Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2)

 AGTR2_RAT               Reviewed;         363 AA.
P35351;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
07-NOV-2018, entry version 136.
RecName: Full=Type-2 angiotensin II receptor;
AltName: Full=Angiotensin II type-2 receptor;
Short=AT2;
Name=Agtr2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8227011;
Kambayashi Y., Bardhan S., Takahashi K., Tsuzuki S., Inui H.,
Hamakubo T., Inagami T.;
"Molecular cloning of a novel angiotensin II receptor isoform involved
in phosphotyrosine phosphatase inhibition.";
J. Biol. Chem. 268:24543-24546(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Sprague-Dawley; TISSUE=Fetus;
PubMed=8227010;
Mukoyama M., Nakajima M., Horiuchi M., Sasamura H., Pratt R.E.,
Dzau V.J.;
"Expression cloning of type 2 angiotensin II receptor reveals a unique
class of seven-transmembrane receptors.";
J. Biol. Chem. 268:24539-24542(1993).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Fischer; TISSUE=Liver;
PubMed=7490161; DOI=10.1161/01.HYP.26.6.998;
Koike G., Winer E.S., Horiuchi M., Brown D.M., Szpirer C., Dzau V.J.,
Jacob H.J.;
"Cloning, characterization, and genetic mapping of the rat type 2
angiotensin II receptor gene.";
Hypertension 26:998-1002(1995).
[4]
NUCLEOTIDE SEQUENCE.
PubMed=7713098; DOI=10.1093/eurheartj/15.suppl_D.104;
Inagami T., Iwai N., Sasaki K., Yamano Y., Bardhan S., Chaki S.,
Guo D.F., Furuta H., Ohyama K., Kambayashi Y., Takahashi K.,
Ichiki T.;
"Cloning, expression and regulation of angiotensin II receptors.";
Eur. Heart J. 15:104-107(1994).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
STRAIN=Sprague-Dawley;
PubMed=7599191; DOI=10.1016/0167-4781(95)00076-S;
Kobayashi S., Ohnishi J., Nibu Y., Nishimatsu S., Umemura S.,
Ishii M., Murakami K., Miyazaki H.;
"Cloning of the rat angiotensin II type 2 receptor gene and
identification of its functional promoter region.";
Biochim. Biophys. Acta 1262:155-158(1995).
[6]
DISULFIDE BONDS.
PubMed=11068047; DOI=10.1016/S0014-5793(00)02141-4;
Feng Y.H., Saad Y., Karnik S.S.;
"Reversible inactivation of AT(2) angiotensin II receptor from
cysteine-disulfide bond exchange.";
FEBS Lett. 484:133-138(2000).
-!- FUNCTION: Receptor for angiotensin II. Cooperates with MTUS1 to
inhibit ERK2 activation and cell proliferation (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Interacts with MTUS1. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Abundant expression in fetal tissues, immature
brain, skin wound and atretic ovarian follicles.
-!- DEVELOPMENTAL STAGE: Abundant in whole fetus but decreases rapidly
after birth. In adults is highly expressed in the adrenal, present
in the brain and uterus but undetectable in the heart.
-!- PTM: C-terminal Ser or Thr residues may be phosphorylated.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; D16840; BAA04116.1; -; mRNA.
EMBL; U01908; AAC52126.1; -; Genomic_DNA.
EMBL; U22663; AAA86509.1; -; Genomic_DNA.
EMBL; D43778; BAA07833.1; -; Genomic_DNA.
PIR; A49092; A49092.
RefSeq; NP_036626.1; NM_012494.3.
RefSeq; XP_006257494.1; XM_006257432.3.
UniGene; Rn.162367; -.
PDB; 2G2A; Model; -; A=1-363.
PDBsum; 2G2A; -.
ProteinModelPortal; P35351; -.
SMR; P35351; -.
BioGrid; 246372; 1.
STRING; 10116.ENSRNOP00000064709; -.
BindingDB; P35351; -.
ChEMBL; CHEMBL257; -.
GuidetoPHARMACOLOGY; 35; -.
iPTMnet; P35351; -.
PhosphoSitePlus; P35351; -.
PaxDb; P35351; -.
PRIDE; P35351; -.
Ensembl; ENSRNOT00000074269; ENSRNOP00000064709; ENSRNOG00000050006.
GeneID; 24182; -.
KEGG; rno:24182; -.
CTD; 186; -.
RGD; 2072; Agtr2.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00760000119055; -.
HOVERGEN; HBG104998; -.
InParanoid; P35351; -.
