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Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH)

 TY3H_MOUSE              Reviewed;         498 AA.
P24529;
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
30-AUG-2017, entry version 149.
RecName: Full=Tyrosine 3-monooxygenase;
EC=1.14.16.2;
AltName: Full=Tyrosine 3-hydroxylase;
Short=TH;
Name=Th;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1674869; DOI=10.1016/0006-291X(91)90472-J;
Ichikawa S., Sasaoka T., Nagatsu T.;
"Primary structure of mouse tyrosine hydroxylase deduced from its
cDNA.";
Biochem. Biophys. Res. Commun. 176:1610-1616(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-30.
STRAIN=BALB/cJ;
Morgan W.W., Bermudez J., Sharp Z.D.;
Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases.
[3]
PROTEIN SEQUENCE OF 78-90.
TISSUE=Brain;
Lubec G., Yang J.W., Zigmond M.;
Submitted (JUL-2007) to UniProtKB.
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-31 AND SER-472,
AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, and Brown adipose tissue;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Plays an important role in the physiology of adrenergic
neurons.
-!- CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O(2) = L-
dopa + 4a-hydroxytetrahydrobiopterin.
-!- COFACTOR:
Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
-!- ENZYME REGULATION: Phosphorylation leads to an increase in the
catalytic activity.
-!- PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis;
dopamine from L-tyrosine: step 1/2.
-!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
hydroxylase family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M69200; AAA40434.1; -; mRNA.
EMBL; X53503; CAA37580.1; -; Genomic_DNA.
CCDS; CCDS22036.1; -.
PIR; JN0068; JN0068.
RefSeq; NP_033403.1; NM_009377.1.
UniGene; Mm.1292; -.
ProteinModelPortal; P24529; -.
SMR; P24529; -.
IntAct; P24529; 1.
MINT; MINT-4138908; -.
STRING; 10090.ENSMUSP00000000219; -.
iPTMnet; P24529; -.
PhosphoSitePlus; P24529; -.
MaxQB; P24529; -.
PaxDb; P24529; -.
PeptideAtlas; P24529; -.
PRIDE; P24529; -.
DNASU; 21823; -.
Ensembl; ENSMUST00000000219; ENSMUSP00000000219; ENSMUSG00000000214.
GeneID; 21823; -.
KEGG; mmu:21823; -.
UCSC; uc009koi.1; mouse.
CTD; 7054; -.
MGI; MGI:98735; Th.
eggNOG; KOG3820; Eukaryota.
eggNOG; COG3186; LUCA.
GeneTree; ENSGT00390000010268; -.
HOGENOM; HOG000233373; -.
HOVERGEN; HBG006841; -.
InParanoid; P24529; -.
KO; K00501; -.
OMA; PKHASEL; -.
OrthoDB; EOG091G05MZ; -.
PhylomeDB; P24529; -.
TreeFam; TF313327; -.
Reactome; R-MMU-209905; Catecholamine biosynthesis.
UniPathway; UPA00747; UER00733.
PRO; PR:P24529; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000000214; -.
CleanEx; MM_TH; -.
ExpressionAtlas; P24529; baseline and differential.
Genevisible; P24529; MM.
GO; GO:0030424; C:axon; IDA:MGI.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; ISO:MGI.
GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0033162; C:melanosome membrane; ISO:MGI.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0043005; C:neuron projection; IDA:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0043204; C:perikaryon; IDA:MGI.
GO; GO:0005790; C:smooth endoplasmic reticulum; ISO:MGI.
GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO; GO:0043195; C:terminal bouton; IEA:Ensembl.
GO; GO:0016597; F:amino acid binding; IEA:Ensembl.
GO; GO:0035240; F:dopamine binding; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; ISO:MGI.
GO; GO:0008199; F:ferric iron binding; IEA:Ensembl.
GO; GO:0008198; F:ferrous iron binding; IEA:Ensembl.
GO; GO:0019825; F:oxygen binding; IEA:Ensembl.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0034617; F:tetrahydrobiopterin binding; IEA:Ensembl.
GO; GO:0004511; F:tyrosine 3-monooxygenase activity; ISO:MGI.
GO; GO:0015842; P:aminergic neurotransmitter loading into synaptic vesicle; IEA:Ensembl.
GO; GO:0009887; P:animal organ morphogenesis; IMP:MGI.
GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO; GO:0071287; P:cellular response to manganese ion; IEA:Ensembl.
GO; GO:0071316; P:cellular response to nicotine; IEA:Ensembl.
GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO; GO:0042745; P:circadian sleep/wake cycle; IEA:Ensembl.
GO; GO:0042416; P:dopamine biosynthetic process; ISO:MGI.
GO; GO:0006585; P:dopamine biosynthetic process from tyrosine; IDA:MGI.
GO; GO:0042755; P:eating behavior; IMP:MGI.
GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IMP:BHF-UCL.
GO; GO:0042418; P:epinephrine biosynthetic process; ISO:MGI.
GO; GO:0042462; P:eye photoreceptor cell development; IMP:BHF-UCL.
