEM 28 52 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 53 64 Cytoplasmic. {ECO:0000255}.
TRANSMEM 65 87 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 88 102 Extracellular. {ECO:0000255}.
TRANSMEM 103 124 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 125 142 Cytoplasmic. {ECO:0000255}.
TRANSMEM 143 162 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 163 192 Extracellular. {ECO:0000255}.
TRANSMEM 193 214 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 215 240 Cytoplasmic. {ECO:0000255}.
TRANSMEM 241 262 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 263 275 Extracellular. {ECO:0000255}.
TRANSMEM 276 296 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 297 359 Cytoplasmic. {ECO:0000255}.
LIPID 355 355 S-palmitoyl cysteine. {ECO:0000255}.
CARBOHYD 4 4 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 176 176 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 188 188 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 101 180 {ECO:0000255|PROSITE-ProRule:PRU00521}.
CONFLICT 81 81 L -> C (in Ref. 2; AAA40738).
{ECO:0000305}.
CONFLICT 109 109 S -> T (in Ref. 2 and 5). {ECO:0000305}.
SEQUENCE 359 AA; 40890 MW; 200EAE56DB4DA678 CRC64;
MALNSSAEDG IKRIQDDCPK AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL CKIASASVSF NLYASVFLLT
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLMAGLAS LPAVIHRNVY FIENTNITVC
AFHYESRNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR
IIMAIVLFFF FSWVPHQIFT FLDVLIQLGV IHDCKISDIV DTAMPITICI AYFNNCLNPL
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSSAK KPASCFEVE


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