KO; K04167; -.
OMA; HKPSDKH; -.
OrthoDB; EOG091G0HEN; -.
PhylomeDB; P35351; -.
Reactome; R-RNO-375276; Peptide ligand-binding receptors.
Reactome; R-RNO-418594; G alpha (i) signalling events.
PRO; PR:P35351; -.
Proteomes; UP000002494; Chromosome X.
Bgee; ENSRNOG00000050006; Expressed in 2 organ(s), highest expression level in brain.
ExpressionAtlas; P35351; baseline and differential.
Genevisible; P35351; RN.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0004945; F:angiotensin type II receptor activity; TAS:RGD.
GO; GO:0001965; F:G-protein alpha-subunit binding; TAS:RGD.
GO; GO:0017046; F:peptide hormone binding; IMP:RGD.
GO; GO:0008134; F:transcription factor binding; IPI:RGD.
GO; GO:0035932; P:aldosterone secretion; IMP:RGD.
GO; GO:0002033; P:angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure; IEA:Ensembl.
GO; GO:0002035; P:brain renin-angiotensin system; IEA:Ensembl.
GO; GO:0061049; P:cell growth involved in cardiac muscle cell development; IMP:RGD.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; IDA:UniProtKB.
GO; GO:0006883; P:cellular sodium ion homeostasis; IMP:RGD.
GO; GO:0021695; P:cerebellar cortex development; IMP:RGD.
GO; GO:0042416; P:dopamine biosynthetic process; IMP:RGD.
GO; GO:0035640; P:exploration behavior; IEA:Ensembl.
GO; GO:0007199; P:G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IDA:RGD.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEP:RGD.
GO; GO:0060993; P:kidney morphogenesis; IMP:RGD.
GO; GO:0048147; P:negative regulation of fibroblast proliferation; IMP:RGD.
GO; GO:0010459; P:negative regulation of heart rate; IEA:Ensembl.
GO; GO:0032304; P:negative regulation of icosanoid secretion; IMP:RGD.
GO; GO:0051387; P:negative regulation of neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
GO; GO:0010700; P:negative regulation of norepinephrine secretion; IDA:RGD.
GO; GO:0030182; P:neuron differentiation; TAS:RGD.
GO; GO:0097755; P:positive regulation of blood vessel diameter; IMP:RGD.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
GO; GO:0050715; P:positive regulation of cytokine secretion; IMP:RGD.
GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0072300; P:positive regulation of metanephric glomerulus development; IEA:Ensembl.
GO; GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Ensembl.
GO; GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IEA:Ensembl.
GO; GO:0035815; P:positive regulation of renal sodium excretion; IMP:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0035566; P:regulation of metanephros size; IEA:Ensembl.
GO; GO:0042306; P:regulation of protein import into nucleus; IDA:RGD.
GO; GO:0001991; P:regulation of systemic arterial blood pressure by circulatory renin-angiotensin; IEA:Ensembl.
GO; GO:0002018; P:renin-angiotensin regulation of aldosterone production; IMP:RGD.
GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
CDD; cd15191; 7tmA_AT2R; 1.
InterPro; IPR000147; ATII_AT2_rcpt.
InterPro; IPR000248; ATII_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00241; ANGIOTENSINR.
PRINTS; PR00636; ANGIOTENSN2R.
PRINTS; PR00237; GPCRRHODOPSN.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 363 Type-2 angiotensin II receptor.
/FTId=PRO_0000069170.
TOPO_DOM 1 45 Extracellular. {ECO:0000255}.
TRANSMEM 46 71 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 72 80 Cytoplasmic. {ECO:0000255}.
TRANSMEM 81 102 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 103 119 Extracellular. {ECO:0000255}.
TRANSMEM 120 140 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 141 160 Cytoplasmic. {ECO:0000255}.
TRANSMEM 161 179 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 180 208 Extracellular. {ECO:0000255}.
TRANSMEM 209 234 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 235 256 Cytoplasmic. {ECO:0000255}.
TRANSMEM 257 278 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 279 297 Extracellular. {ECO:0000255}.
TRANSMEM 298 318 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 319 363 Cytoplasmic. {ECO:0000255}.
MOD_RES 354 354 Phosphoserine; by PKC. {ECO:0000255}.
CARBOHYD 4 4 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13 13 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 24 24 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 29 29 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 34 34 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 35 290 {ECO:0000255|PROSITE-ProRule:PRU00521,
ECO:0000269|PubMed:11068047}.