GO; GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO; GO:0016137; P:glycoside metabolic process; IEA:Ensembl.
GO; GO:0007507; P:heart development; IMP:MGI.
GO; GO:0033076; P:isoquinoline alkaloid metabolic process; IEA:Ensembl.
GO; GO:0007612; P:learning; IMP:MGI.
GO; GO:0007626; P:locomotory behavior; IMP:MGI.
GO; GO:0007617; P:mating behavior; IMP:MGI.
GO; GO:0007613; P:memory; IMP:MGI.
GO; GO:0010259; P:multicellular organism aging; IEA:Ensembl.
GO; GO:0042136; P:neurotransmitter biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0042421; P:norepinephrine biosynthetic process; ISO:MGI.
GO; GO:0018963; P:phthalate metabolic process; IEA:Ensembl.
GO; GO:0052314; P:phytoalexin metabolic process; IEA:Ensembl.
GO; GO:0008016; P:regulation of heart contraction; IMP:MGI.
GO; GO:0014823; P:response to activity; IEA:Ensembl.
GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
GO; GO:0051602; P:response to electrical stimulus; IEA:Ensembl.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0045471; P:response to ethanol; ISO:MGI.
GO; GO:0045472; P:response to ether; IEA:Ensembl.
GO; GO:0009635; P:response to herbicide; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; ISO:MGI.
GO; GO:0035902; P:response to immobilization stress; IEA:Ensembl.
GO; GO:0035900; P:response to isolation stress; IEA:Ensembl.
GO; GO:0009416; P:response to light stimulus; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0031667; P:response to nutrient levels; IEA:Ensembl.
GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
GO; GO:0046684; P:response to pyrethroid; IEA:Ensembl.
GO; GO:0009651; P:response to salt stress; IEA:Ensembl.
GO; GO:0009414; P:response to water deprivation; IEA:Ensembl.
GO; GO:0010043; P:response to zinc ion; IEA:Ensembl.
GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
GO; GO:0035176; P:social behavior; IEA:Ensembl.
GO; GO:0006665; P:sphingolipid metabolic process; IEA:Ensembl.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IMP:MGI.
GO; GO:0042214; P:terpene metabolic process; IEA:Ensembl.
GO; GO:0007601; P:visual perception; IMP:BHF-UCL.
Gene3D; 1.10.800.10; -; 1.
InterPro; IPR001273; ArAA_hydroxylase.
InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
InterPro; IPR005962; Tyr_3_mOase.
InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
InterPro; IPR021164; Tyrosine_hydroxylase_CS.
PANTHER; PTHR11473; PTHR11473; 1.
Pfam; PF00351; Biopterin_H; 1.
Pfam; PF12549; TOH_N; 2.
PIRSF; PIRSF000336; TH; 1.
PRINTS; PR00372; FYWHYDRXLASE.
SUPFAM; SSF56534; SSF56534; 1.
TIGRFAMs; TIGR01269; Tyr_3_monoox; 1.
PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
1: Evidence at protein level;
Catecholamine biosynthesis; Complete proteome;
Direct protein sequencing; Iron; Metal-binding; Monooxygenase;
Neurotransmitter biosynthesis; Oxidoreductase; Phosphoprotein;
Reference proteome.
CHAIN 1 498 Tyrosine 3-monooxygenase.
/FTId=PRO_0000205562.
COMPBIAS 51 59 Poly-Ala.
METAL 331 331 Iron. {ECO:0000250}.
METAL 336 336 Iron. {ECO:0000250}.
METAL 376 376 Iron. {ECO:0000250}.
MOD_RES 19 19 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 31 31 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 40 40 Phosphoserine; by CaMK2 and PKA.
{ECO:0000250|UniProtKB:P07101}.
MOD_RES 472 472 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
SEQUENCE 498 AA; 55993 MW; 62790179664F6DC6 CRC64;
MPTPSASSPQ PKGFRRAVSE QDTKQAEAVT SPRFIGRRQS LIEDARKERE AAAAAAAAAV
ASAEPGNPLE AVVFEERDGN AVLNLLFSLR GTKPSSLSRA LKVFETFEAK IHHLETRPAQ
RPLAGSPHLE YFVRFEVPSG DLAALLSSVR RVSDDVRSAR EDKVPWFPRK VSELDKCHHL
VTKFDPDLDL DHPGFSDQAY RQRRKLIAEI AFQYKQGEPI PHVEYTKEEI ATWKEVYATL
KGLYATHACR EHLEAFQLLE RYCGYREDSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF
LASLAFRVFQ CTQYIRHASS PMHSPEPDCC HELLGHVPML ADRTFAQFSQ DIGLASLGAS
DEEIEKLSTV YWFTVEFGLC KQNGELKAYG AGLLSSYGEL LHSLSEEPEV RAFDPDTAAV
QPYQDQTYQP VYFVSESFSD AKDKLRNYAS RIQRPFSVKF DPYTLAIDVL DSPHTIRRSL
EGVQDELHTL TQALSAIS


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