DISULFID 117 195 {ECO:0000255|PROSITE-ProRule:PRU00521,
ECO:0000269|PubMed:11068047}.
SEQUENCE 363 AA; 41331 MW; 4FE4551A41336650 CRC64;
MKDNFSFAAT SRNITSSLPF DNLNATGTNE SAFNCSHKPA DKHLEAIPVL YYMIFVIGFA
VNIVVVSLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF
GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY
FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK
TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR KSSSLREMDT
FVS


Related products :

Catalog number Product name Quantity
U1658h CLIA AGTR1,AGTR1A,AGTR1B,Angiotensin II type-1 receptor,AT1,AT1AR,AT1BR,AT2R1,AT2R1B,Homo sapiens,Human,Type-1 angiotensin II receptor 96T
E1658h ELISA AGTR1,AGTR1A,AGTR1B,Angiotensin II type-1 receptor,AT1,AT1AR,AT1BR,AT2R1,AT2R1B,Homo sapiens,Human,Type-1 angiotensin II receptor 96T
E1658h ELISA kit AGTR1,AGTR1A,AGTR1B,Angiotensin II type-1 receptor,AT1,AT1AR,AT1BR,AT2R1,AT2R1B,Homo sapiens,Human,Type-1 angiotensin II receptor 96T
U1658m CLIA Agtr1,Agtr1a,Angiotensin II type-1A receptor,AT1A,Mouse,Mus musculus,Type-1A angiotensin II receptor 96T
E1658m ELISA kit Agtr1,Agtr1a,Angiotensin II type-1A receptor,AT1A,Mouse,Mus musculus,Type-1A angiotensin II receptor 96T
E1658m ELISA Agtr1,Agtr1a,Angiotensin II type-1A receptor,AT1A,Mouse,Mus musculus,Type-1A angiotensin II receptor 96T
E0973h ELISA AGTR2,Angiotensin II type-2 receptor,AT2,Homo sapiens,Human,Type-2 angiotensin II receptor 96T
E0973h ELISA kit AGTR2,Angiotensin II type-2 receptor,AT2,Homo sapiens,Human,Type-2 angiotensin II receptor 96T
U1658Rb CLIA AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor 96T
E1658Rb ELISA kit AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor 96T
E1658Rb ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Oryctolagus cuniculus,Rabbit,Type-1 angiotensin II receptor 96T
U0973h CLIA AGTR2,Angiotensin II type-2 receptor,AT2,Homo sapiens,Human,Type-2 angiotensin II receptor 96T
E1658b ELISA kit AGTR1,Angiotensin II type-1 receptor,AT1,Bos taurus,Bovine,Type-1 angiotensin II receptor 96T
E0973r ELISA Agtr2,Angiotensin II type-2 receptor,AT2,Rat,Rattus norvegicus,Type-2 angiotensin II receptor 96T
E0973r ELISA kit Agtr2,Angiotensin II type-2 receptor,AT2,Rat,Rattus norvegicus,Type-2 angiotensin II receptor 96T
U0973m CLIA Agtr2,Angiotensin II type-2 receptor,AT2,Mouse,Mus musculus,Type-2 angiotensin II receptor 96T
E0973m ELISA kit Agtr2,Angiotensin II type-2 receptor,AT2,Mouse,Mus musculus,Type-2 angiotensin II receptor 96T
U0973r CLIA Agtr2,Angiotensin II type-2 receptor,AT2,Rat,Rattus norvegicus,Type-2 angiotensin II receptor 96T
E1658b ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Bos taurus,Bovine,Type-1 angiotensin II receptor 96T
U1658b CLIA AGTR1,Angiotensin II type-1 receptor,AT1,Bos taurus,Bovine,Type-1 angiotensin II receptor 96T
E0973m ELISA Agtr2,Angiotensin II type-2 receptor,AT2,Mouse,Mus musculus,Type-2 angiotensin II receptor 96T
E1658p ELISA kit AGTR1,Angiotensin II type-1 receptor,AT1,Pig,Sus scrofa,Type-1 angiotensin II receptor 96T
U1658p CLIA AGTR1,Angiotensin II type-1 receptor,AT1,Pig,Sus scrofa,Type-1 angiotensin II receptor 96T
E1658p ELISA AGTR1,Angiotensin II type-1 receptor,AT1,Pig,Sus scrofa,Type-1 angiotensin II receptor 96T
E1658r ELISA kit Agtr1,Agtr1a,Angiotensin II type-1A receptor,AT1A,At1a,Rat,Rattus norvegicus,Type-1A angiotensin II receptor 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur